p16INK4A immunohistochemical overexpression in premalignant and malignant oral lesions infected with human papillomavirus

Journal of Histochemistry and Cytochemistry

Volumn 51, Issue 10, 2003, Pages 1291-1297

  Fregonesi, Paula Andrea Gabrielli ^a   Teresa, Debora Barreto ^a   Duarte, Roberta Aparecida ^a   Neto, Carlos Benatti ^a   De Oliveira, Maria Rita Brancini ^a   Soares, Christiane Pienna ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

HPV; Immunohistochemistry; In situ hybridization; Oral cancer; p16INK4A

Indexed keywords

ONCOPROTEIN; PROTEIN P16; VIRUS DNA;

ARTICLE; BENIGN TUMOR; CARCINOGENICITY; CLINICAL ARTICLE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALIGNANT NEOPLASTIC DISEASE; MOUTH CANCER; MOUTH LESION; ORAL BIOPSY; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS INFECTION; WART VIRUS;

DNA VIRUSES; HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPES; PAPILLOMAVIRUS;

EID: 0141731157     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215540305101006     Document Type: Article

References (46)

1. Akanuma D, Uzawa N, Yoshida MA, Negishi A, Amagasa T, Ikeuchi I (1999) Inactivation patterns of the p16(INK4A) gene in oral squamous cell carcinoma. Oral Oncol 35:476-483
2. Bibbo M, DeCecco J, Kovatich AJ (2003) P16INK4A as an adjunct test in liquid-based cytology. Anal Quant Cytol and Histol 25:8-11
3. Bibbo M, Klump WJ, DeCecco J, Kovatich AJ (2002) Procedure for immunocytochemical detection of P16INK4A antigen in thin-layer, liquid-based specimens. Acta Cytol 46:25-29
4. Birner P, Bachtiary B, Dreier B, Schindl M, Joura EA, Breitenecker G, Oberhuber G (2001) Signal-amplified colorimetric in situ hybridization for assessment of human papillomavirus in cervical lesions. Mod Pathol 14:702-709
5. Chen QM, Luo G, Li BQ, Samaranayake LP (1999) Expression of p16 and CDK4 in oral premalignant lesions and oral squamous cell carcinomas: a semi-quantitative immunohistochemical study. J Oral Pathol Med 28:158-164
6. D'Costa J, Saranath D, Dedhia P, Sanghvi V, Mehra AR (1998) Detection of HPV-16 genome in human oral cancers and potentially malignant lesions from India. Oral Oncol 34:413-420
7. De Villiers EM (1997) Papillomavirus and HPV typing. Clin Dermatol 15:199-206
8. Doeberitz MK (2002) New marker for cervical dysplasia to visualise the genomic chaos created by aberrant oncogenic papillomavirus infection. Eur J Cancer 38:2220-2242
9. Faulkner-Jones BE, Bellomarino VM, Borg AJ, Orzeszko K, Garland SM (1990) Detection and typing of human papillomavirus using ViraType in situ hybridization kit: comparison with a conventional dot blot technique. J Clin Pathol 43:913-917
10. Fornatora M, Jones AC, Kerpel S, Freedman P (1996) Human papillomavirus-associated oral epithelial dysplasia (koilocytic dysplasia): an entity of unknown biologic potential. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 82:47-56
11. INK4A in archival human solid tumors: correlation with retinoblastoma protein expression. Cancer Res 55:6006-6011
12. Hall M, Peters G (1996) Genetic alterations of cyclins, cyclin-dependent kinases and CDK inhibitors in human cancer. Adv Cancer Res 68:67-108
13. INK4A gene alterations in primary cervical carcinoma tissues and cell lines with human papillomavirus infection. Gynecol Oncol 70:75-79
14. INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol 26:1389-1399
15. Klaes R, Friedrich T, Spitkovsky D, Ridder R, Rudy W, Petry U, Dallenbach-Hellweg G, et al. (2001) Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer 92:276-284
16. Lizard G, Demares-Poulet MJ, Roignot P, Gambert P (2001) In situ hybridization detection of single-copy human papillomavirus on isolated cells, using catalyzed signal amplification system: Gen-point. Diagn Cytopathol 24:112-116
17. Llewellyn CD, Johnson NW, Warnakulasuriya KAAS (2001) Risk factors for squamous cell carcinoma of the oral cavity in young people - a comprehensive literature review. Oral Oncol 37:401-418
18. Mao EJ (1995) Prevalence of human papillomavirus 16 and nucleolar organizer region counts in oral exfoliated cells from normal and malignant epithelia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 80:320-329
19. Miguel RE, Villa LL, Cordeiro AC, Prado JC, Sobrinho JS, Kowalski LP (1998) Low prevalence of human papillomavirus in a geographic region with a high incidence of head and neck cancer. Am J Surg 176:428-429
20. Miller CS, Johnstone BM (2001) Human papillomavirus as a risk factor for oral squamous cell carcinoma: a meta-analysis, 1982-1997. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:622-635
21. Miller CS, White DK (1996) Human papillomavirus expression in oral mucosa, premalignant conditions, and squamous cell carcinoma: a retrospective review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 82:57-68
22. Nagpal JK, Das Bibhu R (2003). Oral cancer: reviewing the present understanding of its molecular mechanism and exploring the future directions for its effective management. Oral Oncol 39:213-221
23. Olshan AF, Weissler MC, Pei H, Conway K, Anderson S, Fried DB, Yarbrough WG (1997) Alterations of p16 gene in head and neck: frequency and association with p53, PRAD-1 and HPV. Oncogene 14:811-818
24. Pande P, Mathur M, Shukla NK, Ralham R (1998) pRB and p16 protein alteration in human oral tumorigenesis. Oral Oncol 34:396-403
25. INK4a in oral premalignant lesions. Oncogene 14:1799-1803
26. Paparotto Lopes SM, Meeks VI (2001) Analysis of HPV 16 and 18 by in situ hybridization in oral papilloma of HIV+ patients. Gen Dent 49:386-389
27. Reed AL, Califano J, Cairins P, Westra WH, Jones RM, Koch W, Ahrendt S, et al. (1996) High frequency of p16 (CDKN2/MST-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res 56:3630-3633
28. INK4A enrichment and premature senescence of oral fibroblasts. Oncogene 16:1113-1123
29. Rocco JW, Sidransky D (2001) p16(MTS-1/CDKN2/INK4a) in cancer progression. Exp Cell Res 264:42-55
30. Saito T, Nakajima T, Mogi K (1999) Immunohistochemical analysis of cell cycle-associated proteins p16, pRB, p53, p27 and Ki-67 in oral cancer and precancer with special reference to verrucous carcinomas. J Oral Pathol Med 28:226-232
31. Sand L, Jalouli J, Larsson PA, Hirsch JM (2000) Human papillomaviruses in oral lesions. Anticancer Res 20:1183-1188
32. Sano T, Oyama T, Kashiwabara K, Fukuda T, Nakailma T (1998) Immunohistochemical overexpression of p16 protein associated with intact retinoblastoma protein expression in cervical cancer and cervical intraepithelial neoplasia. Pathol Int 48:580-585
33. Schneider A, Meinhardt G, Kirchmayer E, Schneider V (1991) Prevalence of human papillomavirus genomes in tissues from the lower genital tract as detected by molecular in situ hybridization. Int J Gynecol Pathol 10:1-14
34. Schoelch ML, Regezi JA, Dekker NP, Ngi OL, McMillan A, Ziober BL, Thu le Q, et al. (1999) Cell-cycle proteins and the development of oral squamous cell carcinoma. Oral Oncol 35:333-342
35. Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, De Pinho RA (1996) Role of the INK4a locus in tumor suppressor and cell mortality. Cell 85:27-37
36. Sherr CJ (1996) Cancer cell cycles. Science 274:1672-1677
37. INK4A gene is a frequent event in human oral squamous cell carcinomas. Oral Oncol 37:498-504
38. Soares CP, Neto CB, Fregonesi PAG, Teresa DB, Longatto Filho A, Maeda MYS, Santos RTM (2003) Computer-assisted analysis of p53 and PCNA expression on oral lesions infected with human papillomavirus. Anal Quant Cytol Histol 25:19-24
39. Stillman B (1996) Cell cycle control of DNA replication. Science 274:1659-1664
40. Tanaka N, Odajima T, Mimura N, Ogi K, Dehari H, Kimijima Y, Kohama G (2001) Expression of Rb, pRB/p130, p53 and p16 proteins in malignant melanoma of oral mucosa. Oral Oncol 37:308-314
41. Tsai YH, Yang C, Chou SS, Chou CY (2001) The correlation between alteration of p16 gene and clinical status in oral squamous cell carcinoma. J Oral Pathol Med 30:527-531
42. Van der Waal J, Schepmam KP, Van der Mey EH (2000) A modified classification and staging system for oral leukoplakia. Oral Oncol 36:264-266
43. Yamato K, Hashimoto S, Okahashi N, Ishisaki A, Nonaka K, Koseki T, Kizaki M, et al. (2000) Dissociation of bone morphogenetic protein-mediated growth arrest and apoptosis of mouse cells by HPV-16 E6/E7. Exp Cell Res 257:198-205
44. Yoo J, Park SY, Kang SJ, Shim SI, Kim BK (2002) Altered expression of G1 regulatory proteins in human soft tissue sarcomas. Arch Pathol Lab Med 126:567-573
45. Zhang SY, Klein-Szanto AJP, Sauterer Shafarenko M, Mitsunaga S, Nobori T, Carson DA, et al. (1994) Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck. Cancer Res 54:5050-5053
46. Zur Hausen H (2002) Papillomavirus and cancer: from basic studies to clinical application. Nature Rev Cancer 2:342-350