Expression of p16 in oral cancer and premalignant lesions

Journal of Oral Pathology and Medicine

Volumn 38, Issue 1, 2009, Pages 104-108

  Buajeeb, Waranun ^a   Poomsawat, Sopee ^a   Punyasingh, Jirapa ^a   Sanguansin, Sirima ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Dysplasia; Oral leukoplakia; Oral squamous cell carcinoma; p16

Indexed keywords

PROTEIN P16;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DYSPLASIA; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEUKOPLAKIA; MALE; MOUTH CANCER; MOUTH MUCOSA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYTOPLASM; EPITHELIAL CELLS; FEMALE; GENES, P16; HUMANS; KERATINOCYTES; LEUKOPLAKIA, ORAL; MALE; MIDDLE AGED; MOUTH MUCOSA; MOUTH NEOPLASMS; PRECANCEROUS CONDITIONS; TUMOR SUPPRESSOR PROTEIN P14ARF;

EID: 58149175944     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2008.00710.x     Document Type: Article

References (35)

1. Silverman S Jr. Demographics and occurrence of oral and pharyngeal cancers: the outcomes, the trends, the challenge. J Am Dent Assoc 2001 132 (Suppl. 7S 11S.
2. Schepman K, van der Meij EH, Smeele L, van der Waal I. Concomitant leukoplakia in patients with oral squamous cell carcinoma. Oral Dis 1999 5 : 206 9.
3. Schepman KP, van der Meij EH, Smeele LE, van der Waal I. Malignant transformation of oral leukoplakia: a follow-up study of a hospital-based population of 166 patients with oral leukoplakia from The Netherlands. Oral Oncol 1998 34 : 270 5.
4. Perez-Ordonez B, Beauchemin M, Jordan RC. Molecular biology of squamous cell carcinoma of the head and neck. J Clin Pathol 2006 59 : 445 53.
5. Reed AL, Califano J, Cairns P, et al. High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res 1996 56 : 3630 3.
6. van Houten VM, Tabor MP, van den Brekel MW, et al. Mutated p53 as a molecular marker for the diagnosis of head and neck cancer. J Pathol 2002 198 : 476 86.
7. Papadimitrakopoulou V, Izzo J, Lippman SM, et al. Frequent inactivation of p16INK4a in oral premalignant lesions. Oncogene 1997 14 : 1799 803.
8. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993 366 : 704 7.
9. Sherr CJ. G1 phase progression: cycling on cue. Cell 1994 79 : 551 5.
10. Morgan DO. Principles of CDK regulation. Nature 1995 374 : 131 4.
11. Li Y, Nichols MA, Shay JW, Xiong Y. Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb. Cancer Res 1994 54 : 6078 82.
12. Pande P, Mathur M, Shukla NK, Ralhan R. pRb and p16 protein alterations in human oral tumorigenesis. Oral Oncol 1998 34 : 396 403.
13. Ai L, Stephenson KK, Ling W, et al. The p16 (CDKN2a/INK4a) tumor-suppressor gene in head and neck squamous cell carcinoma: a promoter methylation and protein expression study in 100 cases. Mod Pathol 2003 16 : 944 50.
14. Bradley KT, Budnick SD, Logani S. Immunohistochemical detection of p16INK4a in dysplastic lesions of the oral cavity. Mod Pathol 2006 19 : 1310 6.
15. Gologan O, Barnes EL, Hunt JL. Potential diagnostic use of p16INK4A, a new marker that correlates with dysplasia in oral squamoproliferative lesions. Am J Surg Pathol 2005 29 : 792 6.
16. Paradiso A, Ranieri G, Stea B, et al. Altered p16INK4a and Fhit expression in carcinogenesis and progression of human oral cancer. Int J Oncol 2004 24 : 249 55.
17. Kramer IR, Lucas RB, Pindborg JJ, Sobin LH. Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol 1978 46 : 518 39.
18. Reibel J. Prognosis of oral pre-malignant lesions: significance of clinical, histopathological, and molecular biological characteristics. Crit Rev Oral Biol Med 2003 14 : 47 62.
19. Cowan CG, Gregg TA, Napier SS, McKenna SM, Kee F. Potentially malignant oral lesions in Northern Ireland: a 20-year population-based perspective of malignant transformation. Oral Dis 2001 7 : 18 24.
20. Ralhan R, Chakravarti N, Kaur J, et al. Clinical significance of altered expression of retinoid receptors in oral precancerous and cancerous lesions: relationship with cell cycle regulators. Int J Cancer 2006 118 : 1077 89.
21. Anderson KM, Stoner GD, Fields HW, et al. Immunohistochemical assessment of Viadent-associated leukoplakia. Oral Oncol 2005 41 : 200 7.
22. Arifin MT, Hama S, Kajiwara Y, et al. Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas. J Neurooncol 2006 77 : 273 7.
23. Evangelou K, Bramis J, Peros I, et al. Electron microscopy evidence that cytoplasmic localization of the p16(INK4A) "nuclear" cyclin-dependent kinase inhibitor (CKI) in tumor cells is specific and not an artifact. A study in non-small cell lung carcinomas. Biotech Histochem 2004 79 : 5 10.
24. Eleuterio J Jr., Giraldo PC, Goncalves AK, et al. Prognostic markers of high-grade squamous intraepithelial lesions: the role of p16INK4a and high-risk human papillomavirus. Acta Obstet Gynecol Scand 2007 86 : 94 8.
25. Natarajan E, Saeb M, Crum CP, Woo SB, Mckee PH, Rheinwald JG. Co-expression of p16(INK4A) and laminin 5 gamma2 by microinvasive and superficial squamous cell carcinomas in vivo and by migrating wound and senescent keratinocytes in culture. Am J Pathol 2003 163 : 477 91.
26. Rocco JW, Sidransky D. p16(MTS-1/CDKN2/INK4a) in cancer progression. Exp Cell Res 2001 264 : 42 55.
27. Poi MJ, Yen T, Li J, et al. Somatic INK4a-ARF locus mutations: a significant mechanism of gene inactivation in squamous cell carcinomas of the head and neck. Mol Carcinog 2001 30 : 26 36.
28. Lohi J. Laminin-5 in the progression of carcinomas. Int J Cancer 2001 94 : 763 7.
29. Kainulainen T, Utio-Harmainen H, Oikarinen A, Salo S, Tryggvason K, Salo T. Altered distribution and synthesis of laminin-5 (kalinin) in oral lichen planus, epithelial dysplasias and squamous cell carcinomas. Br J Dermatol 1997 136 : 331 6.
30. Fregonesi PA, Teresa DB, Duarte RA, Neto CB, de Oliveira MR, Soares CP. p16(INK4A) immunohistochemical overexpression in premalignant and malignant oral lesions infected with human papillomavirus. J Histochem Cytochem 2003 51 : 1291 7.
31. Konig F, Krekeler G, Honig JF, Cordon-Cardo C, Fischer G, Korabiowska M. Relation between human papillomavirus positivity and p16 expression in head and neck carcinomas - a tissue microarray study. Anticancer Res 2007 27 : 283 8.
32. Hafkamp HC, Speel EJ, Haesevoets A, et al. A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5-8. Int J Cancer 2003 107 : 394 400.
33. Wiest T, Schwarz E, Enders C, Flechtenmacher C, Bosch FX. Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control. Oncogene 2002 21 : 1510 7.
34. Cruz IB, Snijders PJ, Steenbergen RD, et al. Age-dependence of human papillomavirus DNA presence in oral squamous cell carcinomas. Eur J Cancer B Oral Oncol 1996 32B : 55 62.
35. Nemes JA, Deli L, Nemes Z, Marton IJ. Expression of p16(INK4A), p53, and Rb proteins are independent from the presence of human papillomavirus genes in oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006 102 : 344 52.