-
1
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire A, Xu S, Montgomery M, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998;391:806-11
-
(1998)
Nature
, vol.391
, pp. 806-11
-
-
Fire, A.1
Xu, S.2
Montgomery, M.3
-
2
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir SM, Harborth J, Lendeckel W, et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001;411:494-8
-
(2001)
Nature
, vol.411
, pp. 494-8
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
-
3
-
-
38749136602
-
Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)
-
DeVincenzo J, Cehelsky JE, Alvarez R, et al. Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV). Antiviral Res 2008;77:225-31
-
(2008)
Antiviral Res
, vol.77
, pp. 225-31
-
-
Devincenzo, J.1
Cehelsky, J.E.2
Alvarez, R.3
-
4
-
-
77951132901
-
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
-
Davis ME, Zuckerman JE, Choi CH, et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 2010;464(7291):1067-70
-
(2010)
Nature
, vol.464
, Issue.7291
, pp. 1067-70
-
-
Davis, M.E.1
Zuckerman, J.E.2
Choi, C.H.3
-
5
-
-
76349084709
-
First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder
-
Leachman SA, Hickerson RP, Schwartz ME, et al. First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder. Mol Ther 2010;18:442-6
-
(2010)
Mol Ther
, vol.18
, pp. 442-6
-
-
Leachman, S.A.1
Hickerson, R.P.2
Schwartz, M.E.3
-
6
-
-
35348952690
-
Antisense technology: A selective tool for gene expression regulation and gene targeting
-
Sahu NK, Shilakari G, Nayak A, Kohli DV. Antisense technology: a selective tool for gene expression regulation and gene targeting. Curr Pharm Biotechnol 2007;8:291-304
-
(2007)
Curr Pharm Biotechnol
, vol.8
, pp. 291-304
-
-
Sahu, N.K.1
Shilakari, G.2
Nayak, A.3
Kohli, D.V.4
-
7
-
-
36849044732
-
Non-viral delivery of synthetic siRNAs in vivo
-
Ahktar S, Benter I. Non-viral delivery of synthetic siRNAs in vivo. J Clin Invest 2007;117:3623-32
-
(2007)
J Clin Invest
, vol.117
, pp. 3623-32
-
-
Ahktar, S.1
Benter, I.2
-
9
-
-
0038606999
-
Structural variations and stabilizing modifications of synthetic siRNAs in mammalian cells
-
Czauderna F, Fechtner M, Dames S, et al. Structural variations and stabilizing modifications of synthetic siRNAs in mammalian cells. Nucleic Acids Res 2003;31:270516
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 270516
-
-
Czauderna, F.1
Fechtner, M.2
Dames, S.3
-
10
-
-
0038578021
-
Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA
-
Grunweller A, Wyszko E, Bieber B, et al. Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA. Nucleic Acids Res 2003;31:3185-93
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 3185-93
-
-
Grunweller, A.1
Wyszko, E.2
Bieber, B.3
-
11
-
-
34147180058
-
Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo
-
Mook OR, Baas F, De Wissel MB, Fluiter K. Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo. Mol Cancer Ther 2007;6:833-43
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 833-43
-
-
Mook, O.R.1
Baas, F.2
De Wissel, M.B.3
Fluiter, K.4
-
12
-
-
55049134757
-
RISC-target interaction: Cleavage and translational suppression
-
Van Den Berg A, Mols J, Han J. RISC-target interaction: cleavage and translational suppression. Biochim Biophys Acta 2008;1779:668-77
-
(2008)
Biochim Biophys Acta
, vol.1779
, pp. 668-77
-
-
Van Den Berg, A.1
Mols, J.2
Han, J.3
-
13
-
-
37049000624
-
Dumbbell-shaped nanocircular RNAs for RNA interference
-
Abe N, Abe H, Ito Y. Dumbbell-shaped nanocircular RNAs for RNA interference. J Am Chem Soc 2007;129:15108-9
-
(2007)
J Am Chem Soc
, vol.129
, pp. 15108-9
-
-
Abe, N.1
Abe, H.2
Ito, Y.3
-
14
-
-
57349134691
-
Chemical modification of siRNAs for in vivo use
-
Behlke MA. Chemical modification of siRNAs for in vivo use. Oligonucleotides 2008;18:305-19
-
(2008)
Oligonucleotides
, vol.18
, pp. 305-19
-
-
Behlke, M.A.1
-
15
-
-
1342346710
-
A conserved RNA-degrading RNase negatively regulates RNA interference in C. elegans
-
Kennedy S, Wang D, Ruvkun G. A conserved RNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature 2004;427:645-9
-
(2004)
Nature
, vol.427
, pp. 645-9
-
-
Kennedy, S.1
Wang, D.2
Ruvkun, G.3
-
16
-
-
31044444460
-
Inhibition of RNase A family of enzymes prevents degradation and loss of silencing activity of siRNAs in serum
-
Haupenthal J, Baehr C, Kiermayer S, et al. Inhibition of RNase A family of enzymes prevents degradation and loss of silencing activity of siRNAs in serum. Biochem Pharmacol 2006;71:702-10
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 702-10
-
-
Haupenthal, J.1
Baehr, C.2
Kiermayer, S.3
-
17
-
-
34248593248
-
RNase A-like enzymes inhibit the antineoplastic activity of siRNA targeting polo-like kinase 1
-
Haupenthal J, Baehr C, Zeuzem S, Piiper A. RNase A-like enzymes inhibit the antineoplastic activity of siRNA targeting polo-like kinase 1. Int J Cancer 2007;121:206-10
-
(2007)
Int J Cancer
, vol.121
, pp. 206-10
-
-
Haupenthal, J.1
Baehr, C.2
Zeuzem, S.3
Piiper, A.4
-
18
-
-
33845530239
-
MALDI-TOF mass spectral analysis of siRNA degradation in serum confirms an RNase A-like activity
-
Turner JJ, Jones SW, Moschos SA, et al. MALDI-TOF mass spectral analysis of siRNA degradation in serum confirms an RNase A-like activity. Mol Biosyst 2007;3:43-50
-
(2007)
Mol Biosyst
, vol.3
, pp. 43-50
-
-
Turner, J.J.1
Jones, S.W.2
Moschos, S.A.3
-
19
-
-
0038385504
-
RNA interference in mammalian cells by chemically modified RNA
-
Braasch DA, Jensen S, Liu Y, et al. RNA interference in mammalian cells by chemically modified RNA. Biochemistry 2003;42:7967-75
-
(2003)
Biochemistry
, vol.42
, pp. 7967-75
-
-
Braasch, D.A.1
Jensen, S.2
Liu, Y.3
-
20
-
-
0041331496
-
SiRNA function in RNAi: A chemical modification analysis
-
Chiu YL, Rana TM. siRNA function in RNAi: a chemical modification analysis. RNA 2003;9:1034-48
-
(2003)
RNA
, vol.9
, pp. 1034-48
-
-
Chiu, Y.L.1
Rana, T.M.2
-
21
-
-
0026737788
-
Group i permuted intron-exon (PIE) sequences self-splice to produce circular exons
-
Puttaraju M, Been MD. Group I permuted intron-exon (PIE) sequences self-splice to produce circular exons. Nucleic Acids Res 1992;20:5357-64
-
(1992)
Nucleic Acids Res
, vol.20
, pp. 5357-64
-
-
Puttaraju, M.1
Been, M.D.2
-
23
-
-
0029445280
-
Generation of nuclease resistant circular RNA decoys for HIV-Tat and HIV-Rev by autocatalytic splicing
-
Puttaraju M, Been MD. Generation of nuclease resistant circular RNA decoys for HIV-Tat and HIV-Rev by autocatalytic splicing. Nucleic Acids Symp Ser (Oxf) 1995;33:152-5
-
(1995)
Nucleic Acids Symp ser (Oxf)
, vol.33
, pp. 152-5
-
-
Puttaraju, M.1
Been, M.D.2
-
24
-
-
36049039753
-
Production of circular form of streptavidin RNA aptamer in vitro
-
Umekage S, Kikuchi Y. Production of circular form of streptavidin RNA aptamer in vitro. Nucleic Acids Symp Ser (Oxf) 2006;50:323-4
-
(2006)
Nucleic Acids Symp ser (Oxf)
, vol.50
, pp. 323-4
-
-
Umekage, S.1
Kikuchi, Y.2
-
25
-
-
0029788452
-
A small circular TAR RNA decoy specifically inhibits Tat-activated HIV-1 transcription
-
Bohjanen PR, Colvin RA, Puttaraju M, et al. A small circular TAR RNA decoy specifically inhibits Tat-activated HIV-1 transcription. Nucleic Acids Res 1996;24:3733-8
-
(1996)
Nucleic Acids Res
, vol.24
, pp. 3733-8
-
-
Bohjanen, P.R.1
Colvin, R.A.2
Puttaraju, M.3
-
26
-
-
0025707127
-
Bacterial origin of a chloroplast intron: Conserved self-splicing group i introns in cyanobacteria
-
Xu MQ, Kathe SD, Goodrich-Blair H, et al. Bacterial origin of a chloroplast intron: conserved self-splicing group I introns in cyanobacteria. Science 1990;250:1566-70
-
(1990)
Science
, vol.250
, pp. 1566-70
-
-
Xu, M.Q.1
Kathe, S.D.2
Goodrich-Blair, H.3
-
27
-
-
0344423187
-
Viroids and virusoids are related to Group i introns
-
Dinter-Gottlieb G. Viroids and virusoids are related to Group I introns. Proc Natl Acad Sci USA 1986;83:6250-4
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 6250-4
-
-
Dinter-Gottlieb, G.1
-
28
-
-
76349111051
-
Rational design of cationic lipids for siRNA delivery
-
Semple SC, Akinc A, Chen J, et al. Rational design of cationic lipids for siRNA delivery. Nat Biotechnol 2010;28:172-6
-
(2010)
Nat Biotechnol
, vol.28
, pp. 172-6
-
-
Semple, S.C.1
Akinc, A.2
Chen, J.3
-
29
-
-
76649098887
-
Lipid-like materials for low-dose, in vivo gene silencing
-
Love KT, Mahon KP, Levins CG, et al. Lipid-like materials for low-dose, in vivo gene silencing. Proc Natl Acad Sci USA 2010;107:1864-9
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 1864-9
-
-
Love, K.T.1
Mahon, K.P.2
Levins, C.G.3
-
30
-
-
13744250159
-
Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
-
Elmen J, Thonberg H, Ljungberg K, et al. Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality. Nucleic Acids Res 2005;33:439-47
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 439-47
-
-
Elmen, J.1
Thonberg, H.2
Ljungberg, K.3
-
31
-
-
13844281898
-
Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy
-
Kim DH, Behlke MA, Rose SD, et al. Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nat Biotechnol 2005;23:222-6
-
(2005)
Nat Biotechnol
, vol.23
, pp. 222-6
-
-
Kim, D.H.1
Behlke, M.A.2
Rose, S.D.3
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