Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome

Chemistry and Biology

Volumn 17, Issue 12, 2010, Pages 1325-1333

  Braun, Craig R ^a,b   Mintseris, Julian ^c   Gavathiotis, Evripidis ^a,b   Bird, Gregory H ^a,b   Gygi, Steven P ^c   Walensky, Loren D ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE; PROTEIN BCL 2;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SYNTHESIS; TUMOR CELL LINE; ULTRAVIOLET RADIATION;

AMINO ACID SEQUENCE; BINDING SITES; CELL LINE, TUMOR; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; ULTRAVIOLET RAYS;

HARNESS;

EID: 78650437120     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2010.09.015     Document Type: Article

References (35)

1. F. Arnesano, L. Banci, I. Bertini, and A.M. Bonvin A docking approach to the study of copper trafficking proteins; interaction between metallochaperones and soluble domains of copper ATPases Structure 12 2004 669 676
2. F. Bernal, A.F. Tyler, S.J. Korsmeyer, L.D. Walensky, and G.L. Verdine Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide J. Am. Chem. Soc. 129 2007 2456 2457
3. G.H. Bird, F. Bernal, K. Pitter, and L.D. Walensky Chapter 22 synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains Methods Enzymol. 446 2008 369 386
4. H.E. Blackwell, J.D. Sadowsky, R.J. Howard, J.N. Sampson, J.A. Chao, W.E. Steinmetz, D.J. O'Leary, and R.H. Grubbs Ring-closing metathesis of olefinic peptides: design, synthesis, and structural characterization of macrocyclic helical peptides J. Org. Chem. 66 2001 5291 5302
5. J.H. Blum, T.L. Stevens, and A.L. DeFranco Role of the mu immunoglobulin heavy chain transmembrane and cytoplasmic domains in B cell antigen receptor expression and signal transduction J. Biol. Chem. 268 1993 27236 27245
6. A.T. Brunger, P.D. Adams, G.M. Clore, W.L. DeLano, P. Gros, R.W. Grosse-Kunstleve, J.S. Jiang, J. Kuszewski, M. Nilges, and N.S. Pannu Crystallography & NMR system: a new software suite for macromolecular structure determination Acta Crystallogr. D Biol. Crystallogr. 54 1998 905 921
7. L. Chen, S.N. Willis, A. Wei, B.J. Smith, J.I. Fletcher, M.G. Hinds, P.M. Colman, C.L. Day, J.M. Adams, and D.C. Huang Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function Mol. Cell 17 2005 393 403
8. S. Chen, Y. Dai, H. Harada, P. Dent, and S. Grant Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation Cancer Res. 67 2007 782 791
9. N.N. Danial, L.D. Walensky, C.Y. Zhang, C.S. Choi, J.K. Fisher, A.J. Molina, S.R. Datta, K.L. Pitter, G.H. Bird, and J.D. Wikstrom Dual role of proapoptotic BAD in insulin secretion and beta cell survival Nat. Med. 14 2008 144 153
10. DeLano, W.L. (2002). The PyMOL Molecular Graphics System, http://www.pymol.org. edn (San Carlos, DeLano Scientific).
11. C. Dominguez, R. Boelens, and A.M. Bonvin HADDOCK: a protein-protein docking approach based on biochemical or biophysical information J. Am. Chem. Soc. 125 2003 1731 1737
12. G. Dorman, and G.D. Prestwich Benzophenone photophores in biochemistry Biochemistry 33 1994 5661 5673
13. J.E. Elias, and S.P. Gygi Target-decoy search strategy for mass spectrometry-based proteomics Methods Mol. Biol. 604 2010 55 71
14. J.K. Eng, A.L. McCormack, and J.R. Yates An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database J. Am. Soc. Mass Spectrom. 5 1994 976 989
15. E. Gavathiotis, M. Suzuki, M.L. Davis, K. Pitter, G.H. Bird, S.G. Katz, H.C. Tu, H. Kim, E.H. Cheng, and N. Tjandra BAX activation is initiated at a novel interaction site Nature 455 2008 1076 1081
16. W. Haas, B.K. Faherty, S.A. Gerber, J.E. Elias, S.A. Beausoleil, C.E. Bakalarski, X. Li, J. Villen, and S.P. Gygi Optimization and use of peptide mass measurement accuracy in shotgun proteomics Mol. Cell. Proteomics 5 2006 1326 1337
17. R.W. Hooft, G. Vriend, C. Sander, and E.E. Abola Errors in protein structures Nature 381 1996 272
18. S.J. Hubbard, and J.M. Thornton NACCESS 1993 University College London
19. P.H. Kussie, S. Gorina, V. Marechal, B. Elenbaas, J. Moreau, A.J. Levine, and N.P. Pavletich Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain Science 274 1996 948 953 (Pubitemid 26398409)
20. R.A. Laskowski, J.A. Rullmannn, M.W. MacArthur, R. Kaptein, and J.M. Thornton AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR J. Biomol. NMR 8 1996 477 486
21. J.P. Linge, M. Habeck, W. Rieping, and M. Nilges ARIA: automated NOE assignment and NMR structure calculation Bioinformatics 19 2003 315 316
22. R.E. Moellering, M. Cornejo, T.N. Davis, C. Del Bianco, J.C. Aster, S.C. Blacklow, A.L. Kung, D.G. Gilliland, G.L. Verdine, and J.E. Bradner Direct inhibition of the NOTCH transcription factor complex Nature 462 2009 182 188
23. J. Rappsilber, M. Mann, and Y. Ishihama Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips Nat. Protoc. 2 2007 1896 1906
24. A. Saghatelian, N. Jessani, A. Joseph, M. Humphrey, and B.F. Cravatt Activity-based probes for the proteomic profiling of metalloproteases Proc. Natl. Acad. Sci. USA 101 2004 10000 10005
25. M. Sattler, H. Liang, D. Nettesheim, R.P. Meadows, J.E. Harlan, M. Eberstadt, H.S. Yoon, S.B. Shuker, B.S. Chang, and A.J. Minn Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis Science 275 1997 983 986
26. C. Schafmeister, J. Po, and G. Verdine An all-hydrocarbon cross-linking system for enhancing the helicity and metabolic stability of peptides J. Am. Chem. Soc. 122 2000 5891 5892
27. M.L. Stewart, E. Fire, A.E. Keating, and L.D. Walensky The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer Nat. Chem. Biol 6 2010 595 601
28. D. Van Der Spoel, E. Lindahl, B. Hess, G. Groenhof, A.E. Mark, and H.J. Berendsen GROMACS: fast, flexible, and free J. Comput. Chem. 26 2005 1701 1718
29. E.L. Vodovozova Photoaffinity labeling and its application in structural biology Biochemistry (Mosc.) 72 2007 1 20
30. L.D. Walensky, A.L. Kung, I. Escher, T.J. Malia, S. Barbuto, R.D. Wright, G. Wagner, G.L. Verdine, and S.J. Korsmeyer Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix Science 305 2004 1466 1470
31. L.D. Walensky, K. Pitter, J. Morash, K.J. Oh, S. Barbuto, J. Fisher, E. Smith, G.L. Verdine, and S.J. Korsmeyer A stapled BID BH3 helix directly binds and activates BAX Mol. Cell 24 2006 199 210
32. M.C. Wei, T. Lindsten, V.K. Mootha, S. Weiler, A. Gross, M. Ashiya, C.B. Thompson, and S.J. Korsmeyer tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c Genes Dev. 14 2000 2060 2071
33. W. Weissenhorn, A. Dessen, S.C. Harrison, J.J. Skehel, and D.C. Wiley Atomic structure of the ectodomain from HIV-1 gp41 Nature 387 1997 426 430
34. E. Yang, J. Zha, J. Jockel, L.H. Boise, C.B. Thompson, and S.J. Korsmeyer Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death Cell 80 1995 285 291
35. H. Zhang, Q. Zhao, S. Bhattacharya, A.A. Waheed, X. Tong, A. Hong, S. Heck, F. Curreli, M. Goger, and D. Cowburn A cell-penetrating helical peptide as a potential HIV-1 inhibitor J. Mol. Biol. 378 2008 565 580