β-Adrenergic blockade during systemic inflammation: Impact on cellular immune functions and survival in a murine model of sepsis

Resuscitation

Volumn 72, Issue 2, 2007, Pages 286-294

  Schmitz, Daniel ^a   Wilsenack, Klaus ^a   Lendemanns, Sven ^a   Schedlowski, Manfred ^a   Oberbeck, Reiner ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Adrenergic blockade; Adrenergic receptor; Apoptosis; Catecholamines; Cytokines; Immune system; Propranolol; Septic shock

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; GAMMA INTERFERON; INTERLEUKIN 6; PROPRANOLOL; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BODY WEIGHT; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CRITICALLY ILL PATIENT; CYTOKINE RELEASE; DISEASE MODEL; DRUG EFFECT; FLUID INTAKE; FOOD INTAKE; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POLYMICROBIAL SEPSIS; PRIORITY JOURNAL; SEPSIS; SINGLE DRUG DOSE; SPLEEN CELL; SURVIVAL RATE; TEMPERATURE; URINE VOLUME;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CELL DIVISION; CYTOKINES; DISEASE MODELS, ANIMAL; IMMUNITY, CELLULAR; MALE; MICE; PROPRANOLOL; SURVIVAL RATE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 33846088942     PISSN: 03009572     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2006.07.001     Document Type: Article

References (43)

1. Howell S.J. Peri-operative beta-blockade: a useful treatment that should be greeted with cautious enthusiasm. Br J Anaesth 86 2 (2004) 161-164
2. Herndon D.N., Hart D.W., Wolf S.E., Chinkes D.L., and Wolfe R.R. Reversal of catabolism by beta-blockade after severe burns. New Engl J Med 345 17 (2001) 1223-1229
3. Hart D.W., Wolf S.E., Chinkes D.L., Lal S.O., Ramzy P.I., and Herndon D.N. Beta-blockade and growth hormone after burn. Ann Surg 236 4 (2002) 450-457
4. Dickerson R.N., Fried R.C., Bailey P.M., Stein T.P., Mullen J.L., and Buzby G.P. Effect of propranolol on nitrogen and energy metabolism in sepsis. J Surg Res 48 (1990) 38-41
5. Jetschmann J.U., Benshop R.J., Jacobs R., et al. Expression and in vivo modulation of α- and β-adrenoceptors on human natural killer (CD16) cells. J Neuroimmunol 74 (1997) 159-164
6. Schedlowski M., Hosch W., Oberbeck J.R., et al. Catecholamines modulate human NK-cell circulation and function via spleen-independent β2-adrenergic mechanisms. J Immunol 156 (1996) 93-99
7. Besedovsky H., and del Rey A. Immune-neuro-endocrine interactions: facts and hypothesis. Endocr Rev 17 (1996) 69-102
8. Blalock J.E. The syntax of the immune-neuroendocrine communication. Immunol Today 15 (1994) 504-511
9. Bergmann M., and Sautner T. Immunomodulatory effects of vasoactive catecholamines. Wien Klin Wochenschr 114 (2002) 752-761
10. Baker C.C., Oppenheimer L., Stephens B., Lewis F.R., and Trunkley D.D. Epidemiology of trauma deaths. Am J Surg 140 (1980) 4
11. Waydhas C., Nast-Kolb D., Jochum M., et al. Inflammatory mediators, infection, sepsis, and multiple organ failure after severe trauma. Arch Surg 127 (1992) 460-469
12. Oberbeck R. Therapeutic implications of endocrine-immune interactions in critically ill patients. Curr Drug Targets 4 2 (2004) 129-139
13. Schedlowski M., Falk A., Rohne A., Jacobs R., and Schmidt R.E. Catecholamines induce alterations of distribution and activity of human natural killer cells. J Clin Immunol 13 (1993) 344-351
14. Oberbeck R., v. Griensven M., Nickel E., Tschernig T., Wittwer T., and Pape H.C. Influence of β-adrenoceptor antagonists on hemorrhage induced cellular immune suppression. Shock 18 (2002) 331-335
15. Ablad B., Carlsson E., and Ek L. Pharmacological studies of two new cardioselective adrenergic beta-receptor antagonists. Life Sci 12 (1973) 107-119
16. Brittain R.T., and Levy G.P. A review of the animal pharmacology of labetalol, a combined α- and β-adrenoceptor-blocking drug. Br J Clin Suppl 1 (1976) 681-694
17. Brynne L., Karlsson M.O., and Paalzow L.K. Concentration-effect relationship of propranolol and metoprolol on spontaneous hypertensive rats after exercise induced tachycardia. J Pharmacol Exp Ther 286 (1998) 1152-1158
18. Baker C.C., Chaudry I.H., Gaines H.O., and Bau A.E. Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model. Surgery 94 (1983) 331-335
19. Exton M.S., v. Hörsten S., and Schulte M. Behaviourally conditioned immunosupression using cyclosporine A. J Neuroimmunol 88 (1998) 182-191
20. Cohen J.J. Apoptosis. Immunol Today 14 (1993) 126-130
21. Vermes I., Haanen H., Steffens-Nakken H., and Reutlingsperger C.P. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescin-labeled Annexin V. J Immunol Meth 184 (1993) 39-51
22. Josefsson E., Berquist J., Ekamn R., and Tarkowski R. Catecholamines are synthesized by mouse lymphocytes and regulate function of these cells by induction of apoptosis. Immunology 88 (1996) 140-146
23. Hotchkiss R.S., Tinsley K.W., Swanson P.E., et al. Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc Natl Acad Sci USA 96 (1999) 14541-14546
24. Cioca D.P., Watanabe N., and Isobe M. Apoptosis of peripheral blood lymphocytes is induced by catecholamines. Jpn Heart J 41 (2000) 385-398
25. Hess K.L., Tudor K.R.S., Johnson J.D., Askew D.S., and Cook-Mills J.M. Human and murine high endothelial venule cells phagocytose apoptotic leukocytes. Exp Cell Res 236 (1997) 4004-4011
26. Hotchkiss R.S., Tinsley K.W., and Karl I.E. Role of apoptotic cell death in sepsis. Scand J Infect Dis 35 9 (2003) 585-592
27. Ayala A., Herdon C.D., Lehmann D.L., Ayala C.A., and Chaudry I.H. Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators. Blood 87 (1996) 4261-4275
28. Weiss M., Elsharkawi M., and Schneider E.M. Transient leukocytosis, granulocyte colony-stimulating factor plasma binding concentrations, and apoptosis determined by binding of Annexin V by peripheral leukocytes in patients with severe sepsis. Ann NY Acad Sci 1010 (2003) 742-747
29. Harter L., Keel M., Steckholzer U., Ungethuem U., Trentz O., and Ertel W. Activation of mitogen-activated protein kinases during granulocyte apoptosis in patients with severe sepsis. Shock 18 (2002) 401-406
30. Feterowski C., Weighardt H., Emmanuilidis K., Hartung T., and Holzmann B. Immune protection against septic peritonitis in endotoxin-primed mice is related to reduced neutrophil apoptosis. Eur J Immunol 3 (2001) 1268-1277
31. Keel M., Ungethum U., Steckholzer U., et al. Interleukin-10 counter regulates pro-inflammatory cytokine-induced neutrophil apoptosis during severe sepsis. Blood 90 (1997) 3356-3363
32. Hotchkiss R.S., Tinsley K.W., and Karl I.E. Role of apoptotic cell death in sepsis. Scand J Infect Dis 35 (2003) 585-592
33. Hiramatsu M., Hotchkiss R.S., Karl I.E., and Buchmann T.G. Cecal ligation and puncture (CLP) induced apoptosis in thymus, spleen, lung and gut by an endotoxin and TNF-independent pathway. Shock 7 (1997) 247-253
34. Elenkov I.J., Wilder R.L., Chrousos G.P., and Vizi E.S. The sympathetic nerve-an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 52 (2000) 595-638
35. Pierpaoli W., and Maestroni G.J.M. Pharmacological control of the hormonally modulated immune response: blockade of antibody production by drugs acting on neuroendocrine functions. Immunology 34 (1978) 419-430
36. Rook G.A.W., Hernandez-Pando R., and Lightman S.L. Hormones, peripherally activated prohormones and regulation of the Th1/Th2 imbalance. Immunol Today 9 (1988) 137-139
37. Kohm A.P., and Sanders V.M. Norepinephrine and beta-2 adrenoceptor stimulation regulate CD4+ T- and B-lymphocyte function in vivo and in vitro. Pharmacol Rev 53 4 (2001) 487-525
38. Hotchkiss R.S., and Karl I.E. The pathophysiology and treatment of sepsis. New Engl J Med 348 2 (2003) 138-150
39. Caruana J.A., Whalen D.A., and Maben W.C. Beta adrenergic blockade increases the hepatic extraction of glucose in sepsis. Arch Surg 121 (1986) 319-323
40. Berk J.L., Hagen J.F., and Maly G. The treatment of septic shock with beta adrenergic blockade. Arch Surg 104 (1972) 46-51
41. Halmagyi D.F., Kenney M., Goodman A.H., and Varga D. Simple and combined adrenergic receptor blockade in canine endotoxinemia. Eur Surg Res 3 (1971) 326-339
42. Berk J.L., Hagen J.F., Beyer W.H., Gerber M.J., and Dochat M.A. The treatment of endotoxin shock by beta adrenergic blockade. Ann Surg 169 (1969) 74-81
43. Rogausch H., Del Ray A., Oertel I., and Besedovsky H. Norepinephrine stimulates lymphoid cell mobilization in the perfused rat spleen via beta-adrenergic receptors. Am J Physiol 276 (1999) R724-R730