Small molecule mimetics of an HIV-1 gp41 fusion intermediate as vaccine leads

Journal of Biological Chemistry

Volumn 285, Issue 52, 2010, Pages 40604-40611

  Caulfield, Michael J ^a,b   Dudkin, Vadim Y ^a   Ottinger, Elizabeth A ^a   Getty, Krista L ^a   Zuck, Paul D ^a   Kaufhold, Robin M ^a   Hepler, Robert W ^a   McGaughey, Georgia B ^a   Citron, Michael ^a   Hrin, Renee C ^a   Wang, Ying Jie ^a,c   Miller, Michael D ^a   Joyce, Joseph G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b INTERNATIONAL AIDS VACCINE INITIATIVE   (United States)

^c ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN-BINDING; CARRIER PROTEINS; CONFORMATIONAL EPITOPES; ENVELOPE PROTEINS; HEPTAD REPEAT REGIONS; HIGH THROUGHPUT; HYDROPHOBIC POCKETS; INFECTIOUS DISEASE; MEDICINAL CHEMISTRY; MIMETICS; MODEL SYSTEM; NEUTRALIZING ANTIBODIES; PLATFORM TECHNOLOGY; PROTEIN ANTIGENS; SMALL MOLECULES; VACCINE DEVELOPMENT;

ANTIGENS; BINDING ENERGY; MOLECULES; MONOCLONAL ANTIBODIES; PROTEINS; THROUGHPUT; VACCINES;

DISEASES;

BENZYLPIPERIDINE; CARRIER PROTEIN; GLYCOPROTEIN GP 41 FUSION PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY D5; PEPTIDOMIMETIC AGENT; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HIGH THROUGHPUT SCREENING; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HYDROPHOBICITY; IMMUNIZATION; IMMUNOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VIRUS NEUTRALIZATION;

AIDS VACCINES; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; FEMALE; HAPTENS; HIV ENVELOPE PROTEIN GP41; HIV INFECTIONS; HIV-1; HUMANS; MICE; MICE, INBRED BALB C; PEPTIDOMIMETICS;

HUMAN IMMUNODEFICIENCY VIRUS 1; MUS;

EID: 78650352926     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.172197     Document Type: Article

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