The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent

Journal of Medicinal Chemistry

Volumn 45, Issue 17, 2002, Pages 3692-3702

  Bavetsias, V ^a   Skelton, L A ^a   Yafai, F ^a   Mitchell, F ^a   Wilson, S C ^a   Allan, B ^a   Jackman, A L ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 [N (7 BROMO 3,4 DIHYDRO 2 METHYL 4 OXO 6 QUINAZOLINYLMETHYL) N (2 PROPYNYL)AMINO] N (3 PYRIDYLMETHYL)BENZAMIDE; ANILINE DERIVATIVE; ANTINEOPLASTIC AGENT; FOLIC ACID; QUINAZOLIN 4 ONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MITOSIS INHIBITION; PH; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL DIVISION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; QUINAZOLINES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0037103345     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm011081s     Document Type: Article

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