Discovery of novel benzopyranyl tetracycles that act as inhibitors of osteoclastogenesis induced by receptor activator of NF-κB ligand

Journal of Medicinal Chemistry

Volumn 53, Issue 24, 2010, Pages 8760-8764

  Zhu, Mingyan ^a   Kim, Myung Hee ^a   Lee, Sanghee ^a   Bae, Su Jung ^a   Kim, Seong Hwan ^a   Park, Seung Bum ^a,b  

^a Seoul National University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ACTIN; BENZOPYRAN DERIVATIVE; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN C FOS; PROTEIN FOS;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL VIABILITY; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME PHOSPHORYLATION; IN VITRO STUDY; MOLECULAR LIBRARY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OSTEOCLAST; OSTEOCLASTOGENESIS; TRANSCRIPTION INITIATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; BENZOPYRANS; BONE DENSITY CONSERVATION AGENTS; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HIGH-THROUGHPUT SCREENING ASSAYS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; NF-KAPPA B; OSTEOCLASTS; PHOSPHORYLATION; RANK LIGAND; SMALL MOLECULE LIBRARIES; STEM CELLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650333805     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1011269     Document Type: Article

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