MiRNAs in multiple sclerosis: Regulating the regulators

Journal of Neuroimmunology

Volumn 229, Issue 1-2, 2010, Pages 3-4

  Guerau de Arellano, Mireia ^a   Lovett Racke, Amy E ^a   Racke, Michael K ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; EXPORTIN 5; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN; MICRORNA; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

CD4+ CD25+ T LYMPHOCYTE; EDITORIAL; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; IMMUNOPATHOGENESIS; LYMPHOCYTE DIFFERENTIATION; MEMORY T LYMPHOCYTE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH17 CELL;

ANTIGENS, CD; GENE EXPRESSION REGULATION; HUMANS; MICRORNAS; MULTIPLE SCLEROSIS; T-LYMPHOCYTES, REGULATORY;

EID: 78650310200     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2010.08.025     Document Type: Editorial

References (29)

1. Ambros V. The functions of animal microRNAs. Nature 2004, 431:350-355.
2. Compston A., Coles A. Multiple sclerosis. Lancet 2008, 372:1502-1517.
3. Cui G., Zhang Y., Gong Z., Zhang J.Z., Zang Y.Q. Induction of CD4+CD25+Foxp3+ regulatory T cell response by glatiramer acetate in type 1 diabetes. Cell Res. 2009, 19:574-583.
4. Cullen B.R. Transcription and processing of human microRNA precursors. Mol. Cell 2004, 16:861-865.
5. Du C., Liu C., Kang J., Zhao G., Ye Z., Huang S., Li Z., Wu Z., Pei G. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat. Immunol. 2009, 10:1252-1259.
6. Frohman E.M., Racke M.K., Raine C.S. Multiple sclerosis - the plaque and its pathogenesis. N Engl J. Med. 2006, 354:942-955.
7. Haas J., Hug A., Viehover A., Fritzsching B., Falk C.S., Filser A., Vetter T., Milkova L., Korporal M., Fritz B., Storch-Hagenlocher B., Krammer P.H., Suri-Payer E., Wildemann B. Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur. J. Immunol. 2005, 35:3343-3352.
8. Haas J., Korporal M., Balint B., Fritzsching B., Schwarz A., Wildemann B. Glatiramer acetate improves regulatory T-cell function by expansion of naive CD4(+)CD25(+)FOXP3(+)CD31(+) T-cells in patients with multiple sclerosis. J. Neuroimmunol. 2009, 216:113-117.
9. Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061.
10. Huan J., Culbertson N., Spencer L., Bartholomew R., Burrows G.G., Chou Y.K., Bourdette D., Ziegler S.F., Offner H., Vandenbark A.A. Decreased FOXP3 levels in multiple sclerosis patients. J. Neurosci. Res. 2005, 81:45-52.
11. Jee Y., Piao W.H., Liu R., Bai X.F., Rhodes S., Rodebaugh R., Campagnolo D.I., Shi F.D., Vollmer T.L. CD4(+)CD25(+) regulatory T cells contribute to the therapeutic effects of glatiramer acetate in experimental autoimmune encephalomyelitis. Clin. Immunol. 2007, 125:34-42.
12. Keller A., Leidinger P., Lange J., Borries A., Schroers H., Scheffler M., Lenhof H.P., Ruprecht K., Meese E. Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls. PLoS ONE 2009, 4:e7440.
13. Kumar M., Putzki N., Limmroth V., Remus R., Lindemann M., Knop D., Mueller N., Hardt C., Kreuzfelder E., Grosse-Wilde H. CD4+CD25+FoxP3+ T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis. J. Neuroimmunol. 2006, 180:178-184.
14. Lindberg R.L., Hoffmann F., Mehling M., Kuhle J., Kappos L. Altered expression of miR-17-5p in CD4+ lymphocytes of relapsing-remitting multiple sclerosis patients. Eur. J. Immunol. 2010, 40:888-898.
15. Liu W., Putnam A.L., Xu-Yu Z., Szot G.L., Lee M.R., Zhu S., Gottlieb P.A., Kapranov P., Gingeras T.R., de St Fazekas, Groth B., Clayberger C., Soper D.M., Ziegler S.F., Bluestone J.A. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med. 2006, 203:1701-1711.
16. Michel L., Berthelot L., Pettre S., Wiertlewski S., Lefrere F., Braudeau C., Brouard S., Soulillou J.P., Laplaud D.A. Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor alpha-chain are excluded from the analysis. J. Clin. Invest. 2008, 118:3411-3419.
17. Milo R., Kahana E. Multiple sclerosis: geoepidemiology, genetics and the environment. Autoimmun. Rev. 2010, 9:A387-A394.
18. Otaegui D., Baranzini S.E., Armananzas R., Calvo B., Munoz-Culla M., Khankhanian P., Inza I., Lozano J.A., Castillo-Trivino T., Asensio A., Olaskoaga J., Lopez de Munain A. Differential micro RNA expression in PBMC from multiple sclerosis patients. PLoS ONE 2009, 4:e6309.
19. Petrocca F., Vecchione A., Croce C.M. Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling. Cancer Res. 2008, 68:8191-8194.
20. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995, 155:1151-1164.
21. Seddiki N., Santner-Nanan B., Martinson J., Zaunders J., Sasson S., Landay A., Solomon M., Selby W., Alexander S.I., Nanan R., Kelleher A., de St Fazekas, Groth B. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J. Exp. Med. 2006, 203:1693-1700.
22. Tanzer A., Stadler P.F. Evolution of microRNAs. Meth. Mol. Biol. 2006, 342:335-350.
23. Tili E., Michaille J.J., Costinean S., Croce C.M. MicroRNAs, the immune system and rheumatic disease. Nat. Clin. Pract. Rheumatol. 2008, 4:534-541.
24. Venken K., Hellings N., Hensen K., Rummens J.L., Medaer R., D'Hooghe M.B., Dubois B., Raus J., Stinissen P. Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T-cell function and FOXP3 expression. J. Neurosci. Res. 2006, 83:1432-1446.
25. Venken K., Hellings N., Broekmans T., Hensen K., Rummens J.L., Stinissen P. Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression. J. Immunol. 2008, 180:6411-6420.
26. Venken K., Hellings N., Thewissen M., Somers V., Hensen K., Rummens J.L., Medaer R., Hupperts R., Stinissen P. Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level. Immunology 2008, 123:79-89.
27. Viglietta V., Baecher-Allan C., Weiner H.L., Hafler D.A. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J. Exp. Med. 2004, 199:971-979.
28. Yin Q., McBride J., Fewell C., Lacey M., Wang X., Lin Z., Cameron J., Flemington E.K. MicroRNA-155 is an Epstein-Barr virus-induced gene that modulates Epstein-Barr virus-regulated gene expression pathways. J. Virol. 2008, 82:5295-5306.
29. Zuvich R.L., McCauley J.L., Pericak-Vance M.A., Haines J.L. Genetics and pathogenesis of multiple sclerosis. Semin. Immunol. 2009, 21:328-333.