A rapid vesicle electrokinetic chromatography method for the in vitro prediction of non-specific binding for potential PET ligands

Journal of Pharmaceutical and Biomedical Analysis

Volumn 54, Issue 4, 2011, Pages 722-729

  Jiang, Zhengjin ^a   Reilly, John ^a   Everatt, Brian ^a   Briard, Emmanuelle ^b  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Non specific binding; Positron emission tomography; Vesicle electrokinetic chromatography

Indexed keywords

4 [(3,4 DICHLOROPHENYL)ACETYL] 3 (1 PYRROLIDINYLMETHYL) 1 PIPERAZINECARBOXYLIC ACID METHYL ESTER; 5 ALLYL 1,2 DIHYDRO 10 METHOXY 2,2,4 TRIMETHYL 5H 1 BENZOPYRANO[3,4 F]QUINOLINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ALTANSERIN; AMFEBUTAMONE; CITALOPRAM; CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN; DIPRENORPHINE; DIZOCILPINE; DONEPEZIL; EMAPUNIL; FLUMAZENIL; IMIPRAMINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N ALLYLNORMETAZOCINE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NISOXETINE; NOMIFENSINE; PAROXETINE; PHYSOSTIGMINE; RACLOPRIDE; REBOXETINE; ROLIPRAM; SELEGILINE; SETOPERONE; SPIPERONE; TROPISETRON; UNINDEXED DRUG; VANOXERINE; VOLINANSERIN;

ARTICLE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PREDICTION; PRIORITY JOURNAL;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, MICELLAR ELECTROKINETIC CAPILLARY; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; KINETICS; LIGANDS; LIPOSOMES; MODELS, BIOLOGICAL; POSITRON-EMISSION TOMOGRAPHY; RADIOACTIVE TRACERS; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SURFACE-ACTIVE AGENTS; TIME FACTORS;

EID: 78650242743     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.11.004     Document Type: Article

References (27)

1. Willmann J.K., Van Bruggen N., Dinkelborg L.M., Gambhir S.S. Molecular imaging in drug development. Nat. Rev. Drug Discov. 2008, 7:591-607.
2. Laruelle M., Slifstein M., Huang Y. Relationships between radiotracer properties and image quality in molecular imaging of the brain with positron emission tomography. Mol. Imaging Biol. 2003, 5:363-375.
3. Patel S., Hamill T., Hostetler E., Burns D., Gibson R.E. An in vitro assay for predicting successful imaging radiotracers. Mol. Imaging Biol. 2003, 5:65-71.
4. Cella C.V., Woodhouse S.M., Lewis R.A., Fray A.E. A novel method for the assessment of potential PET ligands using an in vitro assay of non-specific binding. FENS 2004, A059:4.
5. Rosso L., Gee A.D., Gould I.R. Ab initio computational study of positron emission tomography ligands interacting with lipid molecule for the prediction of nonspecific binding. J. Comput. Chem. 2008, 29:2397-2405.
6. Mintun M.A., Raichle M.E., Kilbourn M.R., Wooten G.F., Welch M.J. A quantitative model for the in vivo assessment of drug-binding sites with positron emission tomography. Ann. Neurol. 1984, 15:217-227.
7. Rosso L., Gee A.D., Gould I.R. Towards in silico descriptors of PET ligands non-specific binding. Neuroimage 2008, 41:T99.
8. Guo Q., Brady M., Gunn R.N. A biomathematical modeling approach to central nervous system radioligand discovery and development. J. Nucl. Med. 2009, 50:1715-1723.
9. Reichel A., Begley D.J. Potential of immobilized artificial membranes for predicting drug penetration across the blood-brain barrier. Pharm. Res. 1998, 15:1270-1274.
10. Pidgeon C., Ong S.W., Liu H.L., Qiu X.X., Pidgeon M., Dantzig A.H., Munroe J., Hornback W.J., Kasher J.S., Glunz L., Szczerba T. IAM chromatography: an in vitro screen for predicting drug membrane permeability. J. Med. Chem. 1995, 38:590-594.
11. Pascoe R.J., Masucci J.A., Foley J.P. Investigation of vesicle electrokinetic chromatography as an in vitro assay for the estimation of intestinal permeability of pharmaceutical drug candidates. Electrophoresis 2006, 27:793-804.
12. Liu H.L., Ong S.W., Glunz L., Pidgeon C. Predicting drug-membrane interactions by HPLC: structural requirements of chromatographic surfaces. Anal. Chem. 1995, 67:3550-3557.
13. Jiang Z., Reilly J., Everatt B. A method for rapidly predicting drug tissue distribution using surfactant vesicle electrokinetic chromatography. Electrophoresis 2008, 29:3674-3684.
14. Carrozzino J.M., Khaledi M.G. Interaction of basic drugs with lipid bilayers using liposome electrokinetic chromatography. Pharm. Res. 2004, 21:2327-2335.
15. Kerns E.H., Di L., Petusky S., Kleintop T., Huryn D., McConnell O., Carter G. Pharmaceutical profiling method for lipophilicity and integrity using liquid chromatography-mass spectrometry. J. Chromatogr. B 2003, 79:381-388.
16. Valko K., Du C.M., Bevan C.D., Reynolds D.P., Abraham M.H. Rapid-gradient HPLC method for measuring drug interactions with immobilized artificial membrane: comparison with other lipophilicity measures. J. Pharm. Sci. 2000, 89:1085-1096.
17. Yata N., Toyoda T., Murakami T., Nishiura A., Higashi Y. Phosphatidylserine as a determinant for the tissue distribution of weakly basic drugs in rats. Pharm. Res. 1990, 7:1019-1025.
18. Rodgers T., Leahy D., Rowland M. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J. Pharm. Sci. 2005, 94:1259-1276.
19. Rodgers T., Rowland M. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J. Pharm. Sci. 2006, 95:1238-1257.
20. a and ClogP to predict phospholipidosis-inducing potential-a case study with structurally related piperazines. Exp. Toxicol. Pathol. 2004, 55:347-355.
21. 31P NMR spectroscopy. Magn. Reson. Med. 2000, 44:215-223.
22. Ansell G.B., Hawthorne J.N., Dawson R.M.C. Form and Function of Phsopholipids 1973, Elsevier, Amsterdam.
23. Schwartz A.C., Rathbaum B.O. Review of Sertraline in post-traumatic stress disorder. Expert Opin. Pharmacother. 2002, 3:1489-1499.
24. 11C] Spiroperidol: synthesis, specific activity determination, and biodistribution in mice. J. Nucl. Med. 1982, 23:437-445.
25. 1 receptor tracer, in normal subjects. J. Nucl. Med. 1998, 39:792-797.
26. Xu G.Y., Waki H., Kon K.Z., Ando S. Thin-layer chromatography of phospholipids and their lyse forms: application to determination of extracts from rat hippocampal CA1 region. Microchem. J. 1996, 53:29-33.
27. 11C]methylspiperone. Eur. J. Nucl. Med. 1986, 11:438-443.