HIV replication leads to skewed maturation of CD8-positive T-cell responses in infected children

New Microbiologica

Volumn 33, Issue 4, 2010, Pages 303-309

  Montesano, Carla ^a   Anselmi, Alessia ^a   Palma, Paolo ^a,b   Bernardi, Stefania ^b   Cicconi, Rosella ^a   Mattei, Maurizio ^a   Castelli Gattinara, Guido ^b   Ciccozzi, Massimo ^c   Colizzi, Vittorio ^a   Amicosante, Massimo ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b Bambin Gesii Children's Hospital   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Children; Hiv specific immune response; Na ; Ve memory lymphocytes

Indexed keywords

ANTIRETROVIRUS AGENT; T LYMPHOCYTE RECEPTOR;

ADOLESCENT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CHILD; DISEASE COURSE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTE COUNT; PHYSIOLOGY; TREATMENT OUTCOME; VIREMIA; VIROLOGY; VIRUS LOAD; VIRUS REPLICATION;

ADOLESCENT; ANTI-RETROVIRAL AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CHILD; DISEASE PROGRESSION; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOLOGIC MEMORY; LYMPHOCYTE COUNT; T-CELL ANTIGEN RECEPTOR SPECIFICITY; TREATMENT OUTCOME; VIRAL LOAD; VIREMIA; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 78650231335     PISSN: 11217138     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. AMICOSANTE M., GIOIA C., MONTESANO C., CASETTI R., TOPINO S., D'OFFIZI G., CAPPELLI G., IPPOLITO G., COLIZZI V., POCCIA F., PUCILLO L.R (2002). Computer-based design of an HLA-haplotype and HIV-clade independent CTL assay for monitoring HIV-specific immunity. Mol Med. 8, 798-807.
2. Appay V. Rowland-Jones S.L. Lessons from the study of T-cell differentiation in persistent human virus infection Seminars in Immunology 2004 16 3 205-212 DOI 10.1016/j.smim.2004.02.007, PII S1044532304000259 APPAY V., ROWLAND-JONES S.L. (2004). Lessons from the study of T-cell differentiation in persistent human virus infection. Semin Immunol. 16, 205-212. (Pubitemid 38569901)
3. BORKOWSKY W., STANLEY K., DOUGLAS S.D., LEE S., WIZNIA A., PELTON S., YOGEV R., MCINTOSH K., NACHMAN S. (2000). Immunologic response to combination nucleoside analogue plus protease inhibitor therapy in stable antiretroviral therapy-experienced human immunodeficiency virus-infected children. J Infect Dis. 182, 96-103.
4. BUSEYNE F., SCOTT-ALGARA D., PORROT F., CORRE B., BELLAL N., BURGARD M., ROUZIOUX C., BLANCHE S., RIVIÈRE Y. (2002). Frequencies of ex vivo-activated HPV-1-specific IFN-gamma-producing CD8+ T cells in infected children correlate positively with plasma viral load. J Virology. 76, 24: 12414.
5. BUSEYNE F., SCOTT-ALGARA D., BELLAL N., BURGARD M., ROUZIOUX C., BLANCHE S., RIVIERE Y. (2005). The frequency of HIV-specific IFN-gamma-producing CD8T cells is associated with both age and level of antigenic stimulation in HIV-infected children. J. Infect. Dis. 192, 1781-1786
6. CAMPBELL J.J., BUTCHER E.C. (2000). Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr Opin Immunol. 12, 336-341.
7. CHAMPAGNE P., OGG G.S., KING A.S., KNABENHANS C., ELLEFSEN K., NOBILE M., APPAY V., RIZZARDI G.P., FLEURY S., LIPP M., FÖRSTER R., ROWLAND-JONES S., SÉKALY R.P., MCMICHAEL A.J., PANTALEO G. (2001). Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature. 410, 106-111.
8. CHINEN J., SHEARER W.T. (2002). Molecular virology and immunology of HIV infection. J Allergy Clin Immunol. 110, 189-198.
9. D'OFFIZI G., MONTESANO C., AGRATI C., GIOIA C., AMICOSANTE M., TOPINO S., NARCISO P., PUCILLO L.P., IPPOLITO G., POCCIA F. (2002). Expansion of pre-terminally differentiated CD8 T cells in chronic HIV-positive patients presenting a rapid viral rebound during structured treatment interruption. AIDS. 16, 2431-2438.
10. DOUEK D. (2007). HIV disease progression: immune activation, microbes, and a leaky gut. Top HIV Med. 15, 114-117.
11. DUNN D. AND HIV PAEDIATRIC PROGNOSTIC MARKERS COLLABORATIVE STUDY GROUP. (2003). Short-term risk of disease progression in HPV-1-infected children receiving no antiretroviral therapy or zidovudine monotherapy: a meta-analysis. Lancet. 362 (9396), 1605-1611.
12. GAZZARD B. (2001). BHIVA Writing Committee. British HIV Association (BHIVA) guidelines for the treatment of HIV-infected adults with antiretroviral therapy. HIV Med. 2, 276-313.
13. GOULDER RJ., JEENA P., TUDOR-WILLIAMS G., BURCHETT S. (2001). Paediatric HIV infection: correlates of protective immunity and global perspectives in prevention and management. Br Med Bull. 58, 89-108.
14. HAZENBERG M.D., OTTO S.A., VAN BENTHEM B.H., ROOS M.T., COUTINHO R.A., LANGE J.M., HAMANN D., PRINS M., MIEDEMA F. (2003). Persistent immune activation in HIV-1 infection is associated with progression to AIDS, Aids. 17, 1881-1888.
15. Hintzen R.Q. De Jong R. Lens S.M.A. Brouwer M. Baars P. Van Lier R.A.W. Regulation of CD27 expression on subsets of mature T-lymphocytes Journal of Immunology 1993 151 5 2426-2435 HINTZEN R.Q., DE JONG R., LENS S.M., BROUWER M., BAARS P., VAN LIER R.A. (1993). Regulation of CD27 expression on subsets of mature T-lymphocytes. J Immunol. 151, 2426-2435. (Pubitemid 23264495)
16. MCCLOSKEY T.W., KOHN N., LESSER M., BAKSHI S., PAHWA S. (2001). Immunophenotypic analysis of HIV-infected children: alterations within the first year of life, changes with disease progression, and longitudinal analyses of lymphocyte subsets, Cytometry. 46, 157-165.
17. MCMICHAEL A.J., ROWLAND-JONES S.L. (2001). Cellular immune responses to HIV. Nature. 410, 980-987.
18. OGG G.S., JIN X., BONHOEFFER S., DUNBAR P.R., NOWAK M.A., MONARD S., SEGAL J.P., CAO Y., ROWLAND-JONES S.L., CERUNDOLO V., HURLEY A., MARKOWTTZ M., HO D.D., NIXON D.F., MCMICHAEL A.J. (1998). Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science. 279, 2103-2106.
19. PALMA P., ROMITI M.L., CANCRINI C., PENSIEROSO S., MONTESANO C., SANTUCCI M.B., BERNARDI S., MARTINO A.M., ROSSI P., CASTELLI-GATTINARA G. (2007). Successful simplification of protease inhibitor-based HAART with triple nucleoside regimens in children vertically infected with HIV. AIDS. 21 (18), 2465-2472.
20. PALMA P., ROMITI M.L., CANCRINI C., PENSIEROSO S., MONTESANO C., BERNARDI S., AMICOSANTE M., DI CESARE S., CASTELLI-GATTINARA G., WAHREN B., ROSSI R (2008). Delayed early antiretroviral treatment is associated with an HIV-specific long-term cellular response in HIV-1 vertically infected infants. Vaccine. 26 (40), 5196-5201.
21. RABIN R.L., ROEDERER M., MALDONADO Y., PETRU A., HERZENBERG L.A., HERZENBERG L.A. (1995). Altered representation of naive and memory CD8 T cell subsets in HIV-infected children, J. Clin. Invest. 95, 2054-2060.
22. RESINO S., GALÁN L, PÉREZ A., LEÓN J.A., SEOANE E., GuRBiNDO D., MUÑOZ-FERNANDEZ M.A. (2004). HIV-infected children with moderate/severe immunesuppression: changes in the immune system after highly active antiretroviral therapy Clin. Exp. Immunol. 137, 570-577.
23. RESINO S., CORREA R., J.M. BELLON, MUNOZ-FERNANDEZ M.A. (2003). Preserved immune system in longterm asymptomatic vertically HLV-1 infected children. Clin. Exp. Immunol. 132, 105-112.
24. SALLUSTO F., GEGINAT J., LANZAVECCHIA A. (2004). Central memory and effector memory T cell subsets: function, generation, and maintenance, Annu. Rev. Immunol. 2, 745-763.
25. Sallusto F. Lenig D. Forster R. Lipp M. Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions Nature 1999 401 6754 708-712 SALLUSTO F., LENIG D., FORSTER R., LIPP M., LANZAVECCHIA A. (1999). Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 401, 708-712. (Pubitemid 129515761)
26. + effector and memory T cell generation Nature Immunology 2003 4 9 835-842 DOI 10.1038/ni969 SEDER R.A., AHMED R. (2003). Similarities and differenees in CD4+ and CD8+ effector and memory T cell generation. Nat.Immunol. 4, 835-842. (Pubitemid 37098653)
27. SHARLAND M, BLANCHE S, CASTELLI G, RAMOS J, GIBB DM; PENTA STEERING COMMITTEE. (2004). PENTA guidelines for the use of antiretroviral therapy. HIV Medicine. 5 S2, 61-86.
28. VAN SIGHEM A., ZHANG S., REISS P., GRAS L., VAN DER ENDE M., KROON F., PRINS J., DE WOLF F. (2008). Immunologic, virologic, and clinical consequences of episodes of transient viremia during suppressive combination antiretroviral therapy. J Acquir Immune Defic Syndr. 48, 104-108.
29. WADE A.M., ADES A.E. (1998). Incorporating correlations between measurements into the estimation of age-related reference ranges. Stat. Med. 17, 1989-2002.
30. WALKER B.D., CHAKRABARTI S., MOSS B., PARADIS T.J., FLYNN T., DURNO A.G., BLUMBERG R.S., KAPLAN J.C., HIRSCH M.S., SCHOOLEY R.T. (1987). HIV-specific cytotoxic T lymphocytes in seropositive individuals. Nature. 328, 345-348.