Secretoglobin 3A2/uteroglobin-related protein 1 is a novel marker for pulmonary carcinoma in mice and humans

Lung Cancer

Volumn 71, Issue 1, 2011, Pages 42-48

  Kurotani, Reiko ^a,b   Kumaki, Nobue ^c   Naizhen, Xu ^a   Ward, Jerrold M ^d   Linnoila, R Ilona ^a   Kimura, Shioko ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d Global VetPathology   (United States)

Author keywords

Aging B6 ; 129 mice; Carcinoma marker; CC10TAg transgenic mice; Histopathological and immunohistochemical analysis; NKX2 1; NSCLC; Pulmonary carcinoma; SCGB3A2; TTF1; UGRP1

Indexed keywords

SECRETOGLOBIN 3A2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NKX2.1; TUMOR MARKER; UNCLASSIFIED DRUG; UTEROGLOBIN RELATED PROTEIN 1; VIRUS LARGE T ANTIGEN;

ADULT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL HYPERPLASIA; CLARA CELL; CONTROLLED STUDY; DISEASE MARKER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION;

ADULT; AGE FACTORS; ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MICE; MICE, TRANSGENIC; NUCLEAR PROTEINS; PROTEINS; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; UTEROGLOBIN;

EID: 78650213625     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2010.04.001     Document Type: Article

References (53)

1. Niimi T., Keck-Waggoner C.L., Popescu N.C., Zhou Y., Levitt R.C., Kimura S. UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor. Mol Endocrinol 2001, 15:2021-2036.
2. Klug J., Beier H.M., Bernard A., Chilton B.S., Fleming T.P., Lehrer R.I., et al. Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report. Ann N Y Acad Sci 2000, 923:348-354.
3. Mukherjee A.B., Kundu G.C., Mantile-Selvaggi G., Yuan C.J., Mandal A.K., Chattopadhyay S., et al. Uteroglobin: a novel cytokine?. Cell Mol Life Sci 1999, 55:771-787.
4. Kurotani R., Tomita T., Yang Q., Carlson B.A., Chen C., Kimura S. Role of secretoglobin 3A2 in lung development. Am J Respir Crit Care Med 2008, 178:389-398.
5. Chiba Y., Kurotani R., Kusakabe T., Miura T., Link B.W., Misawa M., et al. Uteroglobin-related protein 1 expression suppresses allergic airway inflammation in mice. Am J Respir Crit Care Med 2006, 173:958-964.
6. Kimura S., Hara Y., Pineau T., Fernandez-Salguero P., Fox C.H., Ward J.M., et al. The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev 1996, 10:60-69.
7. Bruno M.D., Bohinski R.J., Huelsman K.M., Whitsett J.A., Korfhagen T.R. Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interactions between the SP-A promoter and thyroid transcription factor-1. J Biol Chem 1995, 270:6531-6536.
8. Bohinski R.J., Di Lauro R., Whitsett J.A. The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis. Mol Cell Biol 1994, 14:5671-5681.
9. Kelly S.E., Bachurski C.J., Burhans M.S., Glasser S.W. Transcription of the lung-specific surfactant protein C gene is mediated by thyroid transcription factor 1. J Biol Chem 1996, 271:6881-6888.
10. Ray M.K., Chen C.Y., Schwartz R.J., DeMayo F.J. Transcriptional regulation of a mouse Clara cell-specific protein (mCC10) gene by the NKx transcription factor family members thyroid transciption factor 1 and cardiac muscle-specific homeobox protein (CSX). Mol Cell Biol 1996, 16:2056-2064.
11. Poornima S., Christian C., Kresch M.J. Developmental regulation of SP-A receptor in fetal rat lung. Lung 2002, 180:33-46.
12. Strayer M., Savani R.C., Gonzales L.W., Zaman A., Cui Z., Veszelovszky E., et al. Human surfactant protein B promoter in transgenic mice: temporal, spatial, and stimulus-responsive regulation. Am J Physiol Lung Cell Mol Physiol 2002, 282:L394-404.
13. Glasser S.W., Eszterhas S.K., Detmer E.A., Maxfield M.D., Korfhagen T.R. The murine SP-C promoter directs type II cell-specific expression in transgenic mice. Am J Physiol Lung Cell Mol Physiol 2005, 288:L625-632.
14. Xu P., Hashimoto S., Miyazaki H., Asabe K., Shiraishi S., Sueishi K. Morphometric analysis of the immunohistochemical expression of Clara cell 10-kDa protein and surfactant apoproteins A and B in the developing bronchi and bronchioles of human fetuses and neonates. Virchows Arch 1998, 432:17-25.
15. Kwei K.A., Kim Y.H., Girard L., Kao J., Pacyna-Gengelbach M., Salari K., et al. Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer. Oncogene 2008, 27:3635-3640.
16. Tanaka H., Yanagisawa K., Shinjo K., Taguchi A., Maeno K., Tomida S., et al. Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1. Cancer Res 2007, 67:6007-6011.
17. Weir B.A., Woo M.S., Getz G., Perner S., Ding L., Beroukhim R., et al. Characterizing the cancer genome in lung adenocarcinoma. Nature 2007, 450:893-898.
18. Di Loreto C., Di Lauro V., Puglisi F., Damante G., Fabbro D., Beltrami C.A. Immunocytochemical expression of tissue specific transcription factor-1 in lung carcinoma. J Clin Pathol 1997, 50:30-32.
19. Nakamura N., Miyagi E., Murata S., Kawaoi A., Katoh R. Expression of thyroid transcription factor-1 in normal and neoplastic lung tissues. Mod Pathol 2002, 15:1058-1067.
20. Camilo R., Capelozzi V.L., Siqueira S.A., Del Carlo Bernardi F. Expression of p63, keratin 5/6, keratin 7, and surfactant-A in non-small cell lung carcinomas. Hum Pathol 2006, 37:542-546.
21. Bakir K., Kocer N.E., Deniz H., Guldur M.E. TTF-1 and surfactant-B as co-adjuvants in the diagnosis of lung adenocarcinoma and pleural mesothelioma. Ann Diagn Pathol 2004, 8:337-341.
22. Burke L.M., Rush W.I., Khoor A., Mackay B., Oliveira P., Whitsett J.A., et al. Alveolar adenoma: a histochemical, immunohistochemical, and ultrastructural analysis of 17 cases. Hum Pathol 1999, 30:158-167.
23. Yamamoto O., Takahashi H., Hirasawa M., Chiba H., Shiratori M., Kuroki Y., et al. Surfactant protein gene expressions for detection of lung carcinoma cells in peripheral blood. Respir Med 2005, 99:1164-1174.
24. Linnoila R.I., Szabo E., DeMayo F., Witschi H., Sabourin C., Malkinson A. The role of CC10 in pulmonary carcinogenesis: from a marker to tumor suppression. Ann N Y Acad Sci 2000, 923:249-267.
25. Hicks S.M., Vassallo J.D., Dieter M.Z., Lewis C.L., Whiteley L.O., Fix A.S., et al. Immunohistochemical analysis of Clara cell secretory protein expression in a transgenic model of mouse lung carcinogenesis. Toxicology 2003, 187:217-228.
26. Magdaleno S.M., Wang G., Mireles V.L., Ray M.K., Finegold M.J., DeMayo F.J. Cyclin-dependent kinase inhibitor expression in pulmonary Clara cells transformed with SV40 large T antigen in transgenic mice. Cell Growth Differ 1997, 8:145-155.
27. Linnoila R.I., Sahu A., Miki M., Ball D.W., DeMayo F.J. Morphometric analysis of CC10-hASH1 transgenic mouse lung: a model for bronchiolization of alveoli and neuroendocrine carcinoma. Exp Lung Res 2000, 26:595-615.
28. Linnoila R.I., Zhao B., DeMayo J.L., Nelkin B.D., Baylin S.B., DeMayo F.J., et al. Constitutive achaete-scute homologue-1 promotes airway dysplasia and lung neuroendocrine tumors in transgenic mice. Cancer Res 2000, 60:4005-4009.
29. Tachihara-Yoshikawa M., Ishida T., Watanabe K., Sugawawa A., Kanazawa K., Kanno R., et al. Expression of secretoglobin3A2 (SCGB3A2) in primary pulmonary carcinomas. Fukushima J Med Sci 2008, 54:61-72.
30. Haines D.C., Chattopadhyay S., Ward J.M. Pathology of aging B6;129 mice. Toxicol Pathol 2001, 29:653-661.
31. Ward J.M., Anver M.R., Mahler J.F., Devor-Henneman D.E. Pathology of mice commonly used in genetic engineering (C57BL/6; 129; B6, 129 and FVB/N) 2000, Iowa State University Press, Ames.
32. Tomita T., Kido T., Kurotani R., Iemura S., Sterneck E., Natsume T., et al. CAATT/Enhancer-binding proteins {alpha} and {delta} interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression. J Biol Chem 2008, 283:25617-25627.
33. International Classification of Rodent Tumors The mouse. WHO international agency for research on cancer 2001, Springer, Berlin, New York. U. Mohr (Ed.).
34. Ward J.M., Singh G., Katyal S.L., Anderson L.M., Kovatch R.M. Immunocytochemical localization of the surfactant apoprotein and Clara cell antigen in chemically induced and naturally occurring pulmonary neoplasms of mice. Am J Pathol 1985, 118:493-499.
35. Nikitin A.Y., Alcaraz A., Anver M.R., Bronson R.T., Cardiff R.D., Dixon D., et al. Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium. Cancer Res 2004, 64:2307-2316.
36. Histological typing of lung and pleural tumours. WHO international classification of tumors 1999, Springer, New York. W.D. Travis, T.V. Colby, B. Corrin, Y. Shimosato, E. Brambilla (Eds.).
37. Szabo E., Goheer A., Witschi H., Linnoila R.I. Overexpression of CC10 modifies neoplastic potential in lung cancer cells. Cell Growth Differ 1998, 9:475-485.
38. Leyton J., Manyak M.J., Mukherjee A.B., Miele L., Mantile G., Patierno S.R. Recombinant human uteroglobin inhibits the in vitro invasiveness of human metastatic prostate tumor cells and the release of arachidonic acid stimulated by fibroblast-conditioned medium. Cancer Res 1994, 54:3696-3699.
39. Yang Y., Zhang Z., Mukherjee A.B., Linnoila R.I. Increased susceptibility of mice lacking Clara cell 10-kDa protein to lung tumorigenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a potent carcinogen in cigarette smoke. J Biol Chem 2004, 279:29336-29340.
40. Krop I., Parker M.T., Bloushtain-Qimron N., Porter D., Gelman R., Sasaki H., et al. HN-1, an inhibitor of cell growth, invasion, and AKT activation. Cancer Res 2005, 65:9659-9669.
41. Niimi T., Copeland N.G., Gilbert D.J., Jenkins N.A., Srisodsai A., Zimonjic D.B., et al. Cloning, expression, and chromosomal localization of the mouse gene (Scgb3a1, alias Ugrp2) that encodes a member of the novel uteroglobin-related protein gene family. Cytogenet Genome Res 2002, 97:120-127.
42. Krop I.E., Sgroi D., Porter D.A., Lunetta K.L., LeVangie R., Seth P., et al. HN-1 a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells. Proc Natl Acad Sci USA 2001, 98:9796-9801.
43. Krop I., Player A., Tablante A., Taylor-Parker M., Lahti-Domenici J., Fukuoka J., et al. Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types. Mol Cancer Res 2004, 2:489-494.
44. Watson M.A., Dintzis S., Darrow C.M., Voss L.E., DiPersio J., Jensen R., et al. Mammaglobin expression in primary, metastatic, and occult breast cancer. Cancer Res 1999, 59:3028-3031.
45. Zafrakas M., Petschke B., Donner A., Fritzsche F., Kristiansen G., Knuchel R., et al. Expression analysis of mammaglobin A (SCGB2A2) and lipophilin B (SCGB1D2) in more than 300 human tumors and matching normal tissues reveals their co-expression in gynecologic malignancies. BMC Cancer 2006, 6:88.
46. Barlesi F., Pinot D., Legoffic A., Doddoli C., Chetaille B., Torre J.P., et al. Positive thyroid transcription factor 1 staining strongly correlates with survival of patients with adenocarcinoma of the lung. Br J Cancer 2005, 93:450-452.
47. Kang Y., Hebron H., Ozbun L., Mariano J., Minoo P., Jakowlew S.B. Nkx2.1 transcription factor in lung cells and a transforming growth factor-beta1 heterozygous mouse model of lung carcinogenesis. Mol Carcinog 2004, 40:212-231.
48. Bai X.Y., Shen H. Mutational analysis of thyroid transcription factor-1 gene (TTF-1) in lung carcinomas. In Vitro Cell Dev Biol Anim 2008, 44:17-25.
49. Ellis L., Atadja P.W., Johnstone R.W. Epigenetics in cancer: targeting chromatin modifications. Mol Cancer Ther 2009, 8:1409-1420.
50. Grady W.M., Carethers J.M. Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology 2008, 135:1079-1099.
51. Fackenthal J.D., Godley L.A. Aberrant RNA splicing and its functional consequences in cancer cells. Dis Model Mech 2008, 1:37-42.
52. Papagiannakopoulos T., Kosik K.S. MicroRNAs: regulators of oncogenesis and stemness. BMC Med 2008, 6:15.
53. Tomita T., Kimura S. Regulation of mouse Scgb3a1 gene expression by NF-Y and association of CpG methylation with its tissue-specific expression. BMC Mol Biol 2008, 9:5.