Nkx2.1 transcription factor in lung cells and a transforming growth factor-β1 heterozygous mouse model of lung carcinogenesis

Molecular Carcinogenesis

Volumn 40, Issue 4, 2004, Pages 212-231

  Kang, Yang ^a   Hebron, Haroun ^a   Ozbun, Laurent ^a   Mariano, Jennifer ^a   Minoo, Parviz ^b   Jakowlew, Sonia B ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Lung carcinogenesis; Mouse model; Nkx2.1; TGF 1; Transcription factor

Indexed keywords

GENE PRODUCT; LUCIFERASE; MESSENGER RNA; PLASMID VECTOR; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; PROTEIN NKX2.1; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; TUMOR MARKER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER MODEL; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; HETEROZYGOTE; HOMEOBOX; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG ADENOMA; LUNG CARCINOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; BLOTTING, NORTHERN; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, NEOPLASTIC; IMMUNOHISTOCHEMISTRY; LUNG; LUNG NEOPLASMS; MICE; NUCLEAR PROTEINS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; THYMIDINE; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; TRITIUM;

ANIMALIA;

EID: 4043076215     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/mc.20034     Document Type: Article

References (68)

1. Harvey RP. NK-2 homeobox genes and heart development. Dev Biol 1996;178:203-216.
2. Lazzaro D, Price M, De Felice M, Di Lauro R. The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the fetal brain. Development 1991;113:1093-1104.
3. Minoo P, Su G, Drum H, Bringas P, Kimura S. Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos. Dev Biol 1999;209:60-71.
4. Kimura S, Hara Y, Pineau T, Fernandaz-Salguero P, Fox CH, Ward JM, et al. The T/ebp null mouse: Thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev 1996;10:60-69.
5. Bohinski RJ, Di Lauro R, Whitsett JA. The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis. Mol Cell Biol 1994;14:5671-5681.
6. Bruno MD, Bohinski RJ, Huelsman KM, Whitsett JA, Korfhagen TR. Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interaction between the Sp-A promoter and thyroid transcription factor-1. J Biol Chem 1995;270:6531-6536.
7. Kelly SE, Bachurski CJ, Burhans MS, Glasser SW. Transcription of the lung-specific surfactant protein C gene is mediated by thyroid transcription factor 1. J Biol Chem 1996;271:6881-6888.
8. Yan C, Sever Z, Whitsett JA. Upstream enhancer activity in the human surfactant protein B gene is mediated by thyroid transcription factor 1. J Biol Chem 1995;270:24852-24857.
9. Li C, Ling X, Yuan B, Minoo P. A novel DNA element mediates transcription of NKX2.1 by Sp1 and Sp3 in pulmonary epithelial cells. Biochim Biophys Acta 2000;1490:213-224.
10. Li C, Zhu N-L, Tan RC, Ballard PL, Derynck R, Minoo P. Transforming growth factor-β inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors. J Biol Chem 2002;277:38399-38408.
11. Ordonez NG. Thryroid transcription factor-1 is a marker of lung and thyroid carcinomas. Adv Anat Pathol 2000;7:123-127.
12. Serra R, Pelton RW, Moses HL. TGF-β1 inhibits branching morphogenesis and N-myc expression in lung bud organ cultures. Development 1994;120:2153-2161.
13. Zhao J, Bu D, Lee M, Slavkin HC, Hall FL, Warburton D. Abrogation of transforming growth factor-β type II receptor stimulates embryonic mouse lung morphogenesis in culture. Dev Biol 1996;180:242-257.
14. Serra R, Moses HL. pRb is necessary for inhibition of N-myc expression by TGF-β1 in embryonic lung organ cultures. Development 1995;121:3057-3066.
15. Roberts AB, Sporn MB. The transforming growth factor-βs. In: Sporn MB, Roberts AB, editors. Handbook of experimental pharmacolgy. Peptide growth factors and their receptors. Vol. 95/I. Springer-Verlag: Heidelberg, FRG; 1990. pp 419-472.
16. Piek E, Heldin C-H, ten Dijke P. Specificity, diversity, and regulation in TGF-β superfamily signaling. FASEB J 1999;13: 2105-2124.
17. Massagué J, Wotton D. Transcriptional control by the TGF-β/Smad signaling system. EMBO J 2000;19:1745-1754.
18. Kim S-J, Glick A, Sporn MB, Roberts AB. Characterization of the promoter region of the human transforming growth factor-β1 gene. J Biol Chem 1989;264:402-408.
19. Geiser AG, Kim S-J, Roberts AB, Sporn MB. Characterization of the mouse transforming growth factor-β1 promoter and activation by the Ha-ras oncogene. Mol Cell Biol 1991;11: 84-92.
20. Geiser AG, Busam KJ, Kim S-J, et al. Regulation of the transforming growth factor-β1 and -β3 promoters by transcription factor Sp1. Gene 1993;129:223-228.
21. Bloom BB, Humphries DE, Kuang PP, Fine P, Goldstein RH. Structure and expression of the promoter for the R4/ALK5 human type I transforming growth factor-β receptor: Regulation by TGF-β. Biochim Biophys Acta 1996;1312: 243-248.
22. Bae HW, Geiser AG, Kim DH, et al. Characterization of the promoter region of the human transforming growth factor-β type II receptor gene. J Biol Chem 1995;270:29460-29468.
23. Jennings R, Alsarraj M, Wright KL, Muñoz-Antonia T. Regulation of the human transforming growth factor β type II receptor gene promoter by novel Sp1 sites. Oncogene 2001;20:6899-6909.
24. Lania L, Majello B, De Luca P. Transcriptional regulation by the Sp family proteins. Int J Biochem Cell Biol 1997;29:1313-1323.
25. Marin M, Karis A, Visser P, Grosveld F, Philipsen S. Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell 1997;89:619-628.
26. Black AR, Jensen D, Lin SY, Azizkhan JC. Growth/cell cycle regulation of Sp1 phosphorylation. J Biol Chem 1999;274: 1207-1215.
27. Suzuki T, Kimura A, Nagai R, Horikoshi M. Regulation of interaction of the acetyltransferase region of p300 and the DNA-binding domain of Sp1 on and through DNA binding. Genes Cells 2000;5:29-41.
28. Han I, Kudlow JE. Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility. Mol Cell Biol 1997;17:2550-2558.
29. II130 are required for interactions with glutamine-rich transcriptional activators. Mol Cell Biol 1998;18: 5734-5743.
30. Hirano F, Tanaka H, Hirano Y, et al. Functional interference of Sp1 and NF-κB through the same DNA binding site. Mol Cell Biol 1998;18:1266-1274.
31. Suske G. The Sp-family of transcription factors. Gene 1999; 238:291-300.
32. Hagen G, Muller S, Beato M, Suske G. Sp1-mediated transcriptional activation is repressed by Sp3. EMBO J 1994;13: 3843-3851.
33. Birnbaum MJ, van Wijnen AJ, Odgren PR, et al. Sp1 trans-activation of cell-cycle regulated promoters is selectively repressed by Sp3. Biochemistry 1995;34:16503-16508.
34. Kumar AP, Butler AP. Transcription factor Sp3 antagonizes activation of the ornithine decarboxylase promoter by Sp1. Nucleic Acids Res 1997;25:2012-2019.
35. Toonen RFG, Gowan S, Bingle CD. The lung enriched transcription factor TTF-1 and the ubiquitously expressed proteins Sp1 and Sp3 interact with elements located in the minimal promoter of the rat Clara cell secretory protein gene. Biochem J 1996;316:467-473.
36. Margana RK, Boggaram V. Functional analysis of surfactant protein B (SP-B) promoter. Sp1, Sp3, TTF-1, and HNF-3 transcription factors are necessary for lung cell-specific activation of SP-B gene transcription. J Biol Chem 1997; 272:3083-3090.
37. Jakowlew SB, Moody TW, You L, Mariano JM. Transforming growth factor-beta expression in mouse lung carcinogenesis. Exp Lung Res 1998;24:579-593.
38. Jakowlew SB, Moody TW, You L, Mariano JM. Reduction in transforming growth factor-β type II receptor in mouse lung carcinogenesis. Mol Carcinog 1998;22:46-56.
39. Tang B, Bottinger EP, Jakowlew SB, et al. Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency. Nature Med 1998;4:802-807.
40. Kang Y, Mariano JM, Andgisen J, et al. Enhanced tumorigenesis and reduced transforming growth factor-β type II receptor in lung tumors from mice with reduced gene dosage of transforming growth factor-β1. Mol Carcinog 2000;29: 112-126.
41. Malkinson M, Dwyer-Nield LD, Rice PL, Dinsdale D. Mouse lung epithelial cell lines-tools for the study of differentiation and the neoplastic phenotype. Toxicology 1997;123:53-100.
42. Church GM, Gilbert W. Genomic sequencing. Proc Natl Acad Sci USA 1984;80:1991-1995.
43. Hamdan H, Liu H, Li C, et al. Structure of the human Nkx2.1 gene. Biochim Biophys Acta 1998;1396:336-348.
44. Qian SW, Kondaiah P, Roberts AB, Sporn MB. cDNA cloning by PCR of rat transforming growth factor-β1. Nucleic Acids Res 1990;8:3059.
45. Miller DA, Lee A, Pelton RW, Chen EY, Moses HL, Derynck R. Murine transforming growth factor-β2 cDNA sequence and expression in adult tissues and embryos. Mol Endocrinol 1989;3:1108-1114.
46. Denhez F, Lafyatis R, Kondaiah K, Roberts AB, Sporn MB. Cloning by polymerase chain reaction of a new mouse TGF-β, F-β3. Growth Factors 1990;3:1325-1345.
47. Franzen P, ten Dijke P, Ichijo H, et al. Cloning of a type I receptor that forms a heteromeric complex with the TGFβ type II receptor. Cell 1993;75:681-692.
48. Lin HY, Wang X-F, Ng-Eaton E, Weinberg RA, Lodish HF. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell 1992;68:775-785.
49. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72: 248-254.
50. Bonner RF, Emmret-Buck M, Pohida T, Chuaqui R, Goldstein S, Liotta LA. Laser capture microdissection: Molecular analysis of tissue. Science 1997;278:1481-1483.
51. Wang AM, Doyle MV, Mark DF. Quantitation of mRNA by the polymerase chain reaction. Proc Natl Acad Sci USA 1989; 86:9717-9721.
52. 1/S regulatory genes occurs early and frequently in lung carcinogenesis in transforming growth factor-β1 terozygous mice. Carcinogenesis 2002;23:1217-1227.
53. Vivien D, Attisano L, Wrana J, Massagué J. Signaling activity of homologous and heterologous transforming growth factor-β receptor kinase complexes. J Biol Chem 1995;270: 7134-7141.
54. Vindevoghel L, Lechleider RJ, Kon A, et al. SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor β. Proc Natl Acad Sci USA 1998;95:14769-14774.
55. Poncelet A-C, de Caestecker MP, Schnaper HW. The transforming growth factor-β/SMAD signaling pathway is present and functional in human mesangial cells. Kidney Int 1999;56: 1354-1365.
56. de Castecker MP, Yahata T, Wang D, et al. The Smad4 activation domain (SAD) is a proline-rich, p-300-dependent transcriptional activation domain. J Biol Chem 1999;275: 2115-2122.
57. Oguchi H, Pan Y-T, Kimura S. The complete nucleotide sequence of the mouse thyroid-specific enhancer-binding protein (T/EBP) gene: Extensive identity of the deduced amino acid sequence with the human protein. Biochim Biophys Acta 1995;1261:304-306.
58. Derynck R, Zhang Y, Feng X-H. Smads: Transcriptional activators of TGF-β responses. Cell 1998;55:737-740.
59. Feng X-H, Lin X, Derynck R. Smad2, Smad3, and Smad4 cooperate with Sp1 to induce p15 Ink4B transcription in response to TGF-β. EMBO J 2000;19:5178-5193.
60. Letterio JJ, Geiser AG, Kulkarni AB, Roche NS, Sporn MB, Roberts AB. Maternal rescue of transforming growth factor-β1 null mice. Science 1994;264:1936-1938.
61. Sanford LP, Ormsby I, Gittenberger-de Groot AC, et al. TGF-β2 knockout mice have multiple developmental defects that are non-overlapping with other TGF-β knockout phenotypes. Development 1997;124:2659-2670.
62. Kaartinen V, Voncken JW, Shuler C, et al. Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction. Nat Genet 1995;11:415-421.
63. Bowen C, Lukas B, Voeller HJ, et al. Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression. Cancer Res 2000;60:6111-6115.
64. Bhatia-Gaur R, Donjacour AA, Sciavolino PJ, et al. Roles for Nkx3.1 in prostate development and cancer. Genes Dev 1999;13:966-977.
65. Kim MJ, Cardiff RD, Desai N, et al. Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carci carcinogenesis. Proc Natl Acad Sci USA 2002;99:2884-2889.
66. Kaufmann O, Dietel M. Thyroid transcription factor-1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B. Histopathology 2000;36:8-16.
67. Pelosi G, Fraggetta F, Pasini F, Maisonneuve P, Sonzogni A, Iannucci A, et al. Immunoreactivity for thyroid transcription factor-1 in stage I non-small cell carcinomas of the lung. Am J Surg Pathol 2001;25:363-372.
68. Baylin SB, Herman JG. DNA hypermethylation in tumorigenesis. Trends Genet 2000;16:168-174.