Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for detection and identification of albumin phosphylation by organophosphorus pesticides and G- and V-type nerve agents

Analytical and Bioanalytical Chemistry

Volumn 398, Issue 6, 2010, Pages 2677-2691

  John, Harald ^a   Breyer, Felicitas ^b   Thumfart, Jörg Oliver ^c   Höchstetter, Hans ^b   Thiermann, Horst ^a  

^a BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

^b UNIVERSITY OF APPLIED SCIENCES   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Albumin adducts; MALDI TOF MS; Nerve agents; Organophosphorus compounds; Verification

Indexed keywords

AFFINITY EXTRACTION; ALBUMIN ADDUCTS; ANALYTICAL DESIGN; BUTYRYLCHOLINESTERASE; CHLORPYRIFOS-OXON; CYCLOSARIN; ENZYMATIC CLEAVAGE; FLUOROPHOSPHATE; HIGH DOSE; HUMAN SERUM ALBUMINS; IN-VITRO; IN-VIVO; MALDI MS/MS; MALDI-TOF MS; MASS SHIFT; MATRIX-ASSISTED LASER; MATRIX-ASSISTED LASER DESORPTION/IONIZATION-TIME-OF-FLIGHT MASS SPECTROMETRY; MOLAR RATIO; NERVE AGENTS; ORGANOPHOSPHORUS COMPOUNDS; ORGANOPHOSPHORUS PESTICIDE; PARAOXON; PROFENOFOS; SIGNAL INTENSITIES; SODIUM DODECYL SULFATE-POLYACRYLAMIDE GEL ELECTROPHORESIS; TIME OF FLIGHT MASS SPECTROMETRY; VERIFICATION TOOLS;

AGRICULTURAL CHEMICALS; AMINO ACIDS; DESORPTION; ELECTROPHORESIS; GELS; MASS SPECTROMETERS; PESTICIDES; PHOSPHORUS COMPOUNDS; POLYACRYLATES; SODIUM; SODIUM SULFATE; ULTRAFILTRATION;

MASS SPECTROMETRY;

CHEMICAL WARFARE AGENT; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; ORGANOPHOSPHORUS COMPOUND; PESTICIDE; PHOSPHOROTHIOIC ACID DERIVATIVE; SERUM ALBUMIN;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; IN VITRO STUDY; MASS SPECTROMETRY; METHODOLOGY; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; ULTRAFILTRATION;

CHEMICAL WARFARE AGENTS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; MOLECULAR STRUCTURE; ORGANOPHOSPHORUS COMPOUNDS; ORGANOTHIOPHOSPHORUS COMPOUNDS; PESTICIDES; PHOSPHORYLATION; SERUM ALBUMIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; ULTRAFILTRATION;

EID: 78650204213     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-010-4076-y     Document Type: Article

References (37)

1. Casida JE, Quistad GB (2005) Chem Biol Interact 157-158:277-283
2. Bakry NM, El-Rashidy AH, Eldefrawi AT, Eldefrawi ME (1988) J Biochem Toxicol 3:235-259
3. Costa LG (2006) Clin Chim Acta 366:1-13
4. Grigoryan H, Li B, Anderson EK, Xue W, Nachon F, Lockridge O, Schopfer LM (2009) Chem Biol Interact 180:492-498
5. John H, Balszuweit F, Kehe K, Worek F, Thiermann H (2009) In: Gupta R (ed) Handbook of toxicology of chemical warfare agents. Academic, Amsterdam, pp 755-790
6. Schrader G (1950) Angew Chem 62:471-490
7. Fidder A, Hulst AG, Noort D, de Ruiter R, van der Schans MJ, Benschop HP, Langenberg JP (2002) Chem Res Toxicol 15:582-590
8. Tsuge K, Seto Y (2006) J Chromatogr B 838:21-30
9. Noort D, Fidder A, van der Schans MJ, Hulst AG (2006) Anal Chem 78:6640-6644
10. Read RW, Riches JR, Stevens JA, Stubbs SJ, Black RM (2010) Arch Toxicol 84:25-36
11. Peeples ES, Schopfer LM, Duysen EG, Spaulding R, Voelker T, Thompson CM, Lockridge O (2005) Toxicol Sci 83:303-312
12. Williams NH, Harrison JM, Read RW, Black RM (2007) Arch Toxicol 81:627-639
13. Tarhoni MH, Lister T, Ray DE, Carter WG (2008) Biomarkers 13:343-363
14. Graham JR, Wright BS, Rezk PE, Gordon RK, Sciuto AM, Nambiar MP (2006) Inhal Toxicol 18:493-500
15. Noort D, Benschop HP, Black RM (2002) Toxicol Appl Pharmacol 184:116-126
16. Noort D, Hulst AG, van Zuylen A, van Rijssel E, van der Schans MJ (2009) Arch Toxicol 83:1031-1036
17. John H, Worek F, Thiermann H (2008) Anal Bioanal Chem 391:97-116
18. Li B, Schopfer LM, Hinrichs SH, Masson P, Lockridge O (2007) Anal Biochem 361:263-272
19. Ding SJ, Carr J, Carlson JE, Tong L, Xue W, Li Y, Schopfer LM, Li B, Nachon F, Asojo O, Thompson CM, Hinrichs SH, Masson P, Lockridge O (2008) Chem Res Toxicol 21:1787-1794
20. Li B, Nachon F, Froment MT, Verdier L, Debouzy JC, Brasme B, Gillon E, Schopfer LM, Lockridge O, Masson P (2008) Chem Res Toxicol 21:421-431
21. Manoharan I, Boopathy R (2006) Arch Biochem Biophys 452:186-188
22. Sanger F (1963) Proc Chem Soc 5:76-83
23. Liu Y, Patricelli MP, Cravatt BF (1999) Proc Nat Acad Sci USA 96:14694-14699
24. Black RM, Harrison JM, Read RW (1999) Arch Toxicol 73:123-126
25. Li B, Ricordel I, Schopfer LM, Baud F, Megarbane B, Nachon F, Masson P, Lockridge O (2010) Toxicol Sci 116:23-31
26. Lockridge O, Schopfer LM (2010) Chem Biol Interact 187:344-348. doi:10.1016/j.cbi.2010.03.002
27. Schopfer LM, Champion MM, Tamblyn N, Thompson CM, Lockridge O (2005) Anal Biochem 345:122-132
28. Gerhard R, John H, Aktories K, Just I (2003) Mol Pharmacol 63:1349-1355
29. John H, Radtke K, Ständker L, Forssmann WG (2005) Biochim Biophys Acta 1747:161-170
30. John H, Schulz S, Forssmann WG (2007) Biopharm Drug Dispos 28:73-85
31. Elhanany E, Ordentlich A, Dgany O, Kaplan D, Segall Y, Barak R, Velan B, Shafferman A (2001) Chem Res Toxicol 14:912-918
32. Granvogl B, Plöscher M, Eichacker LA (2007) Anal Bioanal Chem 388:991-1002
33. Schopfer LM, Grigoryan H, Li B, Nachon F, Masson P, Lockridge O (2010) J Chromatogr B 878:1297-1311
34. Gilley C, MacDonald M, Nachon F, Schopfer LM, Zhang J, Cashman JR, Lockridge O (2009) Chem Res Toxicol 22:1680-1688
35. Schuerenberg M, Luebbert C, Eickhoff H, Kalkum M, Lehrach H, Nordhoff E (2000) Anal Chem 72:3436-3442
36. Worek F, Diepold C, Eyer P (1999) Arch Toxicol 73:7-13
37. Benschop HP, De Jong LPA (2001) In: Somani SM, Romano JA Jr (eds) Chemical warfare agents: Toxicity at low levels. CRC, Boca Raton, pp 25-81