Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: Characteristic mass fragments and a new binding motif for organophosphates

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 17-18, 2010, Pages 1297-1311

  Schopfer, Lawrence M ^a   Grigoryan, Hasmik ^a   Li, Bin ^a   Nachon, Florian ^b   Masson, Patrick ^b   Lockridge, Oksana ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b CENTRE DE RECHERCHES   (France)

Author keywords

Characteristic ions; Covalent bond; Mass spectrometry; Organophosphorus; Tyrosine

Indexed keywords

AMINO ACIDS; BINS; COVALENT BONDS; DRUG PRODUCTS; IONS; MASS SPECTROMETRY; PEPTIDES; SPECTRUM ANALYZERS;

CHARACTERISTIC MASS; CONSENSUS SEQUENCE; DIISOPROPYLFLUOROPHOSPHATE; FRAGMENTATION PATTERNS; ORGANOPHOSPHORUS; PHENOLIC HYDROXYL GROUP; POSITIVELY CHARGED; TYROSINE;

PROTEINS;

BIOTIN; CHLORPYRIFOS; DYFLOS; HYDROXYL GROUP; ORGANOPHOSPHATE; PEPTIDE DERIVATIVE; SARIN; SERINE; SOMAN; TRYPSIN; TYROSINE; PEPTIDE FRAGMENT; PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMICAL LABELING; CONSENSUS SEQUENCE; COVALENT BOND; ELECTRIC POTENTIAL; FRAGMENTATION REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN PROCESSING; QUADRUPOLE MASS SPECTROMETRY; ANIMAL; CATTLE; CHEMISTRY; METABOLISM; METHODOLOGY; TANDEM MASS SPECTROMETRY;

AMINO ACID MOTIFS; ANIMALS; BINDING SITES; BIOTIN; CATTLE; HUMANS; PEPTIDE FRAGMENTS; PHOSPHORIC ACID ESTERS; PROTEINS; TANDEM MASS SPECTROMETRY; TRYPSIN; TYROSINE;

EID: 77954087882     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.07.026     Document Type: Article

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