Antioxidant responses to acute ozone challenge in the healthy human airway

Inhalation Toxicology

Volumn 21, Issue 11, 2009, Pages 933-942

  Behndig, Annelie F ^a   Blomberg, Anders ^a   Helleday, Ragnberth ^a   Duggan, Sean T ^b   Kelly, Frank J ^b   Mudway, Ian S ^b  

^a UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Air pollution; Bronchial biopsies; Glutathione; Respiratory tract lining fluid

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; GLUTATHIONE; OZONE; SUPEROXIDE DISMUTASE; THIOL; URATE;

ADULT; AIRWAY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BRONCHOSCOPY; BRONCHUS BIOPSY; BRONCHUS MUCOSA; ENVIRONMENTAL IMPACT; FEMALE; HUMAN; HUMAN TISSUE; LEUKOCYTE; LUNG ALVEOLUS SURFACE TENSION; LUNG BIOPSY; LUNG LAVAGE; MACROPHAGE; MALE; NEUTROPHIL; NORMAL HUMAN; NOSE MUCUS; PRIORITY JOURNAL; RESPIRATORY SYSTEM; TRACHEOBRONCHIAL TOILET;

ADULT; ANTIOXIDANTS; BIOPSY; BRONCHI; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INHALATION EXPOSURE; LEUKOCYTES; MALE; OXIDANTS, PHOTOCHEMICAL; OZONE; RESPIRATORY FUNCTION TESTS; YOUNG ADULT;

EID: 70350664449     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370802603789     Document Type: Article

References (47)

1. Aoshiba, K., Nagai, A., Yasui, S., Konno, K. 1996. Nicotine prolongs neutrophil survival by suppressing apoptosis. J Lab Clin Med 127: 186-194.
2. Behndig, A.F., Mudway, I.S., Brown, J.L., Stenfors, N., Helleday, R., Duggan, S.T., Wilson, S.J., Boman, C., Cassee, F.R., Frew, A.J., Kelly, F.J., Sandstrom, T., and Blomberg, A. 2006. Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans. Eur Respir J 27: 359-365.
3. Blomberg, A., Mudway, I.S., Nordenhall, C., Hedenstrom, H., Kelly, F.J., Frew, A.J., Holgate, S.T., and Sandstrom, T. 1999. Ozone-induced lung function decrements do not correlate with early airway inflammatory or antioxidant responses. Eur Respir J 13: 1418-1428.
4. Boehme, D.S., Hotchkiss, J.A., and Henderson, R.F. 1992. Glutathione and GSH-dependent enzymes in bronchoalveolar lavage fluid cells in response to ozone. Exp Mol Pathol 56: 37-48.
5. Bunnell, E., and Pacht, E.R. 1993. Oxidized glutathione is increased in the alveolar fluid of patients with the adult respiratory distress syndrome. Am Rev Respir Dis 148: 1174-1178.
6. Duan, X., Buckpitt, A.R., Pinkerton, K.E., Ji, C., and Plopper, C.G. 1996. Ozoneinduced alterations in glutathione in lung subcompartments of rats and monkeys. Am J Respir Cell Mol Biol 14: 70-75.
7. Dunster, C., Mudway, I., Blomberg, A., Stenfors, N., Helleday, R., Sandstrom, T., and Kelly, F. 2003. Antioxidant kinetics in human respiratory tract lining fluid following exposure to ozone. Am J Respir Crit Care Med 167: A127 .
8. Esteve, M.J., Farre, R., Frigola, A., and Garcia-Cantabella, J.M. 1997. Determination of ascorbic and dehydroascorbic acids in blood plasma and serum by liquid chromatography. J Chromatogr B Biomed Sci Appl 688: 345-349.
9. Flens, M.J., Zaman, G.J., van der Valk, P., Izquierdo, M.A., Schroeijers, A.B., Scheffer, G.L., van der Groep, P., de Haas, M., Meijer, C.J., and Scheper, R.J. 1996. Tissue distribution of the multidrug resistance protein. Am J Pathol 148: 1237-1247. (Pubitemid 26111082)
10. Halliwell, B. 2000. The antioxidant paradox. Lancet 355(9210): 1179-1180
11. Hamilton, R.F. Jr., Li, L., Eschenbacher, W.L., Szweda, L., and Holian, A. 1998. Potential involvement of 4-hydroxynonenal in the response of human lung cells to ozone. Am J Physiol 274: 8-16.
12. Housley, D.G., Mudway, I., Kelly, F.J., Eccles, R., and Richards, R.J. 1995. Depletion of urate in human nasal lavage following in vitro ozone exposure. Int J Biochem Cell Biol 27: 1153-1159.
13. Iriyama, K., Yoshiura, M., Iwamoto, T., and Ozaki, Y. 1984. Simultaneous determination of uric and ascorbic acids in human serum by reversedphase high-performance liquid chromatography with electrochemical detection. Anal Biochem 141: 238-243. (Pubitemid 14043278)
14. Jörres, R.A., Holz, O., Zachgo, W., Timm, P., Koschyk, S., Muller, B., Grimminger, F., Seeger, W., Kelly, F.J., Dunster, C., Frischer, T., Lubec, G., Waschewski, M., Niendorf, A., and Magnussen, H. 2000. The effect of repeated ozone exposures on inflammatory markers in bronchoalveolar lavage fluid and mucosal biopsies. Am J Respir Crit Care Med 161: 1855-1861.
15. Kelly, F.J., Blomberg, A., Frew, A., Holgate, S.T., and Sandstrom, T. 1996. Antioxidant kinetics in lung lavage fluid following exposure of humans to nitrogen dioxide. Am J Respir Crit Care Med 154: 1700-1705.
16. Kirichenko, A., Li, L., Morandi, M.T., and Holian, A. 1996. 4-hydroxy-2- nonenal-protein adducts and apoptosis in murine lung cells after acute ozone exposure. Toxicol Appl Pharmacol 141(2): 416-424
17. Kermani, S., Ben-Jebria, A., and Ultman, J.S. 2006. Kinetics of ozone reaction with uric acid, ascorbic acid, and glutathione at physiologically relevant conditions. Arch Biochem Biophys 451: 8-16.
18. Kirschvink, N., Fievez, L., Bureau, F., Degand, G., Maghuin-Rogister, G., Smith, N., Art, T., and Lekeux, P. 2002. Adaptation to multiday ozone exposure is associated with a sustained increase of bronchoalveolar uric acid. Free Radical Res 36: 23-32.
19. Kodavanti, U.P., Costa, D.L., Dreher, K.L., Crissman, K., and Hatch, G.E. 1995. Ozone-induced tissue injury and changes in antioxidant homeostasis in normal and ascorbate-deficient guinea pigs. Biochem Pharmacol 50: 243-251.
20. Kodavanti, U.P., Costa, D.L., Richards, J., Crissman, K.M., Slade, R., and Hatch, G.E. 1996. Antioxidants in bronchoalveolar lavage fluid cells isolated from ozone-exposed normal and ascorbate-deficient guinea pigs. Exp Lung Res 22: 435-448.
21. Koren, H.S., Hatch, G.E., and Graham, D.E. 1990. Nasal lavage as a tool in assessing acute inflammation in response to inhaled pollutants. Toxicology 60: 15-25.
22. Krysko, D.V., Vanden Berghe, T., D'Herde, K., and Vandenabeele, P. 2008. Apoptosis and necrosis: Detection, discrimination and phagocytosis. Methods 44(3): 205-221
23. Marklund, S.L., Holme, E., and Hellner, L. 1982. Superoxide dismutase in extracellular fluids. Clin Chim Acta 126: 41-51.
24. Mills, P.C., Roberts, C.A., and Smith, N.C. 1996. Effects of ozone and airway inflammation on glutathione status and iron homeostasis in the lungs of horses. Am J Vet Res 57: 1359-1363.
25. Mudway, I.S., Blomberg, A., Frew, A.J., Holgate, S.T., Sandstrom, T., and Kelly, F.J. 1999. Antioxidant consumption and repletion kinetics in nasal lavage fluid following exposure of healthy human volunteers to ozone. Eur Respir J 13: 1429-1438.
26. Mudway, I.S., Housley, D., Eccles, R., Richards, R.J., Datta, A.K., Tetley, T.D., and Kelly, F.J. 1996. Differential depletion of human respiratory tract antioxidants in response to ozone challenge. Free Radical Res 25: 499-513.
27. Mudway, I.S., and Kelly, F.J. 2004. An investigation of inhaled ozone dose and the magnitude of airway inflammation in healthy adults. Am J Respir Crit Care Med 169(10): 1089-1095.
28. Mudway, I.S., and Kelly, F.J. 1998. Modeling the interactions of ozone with pulmonary epithelial lining fluid antioxidants. Toxicol Appl Pharmacol 148: 91-100.
29. Mudway, I.S., and Kelly, F.J. 2000. Ozone and the lung: A sensitive issue. Mol Aspects Med 21: 41-48.
30. Mudway, I.S., Stenfors, N., Blomberg, A., Helleday, R., Dunster, C., Marklund, S.L., Frew, A.J., Sandstrom, T., and Kelly, F.J. 2001. Differences in basal airway antioxidant concentrations are not predictive of individual responsiveness to ozone: A comparison of healthy and mild asthmatic subjects. Free Radical Biol Med 31: 962-974.
31. Mudway, I.S., Stenfors, N., Duggan, S.T., Roxborough, H., Zielinski, H., Marklund, S.L., Blomberg, A., Frew, A.J., Sandstrom, T., and Kelly, F.J. 2004. An in vitro and in vivo investigation of the effects of diesel exhaust on human airway lining fluid antioxidants. Arch Biochem Biophys 423: 200-212.
32. Panus, P.C., Burgess, B., and Freeman, B.A. 1991. Characterization of cultured alveolar epithelial cell xanthine dehydrogenase/oxidase. Biochim Biophys Acta 1091: 303-309.
33. Peden, D.B., Swiersz, M., Ohkubo, K., Hahn, B., Emery, B., and Kaliner, M.A. 1993. Nasal secretion of the ozone scavenger uric acid. Am Rev Respir Dis 148: 455-461.
34. Pietarinen-Runtti, P., Lakari, E., Raivio, K.O., and Kinnula, V.L. 2000. Expression of antioxidant enzymes in human inflammatory cells. Am J Physiol Cell Physiol 278: C118-C125.
35. Plopper, C.G., Duan, X., Buckpitt, A.R., and Pinkerton, K.E. 1994. Dosedependent tolerance to ozone. IV. Site-specific elevation in antioxidant enzymes in the lungs of rats exposed for 90 days or 20 months. Toxicol Appl Pharmacol 127: 124-131.
36. Rahman, I., Clerch, L.B., and Massaro, D. 1991. Rat lung antioxidant enzyme induction by ozone. Am J Physiol 260: 412-418.
37. Rahman, I., and MacNee, W. 1996. Role of oxidants/antioxidants in smokinginduced lung diseases. Free Radical Biol Med 21: 669-681.
38. Ricciardolo, F.L., Caramori, G., Ito, K., Capelli, A., Brun, P., Abatangelo, G., Papi, A., Chung, K.F., Adcock, I., Barnes, P.J., Donner, C.F., Rossi, A., and Di Stefano, A. 2005. Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease. J Allergy Clin Immunol 116: 1028-1035. (Pubitemid 41571783)
39. Smith, P.K., Krohn, R.I., Hermanson, G.T., Mallia, A.K., Gartner, F.H., Provenzano, M.D., Fujimoto, E.K., Goeke, N.M., Olson, B.J., and Klenk, D.C. 1985. Measurement of protein using bicinchoninic acid. Anal Biochem 150: 76-85.
40. Steck-Scott, S., Arab, L., Craft, N.M., and Samet, J.M. 2004. Plasma and lung macrophage responsiveness to carotenoid supplementation and ozone exposure in humans. Eur J Clin Nutr 58: 1571-1579.
41. Stenfors, N., Pourazar, J., Blomberg, A., Krishna, M.T., Mudway, I., Helleday, R., Kelly, F.J., Frew, A.J., and Sandstrom, T. 2002. Effect of ozone on bronchial mucosal inflammation in asthmatic and healthy subjects. Respir Med 96: 352-358.
42. van den Dobbelsteen, D.J., Nobel, C.S., Schlegel, J., Cotgreave, I.A., Orrenius, S., and Slater, A.F. 1996. Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody. J Biol Chem 271(26): 15420-15427.
43. Wang, Y., Russo, T.A., Kwon, O., Chanock, S., Rumsey, S.C., and Levine, M. 1997. Ascorbate recycling in human neutrophils: Induction by bacteria. Proc Natl Acad Sci USA 94(25): 13816-13819.
44. Weller, B.L., Witschi, H., and Pinkerton, K.E. 2000. Quantitation and localization of pulmonary manganese superoxide dismutase and tumor necrosis factor alpha following exposure to ozone and nitrogen dioxide. Toxicol Sci 54: 452-461.
45. Widdicombe, J. 1997. Microvascular anatomy of the nose. Allergy 52: 7-11.
46. Xiao, G.G., Wang, M., Li, N., Loo, J.A., and Nel, A.E. 2003. Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line. J Biol Chem 278(50): 50781-50790.
47. Yeadon, M., Wilkinson, D., Darley-Usmar, V., O'Leary, V.J., and Payne, A.N. 1992. Mechanisms contributing to ozone-induced bronchial hyperreactivity in guinea-pigs. Pulm Pharmacol 5: 39-50.