TASTPM mice expressing amyloid precursor protein and presenilin-1 mutant transgenes are sensitive to γ-secretase modulation and amyloid-β42 lowering by GSM-10h

Neurodegenerative Diseases

Volumn 8, Issue 1-2, 2010, Pages 15-24

  Hussain, Ishrut ^a   Harrison, David C ^a   Hawkins, Julie ^a   Chapman, Trevor ^a   Marshall, Ian ^a   Facci, Laura ^a   Ahmed, Sharlin ^a   Brackenborough, Kim ^a   Skaper, Stephen D ^a   Mead, Tania L ^a   Smith, Beverley B ^a   Giblin, Gerard M P ^a   Hall, Adrian ^a   Gonzalez, M Isabel ^a   Richardson, Jill C ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Secretase; Alzheimer's disease; Amyloid precursor protein; Amyloid ; Modulator; TASTPM

Indexed keywords

[1 [4 METHYL 1 [6 (TRIFLUOROMETHYL) 3 PYRIDINYL]PENTYL] 2 [4 (TRIFLUOROMETHYL)PHENYL] 4 PIPERIDINYL]ACETIC ACID; AMYLOID BETA PROTEIN[1-37]; AMYLOID BETA PROTEIN[1-38]; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; GSM 10H; NOTCH RECEPTOR; PRESENILIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CELL LEVEL; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; TRANSGENE; TRANSGENIC ANIMAL;

ACETIC ACIDS; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL DEATH; CEREBRAL CORTEX; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; MICE; MICE, TRANSGENIC; NEURONS; PEPTIDE FRAGMENTS; PIPERIDINES; PRESENILIN-1; RNA, MESSENGER; TRANSGENES;

EID: 78650179098     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000313903     Document Type: Article

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