Crataegus oxycantha extract attenuates apoptotic incidence in myocardial ischemia-reperfusion injury by regulating akt and Hif-1 signaling pathways

Journal of Cardiovascular Pharmacology

Volumn 56, Issue 5, 2010, Pages 526-531

  Jayachandran, Kesavan S ^a,b   Khan, Mahmood ^a   Selvendiran, Karuppaiyah ^a   Devaraj, S Niranjali ^b   Kuppusamy, Periannan ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MADRAS   (India)

Author keywords

apoptosis; Crataegus oxycantha; ischemia reperfusion; myocardial infarction

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; APOPTOSIS INDUCING FACTOR; CASPASE 7; CASPASE 9; CRATAEGUS EXTRACT; CREATINE KINASE; CYTOCHROME C; HYPOXIA INDUCIBLE FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEIN KINASE; RAF PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REPERFUSION INJURY; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CRATAEGUS; CREATINE KINASE; HYPOXIA-INDUCIBLE FACTOR 1; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PHYTOTHERAPY; PLANT EXTRACTS; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 78650173225     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3181f64c51     Document Type: Article

References (35)

1. Rigelsky JM, Sweet BV. Hawthorn: pharmacology and therapeutic uses. Am J Health Syst Pharm. 2002;59:417-422.
2. Zhang Z, Chang Q, Zhu M, et al. Characterization of antioxidants present in hawthorn fruits. J Nutr Biochem. 2001;12:144-152.
3. Jayalakshmi R, Thirupurasundari CJ, Devaraj SN. Pretreatment with alcoholic extract of Crataegus oxycantha (AEC) activates mitochondrial protection during isoproterenol-induced myocardial infarction in rats. Mol Cell Biochem. 2006;292:59-67.
4. Kim SH, Kang KW, Kim KW, et al. Procyanidins in Crataegus extract evoke endothelium-dependent vasorelaxation in rat aorta. Life Sci. 2000; 67:121-131.
5. Pittler MH, Schmidt K, Ernst E. Hawthorn extract for treating chronic heart failure: meta-analysis of randomized trials. Am J Med. 2003;114: 665-674
6. al Makdessi S, Sweidan H, Dietz K, et al. Protective effect of Crataegus oxyacantha against reperfusion arrhythmias after global no-flow ischemia in the rat heart. Basic Res Cardiol. 1999;94:71-77.
7. Sato M, Ray PS, Maulik G, et al. Myocardial protection with red wine extract. J Cardiovasc Pharmacol. 2000;35:263-268.
8. Pataki T, Bak I, Kovacs P, et al. Grape seed proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rat hearts. Am J Clin Nutr. 2002;75:894-899.
9. Swaminathan JK, Khan M, Mohan IK, et al. Cardioprotective properties of Crataegus oxycantha extract against ischemia-reperfusion injury. Phytomedicine. 2010;17:744-752.
10. Kutala VK, Khan M, Angelos MG, et al. Role of oxygen in postischemic myocardial injury. Antioxid Redox Signal. 2007;9:1193-1206.
11. Buja LM, Vela D. Cardiomyocyte death and renewal in the normal and diseased heart. Cardiovasc Pathol. 2008;17:349-374.
12. Tobing D, French J, Varigos J, et al. Do patients with heart failure appropriately undergo invasive procedures post-myocardial infarction? Results from a prospective multicentre study. Intern Med J. 2008;38:845-851.
13. Maulik N, Yoshida T, Das DK. Oxidative stress developed during the reperfusion of ischemic myocardium induces apoptosis. Free Radic Biol Med. 1998;24:869-875.
14. Takemura G, Fujiwara H. Role of apoptosis in remodeling after myocardial infarction. Pharmacol Ther. 2004;104:1-16.
15. Long SR, Carey RA, Crofoot KM, et al. Effect of hawthorn (Crataegus oxycantha) crude extract and chromatographic fractions on multiple activities in a cultured cardiomyocyte assay. Phytomedicine. 2006;13:643-650.
16. Selvendiran K, Tong L, Vishwanath S, et al. EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression. J Biol Chem. 2007;282:28609-28618. (Pubitemid 47606012)
17. Vierling W, Brand N, Gaedcke F, et al. Investigation of the pharmaceutical and pharmacological equivalence of different hawthorn extracts. Phytomedicine. 2003;10:8-16.
18. Schwartzbauer G, Robbins J. The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival. J Biol Chem. 2001;276:35786-35793.
19. Oudit GY, Sun H, Kerfant BG, et al. The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol. 2004;37:449-471.
20. Kim Y, Song YB, Kim TY, et al. Redox regulation of the tumor suppressor PTEN by glutathione. FEBS Lett. 2010;584:3550-3556.
21. Parcellier A, Tintignac LA, Zhuravleva E, et al. PKB and the mitochondria: AKTing on apoptosis. Cell Signal. 2008;20:21-30.
22. Cherney BW, McBride OW, Chen DF, et al. cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase. Proc Natl Acad Sci USA. 1987;84:8370-8374.
23. Wilson SH, Caplice NM, Simari RD, et al. Activated nuclear factor-kappaB is present in the coronary vasculature in experimental hypercholesterolemia. Atherosclerosis. 2000;148:23-30.
24. Rodriguez-Porcel M, Lerman LO, Holmes DR Jr, et al. Chronic antioxidant supplementation attenuates nuclear factor-kappa B activation and preserves endothelial function in hypercholesterolemic pigs. Cardiovasc Res. 2002;53:1010-1018.
25. Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med. 1996;20:933-956.
26. Svedstrom U, Vuorela H, Kostiainen R, et al. High-performance liquid chromatographic determination of oligomeric procyanidins from dimers up to the hexamer in hawthorn. J Chromatogr A. 2002;968:53-60.
27. Zhang J, Li XX, Bian HJ, et al. Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation. Clin Chim Acta. 2009;401:76-80.
28. Susin SA, Lorenzo HK, Zamzami N, et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 1999;397:441-446.
29. Patiar S, Harris AL. Role of hypoxia-inducible factor-1alpha as a cancer therapy target. Endocr Relat Cancer. 2006;13(Suppl 1):S61-S75.
30. Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science. 2001;294:1337-1340.
31. Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 2001;107:43-54.
32. Denko NC, Fontana LA, Hudson KM, et al. Investigating hypoxic tumor physiology through gene expression patterns. Oncogene. 2003;22: 5907-5914.
33. Piret JP, Mottet D, Raes M, et al. Is HIF-1alpha a pro-or an anti-apoptotic protein? Biochem Pharmacol. 2002;64:889-892.
34. Vengellur A, Woods BG, Ryan HE, et al. Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts. Gene Expr. 2003;11:181-197.
35. Qutub AA, Popel AS. A computational model of intracellular oxygen sensing by hypoxia-inducible factor HIF1 alpha. J Cell Sci. 2006;119: 3467-3480.