Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation

Clinica Chimica Acta

Volumn 401, Issue 1-2, 2009, Pages 76-80

  Zhang, Juan ^a   Li, Xiao Xing ^a   Bian, Hong Jun ^a   Liu, Xiao Bo ^b   Ji, Xiao Ping ^a   Zhang, Yun ^a  

^a SHANDONG UNIVERSITY   (China)

^b Blood Center of Shandong Province   (China)

Author keywords

Apoptosis; Apoptosis inducing factor; c Jun NH2 terminal kinase; Heart I R; Rho kinase

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; APOPTOSIS INDUCING FACTOR; FASUDIL; RHO KINASE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HISTOPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; ANTHRACENES; APOPTOSIS; APOPTOSIS INDUCING FACTOR; FEMALE; MAP KINASE KINASE 4; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; PROTEIN KINASE INHIBITORS; RATS; RATS, WISTAR; REPERFUSION INJURY; RHO-ASSOCIATED KINASES;

RATTUS NORVEGICUS;

EID: 58549086728     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2008.11.016     Document Type: Article

References (22)

1. Amano M., Chihara K., Kimura K., et al. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science 275 (1997) 1308-1311
2. Yasui Y., Amano M., Nagata K., et al. Roles of Rho-associated kinase in cytokinesis; mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments. J Cell Biol 143 (1998) 1249-1258
3. Bao W., Hu E., Tao L., et al. Inhibition of Rho-kinase protects the heart against I/R injury. Cardiovasc Res 61 (2004) 548-558
4. Daugas E., Nochy D., Ravaqnan L., et al. Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. FEBS Lett 476 (2000) 118-123
5. Lipton S.A., and Bossy-Wetzel E. Dueling activities of AIF in cell death versus survival: DNA binding and redox activity. Cell 111 (2002) 147-150
6. Susin S.A., Lorenzo H.K., and Zamzami N. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature (1999) 397441-397446
7. Xiao C.Y., Chen M., Zsengeller Z., et al. Poly(ADP-Ribose) polymerase promotes cardiac remodeling, contractile failure, and translocation of apoptosis-inducing factor in a murine experimental model of aortic banding and heart failure. J Pharmacol Exp Ther 312 (2005) 891-898
8. Kim G.T., Chun Y.S., Park J.W., et al. Role of apoptosis-inducing factor in myocardial cell death by ischemia-reperfusion. Biochem Biophys Res Commun 309 (2003) 619-624
9. Demiryurek S., Kara A.F., Celik A., et al. Effects of fasudil, a Rho-kinase inhibitor, on myocardial preconditioning in anesthetized rats. Eur J Pharmacol 527 (2005) 129-140
10. Ji E.S., Yue H., Wu Y.M., et al. Effects of phytoestrogen genistein on myocardial I/R injury and apoptosis in rabbits. Acta Pharmacol Sin 25 (2004) 306-312
11. Mohanty I., Arya D.S., and Gupta S.K. Effect of Curcuma longa and Ocimum sanctum on myocardial apoptosis in experimentally induced myocardial ischemic-reperfusion injury. BMC Complement Altern Med 6 (2006) 3
12. Erwig L.P., McPhilips K.A., Wynes M.W., et al. Differential regulation of phagosome maturation in macrophages and dendritic cells mediated by Rho GTPases and ezrin-radixin-moesin (ERM) proteins. Proc Natl Acad Sci U S A 103 (2006) 12825-12830
13. Tosello-Trampont A.C., Nakada-Tsukui K., and Ravichandran K.S. Engulfment of apoptotic cells is negatively regulated by Rho-mediated signaling. J Biol Chem 278 (2003) 49911-49919
14. Zhao Z.Q., and Vinten-Johansen J. Myocardial apoptosis and ischemia preconditioning. Cardiovasc Res 55 (2002) 438-455
15. Song Z.F., Ji X.P., Li X.X., et al. Inhibition of the activity of Poly(ADP-Ribose) Polymerase reduces heart ischemia/reperfusion injury via suppressing JNK mediated AIF translocation. J Cell Mol Med 12 (2008) 1220-1228
16. Parone P.A., James D., and Martinou J.C. Mitochondria: regulating the inevitable. Biochimie 84 (2002) 105-111
17. Marinissen M.J., Chiariello M., Tanos T., et al. The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis. Mol Cell 14 (2004) 29-41
18. Jaffe A.B., Hall A., and Schmidt A. Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho. Curr Biol 15 (2005) 405-412
19. Ventura J.J., Cogswell P., Flavell R.A., et al. JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev 18 (2004) 2905-2915
20. Ferrandi C., Ballerio R., Gaillard P., et al. Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats. Br J Pharmacol 142 (2004) 953-960
21. Omura T., Yoshiyama M., Shimada T., et al. Activation of mitogen-activated protein kinases in vivo ischemia/reperfused myocardium in rats. J Mol Cell Cardiol 31 (1999) 1269-1279
22. Kaiser R.A., Liang Q., Bueno O., et al. Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo. J Biol Chem 280 (2005) 32602-32608