A mild and efficient synthesis of monofluorinated α-lactam pseudopeptides via a novel dehydrofluorination of Ugi products

Molecular Diversity

Volumn 14, Issue 3, 2010, Pages 501-506

  Liu, Nianjin ^a   Cao, Song ^a   Wu, Jingjing ^a   Shen, Li ^a   Yu, Jinlong ^a   Zhang, Jian ^a   Li, Hui ^a   Qian, Xuhong ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Dehydrofluorination; Monofluorinated lactam pseudopeptide; Ugi reaction

Indexed keywords

2 [[[[(1 CYLCOHEXYL 2 FLUORO 3 OXO AZIRIDIN 2 YL)PHENYL METHYL]CARBAMOYL]PHENYL METHYL]AMINO]BENZOIC ACID METHYL ESTER; 4 METHYL 2 [[[[(1 CYCLOHEXYL 2 FLUORO 3 OXO AZIRIDIN 2 YL)PHENYL METHYL]CARBAMOYL]PHENYL METHYL]AMINO]PENTANOIC ACID METHYL; CYANIDE; LACTAM DERIVATIVE; N (2,4 DIMETHOXY BENZYL) N [(3 BROMO PHENYL) [[(1 CYCLOHEXYL 2 FLUORO 3 OXO AZIRIDIN 2 YL)PHENYL METHYL]CARBAMOYL]METHYL]BUTYRAMIDE; N BENZYL N [[[(1 CYCLOHEXYL 2 FLUORO 3 OXO AZIRIDIN 2 YL)PHENYL METHYL]CARBAMOYL]PHENYL METHYL]BENZAMIDE; N BENZYL N[[[(1 CYCLOHEXYL 2 FLUORO 3 OXO AZIRIDIN 2 YL)PHENYL METHYL]CARBAMOYL]PHENYL METHYL]BUTYRAMIDE; N BUTYL N [[[(1 CYCLOHEXYL 2 FLUORO 3 OXO AZIRIDIN 2 YL)PHENYL METHYL]CARBAMOYL]PHENYL METHYL]BENZAMIDE; PSEUDOPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; FLUORINATION; ONE POT SYNTHESIS; PRIORITY JOURNAL; SYNTHESIS;

CHEMISTRY, ORGANIC; HALOGENATION; LACTAMS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; PEPTIDES; SOLVENTS;

EID: 78650171113     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11030-009-9209-x     Document Type: Article

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