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Volumn 75, Issue 11, 2008, Pages 2703-2711

A facile synthesis of 2-difluoromethyl-6-methylpyridine-3,5-dicarboxylates

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EID: 78650176672     PISSN: 03855414     EISSN: 18810942     Source Type: Journal    
DOI: 10.3987/COM-08-11434     Document Type: Review
Times cited : (4)

References (41)
  • 6
    • 0002057265 scopus 로고    scopus 로고
    • The finding of the synthesis of 4 was previously reported as a preliminary short papar. See, and
    • The finding of the synthesis of 4 was previously reported as a preliminary short papar. See I. Katsuyama, K. Funabiki, M. Matsui, H. Muramatsu, and K. Shibata, Synlett, 1997, 591.
    • (1997) Synlett , pp. 591
    • Katsuyama, I.1    Funabiki, K.2    Matsui, M.3    Muramatsu, H.4    Shibata, K.5
  • 7
    • 79751482696 scopus 로고    scopus 로고
    • For examples, see
    • For examples, see:
  • 24
    • 79751473311 scopus 로고    scopus 로고
    • An appropriate method was reported for the synthesis of 2-difluoromethyl-6-trifluoromethylpyridines
    • An appropriate method was reported for the synthesis of 2-difluoromethyl-6-trifluoromethylpyridines.
  • 25
    • 0025144028 scopus 로고
    • See, and, However, this method is not suitable for the preparation of 2-alkyl-6-difluoromethylpyridines such as 4; it led to a considerable decrease in the yield since the reaction was sluggish and required higher reaction temperature 110-150 °C
    • See L. F. Lee, G. L. Stikes, J. M. Molyneaux, Y. L. Sing, J. P. Chupp, and S. S. Woodard, J. Org. Chem., 1990, 55, 2872. However, this method is not suitable for the preparation of 2-alkyl-6-difluoromethylpyridines such as 4; it led to a considerable decrease in the yield since the reaction was sluggish and required higher reaction temperature (110-150 °C).
    • (1990) J. Org. Chem. , vol.55 , pp. 2872
    • Lee, L.F.1    Stikes, G.L.2    Molyneaux, J.M.3    Sing, Y.L.4    Chupp, J.P.5    Woodard, S.S.6
  • 31
    • 79751496665 scopus 로고    scopus 로고
    • It has been reported that CF3 groups attached to aromatic rings can be reduced under specific conditions
    • It has been reported that CF3 groups attached to aromatic rings can be reduced under specific conditions.
  • 34
    • 33846540268 scopus 로고    scopus 로고
    • Idem
    • (b) Idem, Heterocycles, 2006, 68, 2087.
    • (2006) Heterocycles , vol.68 , pp. 2087
  • 35
    • 79751480018 scopus 로고    scopus 로고
    • For examples of the dehydrofluorination agents, NaH and/or lithium amides, see
    • For examples of the dehydrofluorination agents, NaH and/or lithium amides, see:


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.