-
4
-
-
0030729427
-
-
(a) I. Katsuyama, S. Ogawa, Y. Yamaguchi, K. Funabiki, M. Matsui, H. Muramatsu, and K. Shibata, Synthesis, 1997, 1321.
-
(1997)
Synthesis
, pp. 1321
-
-
Katsuyama, I.1
Ogawa, S.2
Yamaguchi, Y.3
Funabiki, K.4
Matsui, M.5
Muramatsu, H.6
Shibata, K.7
-
5
-
-
0000376885
-
-
(b) I. Katsuyama, S. Ogawa, H. Nakamura, Y. Yamaguchi, K. Funabiki, M. Matsui, H. Muramatsu, and K. Shibata, Heterocycles, 1998, 48, 779.
-
(1998)
Heterocycles
, vol.48
, pp. 779
-
-
Katsuyama, I.1
Ogawa, S.2
Nakamura, H.3
Yamaguchi, Y.4
Funabiki, K.5
Matsui, M.6
Muramatsu, H.7
Shibata, K.8
-
6
-
-
0002057265
-
-
The finding of the synthesis of 4 was previously reported as a preliminary short papar. See, and
-
The finding of the synthesis of 4 was previously reported as a preliminary short papar. See I. Katsuyama, K. Funabiki, M. Matsui, H. Muramatsu, and K. Shibata, Synlett, 1997, 591.
-
(1997)
Synlett
, pp. 591
-
-
Katsuyama, I.1
Funabiki, K.2
Matsui, M.3
Muramatsu, H.4
Shibata, K.5
-
7
-
-
79751482696
-
-
For examples, see
-
For examples, see:
-
-
-
-
9
-
-
0343070655
-
-
(b) K. Miyashita, K. Kondoh, K. Tsuchiya, H. Miyabe, and T. Imanishi, J. Chem. Soc., Perkin Trans. 1, 1996, 1261.
-
(1996)
J. Chem. Soc., Perkin Trans.
, vol.1
, pp. 1261
-
-
Miyashita, K.1
Kondoh, K.2
Tsuchiya, K.3
Miyabe, H.4
Imanishi, T.5
-
10
-
-
0029873426
-
-
(c) H. Yamanaka, T. Takekawa, K. Morita, T. Ishihara, and J. T. Gupton, Tetrahedron Lett., 1996, 37, 1829.
-
(1996)
Tetrahedron. Lett.
, vol.37
, pp. 1829
-
-
Yamanaka, H.1
Takekawa, T.2
Morita, K.3
Ishihara, T.4
Gupton, J.T.5
-
12
-
-
0001372567
-
-
(e) E. Okada, T. Kinomura, H. Takeuchi, and M. Hojo, Heterocycles, 1997, 44, 349.
-
(1997)
Heterocycles
, vol.44
, pp. 349
-
-
Okada, E.1
Kinomura, T.2
Takeuchi, H.3
Hojo, M.4
-
13
-
-
0033522949
-
-
(f) M. T. Cocco, C. Congiu, and V. Onnis, Tetrahedron Lett., 1999, 40, 4407.
-
(1999)
Tetrahedron. Lett.
, vol.40
, pp. 4407
-
-
Cocco, M.T.1
Congiu, C.2
Onnis, V.3
-
14
-
-
0001773607
-
-
(g) T. Konakahara, M. Hojahmat, and S. Tamura, J. Chem. Soc., Perkin Trans. 1, 1999, 2803.
-
(1999)
J. Chem. Soc., Perkin Trans.
, vol.1
, pp. 2803
-
-
Konakahara, T.1
Hojahmat, M.2
Tamura, S.3
-
15
-
-
0035799153
-
-
(h) V. I. Tyvorskii, D. N. Bobrov, O. G. Kulinkovich, K. A. Tehrani, and N. de Kimpe, Tetrahedron, 2001, 57, 2051.
-
(2001)
Tetrahedron.
, vol.57
, pp. 2051
-
-
Tyvorskii, V.I.1
Bobrov, D.N.2
Kulinkovich, O.G.3
Tehrani, K.A.4
De Kimpe, N.5
-
16
-
-
0035537555
-
-
(i) B. Jiang, W. Xiong, X. Zhang, and F. Zhang, Org. Proc. Res. Dev., 2001, 5, 531.
-
(2001)
Org. Proc. Res. Dev.
, vol.5
, pp. 531
-
-
Jiang, B.1
Xiong, W.2
Zhang, X.3
Zhang, F.4
-
17
-
-
0242660834
-
-
(j) S. Gille, A. Ferry, T. Billard, and B. R. Langlois, J. Org. Chem., 2003, 68, 8932.
-
(2003)
J. Org. Chem.
, vol.68
, pp. 8932
-
-
Gille, S.1
Ferry, A.2
Billard, T.3
Langlois, B.R.4
-
20
-
-
30944441071
-
-
references are cited therein
-
(m) C. Brulé, J.-P. Bouillon, E. Nicolaï, and C. Portella, Synthesis, 2006, 103 and references are cited therein.
-
(2006)
Synthesis
, pp. 103
-
-
Brulé, C.1
Bouillon, J.-P.2
Nicolaï, E.3
Portella, C.4
-
23
-
-
79751473035
-
-
US Pat.
-
(c) H.-L. Elbe, H. Rieck, R. Dunkel, U. Wachendorff-Neumann, K.-H. Kuck, A. Mauler-Machnik, M. Kugler, T. Jaetsch, and P. Wachtler, US Pat., 2005, 0124815.
-
(2005)
, pp. 0124815
-
-
Elbe, H.-L.1
Rieck, H.2
Dunkel, R.3
Wachendorff-Neumann, U.4
Kuck, K.-H.5
Mauler-Machnik, A.6
Kugler, M.7
Jaetsch, T.8
Wachtler, P.9
-
24
-
-
79751473311
-
-
An appropriate method was reported for the synthesis of 2-difluoromethyl-6-trifluoromethylpyridines
-
An appropriate method was reported for the synthesis of 2-difluoromethyl-6-trifluoromethylpyridines.
-
-
-
-
25
-
-
0025144028
-
-
See, and, However, this method is not suitable for the preparation of 2-alkyl-6-difluoromethylpyridines such as 4; it led to a considerable decrease in the yield since the reaction was sluggish and required higher reaction temperature 110-150 °C
-
See L. F. Lee, G. L. Stikes, J. M. Molyneaux, Y. L. Sing, J. P. Chupp, and S. S. Woodard, J. Org. Chem., 1990, 55, 2872. However, this method is not suitable for the preparation of 2-alkyl-6-difluoromethylpyridines such as 4; it led to a considerable decrease in the yield since the reaction was sluggish and required higher reaction temperature (110-150 °C).
-
(1990)
J. Org. Chem.
, vol.55
, pp. 2872
-
-
Lee, L.F.1
Stikes, G.L.2
Molyneaux, J.M.3
Sing, Y.L.4
Chupp, J.P.5
Woodard, S.S.6
-
27
-
-
0033578943
-
-
G. S. Lal, G. P. Pez, F. M. Pesaresi, and H. Cheng, J. Org. Chem., 1999, 64, 7048.
-
(1999)
J. Org. Chem.
, vol.64
, pp. 7048
-
-
Lal, G.S.1
Pez, G.P.2
Pesaresi, F.M.3
Cheng, H.4
-
28
-
-
0036073388
-
-
H. Hayashi, H. Sonoda, K. Fukumura, and T. Nagata, J. Chem. Soc., Chem. Commun., 2002, 1618.
-
(2002)
J. Chem. Soc., Chem. Commun.
, pp. 1618
-
-
Hayashi, H.1
Sonoda, H.2
Fukumura, K.3
Nagata, T.4
-
29
-
-
3142777646
-
-
S. Kobayashi, A. Yoneda, T. Fukuhara, and S. Hara, Tetrahedron, 2004, 60, 6923.
-
(2004)
Tetrahedron.
, vol.60
, pp. 6923
-
-
Kobayashi, S.1
Yoneda, A.2
Fukuhara, T.3
Hara, S.4
-
30
-
-
18644361893
-
-
T. Furuya, T. Fukuhara, and S. Hara, J. Fluorine Chem., 2005, 126, 721.
-
(2005)
J. Fluorine Chem.
, vol.126
, pp. 721
-
-
Furuya, T.1
Fukuhara, T.2
Hara, S.3
-
31
-
-
79751496665
-
-
It has been reported that CF3 groups attached to aromatic rings can be reduced under specific conditions
-
It has been reported that CF3 groups attached to aromatic rings can be reduced under specific conditions.
-
-
-
-
33
-
-
0029975542
-
-
(a) I. Katsuyama, K. Funabiki, M. Matsui, H. Muramatsu, and K. Shibata, Tetrahedron Lett., 1996, 37, 4177.
-
(1996)
Tetrahedron. Lett.
, vol.37
, pp. 4177
-
-
Katsuyama, I.1
Funabiki, K.2
Matsui, M.3
Muramatsu, H.4
Shibata, K.5
-
34
-
-
33846540268
-
-
Idem
-
(b) Idem, Heterocycles, 2006, 68, 2087.
-
(2006)
Heterocycles
, vol.68
, pp. 2087
-
-
-
35
-
-
79751480018
-
-
For examples of the dehydrofluorination agents, NaH and/or lithium amides, see
-
For examples of the dehydrofluorination agents, NaH and/or lithium amides, see:
-
-
-
-
36
-
-
0011973002
-
-
(a) J. A. Howarth, W. M. Owton, and J. M. Percy, J. Chem. Soc., Chem. Commun., 1995, 757.
-
(1995)
J. Chem. Soc., Chem. Commun.
, pp. 757
-
-
Howarth, J.A.1
Owton, W.M.2
Percy, J.M.3
-
38
-
-
0028904369
-
-
butyl lithium
-
(c) G.-Q. Shi, Z.-Y. Cao, and W.-L. Cai, Tetrahedron, 1995, 51, 5011, butyl lithium
-
(1995)
Tetrahedron.
, vol.51
, pp. 5011
-
-
Shi, G.-Q.1
Cao, Z.-Y.2
Cai, W.-L.3
-
39
-
-
0002271032
-
-
see: K. Funabiki, T. Ohtsuki, T. Ishihara, and H. Yamanaka, Chem. Lett., 1994, 1075.
-
(1994)
Chem. Lett.
, pp. 1075
-
-
Funabiki, K.1
Ohtsuki, T.2
Ishihara, T.3
Yamanaka, H.4
-
40
-
-
0000591872
-
-
(a) I. Katsuyama, K. Funabiki, M. Matsui, H. Muramatsu, and K. Shibata, Chem. Lett., 1996, 179.
-
(1996)
Chem. Lett.
, pp. 179
-
-
Katsuyama, I.1
Funabiki, K.2
Matsui, M.3
Muramatsu, H.4
Shibata, K.5
|