Non-alcoholic fatty liver disease in older people

Gerontology

Volumn 55, Issue 6, 2009, Pages 607-613

  Frith, James ^a   Day, Christopher P ^a   Henderson, Elsbeth ^a   Burt, Alastair D ^a   Newton, Julia L ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Liver disease severity; Metabolic syndrome; Non alcoholic fatty liver disease in elderly; Steatosis

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GLUCOSE; HEMOGLOBIN A1C; INSULIN; ORAL ANTIDIABETIC AGENT;

ADOLESCENT; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BLOOD PRESSURE; BODY MASS; COHORT ANALYSIS; DIABETES MELLITUS; FATTY LIVER; FEMALE; GLUCOSE BLOOD LEVEL; GROUPS BY AGE; HEMOGLOBIN BLOOD LEVEL; HEPATITIS; HISTOLOGY; HUMAN; HUMAN TISSUE; HYPERLIPIDEMIA; HYPERTENSION; INSULIN RESISTANCE; LABORATORY TEST; LIPID BLOOD LEVEL; LIVER BIOPSY; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR VOLUME; MIDDLE AGED; NONALCOHOLIC FATTY LIVER; OBESITY; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; TERTIARY HEALTH CARE; THROMBOCYTE COUNT; UNITED KINGDOM;

ADULT; AGE DISTRIBUTION; AGED; BIOPSY; DIABETES MELLITUS; FATTY LIVER; FEMALE; GLUCOSE INTOLERANCE; GREAT BRITAIN; HUMANS; HYPERLIPIDEMIAS; HYPERTENSION; INSULIN RESISTANCE; LIVER; MALE; MIDDLE AGED; OBESITY; PREVALENCE; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 70449521078     PISSN: 0304324X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000235677     Document Type: Article

References (24)

1. Bellentani S, Saccoccio G, Masutti F, et al: Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med 2000; 132: 112-117.
2. Browning J, Szczepaniak L, Dobbins R, et al: Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004; 40: 1387-1395.
3. Bedogni G, Miglioli L, Masutti F, et al: Prevalence of and risk factors for non-alcoholic fatty liver disease: the Dionysos Nutrition and Liver Study. Hepatology 2005; 42: 44-52.
4. Skelly M, James P, Ryder S: Findings on liver biopsy to investigate abnormal liver function tests in the absence of diagnostic serology. J Hepatol 2001; 35: 195-199.
5. Day C: Non-alcoholic fatty liver disease: current concepts and management strategies. Clin Med 2006; 6: 19-25. (Pubitemid 43302594)
6. Marchesini G, Marzocchi R, Agostini F, et al: Non-alcoholic fatty liver disease and the metabolic syndrome. Curr Opin Lipidol 2005; 16: 421-427. (Pubitemid 41017626)
7. Rodriguez A, Muller D, Metter E, et al: Aging, androgens, and the metabolic syndrome in a longitudinal study of aging. J Clin Endocrinol Metab 2007; 92: 3568-3572. (Pubitemid 47435336)
8. Zelber-Sagi S, Nitzan-Kaluski D, Halpern Z, et al: Prevalence of primary non-alcoholic fatty liver disease in a population-based study and its association with biochemical and anthropometric measures. Liver Int 2006; 26: 856-863.
9. Angulo P, Keach J, Batts K, et al: Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 1999; 30: 1356-1362.
10. Adams L, Lymp J, St Sauver J, et al: The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005; 126: 113-121.
11. http://www.idf.org/webdata/docs/IDF-Metasyndrome-definition.pdf.
12. Anonymous: Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. The Expert Panel. Arch Intern Med 1988; 148: 36-69.
13. Anonymous: The hypertriglyceridemias: risk and management (erratum appears in Am J Cardiol 1991; 68: 982). Am J Cardiol 1991; 68: 1A-42A.
14. Matthews DR, Hosker JP, Rudenski AS, et al: Homeostasis model assessment: insulin resistance and B-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
15. Ishak K, Baptista A, Bianchi L, et al: Histological grading and staging of chronic hepatitis. J Hepatol 1995; 22: 696-699.
16. Miyaaki H, Ichikawa T, Nakao K, et al: Clinicopathological study of nonalcoholic fatty liver disease in Japan: the risk factors for fibrosis. Liver Int 2008; 28: 519-524.
17. Kagansky N, Levy S, Keter D, et al: Non-alcoholic fatty liver disease - a common and benign finding in octogenarian patients. Liver Int 2004; 24: 588-594.
18. Ford E, Giles W, Dietz W: Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002; 287: 356-359.
19. Bjornsson E, Angulo P: Non-alcoholic fatty liver disease. Scand J Gastroenterol 2007; 42: 1023-1030.
20. Shoelson S, Herrero L, Naaz A: Obesity, inflammation, and insulin resistance. Gastroenterology 2007; 132: 2169-2180.
21. Platt D: Age-Dependent Morphological and Biochemical Studies of the Normal and Injured Rat Liver. Liver and Ageing. Stuttgart, Schattauer, 1977, pp 75-83.
22. Brouwer A, Horan M, Barelds R, et al: Cellular aging of the reticuloendothelial system. Arch Gerontol Geriatr 1986; 5: 317-324.
23. Gilmore I, Burroughs A, Murray-Lyon I, et al: Indications, methods and outcomes of percutaneous liver biopsy in England and Wales: an audit by the British Society of Gastroenterology and the Royal College of Physicians of London. Gut 1995; 36: 437-441.
24. Ekstedt M, Franzen L, Mathiesen U, et al: Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006; 44: 865-873.