Pineapple bromelain induces autophagy, facilitating apoptotic response in mammary carcinoma cells

BioFactors

Volumn 36, Issue 6, 2010, Pages 474-482

  Bhui, Kulpreet ^a   Tyagi, Shilpa ^a   Prakash, Bharti ^b   Shukla, Yogeshwer ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b Government College Ajmer   (India)

Author keywords

Autophagy; Bromelain; Light chain 3 protein II; MAP kinases

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 METHYLADENINE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BECLIN 1; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; BROMELAIN; DANSYLCADAVERINE; ESTROGEN RECEPTOR; TAMOXIFEN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BREAST CARCINOMA; CANCER INHIBITION; CELL DEATH; CELL DIVISION; CELL FRACTIONATION; CELL POPULATION; CELL STRAIN MCF 7; CHROMATIN CONDENSATION; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; OUTCOME ASSESSMENT; PINEAPPLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ADENINE; ANANAS; APOPTOSIS; AUTOPHAGY; BREAST NEOPLASMS; BROMELAINS; CELL LINE, TUMOR; FLOW CYTOMETRY; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASE 3; P38 MITOGEN-ACTIVATED PROTEIN KINASES;

ANANAS COMOSUS;

EID: 78650078659     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.121     Document Type: Article

References (42)

1. Pattingre, S., Bauvy, C., and Codogno, P. ( 2003) Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. J. Biol. Chem. 278, 16667-16674.
2. Mortimore, G.-E. and Schworer, C. M. ( 1977) Induction of autophagy by amino-acid deprivation in perfused rat liver. Nature 270, 174-176.
3. Mortimore, G. E. and Kadowaki, M. ( 1994) Autophagy: its mechanism and regulation. In Cellular Proteolytic Systems ( Ciechanover, A.-J. and Schwartz, A.-L., eds.). pp. 65-87, Wiley-Liss, Inc., New York.
4. Van Sluijters, D.A., Dubbelhuis, P.F., Blommaart, E.F.C., and Meijer, A.J. ( 2000) Amino-acid-dependent signal transduction. Biochem. J. 351, 545-550.
5. Arico, S., Petiot, A., Bauvy, C., Dubbelhuis, P. F., Meijer, A. J., Codogno, P., and Ogier-Denis, E. ( 2001) The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J. Biol. Chem. 276, 35243-35246.
6. Klionsky, D.T. and Ohsumi, Y. ( 1999) Vacuolar import of proteins and organelles from the cytoplasm. Annu. Rev. Cell Dev. Biol. 15, 1-32.
7. Thumm, M. ( 2000) Structure and function of the yeast vacuole and its role in autophagy. Microsc. Res. Tech. 51, 563-572.
8. Ohsumi, Y. ( 2001) Molecular dissection of autophagy: two ubiquitin-like systems. Nat. Rev. Mol. Cell Biol. 2, 211-216.
9. Kihara, Noda, T., Ishihara, N., and Ohsumi, Y. ( 2001) Two distinct Vps 34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell. Biol. 152, 519-530.
10. Komatsu, M., Tanida, I., Ueno, T., Ohsumi, M., Ohsumi, Y., and Kominami, E. ( 2001) The C-terminal region of an Apg7p/Cvt2p is required for homodimerization and is essential for its E1 activity and E1-E2 complex formation. J. Biol. Chem. 276, 9846-9854.
11. Yue, Z., Jin, S., and Yang, C. ( 2003) Beclin-1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. USA 100, 15077-15082.
12. Liang, X.H., Yu, J., Brown, K., and Levine, B. ( 2001) Beclin-1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. Cancer Res. 61, 3443-3449.
13. Liang, X.H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., and Levine, B. ( 1999) Induction of autophagy and inhibition of tumorigenesis by beclin-1. Nature 402, 672-676.
14. Furuya, N., Liang, X.-H., and Levine, B. ( 2004). Autophagy and cancer. In Autophagy ( Klionsky, D.J., ed.). pp. 244-253, Landes Bioscience, Georgetown, TX.
15. Ichimura, Y., Kirisako, T., Takao, T., Satomi, Y., Shimonishi, Y., Ishihara, N., Mizushima, N., Tanida, I., Kominami, E., Ohsumi, M., Noda, T., and Ohsumi, Y. ( 2000) A ubiquitin-like system mediates protein lipidation. Nature 408, 488-492.
16. Tanida, I., Tanida Miyake, E., Ueno, T., and Kominami, E. ( 2001) The human homolog of Saccharomyces cerevisiae Apg7p is a protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3. J. Biol. Chem. 276, 1701-1706.
17. Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., and Yoshimori, T. ( 2003) LC3, a mammalian homolog of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19, 5720-5728; Erratum in EMBO J. ( 2003), 22, 4577.
18. Bursch, W., Hochegger, K., Török, L., Marian, B., Ellinger, A., and Hermann, R. S. ( 2000) Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments. J. Cell Sci. 113, 1189-1198.
19. Okada, H. and Mak, T. W. ( 2004) Pathways of apoptotic and non-apoptotic death in tumor cells. Nat. Rev. Cancer 4, 592-603.
20. Tiwari, M., Bajpai, V. K., Sahasrabuddhe, A. A., Kumar, A., Sinha, R. A., Behari, S., and Godbole, M. M. ( 2008) Inhibition of N-(4-hydroxyphenyl) retinamide-induced autophagy at a lower dose enhances cell death in malignant glioma cells. Carcinogenesis 29, 600-609.
21. Cui, Q., Tashiro, S., Onodera, S., Mutsuhiko, M., and Takashi, T. ( 2007) Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells. Biol. Pharm. Bull. 30, 859-864.
22. Gonzalez Polo, R.-A., Boya, P., Pauleau, A. L., Jalil, A., Larochette, N. Souquère, S., Eskelinen, E. L., Pierron, G., Saftig, P., and Kroemer, G. ( 2005) The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death. J. Cell Sci. 118, 3091-3102.
23. Hail, N. Jr., Kim, H. J., and Lotan, R. ( 2006) Mechanisms of fenretinide-induced apoptosis. Apoptosis 11, 1677-1694.
24. Detre, S., Salter, J., Barnes, D. M., Riddler, S., Hills, M., Johnston, S. R., Gillett, C., A'Hern, R., and Dowsett, M. ( 1999) Time-related effects of estrogen withdrawal on proliferation- and cell death-related events in MCF-7 xenografts. Int. J. Cancer 81, 309-313.
25. Johnston, S.-R.-D., Smith, I.-E., Haynes, B.-P., Jarman, M. and Dowsett, M. ( 1997) The effects of a novel antiestrogen, idoxifene, on the growth of tamoxifen-sensitive and resistant MCF-7 xenografts in athymic mice. Brit. J. Cancer 75, 804-808.
26. Otto, A. M., Paddenberg, R., Schubert, S., and Mannherz, H. G. ( 1996) Cell-cycle arrest, micronucleus formation and cell death in growth inhibition of MCF-7 breast cancer cells by tamoxifen and cisplatin. J. Cancer Res. Clin. Oncol. 122, 603-612.
27. Wilson, J.-W., Wakeling, A.-E., Morris, I.-D., Hickman, J. A., and Dive, C. ( 1995) MCF-7 human mammary adenocarcinoma cell death in vitro in response to hormone-withdrawal and DNA damage. Int. J. Cancer 61, 502-508.
28. Maurer, H.R. ( 2001) Bromelain: biochemistry, pharmacology and medical use. Cell Mol. Life Sci. 58, 1234-1245.
29. Bhui, K., Prasad, S., George, J., and Shukla, Y. ( 2009) Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway. Cancer Lett. 282, 167-176.
30. Kalra, N., Bhui, K., Roy, P., Srivastava, S., George, J., Prasad, S., and Shukla, Y. ( 2008) Regulation of p53, nuclear factor kappa B and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin. Toxicol Appl. Pharmacol. 226, 30-37.
31. Arora, A., Seth, K., and Shukla, Y. ( 2004) Reversal of P-glycoprotein-mediated multidrug resistance by diallyl sulphide in K562 leukemic cells and in mouse liver. Carcinogenesis 25, 941-949.
32. Biederbick, A., Kern, H.F., and Elsasser, H.P. ( 1995) Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles. Eur. J. Cell Biol. 66, 3-14.
33. Towbin, H., Staehelin, T., and Gordon, J. ( 1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76, 4350-4354.
34. Lowry, O. H., Rosenbrough, N. K., Farr, A. L., and Randall, R. J. ( 1951) Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265-275.
35. Ramos, J.W. ( 2008) The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells. Int. J. Biochem. Cell Biol. 40, 2707-2719.
36. Bursch, W., Ellinger, A., Gerner, C., Fröhwein, U., and Schulte-Hermann, R. ( 2000) Programmed cell death (PCD). Apoptosis, autophagic PCD, or others? Ann. N. Y. Acad. Sci. 926, 1-12.
37. Høyer Hansen, M., Bastholm, L., Mathiasen, I.S., Elling, F., and Jäättelä, M. ( 2005) Vitamin D analog EB1089 triggers dramatic lysosomal changes and beclin-1-mediated autophagic cell death. Cell Death Differ. 12, 1297-309.
38. Zakeri, Z. ( 1995) Cell death: programmed apoptosis, necrosis, or other? Cell Death Differ. 2, 83-92.
39. Eisenberg Lerner, A., Bialik, S., Simon, H.U., and Kimchi, A. ( 2009) Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ. 16, 966-975.
40. Bursch, W., Ellinger, A., Kienzl, H., Török, L., Pandey, S., Sikorska, M., Walker, R., and Schulte-Hermann, R. ( 1996) Active cell death induced by antiestrogens tamoxifen and ICI 164384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy. Carcinogenesis 17, 1595-1607.
41. Lamparska Przybysz, M., Gajkowska, B., and Motyl, T. ( 2005) Cathepsins and BID are involved in the molecular switch between apoptosis and autophagy in breast cancer mcf-7 cells exposed to camptothecin. J. Physiol. Pharmacol. 56, 159-179.
42. Jia, L., Dourmashkin, R. R., Allen, P. D., Gray, A. B., Newland, A. C., and Kelsey, S. M. ( 1997) Inhibition of autophagy abrogates tumor necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells. Br. J. Haematol. 98, 673-685.