Oleic acid inhibits stearic acid-induced inhibition of cell growth and pro-inflammatory responses in human aortic endothelial cells

Journal of Lipid Research

Volumn 51, Issue 12, 2010, Pages 3470-3480

  Harvey, Kevin A ^a   Walker, Candace L ^a   Xu, Zhidong ^a   Whitley, Phillip ^a   Pavlina, Thomas M ^b   Hise, Mary ^b   Zaloga, Gary P ^b   Siddiqui, Rafat A ^a,c  

^a METHODIST RESEARCH INSTITUTE   (United States)

^b BAXTER HEALTHCARE CORPORATION   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Dietary lipid; Fatty acid; Inflammation; Lipid droplet; Triglyceride

Indexed keywords

FATTY ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LONG CHAIN FATTY ACID; OLEIC ACID; PHOSPHOLIPID; SATURATED FATTY ACID; STEARIC ACID; TRIACYLGLYCEROL;

AORTA; ARTICLE; CELL GROWTH; CONTROLLED STUDY; CYTOTOXICITY; ENDOTHELIUM CELL; FATTY ACID ANALYSIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

AORTA; APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; DIETARY FATS, UNSATURATED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; LIPID METABOLISM; NF-KAPPA B; OLEIC ACID; STEARIC ACIDS; TRIGLYCERIDES;

EID: 78650053923     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M010371     Document Type: Article

References (48)

1. Jakobsen, M. U., E. J. O'Reilly, B. L. Heitmann, M. A. Pereira, K. Balter, G. E. Fraser, U. Goldbourt, G. Hallmans, P. Knekt, S. Liu, et al. 2009. Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am. J. Clin. Nutr. 89: 1425-1432.
2. Eckel, R. H., W. W. Barouch, and A. G. Ershow. 2002. Report of the National Heart, Lung, and Blood Institute-National Institute of Diabetes and Digestive and Kidney Diseases Working Group on the pathophysiology of obesity-associated cardiovascular disease. Circulation. 105: 2923-2928.
3. Sheehan, M. T., and M. D. Jensen. 2000. Metabolic complications of obesity. Pathophysiologic considerations. Med. Clin. North Am. 84: 363-385 (vi.).
4. Unger, R. H. 2002. Lipotoxic diseases. Annu. Rev. Med. 53: 319-336.
5. Schaffer, J. E. 2003. Lipotoxicity: when tissues overeat. Curr. Opin. Lipidol. 14: 281-287.
6. Rioux, V., and P. Legrand. 2007. Saturated fatty acids: simple molecular structures with complex cellular functions. Curr. Opin. Clin. Nutr. Metab. Care. 10: 752-758.
7. Mensink, R. P., P. L. Zock, A. D. Kester, and M. B. Katan. 2003. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am. J. Clin. Nutr. 77: 1146-1155.
8. Lundblad, J. L., and R. L. Seng. 1991. Inactivation of lipid-enveloped viruses in proteins by caprylate. Vox Sang. 60: 75-81.
9. Dichtelmuller, H., D. Rudnick, and M. Kloft. 2002. Inactivation of lipid enveloped viruses by octanoic Acid treatment of immunoglobulin solution. Biologicals. 30: 135-142.
10. Takeuchi, H., S. Sekine, K. Kojima, and T. Aoyama. 2008. The application of medium-chain fatty acids: edible oil with a suppressing effect on body fat accumulation. Asia Pac. J. Clin. Nutr. 17 (Suppl 1): 320-323.
11. St-Onge, M. P., and P. J. Jones. 2002. Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity. J. Nutr. 132: 329-332.
12. Rioux, V., D. Catheline, M. Bouriel, and P. Legrand. 2005. Dietary myristic acid at physiologically relevant levels increases the tissue content of C20:5 n-3 and C20:3 n-6 in the rat. Reprod. Nutr. Dev. 45: 599-612.
13. Beauchamp, E., D. Goenaga, J. Le Bloc'h, D. Catheline, P. Legrand, and V. Rioux. 2007. Myristic acid increases the activity of dihydroceramide Delta4-desaturase 1 through its N-terminal myristoylation. Biochimie. 89: 1553-1561.
14. Lockridge, J. B., M. L. Sailors, D. J. Durgan, O. Egbejimi, W. J. Jeong, M. S. Bray, W. C. Stanley, and M. E. Young. 2008. Bioinformatic profiling of the transcriptional response of adult rat cardiomyocytes to distinct fatty acids. J. Lipid Res. 49: 1395-1408.
15. Resh, M. D. 1999. Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. Biochim. Biophys. Acta. 1451: 1-16.
16. Smotrys, J. E., and M. E. Linder. 2004. Palmitoylation of intracellular signaling proteins: regulation and function. Annu. Rev. Biochem. 73: 559-587.
17. Harvey, K. A., C. L. Walker, T. M. Pavlina, Z. Xu, G. P. Zaloga, and R. A. Siddiqui. 2010. Long-chain saturated fatty acids induce proinflammatory responses and impact endothelial cell growth. Clin. Nutr. 29: 492-500.
18. Rho, M. C., K. Ah Lee, S. Mi Kim, C. Sik Lee, M. Jeong Jang, Y. Kook Kim, H. Sun Lee, Y. Hyun Choi, B. Yong Rhim, and K. Kim. 2007. Sensitization of vascular smooth muscle cell to TNFalpha-mediated death in the presence of palmitate. Toxicol. Appl. Pharmacol. 220: 311-319.
19. Hickson-Bick, D. L., G. C. Sparagna, L. M. Buja, and J. B. McMillin. 2002. Palmitate-induced apoptosis in neonatal cardiomyocytes is not dependent on the generation of ROS. Am. J. Physiol. Heart Circ. Physiol. 282: H656-H664.
20. Artwohl, M., M. Roden, W. Waldhausl, A. Freudenthaler, and S. M. Baumgartner-Parzer. 2004. Free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular endothelial cells. FASEB J. 18: 146-148.
21. Staiger, K., H. Staiger, C. Weigert, C. Haas, H. U. Haring, and M. Kellerer. 2006. Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-kappaB activation. Diabetes. 55: 3121-3126. (Pubitemid 44923651)
22. de Vries, J. E., M. M. Vork, T. H. Roemen, Y. F. de Jong, J. P. Cleutjens, G. J. van der Vusse, and M. van Bilsen. 1997. Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes. J. Lipid Res. 38: 1384-1394.
23. Hansson, G. K. 2005. Inflammation, atherosclerosis, and coronary artery disease. N. Engl. J. Med. 352: 1685-1695.
24. Shimokawa, H. 1999. Primary endothelial dysfunction: atherosclerosis. J. Mol. Cell. Cardiol. 31: 23-37.
25. Davignon, J., and P. Ganz. 2004. Role of endothelial dysfunction in atherosclerosis. Circulation. 109: III27-III32.
26. Blann, A. D., and C. N. McCollum. 1994. Circulating endothelial cell/leukocyte adhesion molecules in atherosclerosis. Thromb. Haemost. 72: 151-154.
27. Roden, M., T. B. Price, G. Perseghin, K. F. Petersen, D. L. Rothman, G. W. Cline, and G. I. Shulman. 1996. Mechanism of free fatty acid-induced insulin resistance in humans. J. Clin. Invest. 97: 2859-2865.
28. Reaven, G. M., C. Hollenbeck, C. Y. Jeng, M. S. Wu, and Y. D. Chen. 1988. Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes. 37: 1020-1024.
29. Fagot-Campagna, A., B. Balkau, D. Simon, J. M. Warnet, J. R. Claude, P. Ducimetiere, and E. Eschwege. 1998. High free fatty acid concentration: an independent risk factor for hypertension in the Paris Prospective Study. Int. J. Epidemiol. 27: 808-813.
30. Stingl, H., W. Raffesberg, P. Nowotny, W. Waldhausl, and M. Roden. 2002. Reduction of plasma leptin concentrations by arginine but not lipid infusion in humans. Obes. Res. 10: 1111-1119.
31. Diet, nutrition, and the prevention of chronic diseases. Report of a WHO Study Group. 1990. WHO technical report series, No. 797-TRS 797. World Health Organization, Geneva.
32. Keys, A., A. Menotti, M. J. Karvonen, C. Aravanis, H. Blackburn, R. Buzina, B. S. Djordjevic, A. S. Dontas, F. Fidanza, M. H. Keys, et al. 1986. The diet and 15-year death rate in the seven countries study. Am. J. Epidemiol. 124: 903-915.
33. Fernandez-Jarne, E., E. Martinez-Losa, M. Prado-Santamaria, C. Brugarolas-Brufau, M. Serrano-Martinez, and M. A. Martinez-Gonzalez. 2002. Risk of first non-fatal myocardial infarction negatively associated with olive oil consumption: a case-control study in Spain. Int. J. Epidemiol. 31: 474-480.
34. Carluccio, M. A., M. Massaro, C. Bonfrate, L. Siculella, M. Maffia, G. Nicolardi, A. Distante, C. Storelli, and R. De Caterina. 1999. Oleic acid inhibits endothelial activation: a direct vascular antiatherogenic mechanism of a nutritional component in the Mediterranean diet. Arterioscler. Thromb. Vasc. Biol. 19: 220-228.
35. Fuentes, F., J. Lopez-Miranda, P. Perez-Martinez, Y. Jimenez, C. Marin, P. Gomez, J. M. Fernandez, J. Caballero, J. Delgado-Lista, and F. Perez-Jimenez. 2008. Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with alpha-linolenic acid on postprandial endothelial function in healthy men. Br. J. Nutr. 100: 159-165.
36. Listenberger, L. L., X. Han, S. E. Lewis, S. Cases, R. V. Farese, Jr., D. S. Ory, and J. E. Schaffer. 2003. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc. Natl. Acad. Sci. USA. 100: 3077-3082.
37. Gao, D., H. R. Griffiths, and C. J. Bailey. 2009. Oleate protects against palmitate-induced insulin resistance in L6 myotubes. Br. J. Nutr. 102: 1557-1563.
38. Hardy, S., W. El-Assaad, E. Przybytkowski, E. Joly, M. Prentki, and Y. Langelier. 2003. Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin. J. Biol. Chem. 278: 31861-31870.
39. Coll, T., E. Eyre, R. Rodriguez-Calvo, X. Palomer, R. M. Sanchez, M. Merlos, J. C. Laguna, and M. Vazquez-Carrera. 2008. Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells. J. Biol. Chem. 283: 11107-11116.
40. Mishra, R., and M. S. Simonson. 2005. Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates proapoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G. Cardiovasc. Diabetol. 4: 2.
41. van Greevenbroek, M. M., W. F. Voorhout, D. W. Erkelens, G. van Meer, and T. W. de Bruin. 1995. Palmitic acid and linoleic acid metabolism in Caco-2 cells: different triglyceride synthesis and lipoprotein secretion. J. Lipid Res. 36: 13-24.
42. Folch, J., M. Lees, and G. H. Sloane-Stanley. 1957. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226: 497-509.
43. Lepage, G., and C. C. Roy. 1986. Direct transesterification of all classes of lipids in a one-step reaction. J. Lipid Res. 27: 114-120.
44. Wang, T., X. Zhang, and J. J. Li. 2002. The role of NF-kappaB in the regulation of cell stress responses. Int. Immunopharmacol. 2: 1509-1520.
45. Paumen, M. B., Y. Ishida, M. Muramatsu, M. Yamamoto, and T. Honjo. 1997. Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. J. Biol. Chem. 272: 3324-3329.
46. Artwohl, M., A. Lindenmair, V. Sexl, C. Maier, G. Rainer, A. Freudenthaler, N. Huttary, M. Wolzt, P. Nowotny, A. Luger, et al. 2008. Different mechanisms of saturated versus polyunsaturated FFA-induced apoptosis in human endothelial cells. J. Lipid Res. 49: 2627-2640.
47. Lu, Z. H., Y. M. Mu, B. A. Wang, X. L. Li, J. M. Lu, J. Y. Li, C. Y. Pan, T. Yanase, and H. Nawata. 2003. Saturated free fatty acids, palmitic acid and stearic acid, induce apoptosis by stimulation of ceramide generation in rat testicular Leydig cell. Biochem. Biophys. Res. Commun. 303: 1002-1007.
48. Porter, A. G., and R. U. Janicke. 1999. Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 6: 99-104.