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Volumn 4, Issue , 2010, Pages 117-128

Clopidogrel: A pharmacogenomic perspective on its use in coronary artery disease

Author keywords

ABCB1; Clopidogrel; Cytochrome P4502c19; On treatment platelet reactivity

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; CILOSTAZOL; CLOPIDOGREL; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; MULTIDRUG RESISTANCE PROTEIN 1; OMEPRAZOLE; PRASUGREL; TICAGRELOR;

EID: 78650040544     PISSN: 11795468     EISSN: 11795468     Source Type: Journal    
DOI: 10.4137/CMC.S4323     Document Type: Review
Times cited : (21)

References (68)
  • 2
    • 44449107747 scopus 로고    scopus 로고
    • Update to the AHA/ASA Recommendations for the Prevention of Stroke in Patients with Stroke and Transient Ischemic Attack
    • Adams RJ, Albers G, Alberts MJ, et al. Update to the AHA/ASA Recommendations for the Prevention of Stroke in Patients with Stroke and Transient Ischemic Attack. Stroke. 2008;39(5):1647-1652.
    • (2008) Stroke , vol.39 , Issue.5 , pp. 1647-1652
    • Adams, R.J.1    Albers, G.2    Alberts, M.J.3
  • 3
    • 44449094159 scopus 로고    scopus 로고
    • Guidelines for Management of Ischaemic Stroke and Transient Ischaemic Attack 2008
    • The European Stroke Organisation Executive Committee, European Stroke Organization Writing Committee
    • The European Stroke Organisation Executive Committee, European Stroke Organization Writing Committee. Guidelines for Management of Ischaemic Stroke and Transient Ischaemic Attack 2008. Cerebrovasc Dis. 2008;25(5):457-507.
    • (2008) Cerebrovasc Dis , vol.25 , Issue.5 , pp. 457-507
  • 4
    • 77958128969 scopus 로고    scopus 로고
    • Guidelines on myocardial revasculariza-tion
    • Wijns W, Kolh P, Danchin N, et al. Guidelines on myocardial revasculariza-tion. Eur Heart J. 2010;31(20):2501-2555.
    • (2010) Eur Heart J , vol.31 , Issue.20 , pp. 2501-2555
    • Wijns, W.1    Kolh, P.2    Danchin, N.3
  • 5
    • 73449142798 scopus 로고    scopus 로고
    • Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update): A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
    • Kushner FG, Hand M, Smith SC Jr, et al. 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update): A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2009;120(22):2271-2306.
    • (2009) Circulation , vol.120 , Issue.22 , pp. 2271-2306
    • Kushner, F.G.1    Hand, M.2    Smith Jr., S.C.3
  • 6
    • 3543102539 scopus 로고    scopus 로고
    • Role of clopidogrel in unstable angina and non-ST-segment elevation myocardial infarction: From literature and guidelines to practice
    • Kerr JL, Oppelt TE, Rowen RC. Role of clopidogrel in unstable angina and non-ST-segment elevation myocardial infarction: from literature and guidelines to practice. Pharmacotherapy. 2004;24(8):1037-1049.
    • (2004) Pharmacotherapy , vol.24 , Issue.8 , pp. 1037-1049
    • Kerr, J.L.1    Oppelt, T.E.2    Rowen, R.C.3
  • 7
    • 0038649988 scopus 로고    scopus 로고
    • Clopidogrel for Coronary Stenting: Response Variability, Drug Resistance, and the Effect of Pretreatment Platelet Reactivity
    • Gurbel PA, Bliden KP, Hiatt BL, O'Connor CM. Clopidogrel for Coronary Stenting: Response Variability, Drug Resistance, and the Effect of Pretreatment Platelet Reactivity. Circulation. 2003;107(23):2908-2913.
    • (2003) Circulation , vol.107 , Issue.23 , pp. 2908-2913
    • Gurbel, P.A.1    Bliden, K.P.2    Hiatt, B.L.3    O'Connor, C.M.4
  • 9
    • 73149119363 scopus 로고    scopus 로고
    • Identifcation of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite
    • Kazui M, Nishiya Y, Ishizuka T, et al. Identifcation of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite. Drug Metab Disp. 2010;38(1):92-99.
    • (2010) Drug Metab Disp , vol.38 , Issue.1 , pp. 92-99
    • Kazui, M.1    Nishiya, Y.2    Ishizuka, T.3
  • 10
    • 85047693299 scopus 로고    scopus 로고
    • Central role of the P2Y12 receptor in platelet activation
    • Dorsam RT, Kunapuli SP. Central role of the P2Y12 receptor in platelet activation. J Clin Invest. 2004;113(3):340-345.
    • (2004) J Clin Invest , vol.113 , Issue.3 , pp. 340-345
    • Dorsam, R.T.1    Kunapuli, S.P.2
  • 11
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome P-450 Polymorphisms and Response to Clopidogrel
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome P-450 Polymorphisms and Response to Clopidogrel. N Engl J Med. 2009;360(4):354-362.
    • (2009) N Engl J Med , vol.360 , Issue.4 , pp. 354-362
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 12
    • 58749090547 scopus 로고    scopus 로고
    • Genetic Determinants of Response to Clopidogrel and Cardiovascular Events
    • Simon T, Verstuyft C, Mary-Krause M, et al. Genetic Determinants of Response to Clopidogrel and Cardiovascular Events. N Engl J Med. 2009; 360(4):363-375.
    • (2009) N Engl J Med , vol.360 , Issue.4 , pp. 363-375
    • Simon, T.1    Verstuyft, C.2    Mary-Krause, M.3
  • 13
    • 77649230712 scopus 로고    scopus 로고
    • Genetic causes of clopidogrel nonresponsiveness: Which ones really count?
    • Momary KM, Dorsch MP, Bates ER. Genetic causes of clopidogrel nonresponsiveness: which ones really count? Pharmacotherapy. 2010;30(3): 265-74.
    • (2010) Pharmacotherapy , vol.30 , Issue.3 , pp. 265-274
    • Momary, K.M.1    Dorsch, M.P.2    Bates, E.R.3
  • 15
    • 0035028479 scopus 로고    scopus 로고
    • Molecular basis of ethnic differences in drug disposition and response
    • Xie H-G, Kim RB, Wood AJJ, Stein CM. Molecular basis of ethnic differences in drug disposition and response. Ann Rev Pharm Toxicol. 2001; 41(1):815-850.
    • (2001) Ann Rev Pharm Toxicol , vol.41 , Issue.1 , pp. 815-850
    • Xie, H.-G.1    Kim, R.B.2    Wood, A.J.J.3    Stein, C.M.4
  • 16
    • 0042357440 scopus 로고    scopus 로고
    • PM Frequencies of Major CYPs in Asians and Caucasians
    • Mizutani T. PM Frequencies of Major CYPs in Asians and Caucasians. Drug Metabol Rev. 2003;35(2-3):99-106.
    • (2003) Drug Metabol Rev , vol.35 , Issue.2-3 , pp. 99-106
    • Mizutani, T.1
  • 17
    • 68949159999 scopus 로고    scopus 로고
    • Personalized medicine and antiplatelet therapy: Ready for prime time?
    • Verstuyft C, Simon T, Kim RB. Personalized medicine and antiplatelet therapy: ready for prime time? Eur Heart J. 2009;30(16):1943-1963.
    • (2009) Eur Heart J , vol.30 , Issue.16 , pp. 1943-1963
    • Verstuyft, C.1    Simon, T.2    Kim, R.B.3
  • 18
    • 76649115043 scopus 로고    scopus 로고
    • Pharmacogenetics of CYP2C19: Functional and clinical implications of a new variant CYP2C19*17
    • Li-Wan-Po A, Girard T, Farndon P, Cooley C, Lithgow J. Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17. Br J Clin Pharmacol. 2010;69(3):222-230.
    • (2010) Br J Clin Pharmacol , vol.69 , Issue.3 , pp. 222-230
    • Li-Wan-Po, A.1    Girard, T.2    Farndon, P.3    Cooley, C.4    Lithgow, J.5
  • 19
    • 33749339075 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of- function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
    • Hulot J-S, Bura A, Villard E, et al. Cytochrome P450 2C19 loss-of- function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects. Blood. 2006;108(7):2244-2247.
    • (2006) Blood , vol.108 , Issue.7 , pp. 2244-2247
    • Hulot, J.-S.1    Bura, A.2    Villard, E.3
  • 20
    • 45249088224 scopus 로고    scopus 로고
    • The Effect of CYP2C19 Polymorphism on the Pharmacokinetics and Pharmacodynamics of Clopidogrel: A Possible Mechanism for Clopidogrel Resistance
    • Kim KA, Park PW, Hong SJ, Park JY. The Effect of CYP2C19 Polymorphism on the Pharmacokinetics and Pharmacodynamics of Clopidogrel: A Possible Mechanism for Clopidogrel Resistance. Clin Pharmacol Ther. 2008;84(2):236-42.
    • (2008) Clin Pharmacol Ther , vol.84 , Issue.2 , pp. 236-242
    • Kim, K.A.1    Park, P.W.2    Hong, S.J.3    Park, J.Y.4
  • 21
    • 69249219296 scopus 로고    scopus 로고
    • Association of Cytochrome P450 2C19 Genotype with the Antiplatelet Effect and Clinical Effcacy of Clopidogrel Therapy
    • Shuldiner AR, O'Connell JR, Bliden KP, et al. Association of Cytochrome P450 2C19 Genotype with the Antiplatelet Effect and Clinical Effcacy of Clopidogrel Therapy. JAMA. 2009;302(8):849-57.
    • (2009) JAMA , vol.302 , Issue.8 , pp. 849-857
    • Shuldiner, A.R.1    O'Connell, J.R.2    Bliden, K.P.3
  • 22
    • 76349098199 scopus 로고    scopus 로고
    • Cytochrome 2C19*17 Allelic Variant, Platelet Aggregation, Bleeding Events, and Stent Thrombosis in Clopidogrel-Treated Patients With Coronary Stent Placement
    • Sibbing D, Koch W, Gebhard D, et al. Cytochrome 2C19*17 Allelic Variant, Platelet Aggregation, Bleeding Events, and Stent Thrombosis in Clopidogrel-Treated Patients With Coronary Stent Placement. Circulation. 2010;121(4):512-8.
    • (2010) Circulation , vol.121 , Issue.4 , pp. 512-518
    • Sibbing, D.1    Koch, W.2    Gebhard, D.3
  • 23
    • 79957472412 scopus 로고    scopus 로고
    • Cytochrome P450 2C19*2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: A meta-analysis
    • E-published 2010 Mar 30. doi:10.1038/tpj.2010.21
    • Sof F, Giusti B, Marcucci R, Gori AM, Abbate R, Gensini GF. Cytochrome P450 2C19*2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: a meta-analysis. Pharmacogenomics J. 2010. E-published 2010 Mar 30. doi:10.1038/tpj.2010.21.
    • (2010) Pharmacogenomics J
    • Sof, F.1    Giusti, B.2    Marcucci, R.3    Gori, A.M.4    Abbate, R.5    Gensini, G.F.6
  • 24
    • 77953896604 scopus 로고    scopus 로고
    • Cardiovascular Risk in Clopidogrel-Treated Patients According to Cytochrome P450 2C19*2 Loss-of-Function Allele or Proton Pump Inhibitor Coadministration: A Systematic Meta-Analysis
    • Hulot J-S, Collet J-P, Silvain J, et al. Cardiovascular Risk in Clopidogrel-Treated Patients According to Cytochrome P450 2C19*2 Loss-of-Function Allele or Proton Pump Inhibitor Coadministration: A Systematic Meta-Analysis. J Am Coll Cardiol. 2010;56(2):134-43.
    • (2010) J Am Coll Cardiol , vol.56 , Issue.2 , pp. 134-143
    • Hulot, J.-S.1    Collet, J.-P.2    Silvain, J.3
  • 25
    • 77958100874 scopus 로고    scopus 로고
    • Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLATO trial
    • Wallentin L, James S, Storey RF, et al. Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial. Lancet. 2010;376(9749):1320-8.
    • (2010) Lancet , vol.376 , Issue.9749 , pp. 1320-1328
    • Wallentin, L.1    James, S.2    Storey, R.F.3
  • 26
    • 78049433100 scopus 로고    scopus 로고
    • Effects of CYP2C19 Genotype on Outcomes of Clopidogrel Treatment
    • E-published 2010 Aug 29. doi:10.1056/NEJMoa1008410
    • Pare G, Mehta SR, Yusuf S, et al. Effects of CYP2C19 Genotype on Outcomes of Clopidogrel Treatment. New England Journal of Medicine. 2010. E-published 2010 Aug 29. doi:10.1056/NEJMoa1008410.
    • (2010) New England Journal of Medicine
    • Pare, G.1    Mehta, S.R.2    Yusuf, S.3
  • 27
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • The Clopidogrel in Unstable angina to prevent Recurrent Events trial investigators
    • The Clopidogrel in Unstable angina to prevent Recurrent Events trial investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345(7):494-502.
    • (2001) N Engl J Med , vol.345 , Issue.7 , pp. 494-502
  • 28
    • 65649145705 scopus 로고    scopus 로고
    • Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation
    • ACTIVE Investigators. Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation. N Engl J Med. 2009;360(20):2066-2078.
    • (2009) N Engl J Med , vol.360 , Issue.20 , pp. 2066-2078
    • Investigators, A.C.T.I.V.E.1
  • 29
    • 77956353400 scopus 로고    scopus 로고
    • Protective effect of the CYP2C19*17 polymorphism with increased activation of clopidogrel on cardiovascular events
    • Tiroch KA, Sibbing D, Koch W, et al. Protective effect of the CYP2C19*17 polymorphism with increased activation of clopidogrel on cardiovascular events. Am Heart J. 2010;160(3):506-512.
    • (2010) Am Heart J , vol.160 , Issue.3 , pp. 506-512
    • Tiroch, K.A.1    Sibbing, D.2    Koch, W.3
  • 30
    • 64649101364 scopus 로고    scopus 로고
    • A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function
    • Fung KL, Gottesman MM. A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function. (BBA)-Proteins and Proteomics. 2009;1794(5):860-871.
    • (2009) BBA-Proteins and Proteomics , vol.1794 , Issue.5 , pp. 860-871
    • Fung, K.L.1    Gottesman, M.M.2
  • 31
    • 1942421704 scopus 로고    scopus 로고
    • Genomic evidence for recent positive selection at the human MDR1 gene locus
    • Tang K, Wong LP, Lee EJD, Chong SS, Lee CGL. Genomic evidence for recent positive selection at the human MDR1 gene locus. Human Mol Genetics. 2004;13(8):783-797.
    • (2004) Human Mol Genetics , vol.13 , Issue.8 , pp. 783-797
    • Tang, K.1    Wong, L.P.2    Lee, E.J.D.3    Chong, S.S.4    Lee, C.G.L.5
  • 32
    • 33744986097 scopus 로고    scopus 로고
    • MDR1 Haplotype Frequencies in Japanese and Caucasian, and in Japanese Patients with Colorectal Cancer and Esophageal Cancer
    • Komoto C, Nakamura T, Sakaeda T, et al. MDR1 Haplotype Frequencies in Japanese and Caucasian, and in Japanese Patients with Colorectal Cancer and Esophageal Cancer. Drug Metab Pharmacokinet. 2006;21(2): 126-132.
    • (2006) Drug Metab Pharmacokinet , vol.21 , Issue.2 , pp. 126-132
    • Komoto, C.1    Nakamura, T.2    Sakaeda, T.3
  • 33
    • 1442277718 scopus 로고    scopus 로고
    • The Role of MDR1 Genetic Polymorphisms in Interindividual Variability in P-glycoprotein Expression and Function
    • Woodahl EL, Ho RJY. The Role of MDR1 Genetic Polymorphisms in Interindividual Variability in P-glycoprotein Expression and Function. Curr Drug Metab. 2004;5(1):11-19.
    • (2004) Curr Drug Metab , vol.5 , Issue.1 , pp. 11-19
    • Woodahl, E.L.1    Ho, R.J.Y.2
  • 34
    • 33751080762 scopus 로고    scopus 로고
    • Impact of P-glycoprotein on clopidogrel absorption
    • Taubert D, von Beckerath N, Grimberg G, et al. Impact of P-glycoprotein on clopidogrel absorption. Clin Pharmacol Ther. 2006;80(5):486-501.
    • (2006) Clin Pharmacol Ther , vol.80 , Issue.5 , pp. 486-501
    • Taubert, D.1    von Beckerath, N.2    Grimberg, G.3
  • 35
    • 72449195234 scopus 로고    scopus 로고
    • Infuence of C3435T multidrug resistance gene-1 (MDR-1) polymorphism on platelet reactivity and prognosis in patients with acute coronary syndromes
    • Spiewak M, Malek L, Kostrzewa G, et al. Infuence of C3435T multidrug resistance gene-1 (MDR-1) polymorphism on platelet reactivity and prognosis in patients with acute coronary syndromes. Kardiol Pol. 2009; 67(8):827-834.
    • (2009) Kardiol Pol , vol.67 , Issue.8 , pp. 827-834
    • Spiewak, M.1    Malek, L.2    Kostrzewa, G.3
  • 36
    • 77958105401 scopus 로고    scopus 로고
    • Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: A pharmacogenetic analysis
    • Mega JL, Close SL, Wiviott SD, et al. Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis. Lancet. 2010;376(9749):1312-1319.
    • (2010) Lancet , vol.376 , Issue.9749 , pp. 1312-1319
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 37
    • 73049113504 scopus 로고    scopus 로고
    • Adenosine diphosphate-inducible platelet reactivity shows a pronounced age dependency in the initial phase of antiplatelet therapy with clopidogrel
    • Gremmel T, Steiner S, Seidinger D, Koppensteiner R, Panzer S, Kopp C. Adenosine diphosphate-inducible platelet reactivity shows a pronounced age dependency in the initial phase of antiplatelet therapy with clopidogrel. J Thromb Haemost. 2010;8(1):37-42.
    • (2010) J Thromb Haemost , vol.8 , Issue.1 , pp. 37-42
    • Gremmel, T.1    Steiner, S.2    Seidinger, D.3    Koppensteiner, R.4    Panzer, S.5    Kopp, C.6
  • 38
    • 33744968214 scopus 로고    scopus 로고
    • Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrel
    • Suh J-W, Koo B-K, Zhang S-Y, et al. Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrel. CMAJ. 2006;174(12):1715-1722.
    • (2006) CMAJ , vol.174 , Issue.12 , pp. 1715-1722
    • Suh, J.-W.1    Koo, B.-K.2    Zhang, S.-Y.3
  • 39
    • 56749183852 scopus 로고    scopus 로고
    • ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use: A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents
    • Bhatt DL, Scheiman J, Abraham NS, et al. ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use: A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. Circulation. 2008;118(18):1894-1909.
    • (2008) Circulation , vol.118 , Issue.18 , pp. 1894-1909
    • Bhatt, D.L.1    Scheiman, J.2    Abraham, N.S.3
  • 40
    • 38349065084 scopus 로고    scopus 로고
    • Infuence of Omeprazole on the Antiplatelet Action of Clopidogrel Associated With Aspirin: The Randomized, Double-Blind OCLA (Omeprazole CLopidogrel Aspirin) Study
    • Gilard M, Arnaud B, Cornily J-C, et al. Infuence of Omeprazole on the Antiplatelet Action of Clopidogrel Associated With Aspirin: The Randomized, Double-Blind OCLA (Omeprazole CLopidogrel Aspirin) Study. J Am Coll Cardiol. 2008;51(3):256-260.
    • (2008) J Am Coll Cardiol , vol.51 , Issue.3 , pp. 256-260
    • Gilard, M.1    Arnaud, B.2    Cornily, J.-C.3
  • 41
    • 77649223721 scopus 로고    scopus 로고
    • Drug interaction between clopidogrel and proton pump inhibitors
    • Liu TJ, Jackevicius CA. Drug interaction between clopidogrel and proton pump inhibitors. Phamacotherapy. 2010;30(3):275-289.
    • (2010) Phamacotherapy , vol.30 , Issue.3 , pp. 275-289
    • Liu, T.J.1    Jackevicius, C.A.2
  • 42
    • 78149487926 scopus 로고    scopus 로고
    • Clopidogrel with or without Omeprazole in Coronary Artery Disease
    • Bhatt DL, Cryer BL, Contant CF, et al. Clopidogrel with or without Omeprazole in Coronary Artery Disease. N Engl J Med. 2010.
    • (2010) N Engl J Med
    • Bhatt, D.L.1    Cryer, B.L.2    Contant, C.F.3
  • 43
    • 77952591958 scopus 로고    scopus 로고
    • Impact of Cytochrome P450 2C19 Loss-of-Function Polymorphism and of Major Demographic Characteristics on Residual Platelet Function After Loading and Maintenance Treatment With Clopidogrel in Patients Undergoing Elective Coronary Stent Placement
    • Hochholzer W, Trenk D, Fromm MF, et al. Impact of Cytochrome P450 2C19 Loss-of-Function Polymorphism and of Major Demographic Characteristics on Residual Platelet Function After Loading and Maintenance Treatment With Clopidogrel in Patients Undergoing Elective Coronary Stent Placement. J Am Coll Cardiol. 2010;55(22): 2427-34.
    • (2010) J Am Coll Cardiol , vol.55 , Issue.22 , pp. 2427-2434
    • Hochholzer, W.1    Trenk, D.2    Fromm, M.F.3
  • 44
    • 79551715419 scopus 로고    scopus 로고
    • Platelet abnormalities in diabetes mellitus
    • E-published 2010 Oct 4. doi:10.1177/1479164110383994
    • Ferreiro JL, Gomez-Hospital JA, Angiolillo DJ. Platelet abnormalities in diabetes mellitus. Diabet Vasc Dis Res. 2010. E-published 2010 Oct 4. doi:10.1177/1479164110383994.
    • (2010) Diabet Vasc Dis Res
    • Ferreiro, J.L.1    Gomez-Hospital, J.A.2    Angiolillo, D.J.3
  • 45
    • 70549107994 scopus 로고    scopus 로고
    • Association of platelet responsiveness with clopidogrel metabolism: Role of compliance in the assessment of resistance
    • Serebruany V, Cherala G, Williams C, et al. Association of platelet responsiveness with clopidogrel metabolism: Role of compliance in the assessment of "resistance". Am Heart J. 2009;158(6):925-932.
    • (2009) Am Heart J , vol.158 , Issue.6 , pp. 925-932
    • Serebruany, V.1    Cherala, G.2    Williams, C.3
  • 46
    • 33847149285 scopus 로고    scopus 로고
    • Prevention of Premature Discontinuation of Dual Antiplatelet Therapy in Patients With Coronary Artery Stents: A Science Advisory From the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions, American College of Surgeons, and American Dental Association, With Representation From the American College of Physicians
    • Grines CL, Bonow RO, Casey DE Jr, et al. Prevention of Premature Discontinuation of Dual Antiplatelet Therapy in Patients With Coronary Artery Stents: A Science Advisory From the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions, American College of Surgeons, and American Dental Association, With Representation From the American College of Physicians. Circulation. 2007;115(6):813-818.
    • (2007) Circulation , vol.115 , Issue.6 , pp. 813-818
    • Grines, C.L.1    Bonow, R.O.2    Casey Jr., D.E.3
  • 47
    • 77955013649 scopus 로고    scopus 로고
    • Overcoming 'resistance' to antiplatelet therapy: Targeting the issue of nonadherence
    • Kolandaivelu K, Bhatt DL. Overcoming 'resistance' to antiplatelet therapy: targeting the issue of nonadherence. Nat Rev Cardiol. 2010;7(8): 461-467.
    • (2010) Nat Rev Cardiol , vol.7 , Issue.8 , pp. 461-467
    • Kolandaivelu, K.1    Bhatt, D.L.2
  • 48
    • 77956353401 scopus 로고    scopus 로고
    • Prognostic signifcance of high on-clopidogrel platelet reactivity after percutaneous coronary intervention: Systematic review and meta-analysis
    • Aradi D, Komócsi A, Vorobcsuk A, et al. Prognostic signifcance of high on-clopidogrel platelet reactivity after percutaneous coronary intervention: Systematic review and meta-analysis. Am Heart J. 2010;160(3): 543-551.
    • (2010) Am Heart J , vol.160 , Issue.3 , pp. 543-551
    • Aradi, D.1    Komócsi, A.2    Vorobcsuk, A.3
  • 49
    • 77249113768 scopus 로고    scopus 로고
    • Comparison of Platelet Function Tests in Predicting Clinical Outcome in Patients Undergoing Coronary Stent Implantation
    • Breet NJ, van Werkum JW, Bouman HJ, et al. Comparison of Platelet Function Tests in Predicting Clinical Outcome in Patients Undergoing Coronary Stent Implantation. JAMA. 2010;303(8):754-762.
    • (2010) JAMA , vol.303 , Issue.8 , pp. 754-762
    • Breet, N.J.1    van Werkum, J.W.2    Bouman, H.J.3
  • 50
    • 77955603691 scopus 로고    scopus 로고
    • Platelet Aggregation and Its Association With Stent Thrombosis and Bleeding in Clopidogrel-Treated Patients: Initial Evidence of a Therapeutic Window
    • Sibbing D, Steinhubl SR, Schulz S, Schömig A, Kastrati A. Platelet Aggregation and Its Association With Stent Thrombosis and Bleeding in Clopidogrel-Treated Patients: Initial Evidence of a Therapeutic Window. J Am Coll Cardiol. 2010;56(4):317-318.
    • (2010) J Am Coll Cardiol , vol.56 , Issue.4 , pp. 317-318
    • Sibbing, D.1    Steinhubl, S.R.2    Schulz, S.3    Schömig, A.4    Kastrati, A.5
  • 51
    • 77953911457 scopus 로고    scopus 로고
    • Consensus and Future Directions on the Defnition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate
    • Bonello L, Tantry US, Marcucci R, et al. Consensus and Future Directions on the Defnition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate. J Am Coll Cardiol. 2010;56(12):919-933.
    • (2010) J Am Coll Cardiol , vol.56 , Issue.12 , pp. 919-933
    • Bonello, L.1    Tantry, U.S.2    Marcucci, R.3
  • 52
    • 77953914877 scopus 로고    scopus 로고
    • Genotyping: One Piece of the Puzzle to Personalize Antiplatelet Therapy
    • Gurbel PA, Tantry US, Shuldiner AR, Kereiakes DJ. Genotyping: One Piece of the Puzzle to Personalize Antiplatelet Therapy. J Am Coll Cardiol. 2010; 56(2):112-116.
    • (2010) J Am Coll Cardiol , vol.56 , Issue.2 , pp. 112-116
    • Gurbel, P.A.1    Tantry, U.S.2    Shuldiner, A.R.3    Kereiakes, D.J.4
  • 53
    • 77956290748 scopus 로고    scopus 로고
    • Dose Comparisons of Clopidogrel and Aspirin in Acute Coronary Syndromes
    • CURRENT-OASIS 7 Investigators
    • CURRENT-OASIS 7 Investigators. Dose Comparisons of Clopidogrel and Aspirin in Acute Coronary Syndromes. N Engl J Med. 2010;363(10): 930-942.
    • (2010) N Engl J Med , vol.363 , Issue.10 , pp. 930-942
  • 54
    • 77958005516 scopus 로고    scopus 로고
    • Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): A randomised factorial trial
    • Mehta SR, Tanguay J-F, Eikelboom JW, et al. Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial. Lancet. 2010;376(9748):1233-1243.
    • (2010) Lancet , vol.376 , Issue.9748 , pp. 1233-1243
    • Mehta, S.R.1    Tanguay, J.-F.2    Eikelboom, J.W.3
  • 55
    • 34948852426 scopus 로고    scopus 로고
    • Meta-Analysis Appraising High Clopidogrel Loading in Patients Undergoing Percutaneous Coronary Intervention
    • Lotrionte M, Biondi-Zoccai GGL, Agostoni P, et al. Meta-Analysis Appraising High Clopidogrel Loading in Patients Undergoing Percutaneous Coronary Intervention. Am J Cardiol. 2007;100(8):1199-206.
    • (2007) Am J Cardiol , vol.100 , Issue.8 , pp. 1199-1206
    • Lotrionte, M.1    Biondi-Zoccai, G.G.L.2    Agostoni, P.3
  • 56
    • 57549092687 scopus 로고    scopus 로고
    • The Pharmacogenetics and Pharmacodynamics of Clopidogrel Response: An Analysis From the PRINC (Plavix Response in Coronary Intervention) Trial
    • Gladding P, Webster M, Zeng I, et al. The Pharmacogenetics and Pharmacodynamics of Clopidogrel Response: An Analysis From the PRINC (Plavix Response in Coronary Intervention) Trial. JACC: Cardiovasc Inter-vent. 2008;1(6):620-627.
    • (2008) JACC: Cardiovasc Inter-vent , vol.1 , Issue.6 , pp. 620-627
    • Gladding, P.1    Webster, M.2    Zeng, I.3
  • 57
    • 77958573028 scopus 로고    scopus 로고
    • Clopidogrel Loading Dose Adjustment According to Platelet Reactivity Monitoring in Patients Carrying the 2C19*2 Loss of Function Polymorphism. J Am Coll Cardiol. 2010
    • E-published 2010 Aug 11. doi:10.1016/j.jacc.2010.07.004
    • Bonello L, Armero S, Ait Mokhtar O, et al. Clopidogrel Loading Dose Adjustment According to Platelet Reactivity Monitoring in Patients Carrying the 2C19*2 Loss of Function Polymorphism. J Am Coll Cardiol. 2010. E-published 2010 Aug 11. doi:10.1016/j.jacc.2010.07.004.
    • (2010) J Am Coll Cardiol. , vol.7
    • Bonello, L.1    Armero, S.2    Mokhtar, O.A.3
  • 58
    • 77955638355 scopus 로고    scopus 로고
    • Approaches to the FDA "Boxed Warning": A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the American Heart Association Endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons
    • Clopidogrel Clinical Alert ACCF/AHA
    • Holmes DR Jr, Dehmer GJ, Kaul S, Leifer D, O'Gara PT, Stein CM. ACCF/AHA Clopidogrel Clinical Alert: Approaches to the FDA "Boxed Warning": A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the American Heart Association Endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. J Am Coll Cardiol. 2010;56(4):321-341.
    • (2010) J Am Coll Cardiol , vol.56 , Issue.4 , pp. 321-341
    • Holmes Jr., D.R.1    Dehmer, G.J.2    Kaul, S.3    Leifer, D.4    O'Gara, P.T.5    Stein, C.M.6
  • 59
    • 77953497679 scopus 로고    scopus 로고
    • Triple antiplatelet therapy for preventing vascular events: A systematic review and meta-analysis
    • Geeganage C, Wilcox R, Bath P. Triple antiplatelet therapy for preventing vascular events: a systematic review and meta-analysis. BMC Med. 2010; 8(1):36.
    • (2010) BMC Med , vol.8 , Issue.1 , pp. 36
    • Geeganage, C.1    Wilcox, R.2    Bath, P.3
  • 60
    • 77950555307 scopus 로고    scopus 로고
    • Effects of Polyunsaturated Omega-3 Fatty Acids on Responsiveness to Dual Antiplatelet Therapy in Patients Undergoing Percutaneous Coronary Intervention: The OMEGA-PCI (OMEGA-3 Fatty Acids After PCI to Modify Responsiveness to Dual Antiplatelet Therapy) Study
    • Gajos G, Rostoff P, Undas A, Piwowarska W. Effects of Polyunsaturated Omega-3 Fatty Acids on Responsiveness to Dual Antiplatelet Therapy in Patients Undergoing Percutaneous Coronary Intervention: The OMEGA-PCI (OMEGA-3 Fatty Acids After PCI to Modify Responsiveness to Dual Antiplatelet Therapy) Study. J Am Coll Cardiol. 2010;55(16):1671-1678.
    • (2010) J Am Coll Cardiol , vol.55 , Issue.16 , pp. 1671-1678
    • Gajos, G.1    Rostoff, P.2    Undas, A.3    Piwowarska, W.4
  • 61
    • 77955428270 scopus 로고    scopus 로고
    • Addition of Cilostazol to Aspirin and a Thienopyri-dine for Prevention of Restenosis After Coronary Artery Stenting: A Meta-Analysis
    • Jennings DL, Kalus JS. Addition of Cilostazol to Aspirin and a Thienopyri-dine for Prevention of Restenosis After Coronary Artery Stenting: A Meta-Analysis. J Clin Pharmacol. 2010;50(4):415-521.
    • (2010) J Clin Pharmacol , vol.50 , Issue.4 , pp. 415-521
    • Jennings, D.L.1    Kalus, J.S.2
  • 62
    • 75249105036 scopus 로고    scopus 로고
    • Triple antiplatelet therapy reduces ischemic events after drug-eluting stent implantation: Drug-Eluting stenting followed by Cilostazol treatment REduces Adverse Serious cardiac Events (DECREASE registry)
    • e281
    • Lee S-W, Park S-W, Yun S-C, et al. Triple antiplatelet therapy reduces ischemic events after drug-eluting stent implantation: Drug-Eluting stenting followed by Cilostazol treatment REduces Adverse Serious cardiac Events (DECREASE registry). Am Heart J. 2010;159(2):284-291.e281.
    • (2010) Am Heart J , vol.159 , Issue.2 , pp. 284-291
    • Lee, S.-W.1    Park, S.-W.2    Yun, S.-C.3
  • 63
    • 72949113621 scopus 로고    scopus 로고
    • Population pharmacokinetic analysis of cilostazol in healthy subjects with genetic polymorphisms of CYP3A5, CYP2C19 and ABCB1
    • Yoo H-D, Cho H-Y, Lee Y-B. Population pharmacokinetic analysis of cilostazol in healthy subjects with genetic polymorphisms of CYP3A5, CYP2C19 and ABCB1. Br J Clin Pharmacol. 2010;69(1):27-37.
    • (2010) Br J Clin Pharmacol , vol.69 , Issue.1 , pp. 27-37
    • Yoo, H.-D.1    Cho, H.-Y.2    Lee, Y.-B.3
  • 64
    • 78650048685 scopus 로고    scopus 로고
    • Cytochrome 2C19 Polymorphism and Response to Adjunctive Cilostazol Versus High Maintenance-Dose Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention
    • Hwang S-J, Jeong Y-H, Kim I-S, et al. Cytochrome 2C19 Polymorphism and Response to Adjunctive Cilostazol Versus High Maintenance-Dose Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention. Circ Cardiovasc Interv. 2010;3(5):450-459.
    • (2010) Circ Cardiovasc Interv , vol.3 , Issue.5 , pp. 450-459
    • Hwang, S.-J.1    Jeong, Y.-H.2    Kim, I.-S.3
  • 65
    • 36148983750 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel in patients with acute coronary syndromes
    • Wiviott SD, Braunwald E, McCabe CH, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2007 Nov 15; 357(20):2001-2015.
    • (2007) N Engl J Med , vol.357 , Issue.20 , pp. 2001-2015
    • Wiviott, S.D.1    Braunwald, E.2    McCabe, C.H.3
  • 66
    • 66349133650 scopus 로고    scopus 로고
    • Cytochrome P450 Genetic Polymorphisms and the Response to Prasugrel: Relationship to Pharmacokinetic, Pharmacodynamic, and Clinical Outcomes
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome P450 Genetic Polymorphisms and the Response to Prasugrel: Relationship to Pharmacokinetic, Pharmacodynamic, and Clinical Outcomes. Circulation. 2009;119(19): 2553-2560.
    • (2009) Circulation , vol.119 , Issue.19 , pp. 2553-2560
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 67
    • 77958567291 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel for cytochrome P450 2C19 genotyped subgroups: Integration of the TRITON-TIMI 38 trial data
    • Sorich M, Vitry A, Ward M, Horowitz J, McKinnon R. Prasugrel versus clopidogrel for cytochrome P450 2C19 genotyped subgroups: integration of the TRITON-TIMI 38 trial data. J Thromb Haemost. 2010;8(8):1678-84.
    • (2010) J Thromb Haemost , vol.8 , Issue.8 , pp. 1678-1684
    • Sorich, M.1    Vitry, A.2    Ward, M.3    Horowitz, J.4    McKinnon, R.5
  • 68
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes
    • Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes. N Engl J Med. 2009;361(11): 1045-57.
    • (2009) N Engl J Med , vol.361 , Issue.11 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budaj, A.3


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