-
1
-
-
0032544181
-
Cilostazol has beneficial effects in treatment of intermittent claudication: Results from a multicenter, randomized, prospective, double-blind trial
-
Dawson DL, Cutler BS, Meissner MH, Strandness DE Jr. Cilostazol has beneficial effects in treatment of intermittent claudication: results from a multicenter, randomized, prospective, double-blind trial. Circulation 1998 98 : 678 686.
-
(1998)
Circulation
, vol.98
, pp. 678-686
-
-
Dawson, D.L.1
Cutler, B.S.2
Meissner, M.H.3
Strandness, Jr.D.E.4
-
2
-
-
0036190096
-
A phosphodiesterase inhibitor, cilostazol, prevents the onset of silent brain infarction in Japanese subjects with Type II diabetes
-
Shinoda-Tagawa T, Yamasaki Y, Yoshida S, Kajimoto Y, Tsujino T, Hakui N, Matsumoto M, Hori M. A phosphodiesterase inhibitor, cilostazol, prevents the onset of silent brain infarction in Japanese subjects with Type II diabetes. Diabetologia 2002 45 : 188 194.
-
(2002)
Diabetologia
, vol.45
, pp. 188-194
-
-
Shinoda-Tagawa, T.1
Yamasaki, Y.2
Yoshida, S.3
Kajimoto, Y.4
Tsujino, T.5
Hakui, N.6
Matsumoto, M.7
Hori, M.8
-
3
-
-
0036175952
-
Neuroprotective effect of cilostazol against focal cerebral ischemia via antiapoptotic action in rats
-
Choi JM, Shin HK, Kim KY, Lee JH, Hong KW. Neuroprotective effect of cilostazol against focal cerebral ischemia via antiapoptotic action in rats. J Pharmacol Exp Ther 2002 300 : 787 793.
-
(2002)
J Pharmacol Exp Ther
, vol.300
, pp. 787-793
-
-
Choi, J.M.1
Shin, H.K.2
Kim, K.Y.3
Lee, J.H.4
Hong, K.W.5
-
4
-
-
0033503548
-
Cilostazol pharmacokinetics after single and multiple oral doses in healthy males and patients with intermittent claudication resulting from peripheral arterial disease
-
Bramer SL, Forbes WP, Mallikaarjun S. Cilostazol pharmacokinetics after single and multiple oral doses in healthy males and patients with intermittent claudication resulting from peripheral arterial disease. Clin Pharmacokinet 1999 37 : Suppl 2 : 1 11.
-
(1999)
Clin Pharmacokinet
, vol.37
, Issue.SUPPL 2
, pp. 1-11
-
-
Bramer, S.L.1
Forbes, W.P.2
Mallikaarjun, S.3
-
5
-
-
0031906875
-
Pharmacokinetics of multiple-dose oral cilostazol in middle-age and elderly men and women
-
Suri A, Forbes WP, Bramer SL. Pharmacokinetics of multiple-dose oral cilostazol in middle-age and elderly men and women. J Clin Pharmacol 1998 38 : 144 150.
-
(1998)
J Clin Pharmacol
, vol.38
, pp. 144-150
-
-
Suri, A.1
Forbes, W.P.2
Bramer, S.L.3
-
6
-
-
0021876264
-
The metabolism of a new antithrombotic and vasodilating agent, cilostazol, in rat, dog and man
-
Akiyama H, Kudo S, Shimizu T. The metabolism of a new antithrombotic and vasodilating agent, cilostazol, in rat, dog and man. Arzneimittelforschung 1985 35 : 1133 1140.
-
(1985)
Arzneimittelforschung
, vol.35
, pp. 1133-1140
-
-
Akiyama, H.1
Kudo, S.2
Shimizu, T.3
-
7
-
-
0034092579
-
In vitro metabolism and interaction of cilostazol with human hepatic cytochrome P450 isoforms
-
Abbas R, Chow CP, Browder NJ, Thacker D, Bramer SL, Fu CJ, Forbes W, Odomi M, Flockhart DA. In vitro metabolism and interaction of cilostazol with human hepatic cytochrome P450 isoforms. Hum Exp Toxicol 2000 19 : 178 184.
-
(2000)
Hum Exp Toxicol
, vol.19
, pp. 178-184
-
-
Abbas, R.1
Chow, C.P.2
Browder, N.J.3
Thacker, D.4
Bramer, S.L.5
Fu, C.J.6
Forbes, W.7
Odomi, M.8
Flockhart, D.A.9
-
8
-
-
69449091820
-
Influence of CYP3A and CYP2C19 genetic polymorphisms on the pharmacokinetics of cilostazol in healthy subjects
-
Yoo HD, Park SA, Cho HY, Lee YB. Influence of CYP3A and CYP2C19 genetic polymorphisms on the pharmacokinetics of cilostazol in healthy subjects. Clin Pharmacol Ther 2009 86 : 281 284.
-
(2009)
Clin Pharmacol Ther
, vol.86
, pp. 281-284
-
-
Yoo, H.D.1
Park, S.A.2
Cho, H.Y.3
Lee, Y.B.4
-
9
-
-
9044254525
-
P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
-
Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Estabrook RW, Gunsalus IC, Nebert DW. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 1996 6 : 1 42.
-
(1996)
Pharmacogenetics
, vol.6
, pp. 1-42
-
-
Nelson, D.R.1
Koymans, L.2
Kamataki, T.3
Stegeman, J.J.4
Feyereisen, R.5
Waxman, D.J.6
Waterman, M.R.7
Gotoh, O.8
Coon, M.J.9
Estabrook, R.W.10
Gunsalus, I.C.11
Nebert, D.W.12
-
10
-
-
0035135258
-
CDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450
-
Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG. cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. Mol Pharmacol 2001 59 : 386 392.
-
(2001)
Mol Pharmacol
, vol.59
, pp. 386-392
-
-
Domanski, T.L.1
Finta, C.2
Halpert, J.R.3
Zaphiropoulos, P.G.4
-
11
-
-
0028237729
-
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
-
Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 1994 270 : 414 423.
-
(1994)
J Pharmacol Exp Ther
, vol.270
, pp. 414-423
-
-
Shimada, T.1
Yamazaki, H.2
Mimura, M.3
Inui, Y.4
Guengerich, F.P.5
-
12
-
-
0037330517
-
Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients
-
Chowbay B, Cumaraswamy S, Cheung YB, Zhou Q, Lee EJ. Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients. Pharmacogenetics 2003 13 : 89 95.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 89-95
-
-
Chowbay, B.1
Cumaraswamy, S.2
Cheung, Y.B.3
Zhou, Q.4
Lee, E.J.5
-
13
-
-
0035071598
-
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
-
Kuehl P, Zhang J, Lin Y, Lamba J, Assem M, Schuetz J, Watkins PB, Daly A, Wrighton SA, Hall SD, Maurel P, Relling M, Brimer C, Yasuda K, Venkataramanan R, Strom S, Thummel K, Boguski MS, Schuetz E. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet 2001 27 : 383 391.
-
(2001)
Nat Genet
, vol.27
, pp. 383-391
-
-
Kuehl, P.1
Zhang, J.2
Lin, Y.3
Lamba, J.4
Assem, M.5
Schuetz, J.6
Watkins, P.B.7
Daly, A.8
Wrighton, S.A.9
Hall, S.D.10
Maurel, P.11
Relling, M.12
Brimer, C.13
Yasuda, K.14
Venkataramanan, R.15
Strom, S.16
Thummel, K.17
Boguski, M.S.18
Schuetz, E.19
-
14
-
-
0038729506
-
CYP3A5*3 and *6 single nucleotide polymorphisms in three distinct Asian populations
-
Balram C, Zhou Q, Cheung YB, Lee EJ. CYP3A5*3 and *6 single nucleotide polymorphisms in three distinct Asian populations. Eur J Clin Pharmacol 2003 59 : 123 126.
-
(2003)
Eur J Clin Pharmacol
, vol.59
, pp. 123-126
-
-
Balram, C.1
Zhou, Q.2
Cheung, Y.B.3
Lee, E.J.4
-
15
-
-
0041881985
-
Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups
-
Lee SJ, Usmani KA, Chanas B, Ghanayem B, Xi T, Hodgson E, Mohrenweiser HW, Goldstein JA. Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups. Pharmacogenetics 2003 13 : 461 472.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 461-472
-
-
Lee, S.J.1
Usmani, K.A.2
Chanas, B.3
Ghanayem, B.4
Xi, T.5
Hodgson, E.6
Mohrenweiser, H.W.7
Goldstein, J.A.8
-
16
-
-
0028260641
-
The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans
-
de Morais SM, Wilkinson GR, Blaisdell J, Nakamura K, Meyer UA, Goldstein JA. The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J Biol Chem 1994 269 : 15419 15422.
-
(1994)
J Biol Chem
, vol.269
, pp. 15419-15422
-
-
De Morais, S.M.1
Wilkinson, G.R.2
Blaisdell, J.3
Nakamura, K.4
Meyer, U.A.5
Goldstein, J.A.6
-
17
-
-
0028044085
-
Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese
-
De Morais SM, Wilkinson GR, Blaisdell J, Meyer UA, Nakamura K, Goldstein JA. Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol Pharmacol 1994 46 : 594 598. (Pubitemid 24334747)
-
(1994)
Molecular Pharmacology
, vol.46
, Issue.4
, pp. 594-598
-
-
De Morais, S.M.F.1
Wilkinson, G.R.2
Blaisdell, J.3
Meyer, U.A.4
Nakamura, K.5
Goldstein, J.A.6
-
18
-
-
0030904031
-
Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations
-
Goldstein JA, Ishizaki T, Chiba K, de Morais SM, Bell D, Krahn PM, Evans DA. Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations. Pharmacogenetics 1997 7 : 59 64.
-
(1997)
Pharmacogenetics
, vol.7
, pp. 59-64
-
-
Goldstein, J.A.1
Ishizaki, T.2
Chiba, K.3
De Morais, S.M.4
Bell, D.5
Krahn, P.M.6
Evans, D.A.7
-
19
-
-
0035478419
-
The drug efflux-metabolism alliance: Biochemical aspects
-
Benet LZ, Cummins CL. The drug efflux-metabolism alliance: biochemical aspects. Adv Drug Deliv Rev 2001 50 (Suppl. 1) : S3 11.
-
(2001)
Adv Drug Deliv Rev
, vol.50
, Issue.SUPPL. 1
, pp. 3-11
-
-
Benet, L.Z.1
Cummins, C.L.2
-
21
-
-
28144440151
-
The role of common variants of ABCB1, CYP3A4, and CYP3A5 genes in lipid-lowering efficacy and safety of simvastatin treatment
-
Fiegenbaum M, da Silveira FR, Van der Sand CR, Van der Sand LC, Ferreira ME, Pires RC, Hutz MH. The role of common variants of ABCB1, CYP3A4, and CYP3A5 genes in lipid-lowering efficacy and safety of simvastatin treatment. Clin Pharmacol Ther 2005 78 : 551 558.
-
(2005)
Clin Pharmacol Ther
, vol.78
, pp. 551-558
-
-
Fiegenbaum, M.1
Da Silveira, F.R.2
Van Der Sand, C.R.3
Van Der Sand, L.C.4
Ferreira, M.E.5
Pires, R.C.6
Hutz, M.H.7
-
22
-
-
0035104031
-
Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects
-
Cascorbi I, Gerloff T, Johne A, Meisel C, Hoffmeyer S, Schwab M, Schaeffeler E, Eichelbaum M, Brinkmann U, Roots I. Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects. Clin Pharmacol Ther 2001 69 : 169 174.
-
(2001)
Clin Pharmacol Ther
, vol.69
, pp. 169-174
-
-
Cascorbi, I.1
Gerloff, T.2
Johne, A.3
Meisel, C.4
Hoffmeyer, S.5
Schwab, M.6
Schaeffeler, E.7
Eichelbaum, M.8
Brinkmann, U.9
Roots, I.10
-
23
-
-
0003747347
-
-
San Francisco, CA. University of California at San Francisco
-
Beal S, Sheiner L. NONMEM User's Guide, Part I. San Francisco, CA : University of California at San Francisco, 1992.
-
(1992)
NONMEM User's Guide, Part I.
-
-
Beal, S.1
Sheiner, L.2
-
24
-
-
0027049043
-
Building population pharmacokinetic-pharmacodynamic models. I. Models for covariate effects
-
Mandema JW, Verotta D, Sheiner LB. Building population pharmacokinetic-pharmacodynamic models. I. Models for covariate effects. J Pharmacokinet Biopharm 1992 20 : 511 528.
-
(1992)
J Pharmacokinet Biopharm
, vol.20
, pp. 511-528
-
-
Mandema, J.W.1
Verotta, D.2
Sheiner, L.B.3
-
25
-
-
0002322365
-
Xpose - An S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM
-
Jonsson EN, Karlsson MO. Xpose - an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM. Comput Meth Programs Biomed 1999 58 : 51 64.
-
(1999)
Comput Meth Programs Biomed
, vol.58
, pp. 51-64
-
-
Jonsson, E.N.1
Karlsson, M.O.2
-
26
-
-
0031784112
-
Automated covariate model building within NONMEM
-
Jonsson EN, Karlsson MO. Automated covariate model building within NONMEM. Pharm Res 1998 15 : 1463 1468.
-
(1998)
Pharm Res
, vol.15
, pp. 1463-1468
-
-
Jonsson, E.N.1
Karlsson, M.O.2
-
27
-
-
35848952270
-
Conditional weighted residuals (CWRES): A model diagnostic for the FOCE method
-
Hooker AC, Staatz CE, Karlsson MO. Conditional weighted residuals (CWRES): a model diagnostic for the FOCE method. Pharm Res 2007 24 : 2187.
-
(2007)
Pharm Res
, vol.24
, pp. 2187
-
-
Hooker, A.C.1
Staatz, C.E.2
Karlsson, M.O.3
-
28
-
-
0011389171
-
-
Available at. (last accessed December 2008)
-
Holford N. Wings for NONMEM. Available at http://wfnsourceforgenet (last accessed December 2008).
-
Wings for NONMEM
-
-
Holford, N.1
-
29
-
-
0036224424
-
Pharmacokinetic and pharmacodynamic modeling of the antiplatelet and cardiovascular effects of cilostazol in healthy humans
-
Woo SK, Kang WK, Kwon KI. Pharmacokinetic and pharmacodynamic modeling of the antiplatelet and cardiovascular effects of cilostazol in healthy humans. Clin Pharmacol Ther 2002 71 : 246 252.
-
(2002)
Clin Pharmacol Ther
, vol.71
, pp. 246-252
-
-
Woo, S.K.1
Kang, W.K.2
Kwon, K.I.3
-
30
-
-
34748868089
-
Characterization of human cytochrome p450 enzymes involved in the metabolism of cilostazol
-
Hiratsuka M, Hinai Y, Sasaki T, Konno Y, Imagawa K, Ishikawa M, Mizugaki M. Characterization of human cytochrome p450 enzymes involved in the metabolism of cilostazol. Drug Metab Dispos 2007 35 : 1730 1732.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1730-1732
-
-
Hiratsuka, M.1
Hinai, Y.2
Sasaki, T.3
Konno, Y.4
Imagawa, K.5
Ishikawa, M.6
Mizugaki, M.7
-
31
-
-
0347359079
-
Increased transcriptional activity of the CYP3A4*1B promoter variant
-
Amirimani B, Ning B, Deitz AC, Weber BL, Kadlubar FF, Rebbeck TR. Increased transcriptional activity of the CYP3A4*1B promoter variant. Environ Mol Mutagen 2003 42 : 299 305.
-
(2003)
Environ Mol Mutagen
, vol.42
, pp. 299-305
-
-
Amirimani, B.1
Ning, B.2
Deitz, A.C.3
Weber, B.L.4
Kadlubar, F.F.5
Rebbeck, T.R.6
-
32
-
-
0034724324
-
Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
-
Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmoller J, Johne A, Cascorbi I, Gerloff T, Roots I, Eichelbaum M, Brinkmann U. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 2000 97 : 3473 3478.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 3473-3478
-
-
Hoffmeyer, S.1
Burk, O.2
Von Richter, O.3
Arnold, H.P.4
Brockmoller, J.5
Johne, A.6
Cascorbi, I.7
Gerloff, T.8
Roots, I.9
Eichelbaum, M.10
Brinkmann, U.11
-
33
-
-
3042772026
-
Identification of functionally variant MDR1 alleles among European Americans and African Americans
-
Kim RB, Leake BF, Choo EF, Dresser GK, Kubba SV, Schwarz UI, Taylor A, Xie HG, McKinsey J, Zhou S, Lan LB, Schuetz JD, Schuetz EG, Wilkinson GR. Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin Pharmacol Ther 2001 70 : 189 199.
-
(2001)
Clin Pharmacol Ther
, vol.70
, pp. 189-199
-
-
Kim, R.B.1
Leake, B.F.2
Choo, E.F.3
Dresser, G.K.4
Kubba, S.V.5
Schwarz, U.I.6
Taylor, A.7
Xie, H.G.8
McKinsey, J.9
Zhou, S.10
Lan, L.B.11
Schuetz, J.D.12
Schuetz, E.G.13
Wilkinson, G.R.14
-
34
-
-
0242290406
-
Limited influence of P-glycoprotein on small-intestinal absorption of cilostazol, a high absorptive permeability drug
-
Toyobuku H, Tamai I, Ueno K, Tsuji A. Limited influence of P-glycoprotein on small-intestinal absorption of cilostazol, a high absorptive permeability drug. J Pharm Sci 2003 92 : 2249 2259.
-
(2003)
J Pharm Sci
, vol.92
, pp. 2249-2259
-
-
Toyobuku, H.1
Tamai, I.2
Ueno, K.3
Tsuji, A.4
|