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Volumn 30, Issue 3, 2010, Pages 275-289

Drug interaction between clopidogrel and proton pump inhibitors

Author keywords

Clopidogrel; Drug drug interaction; Omeprazole; PPI; Proton pump inhibitor; Thienopyridine

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; ESOMEPRAZOLE; LANSOPRAZOLE; OMEPRAZOLE; PANTOPRAZOLE; PRASUGREL; PROTON PUMP INHIBITOR; RABEPRAZOLE;

EID: 77649223721     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.30.3.275     Document Type: Review
Times cited : (30)

References (67)
  • 1
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-elevation
    • Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-elevation. N Engl J Med 2001;345:494-502.
    • (2001) N Engl J Med , vol.345 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3    Chrolavicius, S.4    Tognoni, G.5    Fox, K.K.6
  • 2
    • 0037145863 scopus 로고    scopus 로고
    • Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial
    • Steinhubl SR, Berger PB, Mann JT, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA 2002;288:2411-20.
    • (2002) JAMA , vol.288 , pp. 2411-2420
    • Steinhubl, S.R.1    Berger, P.B.2    Mann, J.T.3
  • 3
    • 58749093909 scopus 로고    scopus 로고
    • Bleeding risk associated with 1-year dual antiplatelet therapy after percutaneous intervention: Insights from the clopidogrel for the reduction of events during observation (CREDO) trial
    • Aronow HD, Steinhubl SR, Brennan DM, Berger PB, Topol EJ. Bleeding risk associated with 1-year dual antiplatelet therapy after percutaneous intervention: insights from the clopidogrel for the reduction of events during observation (CREDO) trial. Am Heart J 2009;157:369-74.
    • (2009) Am Heart J , vol.157 , pp. 369-374
    • Aronow, H.D.1    Steinhubl, S.R.2    Brennan, D.M.3    Berger, P.B.4    Topol, E.J.5
  • 4
    • 37349000957 scopus 로고    scopus 로고
    • Evaluation of proton pump inhibitor use in patients with acute coronary syndromes based on risk factors for gastrointestinal bleed
    • Schreiner GC, Laine L, Murphy SA, Cannon CP. Evaluation of proton pump inhibitor use in patients with acute coronary syndromes based on risk factors for gastrointestinal bleed. Crit Pathways in Cardiol 2007;6:169-72.
    • (2007) Crit Pathways in Cardiol , vol.6 , pp. 169-172
    • Schreiner, G.C.1    Laine, L.2    Murphy, S.A.3    Cannon, C.P.4
  • 5
    • 56749183852 scopus 로고    scopus 로고
    • ACCF/ACG/AHA 2008 expert consensus on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: A report of the American College of Cardiology Foundation task force on clinical expert consensus documents
    • Bhatt DL, Scheiman J, Abraham NS, et al. ACCF/ACG/AHA 2008 expert consensus on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation task force on clinical expert consensus documents. Circulation 2008;118:1894-909.
    • (2008) Circulation , vol.118 , pp. 1894-1909
    • Bhatt, D.L.1    Scheiman, J.2    Abraham, N.S.3
  • 6
    • 77649227821 scopus 로고    scopus 로고
    • Bristol-Myers Squibb-sanofi-aventis. Plavix (clopidogrel) package insert. Bridgewater, NJ; 2008
    • Bristol-Myers Squibb-sanofi-aventis. Plavix (clopidogrel) package insert. Bridgewater, NJ; 2008.
  • 8
    • 33748464209 scopus 로고    scopus 로고
    • Variability of response to clopidogrel: Possible mechanisms and clinical implications
    • Nguyen T, Frishman WH, Nawarskas J, Lerner RG. Variability of response to clopidogrel: possible mechanisms and clinical implications. Cardiol Rev 2006;14:136-42.
    • (2006) Cardiol Rev , vol.14 , pp. 136-142
    • Nguyen, T.1    Frishman, W.H.2    Nawarskas, J.3    Lerner, R.G.4
  • 9
    • 77649205268 scopus 로고    scopus 로고
    • Clopidogrel: Some drugs may reduce its effectiveness [drug interactions]
    • Horn JR, Hanstem PD. Clopidogrel: some drugs may reduce its effectiveness [drug interactions]. Pharm Times 200;4:33.
    • Pharm Times , vol.200 , Issue.4 , pp. 33
    • Horn, J.R.1    Hanstem, P.D.2
  • 10
    • 33748474260 scopus 로고    scopus 로고
    • Pharmacokinetic drug interaction profiles of proton pump inhibitors
    • Blume H, Donath F, Warnke A, Schug BS. Pharmacokinetic drug interaction profiles of proton pump inhibitors. Drug Saf 2006;29:769-84.
    • (2006) Drug Saf , vol.29 , pp. 769-784
    • Blume, H.1    Donath, F.2    Warnke, A.3    Schug, B.S.4
  • 11
    • 0033859564 scopus 로고    scopus 로고
    • Review article: Comparison of the pharmacokinetics, acid suppression and efficacy of proton pump inhibitors
    • Stedman CAM, Barclay ML. Review article: comparison of the pharmacokinetics, acid suppression and efficacy of proton pump inhibitors. Aliment Pharmacol Ther 2000;12:963-78.
    • (2000) Aliment Pharmacol Ther , vol.12 , pp. 963-978
    • Stedman, C.A.M.1    Barclay, M.L.2
  • 12
    • 1642453779 scopus 로고    scopus 로고
    • Contribution of hepatic P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance
    • Lau WC, Gurbel PA, Watkins PB, et al. Contribution of hepatic P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance. Circulation 2004;109:166-71.
    • (2004) Circulation , vol.109 , pp. 166-171
    • Lau, W.C.1    Gurbel, P.A.2    Watkins, P.B.3
  • 13
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome P-450 polymorphisms and response to clopidogrel
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome P-450 polymorphisms and response to clopidogrel. N Engl J Med 2009;360:354-62.
    • (2009) N Engl J Med , vol.360 , pp. 354-362
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 15
    • 48449101872 scopus 로고    scopus 로고
    • The association of cigarette smoking with enhanced platelet inhibition by clopidogrel
    • Bliden KP, Dichiara J, Lawal L, et al. The association of cigarette smoking with enhanced platelet inhibition by clopidogrel. J Am Coll Cardiol 2008;52:531-3.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 531-533
    • Bliden, K.P.1    Dichiara, J.2    Lawal, L.3
  • 16
    • 49849097496 scopus 로고    scopus 로고
    • Smoking behaviour modulates pharmacokinetics of orally administered clopidogrel
    • Yousef AM, Arafat T, Bulatova NR, Al-Zumyli R. Smoking behaviour modulates pharmacokinetics of orally administered clopidogrel. J Clin Pharm Ther 2008;33:439-49.
    • (2008) J Clin Pharm Ther , vol.33 , pp. 439-449
    • Yousef, A.M.1    Arafat, T.2    Bulatova, N.R.3    Al-Zumyli, R.4
  • 17
    • 58649100450 scopus 로고    scopus 로고
    • Clopidogrel but not aspirin prevents acute smoking-induced platelet aggregation in patients with stable coronary artery disease
    • Addad F, Chakroune T, Asma A, et al. Clopidogrel but not aspirin prevents acute smoking-induced platelet aggregation in patients with stable coronary artery disease. Thromb Res 2009;123:640-3.
    • (2009) Thromb Res , vol.123 , pp. 640-643
    • Addad, F.1    Chakroune, T.2    Asma, A.3
  • 18
    • 9144270451 scopus 로고    scopus 로고
    • Expert consensus document on the use of antiplatelet agents: The task force on the use of antiplatelet agents in patients with atherosclerotic cardiovascular disease of the European Society of Cardiology
    • Patrono C, Bachmann F, Baigent C, et al. Expert consensus document on the use of antiplatelet agents: the task force on the use of antiplatelet agents in patients with atherosclerotic cardiovascular disease of the European Society of Cardiology. Eur Heart J 2004;25:166-81.
    • (2004) Eur Heart J , vol.25 , pp. 166-181
    • Patrono, C.1    Bachmann, F.2    Baigent, C.3
  • 19
    • 77649211583 scopus 로고    scopus 로고
    • Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity
    • Gurbel PA, Bliden KP, Hiatt BL, O'Connor CM. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation 2003;108:921-4.
    • (2003) Circulation , vol.108 , pp. 921-924
    • Gurbel, P.A.1    Bliden, K.P.2    Hiatt, B.L.3    O'Connor, C.M.4
  • 20
    • 0038291914 scopus 로고    scopus 로고
    • Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement
    • Müller I, Besta F, Schulz C, Massberg S, Schönig A, Gawaz M. Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement. Thromb Haemost 2003;89:783-7.
    • (2003) Thromb Haemost , vol.89 , pp. 783-787
    • Müller, I.1    Besta, F.2    Schulz, C.3    Massberg, S.4    Schönig, A.5    Gawaz, M.6
  • 21
    • 33748474260 scopus 로고    scopus 로고
    • Pharmacokinetic drug interaction profiles of proton pump inhibitors
    • Blume H, Donath F, Warnke A, Schug BS. Pharmacokinetic drug interaction profiles of proton pump inhibitors. Drug Saf 2006;29:769-84.
    • (2006) Drug Saf , vol.29 , pp. 769-784
    • Blume, H.1    Donath, F.2    Warnke, A.3    Schug, B.S.4
  • 22
    • 0033859564 scopus 로고    scopus 로고
    • Review article: Comparison of the pharmacokinetics, acid suppression and efficacy of proton pump inhibitors
    • Stedman CAM, Barclay ML. Review article: comparison of the pharmacokinetics, acid suppression and efficacy of proton pump inhibitors. Aliment Pharmacol Ther 2000;12:963-78.
    • (2000) Aliment Pharmacol Ther , vol.12 , pp. 963-978
    • Stedman, C.A.M.1    Barclay, M.L.2
  • 23
    • 3242676832 scopus 로고    scopus 로고
    • Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole and rabeprazole on human cytochrome P450 activities
    • Li XQ, Andersson TB, Ahlström M, Weidolf L. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos 2004;32:821-7.
    • (2004) Drug Metab Dispos , vol.32 , pp. 821-827
    • Li, X.Q.1    Andersson, T.B.2    Ahlström, M.3    Weidolf, L.4
  • 24
    • 38349065084 scopus 로고    scopus 로고
    • Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin
    • Gilard M, Arnaud B, Cornily J-C, et al. Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin. J Am Coll Cardiol 2008;51:256-60.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 256-260
    • Gilard, M.1    Arnaud, B.2    Cornily, J.-C.3
  • 25
    • 40749094082 scopus 로고    scopus 로고
    • Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel
    • Small DS, Farid NA, Payne CD, et al. Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel. J Clin Pharmacol 2008;48:475-84.
    • (2008) J Clin Pharmacol , vol.48 , pp. 475-484
    • Small, D.S.1    Farid, N.A.2    Payne, C.D.3
  • 26
    • 57149104093 scopus 로고    scopus 로고
    • Siller-Matula JM, Spiel AO, Lang IM, Kreiner G, Christ G, Jilma B. Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel. Am Heart J 2009;157:148.e1-5.
    • Siller-Matula JM, Spiel AO, Lang IM, Kreiner G, Christ G, Jilma B. Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel. Am Heart J 2009;157:148.e1-5.
  • 27
    • 64849087438 scopus 로고    scopus 로고
    • Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel
    • Sibbing D, Morath T, Stegherr J, et al. Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel. Thromb Haemost 2009;101:714-19.
    • (2009) Thromb Haemost , vol.101 , pp. 714-719
    • Sibbing, D.1    Morath, T.2    Stegherr, J.3
  • 28
    • 70249139788 scopus 로고    scopus 로고
    • Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton pump inhibitor: An analysis of two randomized trials
    • O'Donoghue ML, Braunwald E, Antman EM, et al. Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton pump inhibitor: an analysis of two randomized trials. Lancet 2009;374:989-97.
    • (2009) Lancet , vol.374 , pp. 989-997
    • O'Donoghue, M.L.1    Braunwald, E.2    Antman, E.M.3
  • 29
    • 51049115517 scopus 로고    scopus 로고
    • Initial assessment of clinical impact of a drug interaction between clopidogrel and proton pump inhibitors [letter]
    • Pezalla E, Day D, Pullliadath I. Initial assessment of clinical impact of a drug interaction between clopidogrel and proton pump inhibitors [letter]. J Am Coll Cardiol 2008;52:1038-9.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1038-1039
    • Pezalla, E.1    Day, D.2    Pullliadath, I.3
  • 30
    • 62649164844 scopus 로고    scopus 로고
    • A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
    • Juurlink DN, Gomes T, Ko DT, et al. A population-based study of the drug interaction between proton pump inhibitors and clopidogrel. CMAJ 2009;180:713-18.
    • (2009) CMAJ , vol.180 , pp. 713-718
    • Juurlink, D.N.1    Gomes, T.2    Ko, D.T.3
  • 31
    • 61549124132 scopus 로고    scopus 로고
    • Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome
    • Ho PM, Maddox TM, Wang L, et al. Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome. JAMA 2009;301:937-44.
    • (2009) JAMA , vol.301 , pp. 937-944
    • Ho, P.M.1    Maddox, T.M.2    Wang, L.3
  • 32
    • 57749097363 scopus 로고    scopus 로고
    • Proton pump inhibitors effect on clopidogrel effectiveness: The clopidogrel Medco outcomes study [abstract 3998]
    • Auber RE, Epstein RS, Teagarden JR, et al. Proton pump inhibitors effect on clopidogrel effectiveness: the clopidogrel Medco outcomes study [abstract 3998]. Circulation 2008;118:S815.
    • (2008) Circulation , vol.118
    • Auber, R.E.1    Epstein, R.S.2    Teagarden, J.R.3
  • 33
    • 64849116567 scopus 로고    scopus 로고
    • Baseline proton pump inhibitor use is associated with increased cardiovascular events with and without the use of clopidogrel in the CREDO trial [abstract 3999]
    • Dunn SP, Macaulay TE, Brennan DM, et al. Baseline proton pump inhibitor use is associated with increased cardiovascular events with and without the use of clopidogrel in the CREDO trial [abstract 3999]. Circulation 2008;118:S815.
    • (2008) Circulation , vol.118
    • Dunn, S.P.1    Macaulay, T.E.2    Brennan, D.M.3
  • 34
    • 77649187092 scopus 로고    scopus 로고
    • A national study of the effect of individual proton pump inhibitors on cardiovascular outcomes in patients treated with clopidogrel following coronary stenting: The clopidogrel Medco outcomes study
    • Presented at the, Las Vegas, Nevada, May 6-9
    • Stanek EJ, Aubert RE, Flockhart FA, et al. A national study of the effect of individual proton pump inhibitors on cardiovascular outcomes in patients treated with clopidogrel following coronary stenting: the clopidogrel Medco outcomes study. Presented at the meeting of the society of cardiovascular angiography and interventions, Las Vegas, Nevada, May 6-9, 2009.
    • (2009) meeting of the society of cardiovascular angiography and interventions
    • Stanek, E.J.1    Aubert, R.E.2    Flockhart, F.A.3
  • 35
    • 77649208686 scopus 로고    scopus 로고
    • Clopidogrel and the optimization of GI events trial (COGENT)
    • Presented at the, San Francisco, California, September 21-25
    • Bhatt DL, Cryer B, Contant CF, et al. Clopidogrel and the optimization of GI events trial (COGENT). Presented at the transcatheter cardiovascular therapeutics meeting, San Francisco, California, September 21-25, 2009.
    • (2009) transcatheter cardiovascular therapeutics meeting
    • Bhatt, D.L.1    Cryer, B.2    Contant, C.F.3
  • 36
    • 0038354521 scopus 로고    scopus 로고
    • Resistance to thienopyridines: Clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylation
    • Barragan P, Bouvier JL, Roquebert PO, et al. Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylation. Catheter Cardiovasc Interv 2003;59:295-302.
    • (2003) Catheter Cardiovasc Interv , vol.59 , pp. 295-302
    • Barragan, P.1    Bouvier, J.L.2    Roquebert, P.O.3
  • 37
    • 36348990349 scopus 로고    scopus 로고
    • Utility of whole blood impedance aggregometry for the assessment of clopidogrel action using the novel multiplate analyzer-comparison with two flow cytometric methods
    • Mueller T, Dieplinger B, Poelz W, Calatzis A, Haltmayer M. Utility of whole blood impedance aggregometry for the assessment of clopidogrel action using the novel multiplate analyzer-comparison with two flow cytometric methods. Thromb Res 2007;121:249-58.
    • (2007) Thromb Res , vol.121 , pp. 249-258
    • Mueller, T.1    Dieplinger, B.2    Poelz, W.3    Calatzis, A.4    Haltmayer, M.5
  • 38
    • 42449104755 scopus 로고    scopus 로고
    • Monitoring of clopidogrel-related platelet inhibition: Correlation of nonresponse with clinical outcome in supra-aortic stenting
    • Muller-Schunk S, Linn J, Peters N, et al. Monitoring of clopidogrel-related platelet inhibition: correlation of nonresponse with clinical outcome in supra-aortic stenting. AJNR Am J Neuroradiol 2008;29:786-91.
    • (2008) AJNR Am J Neuroradiol , vol.29 , pp. 786-791
    • Muller-Schunk, S.1    Linn, J.2    Peters, N.3
  • 39
    • 35549008493 scopus 로고    scopus 로고
    • Platelet function monitoring in patients with coronary artery disease
    • Gurbel PA, Becker RC, Mann KG, et al. Platelet function monitoring in patients with coronary artery disease. J Am Coll Cardiol 2007;50:1822-34.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1822-1834
    • Gurbel, P.A.1    Becker, R.C.2    Mann, K.G.3
  • 40
    • 0028815561 scopus 로고
    • Positive and negative inotropic effects of DL-sotalol and D-sotalol in failing and nonfailing human myocardium under physiological experimental conditions
    • Holubarsch C, Schneider R, Pieske B, et al. Positive and negative inotropic effects of DL-sotalol and D-sotalol in failing and nonfailing human myocardium under physiological experimental conditions. Circulation 1995;92:2904-10.
    • (1995) Circulation , vol.92 , pp. 2904-2910
    • Holubarsch, C.1    Schneider, R.2    Pieske, B.3
  • 41
    • 45949103309 scopus 로고    scopus 로고
    • Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians evidencebased clinical practice guidelines
    • Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G. Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians evidencebased clinical practice guidelines. Chest 2008;133:160-98.
    • (2008) Chest , vol.133 , pp. 160-198
    • Ansell, J.1    Hirsh, J.2    Hylek, E.3    Jacobson, A.4    Crowther, M.5    Palareti, G.6
  • 42
    • 33847328353 scopus 로고    scopus 로고
    • Effect of antisecretory drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti-inflammatory drugs, antiplatelet agents, and anticoagulants
    • Lanas A, Garcia-Rodriguez LA, Arroyo MT, et al. Effect of antisecretory drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti-inflammatory drugs, antiplatelet agents, and anticoagulants. Am J Gastroenterol 2007;102:507-15.
    • (2007) Am J Gastroenterol , vol.102 , pp. 507-515
    • Lanas, A.1    Garcia-Rodriguez, L.A.2    Arroyo, M.T.3
  • 43
    • 77649199419 scopus 로고    scopus 로고
    • Predictive and protective factors associated with upper gastrointestinal bleeding after percutaneous intervention: A case control study
    • Chin MW, Yong G, Bulsara MK, Rankin J, Forbes GM. Predictive and protective factors associated with upper gastrointestinal bleeding after percutaneous intervention: a case control study. Am J Gastroenterol 2003;38:693-700.
    • (2003) Am J Gastroenterol , vol.38 , pp. 693-700
    • Chin, M.W.1    Yong, G.2    Bulsara, M.K.3    Rankin, J.4    Forbes, G.M.5
  • 44
    • 0035933056 scopus 로고    scopus 로고
    • Platelets modulate gastric ulcer healing: Role of endostatin and vascular endothelial growth factor release
    • Ma L, Elliott SN, Cirino G, Buret A, Ignarro LJ, Wallace JL. Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release. Proc Natl Acad Sci U.S.A. 2001;98:6470-5.
    • (2001) Proc Natl Acad Sci U.S.A , vol.98 , pp. 6470-6475
    • Ma, L.1    Elliott, S.N.2    Cirino, G.3    Buret, A.4    Ignarro, L.J.5    Wallace, J.L.6
  • 45
    • 33749681586 scopus 로고    scopus 로고
    • Use of single and combined antithrombotic therapy and risk of serious upper gastrointestinal bleeding: Population based case-control study [online exclusive article]
    • Available from
    • Hallas J, Dall M, Andries A, et al. Use of single and combined antithrombotic therapy and risk of serious upper gastrointestinal bleeding: population based case-control study [online exclusive article]. BMJ 2006;333:726. Available from http://www.bmj.com/cgi/content/full/333/7571/726? view=long&pmid=16984924.
    • (2006) BMJ , vol.333 , pp. 726
    • Hallas, J.1    Dall, M.2    Andries, A.3
  • 46
    • 12144275353 scopus 로고    scopus 로고
    • Clopidogrel vs aspirin plus esomeprazole to prevent recurrent ulcer bleeding
    • Chan FKL, Ching JYL, Hung LCT, et al. Clopidogrel vs aspirin plus esomeprazole to prevent recurrent ulcer bleeding. N Engl J Med 2005;352:238-44.
    • (2005) N Engl J Med , vol.352 , pp. 238-244
    • Chan, F.K.L.1    Ching, J.Y.L.2    Hung, L.C.T.3
  • 47
    • 0023680423 scopus 로고
    • Nonsteroidal antiinflammatory drug use and death from peptic ulcer in elderly persons
    • Griffin MR, Ray WA, Schaffner W. Nonsteroidal antiinflammatory drug use and death from peptic ulcer in elderly persons. Ann Intern Med 1988;109:359-63.
    • (1988) Ann Intern Med , vol.109 , pp. 359-363
    • Griffin, M.R.1    Ray, W.A.2    Schaffner, W.3
  • 48
    • 0025853360 scopus 로고
    • Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons
    • Griffin MR, Piper JM, Daugherty JR, Snowden M, Ray WA. Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann Intern Med 1991;114:257-63.
    • (1991) Ann Intern Med , vol.114 , pp. 257-263
    • Griffin, M.R.1    Piper, J.M.2    Daugherty, J.R.3    Snowden, M.4    Ray, W.A.5
  • 49
    • 0025852139 scopus 로고
    • Corticosteroid use and peptic ulcer disease: Role of nonsteroidal antiinflammatory drugs
    • Piper JM, Ray WA, Daugherty JR, Griffin MR. Corticosteroid use and peptic ulcer disease: role of nonsteroidal antiinflammatory drugs. Ann Intern Med 1991;114:735-40.
    • (1991) Ann Intern Med , vol.114 , pp. 735-740
    • Piper, J.M.1    Ray, W.A.2    Daugherty, J.R.3    Griffin, M.R.4
  • 50
    • 0027274773 scopus 로고
    • Concurrent use of nonsteroidal anti-inflammatory drugs and oral anticoagulants places elderly persons at high risk for hemorrhagic peptic ulcer disease
    • Shorr RI, Ray WA, Daugherty JR, Griffin MR. Concurrent use of nonsteroidal anti-inflammatory drugs and oral anticoagulants places elderly persons at high risk for hemorrhagic peptic ulcer disease. Arch Intern Med 1993;153:1665-70.
    • (1993) Arch Intern Med , vol.153 , pp. 1665-1670
    • Shorr, R.I.1    Ray, W.A.2    Daugherty, J.R.3    Griffin, M.R.4
  • 51
    • 77649224093 scopus 로고
    • The relative gastrointestinal toxicity of nonsteroidal anti-inflammatory drugs
    • Carson JL, Strom BL, Morse ML, et al. The relative gastrointestinal toxicity of nonsteroidal anti-inflammatory drugs. Arch Intern Med 1989;149:1019-22.
    • (1989) Arch Intern Med , vol.149 , pp. 1019-1022
    • Carson, J.L.1    Strom, B.L.2    Morse, M.L.3
  • 52
    • 0025953518 scopus 로고
    • Nonsteroidal anti-inflammatory drug-associated gastropathy: Incidence and risk factor models
    • Fries JF, Williams CA, Bloch DA, Michel BA. Nonsteroidal anti-inflammatory drug-associated gastropathy: incidence and risk factor models. Am J Med 1991;91:213-22.
    • (1991) Am J Med , vol.91 , pp. 213-222
    • Fries, J.F.1    Williams, C.A.2    Bloch, D.A.3    Michel, B.A.4
  • 53
    • 0029162250 scopus 로고
    • Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs: A randomized, double-blind, placebo-controlled trial
    • Silverstein FE, Graham DY, Senior JR, et al. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs: a randomized, double-blind, placebo-controlled trial. Ann Intern Med 1995;123:241-9.
    • (1995) Ann Intern Med , vol.123 , pp. 241-249
    • Silverstein, F.E.1    Graham, D.Y.2    Senior, J.R.3
  • 54
    • 33749998907 scopus 로고    scopus 로고
    • Interaction risk with proton pump inhibitors in general practice: Significant disagreement between different drug-related information sources
    • Trifiro G, Corrao S, Alacqua M, et al. Interaction risk with proton pump inhibitors in general practice: significant disagreement between different drug-related information sources. Br J Clin Pharmacol 2006;62:582-90.
    • (2006) Br J Clin Pharmacol , vol.62 , pp. 582-590
    • Trifiro, G.1    Corrao, S.2    Alacqua, M.3
  • 55
    • 34748853031 scopus 로고    scopus 로고
    • Inappropriate continuation of stress ulcer prophylactic therapy after discharge
    • Wohlt PD, Hansen LA, Fish JT. Inappropriate continuation of stress ulcer prophylactic therapy after discharge. Ann Pharmacother 2007;41:1611-16.
    • (2007) Ann Pharmacother , vol.41 , pp. 1611-1616
    • Wohlt, P.D.1    Hansen, L.A.2    Fish, J.T.3
  • 57
    • 0032795968 scopus 로고    scopus 로고
    • Review article: Drug interactions with agents used to treat acid-related diseases
    • Humphries TJ, Merritt GJ. Review article: drug interactions with agents used to treat acid-related diseases. Aliment Pharmacol Ther 1999;13(suppl 3):18-26.
    • (1999) Aliment Pharmacol Ther , vol.13 , Issue.SUPPL. 3 , pp. 18-26
    • Humphries, T.J.1    Merritt, G.J.2
  • 58
    • 37549020378 scopus 로고    scopus 로고
    • Surviving sepsis campaign: International guidelines on management of severe sepsis and septic shock: 2008
    • Dellinger RP, Levy MM, Carlet JM, et al. Surviving sepsis campaign: international guidelines on management of severe sepsis and septic shock: 2008. Crit Care Med 2008;36:1-33.
    • (2008) Crit Care Med , vol.36 , pp. 1-33
    • Dellinger, R.P.1    Levy, M.M.2    Carlet, J.M.3
  • 59
    • 53049088882 scopus 로고    scopus 로고
    • American Gastroenterological Association medical position statement on the management of gastroesophageal reflux disease
    • Hiltz SW, Black E, Land G, et al. American Gastroenterological Association medical position statement on the management of gastroesophageal reflux disease. Gastroenterology 2008;135:1383-91.
    • (2008) Gastroenterology , vol.135 , pp. 1383-1391
    • Hiltz, S.W.1    Black, E.2    Land, G.3
  • 60
    • 0029854798 scopus 로고    scopus 로고
    • Prevention of nonsteroidal anti-inflammatory drug-induced gastrointestinal mucosal injury
    • Koch M, Dezi A, Ferrario F, et al. Prevention of nonsteroidal anti-inflammatory drug-induced gastrointestinal mucosal injury. Arch Intern Med 1996;156:2321-32.
    • (1996) Arch Intern Med , vol.156 , pp. 2321-2332
    • Koch, M.1    Dezi, A.2    Ferrario, F.3
  • 61
    • 9344236529 scopus 로고    scopus 로고
    • Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs
    • Taha AS, Hudson N, Hawkey DM, et al. Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs. N Engl J Med 1996;334:1235-9.
    • (1996) N Engl J Med , vol.334 , pp. 1235-1239
    • Taha, A.S.1    Hudson, N.2    Hawkey, D.M.3
  • 62
    • 0028077024 scopus 로고
    • Ranitidine in the prevention of nonsteroidal anti-inflammatory drug-associated gastric and duodenal ulceration in arthritic patients
    • French PC, Darekar BS, Mills JG, et al. Ranitidine in the prevention of nonsteroidal anti-inflammatory drug-associated gastric and duodenal ulceration in arthritic patients. Eur J Gastroenterol Hepatol 1994;6:1141-7.
    • (1994) Eur J Gastroenterol Hepatol , vol.6 , pp. 1141-1147
    • French, P.C.1    Darekar, B.S.2    Mills, J.G.3
  • 63
    • 77649224308 scopus 로고    scopus 로고
    • TheHeart.org by WebMD. COGENT-1 trial scrapped, sponsor declares bankruptcy, January 2009. Available from http://www.theheart.org/article/936651. do. Accessed March 9, 2009.
    • TheHeart.org by WebMD. COGENT-1 trial scrapped, sponsor declares bankruptcy, January 2009. Available from http://www.theheart.org/article/936651. do. Accessed March 9, 2009.
  • 64
    • 58749090547 scopus 로고    scopus 로고
    • Genetic determinants of response to clopidogrel and cardiovascular events
    • Simon T, Verstuyft C, Mary-Krause M, et al. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med 2009;360:363-75.
    • (2009) N Engl J Med , vol.360 , pp. 363-375
    • Simon, T.1    Verstuyft, C.2    Mary-Krause, M.3
  • 65
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome P-450 polymorphisms and response to clopidogrel
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome P-450 polymorphisms and response to clopidogrel. N Engl J Med 2009;360:354-62.
    • (2009) N Engl J Med , vol.360 , pp. 354-362
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 66
    • 46649089410 scopus 로고    scopus 로고
    • Comparison of higher clopidogrel loading and maintenance dose to standard dose on platelet function and outcomes after percutaneous coronary intervention using drug-eluting stents
    • Abuzahra M, Pillai M, Caldera A, et al. Comparison of higher clopidogrel loading and maintenance dose to standard dose on platelet function and outcomes after percutaneous coronary intervention using drug-eluting stents. Am J Cardiol 2008;102:401-3.
    • (2008) Am J Cardiol , vol.102 , pp. 401-403
    • Abuzahra, M.1    Pillai, M.2    Caldera, A.3
  • 67
    • 58649095289 scopus 로고    scopus 로고
    • Impact of high loading and maintenance dose of clopidogrel within the first 15 days after percutaneous coronary intervention on patient outcome
    • Lemesle G, Delhaye C, Sudre A, et al. Impact of high loading and maintenance dose of clopidogrel within the first 15 days after percutaneous coronary intervention on patient outcome. Am Heart J 2009;157:375-82.
    • (2009) Am Heart J , vol.157 , pp. 375-382
    • Lemesle, G.1    Delhaye, C.2    Sudre, A.3


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