CD4 co-receptor dependent signaling promotes competency for re-stimulation induced cell death of effector T cells

Cellular Immunology

Volumn 266, Issue 2, 2011, Pages 200-207

  Tinsley, Kevin W ^a   Herzog, Dallen ^a   Leitenberg, David ^a,b  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b CHILDREN S RESEARCH INSTITUTE   (United States)

Author keywords

CD4 T cells; FAS; Re stimulation induced cell death

Indexed keywords

CASPASE 8; CD4 ANTIGEN; INTERLEUKIN 2;

ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EFFECTOR CELL; LIPID RAFT; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSGENE;

ANIMALS; ANTIGENS, CD4; ANTIGENS, CD95; APOPTOSIS; CASPASE 8; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MEMBRANE MICRODOMAINS; MICE; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

MUS;

EID: 78649979698     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2010.10.006     Document Type: Article

References (37)

1. Siegel R.M. Caspases at the crossroads of immune-cell life and death. Nat. Rev. Immunol. 2006, 6:308-317.
2. Hughes P.D., Belz G.T., Fortner K.A., Budd R.C., Strasser A., Bouillet P. Apoptosis regulators fas and bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity. Immunity 2008, 28:197-205.
3. Hornung F., Zheng L., Lenardo M.J. Maintenance of clonotype specificity in CD95/Apo-1/Fas-mediated apoptosis of mature T lymphocytes. J. Immunol. 1997, 159:3816-3822.
4. Wong B., Arron J., Choi Y. T cell receptor signals enhance susceptibility to Fas-mediated apoptosis. J. Exp. Med. 1997, 186:1939-1944.
5. Hueber A.O., Bernard A.M., Herincs Z., Couzinet A., He H.T. An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes. EMBO Rep. 2002, 3:190-196.
6. Muppidi J.R., Siegel R.M. Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death. Nat. Immunol. 2004, 5:182-189.
7. Manicassamy S., Sun Z. The critical role of protein kinase C-theta in Fas/Fas ligand-mediated apoptosis. J. Immunol. 2007, 178:312-319.
8. Ramaswamy M., Dumont C., Cruz A.C., Muppidi J.R., Gomez T.S., Billadeau D.D., Tybulewicz V.L., Siegel R.M. Cutting edge: Rac GTPases sensitize activated T cells to die via Fas. J. Immunol. 2007, 179:6384-6388.
9. Tatari-Calderone Z., Brogdon J.L., Tinsley K.W., Ramezani A., Leitenberg D. CD4-dependent signaling is required for a late checkpoint during Th2 development. J. Immunol. 2005, 175:5629-5636.
10. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 1989, 341:746-749.
11. Killeen N., Littman D.R. Helper T-cell development in the absence of CD4-p56lck association. Nature 1993, 364:729-732.
12. Leitenberg D., Boutin Y., Constant S., Bottomly K. CD4 regulation of TCR signaling and T cell differentiation following stimulation with peptides of different affinities for the TCR. J. Immunol. 1998, 161:1194-1203.
13. Balamuth F., Leitenberg D., Unternaehrer J., Mellman I., Bottomly K. Distinct patterns of membrane microdomain partitioning in Th1 and th2 cells. Immunity 2001, 15:729-738.
14. Matechak E.O., Killeen N., Hedrick S.M., Fowlkes B.J. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity 1996, 4:337-347.
15. Lenardo M.J. Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Nature 1991, 353:858-861.
16. Algeciras A., Dockrell D.H., Lynch D.H., Paya C.V. CD4 regulates susceptibility to Fas ligand- and tumor necrosis factor-mediated apoptosis. J. Exp. Med. 1998, 187:711-720.
17. + T lymphocytes in vivo and for activation-induced cell death. J. Immunol. 1999, 162:5973-5980.
18. Hamad A.R., Srikishnan A., Mirmonsef P., Broeren C.P., June C.H., Pardoll D., Schneck J.P. Lack of coreceptor allows survival of chronically stimulated double-negative alpha/beta T cells: implications for autoimmunity. J. Exp. Med. 2001, 193:1113-1121.
19. Golstein P. Signal transduction. FasL binds preassembled Fas. Science 2000, 288:2328-2329.
20. Bi L.L., Pan G., Atkinson T.P., Zheng L., Dale J.K., Makris C., Reddy V., McDonald J.M., Siegel R.M., Puck J.M., Lenardo M.J., Straus S.E. Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib. BMC Med. Genet. 2007, 8:41.
21. Chakrabandhu K., Herincs Z., Huault S., Dost B., Peng L., Conchonaud F., Marguet D., He H.T., Hueber A.O. Palmitoylation is required for efficient Fas cell death signaling. EMBO J. 2007, 26:209-220.
22. Falahati R., Leitenberg D. Changes in the role of the CD45 protein tyrosine phosphatase in regulating Lck tyrosine phosphorylation during thymic development. J. Immunol. 2007, 178:2056-2064.
23. Kneitz B., Herrman T., Yonehara S., Schimpl A. Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. Eur. J. Immunol. 1995, 25:2572-2577.
24. Locksley R.M., Reiner S.L., Hatam F., Littman D.R., Killeen N. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science 1993, 261:1448-1451.
25. Fowell D.J., Magram J., Turck C.W., Killeen N., Locksley R.M. Impaired Th2 subset development in the absence of CD4. Immunity 1997, 6:559-569.
26. Brown D.R., Moskowitz N.H., Killeen N., Reiner S.L. A role for CD4 in peripheral T cell differentiation. J. Exp. Med. 1997, 186:101-108.
27. Balamuth F., Brogdon J.L., Bottomly K. CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. J. Immunol. 2004, 172:5887-5892.
28. Fragoso R., Ren D., Zhang X., Su M.W., Burakoff S.J., Jin Y.J. Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. J. Immunol. 2003, 170:913-921.
29. Holmstrom T.H., Chow S.C., Elo I., Coffey E.T., Orrenius S., Sistonen L., Eriksson J.E. Suppression of Fas/APO-1-mediated apoptosis by mitogen-activated kinase signaling. J. Immunol. 1998, 160:2626-2636.
30. Holmstrom T.H., Schmitz I., Soderstrom T.S., Poukkula M., Johnson V.L., Chow S.C., Krammer P.H., Eriksson J.E. MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly. EMBO J. 2000, 19:5418-5428.
31. Benczik M., Gaffen S.L. The interleukin (IL)-2 family of cytokines: survival and proliferation signaling pathways in T lymphocytes. Immunol. Invest. 2004, 33:109-142.
32. Bouillet P., Metcalf D., Huang D.C., Tarlinton D.M., Kay T.W., Kontgen F., Adams J.M., Strasser A. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 1999, 286:1735-1738.
33. Dustin M.L. Membrane domains and the immunological synapse: keeping T cells resting and ready. J. Clin. Invest. 2002, 109:155-160.
34. Dykstra M., Cherukuri A., Sohn H.W., Tzeng S.J., Pierce S.K. Location is everything: lipid rafts and immune cell signaling. Annu. Rev. Immunol. 2003, 21:457-481.
35. Strauss G., Knape I., Melzner I., Debatin K.M. Constitutive caspase activation and impaired death-inducing signaling complex formation in CD95-resistant, long-term activated, antigen-specific T cells. J. Immunol. 2003, 171:1172-1182.
36. Hsu H.-C., Scott D.K., Mountz J.D. Impaired apoptosis and immune senescence-cause or effect?. Immunol. Rev. 2005, 205:130-146.
37. Shin H., Wherry E.J. CD8 T cell dysfunction during chronic viral infection. Curr. Opin. Immunol. 2007, 19:408-415.