CD4-dependent signaling is required for a late checkpoint during Th2 development associated with resistance to activation-induced cell death

Journal of Immunology

Volumn 175, Issue 9, 2005, Pages 5629-5636

  Tatari Calderpne, Zohreh ^a   Brogdon, Jennifer L ^b   Tinsley, Kevin W ^a   Ramezani, Anahita ^a   Leitenberg, David ^a,c,d  

^a GEORGE WASHINGTON UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^d CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRANSCRIPTION FACTOR GATA 3;

ACTIVATION INDUCED CELL DEATH; ANIMAL CELL; ANTIGEN DETECTION; ARTICLE; CELL DEATH; CELL MATURATION; CONTROLLED STUDY; EFFECTOR CELL; GENE MUTATION; GENETIC RESISTANCE; INHIBITION KINETICS; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFECT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TH2 CELL; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

EID: 27144469843     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.9.5629     Document Type: Article

References (28)

1. Leitenberg, D., and K. Bottomly. 1999. Regulation of naive T cell differentiation by varying the potency of TCR signal transduction. Semin, Immunol. 11 : 283-292.
2. Murphy, K. M., and S. L. Reiner. 2002. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2: 933-944.
3. Ho, I.-C., and L. H. Glimcher. 2002. Transcription: tantalizing times for T cells. Cell 109: S109-S120.
4. Farber, D., M. Luqman, O. Acuto, and K. Bottomly. 1995. Control of memory CD4 T cell activation: MHC class II molecules on antigen presenting cells and CD4 ligation inhibit memory but not naive CD4 T cells. Immunity 2: 249-259.
5. + T cells in the presence of a non-depleting monoclonal to CD4 induces a Th2-type response in vitro. J. Exp. Med. 182: 5-13.
6. Chirmule, N., A. Avots, S. M. Lakshmitamma, S. Pahwa, and E. Serfling. 1999. CD4-mediated signals induce T cell dysfunction in vivo. J. Immunol 163: 644-649.
7. Fowell, D. J., J. Magram, C. W. Turck, N. Killeen, and R. M. Locksley. 1997. Impaired Th2 subset development in the absence of CD4. Immunity 6: 559-569.
8. Brown, D. R., N. H. Moskowitz, N. Killeen, and S. L. Reiner. 1997. A role for CD4 in peripheral T cell differentiation. J. Exp. Med. 186: 101-107.
9. Leitenberg, D., Y. Boutin, S. Constant, and K. Bottomly. 1998. CD4 regulation of T cell receptor signaling and T cell differentiaion following stimulation with peptides of different affinites for the T cell receptor. J. Immunol. 161: 1194-1203.
10. + T cells in transgenic mice express a class II MHC restricted antigen receptor. Nature 341: 746-749.
11. Killeen, N., and D. R. Littman. 1993. Helper T-cell development in the absence of CD4-p561ck association. Nature 364: 729-732.
12. + T cell development. J. Immunol 162: 1348-1358.
13. Matechak, E. O., N. Killeen, S. M. Hedrick, and B. J. Fowlkes. 1996. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity 4: 337-347.
14. Miller, A. T., H. M. Wilcox, Z. Lai, and L. J. Berg. 2004. Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet. Immunity 21 : 67-80.
15. Cannons, J. L., L. J. Yu, B. Hill, L. A. Mijares, D. Dombroski, K. E. Nichols, A. Antonellis, G. A. Koretzky, K. Gardner, and P. L. Schwartzberg. 2004. SAP regulates T(H)2 differentiation and PKC-θ mediated activation of NF-κ1. Immunity 21: 693-706.
16. Davidson, D., X. Shi, S. Zhang, H. Wang, M. Nemer, N. Ono, S. Ohno, Y. Yanagi, and A. Veillette. 2004. Genetic evidence linking SAP, the X-linked lymphoproliferative gene product to src-related kinase FynT in T(H)2 cytokine regulation. Immunity 21: 707-717.
17. Zhang, X., T. Brunner, L. Carter, R. W. Dutton, P. Rogers, L. Bradley, T. Sato, J. C. Reed, D. Green, and S. L. Swain. 1997. Unequal death in T helper cell (Th) 1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J. Exp. Med. 185: 1837-1849.
18. Varadhachary, A. S., S. N. Perdow, C. Hu, M. Ramanarayanan, and P. Salgame. 1997. Differential ability of T cell subsets to undergo activation-induced cell death. Proc. Natl. Acad. Sci. USA 94: 5778-5783.
19. + T cells for IL-4 production. J. Exp. Med. 199: 1619-1630.
20. Zhang, X. R., L. Y. Zhang, S. Devadas, L. Li, A. D. Keegan, and Y. F. Shi. 2003. Reciprocal expression of TRAIL and CD95L in Th1 and Th2 cells: role of apoptosis in T helper subset differentiation. Cell Death Differ. 10: 203-210.
21. + T lymphocytes in vivo and for activation-induced cell death. J. Immunol. 162: 5973-5980.
22. Hamad, A. R., A. Srikishnan, P. Mirmonsef, C. P. Broeren, C. H. June, D. Pardoll, and J. P. Schneck. 2001. Lack of coreceptor allows survival of chronically stimulated double-negative α/β T cells: implications for autoimmunity. J. Exp. Med. 193: 1113-1121.
23. Homung, F., L. Zheng, and M. J. Lenardo. 1997. Maintenance of clonotype specificity in CD95/Apo-1/Fas-mediated apoptosis of mature T lymphocytes. J. Immunol 159: 3816-3822.
24. Wong, B., J. Arron, and Y. Choi. 1997. T cell receptor signals enhance susceptibility to Fas-mediated apoptosis. J. Exp. Med. 186: 1939-1944.
25. Muppidi, J. R., and R. M. Siegel. 2004. Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death. Nat. Immunol 5: 182-189.
26. Balamuth, F., D. Leitenberg, J. Untemaehrer, I. Mellman, and K. Bottomly. 2001. Distinct patterns of membrane microdomain partitioning in Th1 and Th2 cells. Immunity 15: 729-738.
27. Algeciras, A., D. H. Dockrell, D. H. Lynch, and C. V. Paya. 1998. CD4 regulates susceptibility to Fas ligand- and rumor necrosis factor-mediated apoptosis. J. Exp. Med. 187: 711-720.
28. Holmstrom, T. H., I. Schmitz, T. S. Soderstrom, M. Poukkula, V. L. Johnson, S. C. Chow, P. H. Krammer, and J. E. Eriksson. 2000. MAPK/ERK signaling in activatied T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly. EMBO J. 19: 5418-5428.