메뉴 건너뛰기




Volumn 31, Issue 12, 2010, Pages 1611-1617

Cannabidiol attenuates delayed-type hypersensitivity reactions via suppressing T-cell and macrophage reactivity

Author keywords

cannabidiol; cytokine; delayed type hypersensitivity; inteferon ; interleukin 10; interleukin 4; macrophage; T cell; tumor necrosis factor

Indexed keywords

CANNABIDIOL; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; OVALBUMIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 78649937735     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.155     Document Type: Article
Times cited : (26)

References (29)
  • 1
    • 0014933381 scopus 로고
    • Marihuana chemistry
    • Mechoulam R. Marihuana chemistry. Science 1970;168:1159-66.
    • (1970) Science , vol.168 , pp. 1159-1166
    • Mechoulam, R.1
  • 3
    • 0019308268 scopus 로고
    • Constituents of Cannabis sativa L. XVII. A review of the natural constituents
    • Turner CE, Elsohly MA, Boeren EG. Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod 1980;43:169-234.
    • (1980) J. Nat. Prod. , vol.43 , pp. 169-234
    • Turner, C.E.1    Elsohly, M.A.2    Boeren, E.G.3
  • 4
    • 70449522049 scopus 로고    scopus 로고
    • Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis
    • Borrelli F, Aviello G, Romano B, Orlando P, Capasso R, Maiello F, et al. Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis. J Mol Med 2009;87:1111-21.
    • (2009) J. Mol. Med. , vol.87 , pp. 1111-1121
    • Borrelli, F.1    Aviello, G.2    Romano, B.3    Orlando, P.4    Capasso, R.5    Maiello, F.6
  • 5
    • 65549122582 scopus 로고    scopus 로고
    • Cannabinoids, endocannabinoids, and related analogs in infammation
    • Burstein SH, Zurier RB. Cannabinoids, endocannabinoids, and related analogs in infammation. AAPS J 2009;11:109-19.
    • (2009) AAPS J. , vol.11 , pp. 109-119
    • Burstein, S.H.1    Zurier, R.B.2
  • 6
    • 34247359068 scopus 로고    scopus 로고
    • Suppressive effects of cannabidiol on antigen-specifc antibody production and functional activity of splenocytes in ovalbumin-sensitized BALB/c mice
    • Jan TR, Su ST, Wu HY, Liao MH. Suppressive effects of cannabidiol on antigen-specifc antibody production and functional activity of splenocytes in ovalbumin-sensitized BALB/c mice. Int Immuno pharmacol 2007;7:773-80.
    • (2007) Int. Immuno Pharmacol. , vol.7 , pp. 773-780
    • Jan, T.R.1    Su, S.T.2    Wu, H.Y.3    Liao, M.H.4
  • 7
    • 50549105058 scopus 로고    scopus 로고
    • The profle of immune modulation by cannabidiol (CBD) involves deregulation of nuclear factor of activated T cells (NFAT)
    • Kaplan BL, Springs AE, Kaminski NE. The profle of immune modulation by cannabidiol (CBD) involves deregulation of nuclear factor of activated T cells (NFAT). Biochem Pharmacol 2008;76:726-37.
    • (2008) Biochem. Pharmacol. , vol.76 , pp. 726-737
    • Kaplan, B.L.1    Springs, A.E.2    Kaminski, N.E.3
  • 9
    • 18844400058 scopus 로고    scopus 로고
    • Cannabinoid-based drugs as anti-inflammatory therapeutics
    • Klein TW. Cannabinoid-based drugs as anti-inflammatory therapeutics. Nat Rev Immunol 2005;5:400-11.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 400-411
    • Klein, T.W.1
  • 11
    • 41149153235 scopus 로고    scopus 로고
    • A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells
    • Lee CY, Wey SP, Liao MH, Hsu WL, Wu HY, Jan TR. A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells. Int Immunopharmacol 2008;8:732-40.
    • (2008) Int. Immunopharmacol , vol.8 , pp. 732-740
    • Lee, C.Y.1    Wey, S.P.2    Liao, M.H.3    Hsu, W.L.4    Wu, H.Y.5    Jan, T.R.6
  • 12
    • 0034662868 scopus 로고    scopus 로고
    • The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collageninduced arthritis
    • Malfait AM, Gallily R, Sumariwalla PF, Malik AS, Andreakos E, Mechoulam R, et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collageninduced arthritis. Proc Natl Acad Sci USA 2000;97:9561-6.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 9561-9566
    • Malfait, A.M.1    Gallily, R.2    Sumariwalla, P.F.3    Malik, A.S.4    Andreakos, E.5    Mechoulam, R.6
  • 13
    • 0028979327 scopus 로고
    • Delta-9-tetrahydrocannabinol modulates antigen processing by macrophages
    • McCoy KL, Gainey D, Cabral GA. Delta-9-tetrahydrocannabinol modulates antigen processing by macrophages. J Pharmacol Exp Ther 1995;273:1216-23.
    • (1995) J. Pharmacol. Exp. Ther. , vol.273 , pp. 1216-1223
    • McCoy, K.L.1    Gainey, D.2    Cabral, G.A.3
  • 14
    • 38649110505 scopus 로고    scopus 로고
    • Cannabidiolinduced apoptosis in primary lymphocytes is associated with oxidative stress-dependent activation of caspase-8
    • Wu HY, Chu RM, Wang CC, Lee CY, Lin SH, Jan TR. Cannabidiolinduced apoptosis in primary lymphocytes is associated with oxidative stress-dependent activation of caspase-8. Toxicol Appl Pharmacol 2008;226:260-70.
    • (2008) Toxicol. Appl. Pharmacol. , vol.226 , pp. 260-270
    • Wu, H.Y.1    Chu, R.M.2    Wang, C.C.3    Lee, C.Y.4    Lin, S.H.5    Jan, T.R.6
  • 17
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996;383:787-93.
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 18
    • 0032810108 scopus 로고    scopus 로고
    • The molecular basis of T cell differentiation
    • Flavell RA. The molecular basis of T cell differentiation. Immunol Res 1999;19:159-68.
    • (1999) Immunol. Res. , vol.19 , pp. 159-168
    • Flavell, R.A.1
  • 19
    • 0041917266 scopus 로고    scopus 로고
    • Th1/Th2 balance: The hypothesis, its limitations, and implications for health and disease
    • Kidd P. Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Altern Med Rev 2003;8:223-46.
    • (2003) Altern Med. Rev. , vol.8 , pp. 223-246
    • Kidd, P.1
  • 20
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-73.
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 21
    • 4344617762 scopus 로고    scopus 로고
    • Interferon-alpha in systemic lupus erythematosus
    • Crow MK, Kirou KA. Interferon-alpha in systemic lupus erythematosus. Curr Opin Rheumatol 2004;16:541-7.
    • (2004) Curr. Opin. Rheumatol. , vol.16 , pp. 541-547
    • Crow, M.K.1    Kirou, K.A.2
  • 22
    • 21844476213 scopus 로고    scopus 로고
    • The pathophysiologic rationale for biological therapies in infammatory bowel disease
    • Gordon JN, Di Sabatino A, Macdonald TT. The pathophysiologic rationale for biological therapies in infammatory bowel disease. Curr Opin Gastroenterol 2005;21:431-7.
    • (2005) Curr. Opin. Gastroenterol. , vol.21 , pp. 431-437
    • Gordon, J.N.1    Di Sabatino, A.2    Macdonald, T.T.3
  • 23
    • 33644543421 scopus 로고    scopus 로고
    • Immuno modulatory effects of IL-12 secreted by Lactococcus lactis on Th1/Th2 balance in ovalbumin (OVA)-induced asthma model mice
    • Wu C, Yang G, Bermudez-Humaran LG, Pang Q, Zeng Y, Wang J, et al. Immuno modulatory effects of IL-12 secreted by Lactococcus lactis on Th1/Th2 balance in ovalbumin (OVA)-induced asthma model mice. Int Immunopharmacol 2006;6:610-5.
    • (2006) Int. Immunopharmacol , vol.6 , pp. 610-615
    • Wu, C.1    Yang, G.2    Bermudez-Humaran, L.G.3    Pang, Q.4    Zeng, Y.5    Wang, J.6
  • 24
    • 12344250051 scopus 로고    scopus 로고
    • The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro
    • Sacerdote P, Martucci C, Vaccani A, Bariselli F, Panerai AE, Colombo A, et al. The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro. J Neuroimmunol 2005;159:97-105.
    • (2005) J. Neuroimmunol. , vol.159 , pp. 97-105
    • Sacerdote, P.1    Martucci, C.2    Vaccani, A.3    Bariselli, F.4    Panerai, A.E.5    Colombo, A.6
  • 25
    • 0023269443 scopus 로고
    • Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones
    • Cher DJ, Mosmann TR. Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones. J Immunol 1987;138:3688-94.
    • (1987) J. Immunol. , vol.138 , pp. 3688-3694
    • Cher, D.J.1    Mosmann, T.R.2
  • 26
    • 0035872889 scopus 로고    scopus 로고
    • Immunopathogenesis of delayedtype hypersensitivity
    • Kobayashi K, Kaneda K, Kasama T. Immunopathogenesis of delayedtype hypersensitivity. Microsc Res Tech 2001;53:241-5.
    • (2001) Microsc Res. Tech. , vol.53 , pp. 241-245
    • Kobayashi, K.1    Kaneda, K.2    Kasama, T.3
  • 27
    • 0034751335 scopus 로고    scopus 로고
    • Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
    • Bisogno T, Hanus L, De Petrocellis L, Tchilibon S, Ponde DE, Brandi I, et al. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol 2001;134:845-52.
    • (2001) Br. J. Pharmacol. , vol.134 , pp. 845-852
    • Bisogno, T.1    Hanus, L.2    De Petrocellis, L.3    Tchilibon, S.4    Ponde, D.E.5    Brandi, I.6
  • 28
    • 73149113054 scopus 로고    scopus 로고
    • Anandamide enhances IL-10 production in activated microglia by targeting CB (2) receptors: Roles of ERK1/2, JNK, and NF-kappaB
    • Correa F, Hernangómez M, Mestre L, Loría F, Spagnolo A, Docagne F, et al. Anandamide enhances IL-10 production in activated microglia by targeting CB (2) receptors: roles of ERK1/2, JNK, and NF-kappaB. Glia 2010;58:135-47.
    • (2010) Glia , vol.58 , pp. 135-147
    • Correa, F.1    Hernangómez, M.2    Mestre, L.3    Loría, F.4    Spagnolo, A.5    Docagne, F.6
  • 29
    • 29544446576 scopus 로고    scopus 로고
    • The endocannabinoid anandamide protects neurons during CNS infammation by induction of MKP-1 in microglial cells
    • Eljaschewitsch E, Witting A, Mawrin C, Lee T, Schmidt PM, Wolf S, et al. The endocannabinoid anandamide protects neurons during CNS infammation by induction of MKP-1 in microglial cells. Neuron 2006;49:67-79.
    • (2006) Neuron , vol.49 , pp. 67-79
    • Eljaschewitsch, E.1    Witting, A.2    Mawrin, C.3    Lee, T.4    Schmidt, P.M.5    Wolf, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.