메뉴 건너뛰기




Volumn 5, Issue 12, 2010, Pages

Deficiency of vasodilator-stimulated phosphoprotein (VASP) increases blood-brain-barrier damage and edema formation after ischemic stroke in mice

Author keywords

[No Author keywords available]

Indexed keywords

TRIPHENYLTETRAZOLIUM; VASODILATOR STIMULATED PHOSPHOPROTEIN; ACTIN; ACTIN BINDING PROTEIN; CELL ADHESION MOLECULE; PHOSPHOPROTEIN; VASODILATOR-STIMULATED PHOSPHOPROTEIN;

EID: 78649930777     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015106     Document Type: Article
Times cited : (16)

References (52)
  • 2
    • 35649027328 scopus 로고    scopus 로고
    • Antiedema therapy in ischemic stroke
    • Bardutzky J, Schwab S (2007) Antiedema therapy in ischemic stroke. Stroke 38: 3084-3094.
    • (2007) Stroke , vol.38 , pp. 3084-3094
    • Bardutzky, J.1    Schwab, S.2
  • 7
    • 13044264471 scopus 로고    scopus 로고
    • Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo
    • Corada M, Mariotti M, Thurston G, Smith K, Kunkel R, et al. (1999) Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Proc Natl Acad Sci USA 96: 9815-9820.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 9815-9820
    • Corada, M.1    Mariotti, M.2    Thurston, G.3    Smith, K.4    Kunkel, R.5
  • 8
    • 0032776062 scopus 로고    scopus 로고
    • Vascular-endothelial-cadherin modulates endothelial monolayer permeability
    • Hordijk PL, Anthony E, Mul FP, Rientsma R, Oomen LC, et al. (1999) Vascular-endothelial-cadherin modulates endothelial monolayer permeability. J Cell Sci 112: 1915-1923.
    • (1999) J Cell Sci , vol.112 , pp. 1915-1923
    • Hordijk, P.L.1    Anthony, E.2    Mul, F.P.3    Rientsma, R.4    Oomen, L.C.5
  • 9
    • 1842632667 scopus 로고    scopus 로고
    • Endothelial cell-cell junctions: Happy together
    • Dejana E (2004) Endothelial cell-cell junctions: happy together. Nat Rev Mol Cell Biol 5: 261-270.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 261-270
    • Dejana, E.1
  • 10
    • 0037336565 scopus 로고    scopus 로고
    • Signalling to and from tight junctions
    • Matter K, Balda MS (2003) Signalling to and from tight junctions. Nat Rev Mol Cell Biol 4: 225-236.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 225-236
    • Matter, K.1    Balda, M.S.2
  • 11
    • 27744464054 scopus 로고    scopus 로고
    • Critical role of actin in modulating BBB permeability
    • Lai CH, Kuo KH, Leo JM (2005) Critical role of actin in modulating BBB permeability. Brain Res Brain Res Rev 50: 7-13.
    • (2005) Brain Res Brain Res Rev , vol.50 , pp. 7-13
    • Lai, C.H.1    Kuo, K.H.2    Leo, J.M.3
  • 12
    • 33644839612 scopus 로고    scopus 로고
    • Signaling mechanisms regulating endothelial permeability
    • Mehta D, Malik AB (2006) Signaling mechanisms regulating endothelial permeability. Physiol Rev 86: 279-367.
    • (2006) Physiol Rev , vol.86 , pp. 279-367
    • Mehta, D.1    Malik, A.B.2
  • 13
    • 0031944250 scopus 로고    scopus 로고
    • Molecular architecture of tight junctions
    • Mitic LL, Anderson JM (1998) Molecular architecture of tight junctions. Annu Rev Physiol 60: 121-142.
    • (1998) Annu Rev Physiol , vol.60 , pp. 121-142
    • Mitic, L.L.1    Anderson, J.M.2
  • 14
    • 2442696852 scopus 로고    scopus 로고
    • ENA/VASP proteins: Multifunctional regulators of actin cytoskeleton dynamics
    • Sechi AS, Wehland J (2004) ENA/VASP proteins: multifunctional regulators of actin cytoskeleton dynamics. Front Biosci 9: 1294-1310.
    • (2004) Front Biosci , vol.9 , pp. 1294-1310
    • Sechi, A.S.1    Wehland, J.2
  • 16
    • 65249146677 scopus 로고    scopus 로고
    • VASP is involved in cAMP-mediated Rac 1 activation in microvascular endothelial cells
    • Schlegel N, Waschke J (2009) VASP is involved in cAMP-mediated Rac 1 activation in microvascular endothelial cells. Am J Physiol Cell Physiol 296: C453-462.
    • (2009) Am J Physiol Cell Physiol , vol.296
    • Schlegel, N.1    Waschke, J.2
  • 17
    • 50149095154 scopus 로고    scopus 로고
    • VASP involvement in force-mediated adherens junction strengthening
    • Kris AS, Kamm RD, Sieminski AL (2008) VASP involvement in force-mediated adherens junction strengthening. Biochem Biophys Res Commun 375: 134-138.
    • (2008) Biochem Biophys Res Commun , vol.375 , pp. 134-138
    • Kris, A.S.1    Kamm, R.D.2    Sieminski, A.L.3
  • 18
    • 38349046882 scopus 로고    scopus 로고
    • Cytoskeleton assembly at endothelial cell-cell contacts is regulated by alphaII-spectrin-VASP complexes
    • Benz PM, Blume C, Moebius J, Oschatz C, Schuh K, et al. (2008) Cytoskeleton assembly at endothelial cell-cell contacts is regulated by alphaII-spectrin-VASP complexes. J Cell Biol 180: 205-219.
    • (2008) J Cell Biol , vol.180 , pp. 205-219
    • Benz, P.M.1    Blume, C.2    Moebius, J.3    Oschatz, C.4    Schuh, K.5
  • 19
    • 0036550315 scopus 로고    scopus 로고
    • Role of vasodilator-stimulated phosphoprotein in PKA-induced changes in endothelial junctional permeability
    • Comerford KM, Lawrence DW, Synnestvedt K, Levi BP, Colgan SP (2002) Role of vasodilator-stimulated phosphoprotein in PKA-induced changes in endothelial junctional permeability. FASEB J 16: 583-585.
    • (2002) FASEB J , vol.16 , pp. 583-585
    • Comerford, K.M.1    Lawrence, D.W.2    Synnestvedt, K.3    Levi, B.P.4    Colgan, S.P.5
  • 21
    • 0033586662 scopus 로고    scopus 로고
    • Phosphorylation of vasodilator-stimulated phosphoprotein: A consequence of nitric oxide- and cGMP-mediated signal transduction in brain capillary endothelial cells and astrocytes
    • Sporbert AK, Mertsch A, Smolenski RF, Haseloff G, Schonfelder M, et al. (1999) Phosphorylation of vasodilator-stimulated phosphoprotein: a consequence of nitric oxide- and cGMP-mediated signal transduction in brain capillary endothelial cells and astrocytes. Brain Res Mol Brain Res 67: 258-266.
    • (1999) Brain Res Mol Brain Res , vol.67 , pp. 258-266
    • Sporbert, A.K.1    Mertsch, A.2    Smolenski, R.F.3    Haseloff, G.4    Schonfelder, M.5
  • 23
    • 0030794929 scopus 로고    scopus 로고
    • Overexpression of CuZnsuperoxide dismutase reduces hippocampal injury after global ischemia in transgenic mice
    • Murakami K, Kondo T, Epstein CJ, Chan PH (1997) Overexpression of CuZnsuperoxide dismutase reduces hippocampal injury after global ischemia in transgenic mice. Stroke 28: 1797-1804.
    • (1997) Stroke , vol.28 , pp. 1797-1804
    • Murakami, K.1    Kondo, T.2    Epstein, C.J.3    Chan, P.H.4
  • 24
    • 34249852075 scopus 로고    scopus 로고
    • Acute ischemic stroke: Overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia
    • Durukan A, Tatlisumak T (2007) Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia. Pharmacol Biochem Behav 87: 179-197.
    • (2007) Pharmacol Biochem Behav , vol.87 , pp. 179-197
    • Durukan, A.1    Tatlisumak, T.2
  • 25
    • 0041659304 scopus 로고    scopus 로고
    • Animal models of stroke: Do they have value for discovering neuroprotective agents?
    • Green RA, Odergren T, Ashwood T (2003) Animal models of stroke: do they have value for discovering neuroprotective agents? Trends Pharmacol Sci 24: 402-408.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 402-408
    • Green, R.A.1    Odergren, T.2    Ashwood, T.3
  • 26
    • 0028887364 scopus 로고
    • YM796, a novel muscarinic agonist, improves the impairment of learning behavior in a rat model of chronic focal cerebral ischemia
    • Yamaguchi T, Suzuki M, Yamamoto M (1995) YM796, a novel muscarinic agonist, improves the impairment of learning behavior in a rat model of chronic focal cerebral ischemia. Brain Res 669: 107-114.
    • (1995) Brain Res , vol.669 , pp. 107-114
    • Yamaguchi, T.1    Suzuki, M.2    Yamamoto, M.3
  • 27
    • 0029991601 scopus 로고    scopus 로고
    • Intracisternal basic fibroblast growth factor (bFGF) enhances behavioral recovery following focal cerebral infarction in the rat
    • Kawamata T, Alexis NE, Dietrich WD, Finklestein SP (1996) Intracisternal basic fibroblast growth factor (bFGF) enhances behavioral recovery following focal cerebral infarction in the rat. J Cereb Blood Flow Metab 16: 542-547.
    • (1996) J Cereb Blood Flow Metab , vol.16 , pp. 542-547
    • Kawamata, T.1    Alexis, N.E.2    Dietrich, W.D.3    Finklestein, S.P.4
  • 28
    • 34547782309 scopus 로고    scopus 로고
    • Identification of vasodilator-stimulated phosphoprotein (VASP) as an HIFregulated tissue permeability factor during hypoxia
    • Rosenberger P, Khoury J, Kong T, Weissmüller T, Robinson AM, et al. (2007) Identification of vasodilator-stimulated phosphoprotein (VASP) as an HIFregulated tissue permeability factor during hypoxia. FASEB J 21: 2613-2621.
    • (2007) FASEB J , vol.21 , pp. 2613-2621
    • Rosenberger, P.1    Khoury, J.2    Kong, T.3    Weissmüller, T.4    Robinson, A.M.5
  • 29
    • 29244442618 scopus 로고    scopus 로고
    • Endothelial focal adhesions and barrier function
    • Wu MH (2005) Endothelial focal adhesions and barrier function. J Physiol 569: 359-366.
    • (2005) J Physiol , vol.569 , pp. 359-366
    • Wu, M.H.1
  • 30
    • 33644865002 scopus 로고    scopus 로고
    • Ena/ VASP proteins can regulate distinct modes of actin organization at cadherinadhesive contacts
    • Scott JA, Shewan AM, den Elzen NR, Loureiro JJ, Gertler FB, et al. (2006) Ena/ VASP proteins can regulate distinct modes of actin organization at cadherinadhesive contacts. Mol Biol Cell 17: 1085-1095.
    • (2006) Mol Biol Cell , vol.17 , pp. 1085-1095
    • Scott, J.A.1    Shewan, A.M.2    den Elzen, N.R.3    Loureiro, J.J.4    Gertler, F.B.5
  • 31
    • 15544387084 scopus 로고    scopus 로고
    • Rac and Rho play opposing roles in the regulation of hypoxia/reoxygenation-induced permeability changes in pulmonary artery endothelial cells
    • Wojciak-Stothard B, Tsang LY, Haworth SG (2005) Rac and Rho play opposing roles in the regulation of hypoxia/reoxygenation-induced permeability changes in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 288: L749-760.
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.288
    • Wojciak-Stothard, B.1    Tsang, L.Y.2    Haworth, S.G.3
  • 32
    • 33744783930 scopus 로고    scopus 로고
    • Rac1 and RhoA as regulators of endothelial phenotype and barrier function in hypoxia-induced neonatal pulmonary hypertension
    • Wojciak-Stothard B, Tsang LY, Paleolog E, Hall SM, Haworth SG (2006) Rac1 and RhoA as regulators of endothelial phenotype and barrier function in hypoxia-induced neonatal pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 290: L1173-1182.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.290
    • Wojciak-Stothard, B.1    Tsang, L.Y.2    Paleolog, E.3    Hall, S.M.4    Haworth, S.G.5
  • 33
    • 0037044735 scopus 로고    scopus 로고
    • Cytoskeletal changes in hypoxic pulmonary endothelial cells are dependent on MAPK-activated protein kinase MK2
    • Kayyali US, Pennella CM, Trujillo C, Villa O, Gaestel M, et al. (2002) Cytoskeletal changes in hypoxic pulmonary endothelial cells are dependent on MAPK-activated protein kinase MK2. J Biol Chem 277: 42596-42602.
    • (2002) J Biol Chem , vol.277 , pp. 42596-42602
    • Kayyali, U.S.1    Pennella, C.M.2    Trujillo, C.3    Villa, O.4    Gaestel, M.5
  • 34
    • 48749092910 scopus 로고    scopus 로고
    • Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signaling
    • Filiano AJ, Bailey CD, Tucholski J, Gundemir S, Johnson GV (2008) Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signaling. FASEB J 22: 2662-2675.
    • (2008) FASEB J , vol.22 , pp. 2662-2675
    • Filiano, A.J.1    Bailey, C.D.2    Tucholski, J.3    Gundemir, S.4    Johnson, G.V.5
  • 35
    • 49349109477 scopus 로고    scopus 로고
    • HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model
    • Chen W, Jadhav V, Tang J, Zhang JH (2008) HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model. Neurobiol Dis 31: 433-441.
    • (2008) Neurobiol Dis , vol.31 , pp. 433-441
    • Chen, W.1    Jadhav, V.2    Tang, J.3    Zhang, J.H.4
  • 36
    • 60849116409 scopus 로고    scopus 로고
    • Early inhibition of HIF- 1alpha with small interfering RNA reduces ischemic-reperfused brain injury in rats
    • Chen C, Hu Q, Yan J, Yang X, Shi X, et al. (2009) Early inhibition of HIF- 1alpha with small interfering RNA reduces ischemic-reperfused brain injury in rats. Neurobiol Dis 33: 509-517.
    • (2009) Neurobiol Dis , vol.33 , pp. 509-517
    • Chen, C.1    Hu, Q.2    Yan, J.3    Yang, X.4    Shi, X.5
  • 37
    • 77955427718 scopus 로고    scopus 로고
    • Role of vasodilator stimulated phosphoprotein in VEGF induced blood-brain barrier permeability in endothelial cell monolayers
    • Davis BJ, Tang L, Zhang D, Mu X, Jiang V, et al. (2010) Role of vasodilator stimulated phosphoprotein in VEGF induced blood-brain barrier permeability in endothelial cell monolayers. Int J Dev Neurosci 28: 423-428.
    • (2010) Int J Dev Neurosci , vol.28 , pp. 423-428
    • Davis, B.J.1    Tang, L.2    Zhang, D.3    Mu, X.4    Jiang, V.5
  • 38
    • 77952615173 scopus 로고    scopus 로고
    • TRPC-mediated actinmyosin contraction is critical for BBB disruption following hypoxic stress
    • Hicks K, O'Neil RG, Dubinsky WS, Brown RC (2010) TRPC-mediated actinmyosin contraction is critical for BBB disruption following hypoxic stress. Am J Physiol Cell Physiol 298: C1583-1593.
    • (2010) Am J Physiol Cell Physiol , vol.298
    • Hicks, K.1    O'Neil, R.G.2    Dubinsky, W.S.3    Brown, R.C.4
  • 39
    • 72749102734 scopus 로고    scopus 로고
    • Inflammation-associated repression of vasodilator-stimulated phosphoprotein (VASP) reduces alveolar-capillary barrier function during acute lung injury
    • Henes J, Schmit MA, Morote-Garcia JC, Mirakaj V, Kohler D, Glover L, et al. (2009) Inflammation-associated repression of vasodilator-stimulated phosphoprotein (VASP) reduces alveolar-capillary barrier function during acute lung injury. Faseb J 23: 4244-4255.
    • (2009) Faseb J , vol.23 , pp. 4244-4255
    • Henes, J.1    Schmit, M.A.2    Morote-Garcia, J.C.3    Mirakaj, V.4    Kohler, D.5    Glover, L.6
  • 40
    • 60549111207 scopus 로고    scopus 로고
    • Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema
    • Austinat M, Braeuninger S, Pesquero JB, Brede M, Bader M, et al. (2009) Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema. Stroke 40: 285-293.
    • (2009) Stroke , vol.40 , pp. 285-293
    • Austinat, M.1    Braeuninger, S.2    Pesquero, J.B.3    Brede, M.4    Bader, M.5
  • 41
    • 77955174994 scopus 로고    scopus 로고
    • Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation
    • Raslan F, Schwarz T, Meuth SG, Austinat M, Bader M, et al. (2010) Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation. J Cereb Blood Flow Metab 30: 1477-1486.
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 1477-1486
    • Raslan, F.1    Schwarz, T.2    Meuth, S.G.3    Austinat, M.4    Bader, M.5
  • 42
    • 23044478435 scopus 로고    scopus 로고
    • Release of bradykinin and expression of kinin B2 receptors in the brain: Role for cell death and brain edema formation after focal cerebral ischemia in mice
    • Groeger M, Lebesgue D, Pruneau D, Relton J, Kim SW, et al. (2005) Release of bradykinin and expression of kinin B2 receptors in the brain: role for cell death and brain edema formation after focal cerebral ischemia in mice. J Cereb Blood Flow Metab 25: 978-989.
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 978-989
    • Groeger, M.1    Lebesgue, D.2    Pruneau, D.3    Relton, J.4    Kim, S.W.5
  • 43
    • 33751327483 scopus 로고    scopus 로고
    • Bench to bedside: The quest for quality in experimental stroke research
    • Dirnagl U (2006) Bench to bedside: the quest for quality in experimental stroke research. J Cereb Blood Flow Metab 26: 1465-1478.
    • (2006) J Cereb Blood Flow Metab , vol.26 , pp. 1465-1478
    • Dirnagl, U.1
  • 44
    • 0033529302 scopus 로고    scopus 로고
    • Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice
    • Hauser W, Knobeloch KP, Eigentaler M, Gambaryan S, Krenn V, et al. (1999) Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice. Proc Natl Acad Sci USA 96: 8120-8125.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8120-8125
    • Hauser, W.1    Knobeloch, K.P.2    Eigentaler, M.3    Gambaryan, S.4    Krenn, V.5
  • 45
    • 0031439697 scopus 로고    scopus 로고
    • Monofilament intraluminal middle cerebral artery occlusion in the mouse
    • Clark WM, Lessov NS, Dixon MP, Eckenstein F (1997) Monofilament intraluminal middle cerebral artery occlusion in the mouse. Neurol Res 19: 641-648.
    • (1997) Neurol Res , vol.19 , pp. 641-648
    • Clark, W.M.1    Lessov, N.S.2    Dixon, M.P.3    Eckenstein, F.4
  • 46
    • 77952557777 scopus 로고    scopus 로고
    • Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation
    • Kleinschnitz C, Schwab N, Kraft P, Hagedorn I, Dreykluft A, et al. (2010) Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation. Blood 115: 3835-3842.
    • (2010) Blood , vol.115 , pp. 3835-3842
    • Kleinschnitz, C.1    Schwab, N.2    Kraft, P.3    Hagedorn, I.4    Dreykluft, A.5
  • 47
    • 0030060152 scopus 로고    scopus 로고
    • Procedural and strain-related variables significantly affect outcome in a murine model of focal cerebral ischemia
    • Connolly Jr. ES, Winfree CJ, Stern DM, Solomon RA, Pinsky DJ (1996) Procedural and strain-related variables significantly affect outcome in a murine model of focal cerebral ischemia. Neurosurgery 38: 523-532.
    • (1996) Neurosurgery , vol.38 , pp. 523-532
    • Connolly Jr., E.S.1    Winfree, C.J.2    Stern, D.M.3    Solomon, R.A.4    Pinsky, D.J.5
  • 48
    • 0022483434 scopus 로고
    • Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurologic examination
    • Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, et al. (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17: 472-476.
    • (1986) Stroke , vol.17 , pp. 472-476
    • Bederson, J.B.1    Pitts, L.H.2    Tsuji, M.3    Nishimura, M.C.4    Davis, R.L.5
  • 49
    • 0022870943 scopus 로고
    • Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats
    • Bederson JB, Pitts LH, Germano SM, Nishimura MC, Davis RL, et al. (1986) Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 176: 1304-1308.
    • (1986) Stroke , vol.176 , pp. 1304-1308
    • Bederson, J.B.1    Pitts, L.H.2    Germano, S.M.3    Nishimura, M.C.4    Davis, R.L.5
  • 51
    • 41249090758 scopus 로고    scopus 로고
    • Empirical evidence of bias in the design of experimental stroke studies: A metaepidemiologic approach
    • Crossley NA, Sena E, Goehler J, Horn J, van der Worp B, et al. (2008) Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke 39: 929-934.
    • (2008) Stroke , vol.39 , pp. 929-934
    • Crossley, N.A.1    Sena, E.2    Goehler, J.3    Horn, J.4    van der Worp, B.5
  • 52
    • 25144439926 scopus 로고    scopus 로고
    • Methodological quality of animal studies on neuroprotection in focal cerebral ischaemia
    • Van der Worp HB, de Haan P, Morrema E, Kalkman CJ (2005) Methodological quality of animal studies on neuroprotection in focal cerebral ischaemia. J Neurol 252: 1108-1114.
    • (2005) J Neurol , vol.252 , pp. 1108-1114
    • Van der Worp, H.B.1    de Haan, P.2    Morrema, E.3    Kalkman, C.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.