메뉴 건너뛰기




Volumn 48, Issue 2, 2011, Pages 192-199

The GATA-type transcriptional activator Gat1 regulates nitrogen uptake and metabolism in the human pathogen Cryptococcus neoformans

Author keywords

Cryptococcus neoformans; Nitrogen Catabolite Repression; Nitrogen metabolism

Indexed keywords

AMINO ACID; ARGININE; NITROGEN; PROLINE; PROTEIN GAT1; RAPAMYCIN; TRANSCRIPTION FACTOR GATA; UNCLASSIFIED DRUG;

EID: 78649920352     PISSN: 10871845     EISSN: 10960937     Source Type: Journal    
DOI: 10.1016/j.fgb.2010.07.011     Document Type: Article
Times cited : (42)

References (43)
  • 1
    • 0033540030 scopus 로고    scopus 로고
    • The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
    • Beck T., Hall M.N. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 1999, 402:689-692.
    • (1999) Nature , vol.402 , pp. 689-692
    • Beck, T.1    Hall, M.N.2
  • 3
    • 0033573016 scopus 로고    scopus 로고
    • The TOR signaling cascade regulates gene expression in response to nutrients
    • Cardenas M.E., Cutler N.S., Lorenz M.C., Di Como C.J., Heitman J. The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev. 1999, 13:3271-3279.
    • (1999) Genes Dev. , vol.13 , pp. 3271-3279
    • Cardenas, M.E.1    Cutler, N.S.2    Lorenz, M.C.3    Di Como, C.J.4    Heitman, J.5
  • 4
    • 34247547435 scopus 로고    scopus 로고
    • Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans
    • Chang Y.C., Bien C.M., Lee H., Espenshade P.J., Kwon-Chung K.J. Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans. Mol. Microbiol. 2007, 64:614-629.
    • (2007) Mol. Microbiol. , vol.64 , pp. 614-629
    • Chang, Y.C.1    Bien, C.M.2    Lee, H.3    Espenshade, P.J.4    Kwon-Chung, K.J.5
  • 5
    • 0030931118 scopus 로고    scopus 로고
    • Nitrogen GATA factors participate in transcriptional regulation of vacuolar protease genes in Saccharomyces cerevisiae
    • Coffman J.A., Cooper T.G. Nitrogen GATA factors participate in transcriptional regulation of vacuolar protease genes in Saccharomyces cerevisiae. J. Bacteriol. 1997, 179:5609-5613.
    • (1997) J. Bacteriol. , vol.179 , pp. 5609-5613
    • Coffman, J.A.1    Cooper, T.G.2
  • 6
    • 0030028431 scopus 로고    scopus 로고
    • Gat1p, a GATA family protein whose production is sensitive to nitrogen catabolite repression, participates in transcriptional activation of nitrogen-catabolic genes in Saccharomyces cerevisiae
    • Coffman J.A., Rai R., Cunningham T., Svetlov V., Cooper T.G. Gat1p, a GATA family protein whose production is sensitive to nitrogen catabolite repression, participates in transcriptional activation of nitrogen-catabolic genes in Saccharomyces cerevisiae. Mol. Cell Biol. 1996, 16:847-858.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 847-858
    • Coffman, J.A.1    Rai, R.2    Cunningham, T.3    Svetlov, V.4    Cooper, T.G.5
  • 9
    • 0017887028 scopus 로고
    • Nitrogen regulation of amino acid catabolism in Neurospora crassa
    • Facklam T.J., Marzluf G.A. Nitrogen regulation of amino acid catabolism in Neurospora crassa. Biochem. Genet. 1978, 16:343-354.
    • (1978) Biochem. Genet. , vol.16 , pp. 343-354
    • Facklam, T.J.1    Marzluf, G.A.2
  • 11
    • 0142216112 scopus 로고    scopus 로고
    • Recapitulation of the sexual cycle of the primary fungal pathogen Cryptococcus neoformans var. Gattii: implications for an outbreak on Vancouver Island, Canada
    • Fraser J.A., Subaran R.L., Nichols C.B., Heitman J. Recapitulation of the sexual cycle of the primary fungal pathogen Cryptococcus neoformans var. Gattii: implications for an outbreak on Vancouver Island, Canada. Eukaryot. Cell. 2003, 2:1036-1045.
    • (2003) Eukaryot. Cell. , vol.2 , pp. 1036-1045
    • Fraser, J.A.1    Subaran, R.L.2    Nichols, C.B.3    Heitman, J.4
  • 13
    • 11144291814 scopus 로고    scopus 로고
    • Cryptococcus neoformans CAP59 (or Cap59p) is involved in the extracellular trafficking of capsular glucuronoxylomannan
    • Garcia-Rivera J., Chang Y.C., Kwon-Chung K.J., Casadevall A. Cryptococcus neoformans CAP59 (or Cap59p) is involved in the extracellular trafficking of capsular glucuronoxylomannan. Eukaryot. Cell. 2004, 3:385-392.
    • (2004) Eukaryot. Cell. , vol.3 , pp. 385-392
    • Garcia-Rivera, J.1    Chang, Y.C.2    Kwon-Chung, K.J.3    Casadevall, A.4
  • 14
    • 67651205627 scopus 로고    scopus 로고
    • Elucidating the pathogenesis of spores from the human fungal pathogen Cryptococcus neoformans
    • Giles S.S., Dagenais T.R., Botts M.R., Keller N.P., Hull C.M. Elucidating the pathogenesis of spores from the human fungal pathogen Cryptococcus neoformans. Infect. Immun. 2009, 77:3491-3500.
    • (2009) Infect. Immun. , vol.77 , pp. 3491-3500
    • Giles, S.S.1    Dagenais, T.R.2    Botts, M.R.3    Keller, N.P.4    Hull, C.M.5
  • 15
    • 0033592983 scopus 로고    scopus 로고
    • Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins
    • Hardwick J.S., Kuruvilla F.G., Tong J.K., Shamji A.F., Schreiber S.L. Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins. Proc. Natl. Acad. Sci. USA 1999, 96:14866-14870.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 14866-14870
    • Hardwick, J.S.1    Kuruvilla, F.G.2    Tong, J.K.3    Shamji, A.F.4    Schreiber, S.L.5
  • 16
    • 0031818693 scopus 로고    scopus 로고
    • The role of the Aspergillus fumigatus areA gene in invasive pulmonary aspergillosis
    • Hensel M., Arst H.N., Aufauvre-Brown A., Holden D.W. The role of the Aspergillus fumigatus areA gene in invasive pulmonary aspergillosis. Mol. Gen. Genet. 1998, 258:553-557.
    • (1998) Mol. Gen. Genet. , vol.258 , pp. 553-557
    • Hensel, M.1    Arst, H.N.2    Aufauvre-Brown, A.3    Holden, D.W.4
  • 17
    • 0032750741 scopus 로고    scopus 로고
    • Nitrogen catabolite repression in Saccharomyces cerevisiae
    • Hofman-Bang J. Nitrogen catabolite repression in Saccharomyces cerevisiae. Mol. Biotechnol. 1999, 12:35-73.
    • (1999) Mol. Biotechnol. , vol.12 , pp. 35-73
    • Hofman-Bang, J.1
  • 18
    • 4143077083 scopus 로고    scopus 로고
    • Cryptococcus neoformans virulence gene discovery through insertional mutagenesis
    • Idnurm A., Reedy J.L., Nussbaum J.C., Heitman J. Cryptococcus neoformans virulence gene discovery through insertional mutagenesis. Eukaryot. Cell. 2004, 3:420-429.
    • (2004) Eukaryot. Cell. , vol.3 , pp. 420-429
    • Idnurm, A.1    Reedy, J.L.2    Nussbaum, J.C.3    Heitman, J.4
  • 19
    • 0033577745 scopus 로고    scopus 로고
    • Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast
    • Jiang Y., Broach J.R. Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. EMBO J. 1999, 18:2782-2792.
    • (1999) EMBO J. , vol.18 , pp. 2782-2792
    • Jiang, Y.1    Broach, J.R.2
  • 20
    • 53449087032 scopus 로고    scopus 로고
    • Threonine biosynthetic genes are essential in Cryptococcus neoformans
    • Kingsbury J.M., McCusker J.H. Threonine biosynthetic genes are essential in Cryptococcus neoformans. Microbiology 2008, 154:2767-2775.
    • (2008) Microbiology , vol.154 , pp. 2767-2775
    • Kingsbury, J.M.1    McCusker, J.H.2
  • 21
    • 2942595896 scopus 로고    scopus 로고
    • Cryptococcus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37°C and in vivo
    • Kingsbury J.M., Yang Z., Ganous T.M., Cox G.M., McCusker J.H. Cryptococcus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37°C and in vivo. Microbiology 2004, 150:1547-1558.
    • (2004) Microbiology , vol.150 , pp. 1547-1558
    • Kingsbury, J.M.1    Yang, Z.2    Ganous, T.M.3    Cox, G.M.4    McCusker, J.H.5
  • 23
    • 34547658070 scopus 로고    scopus 로고
    • Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformans
    • Lee H., Bien C.M., Hughes A.L., Espenshade P.J., Kwon-Chung K.J., Chang Y.C. Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformans. Mol. Microbiol. 2007, 65:1018-1033.
    • (2007) Mol. Microbiol. , vol.65 , pp. 1018-1033
    • Lee, H.1    Bien, C.M.2    Hughes, A.L.3    Espenshade, P.J.4    Kwon-Chung, K.J.5    Chang, Y.C.6
  • 24
    • 0034687743 scopus 로고    scopus 로고
    • Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct
    • Lengeler K.B., Wang P., Cox G.M., Perfect J.R., Heitman J. Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct. Proc. Natl. Acad. Sci. USA 2000, 97:14455-14460.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 14455-14460
    • Lengeler, K.B.1    Wang, P.2    Cox, G.M.3    Perfect, J.R.4    Heitman, J.5
  • 25
    • 39749203509 scopus 로고    scopus 로고
    • GLN3 encodes a global regulator of nitrogen metabolism and virulence of C. Albicans
    • Liao W.L., Ramon A.M., Fonzi W.A. GLN3 encodes a global regulator of nitrogen metabolism and virulence of C. Albicans. Fungal Genet. Biol. 2008, 45:514-526.
    • (2008) Fungal Genet. Biol. , vol.45 , pp. 514-526
    • Liao, W.L.1    Ramon, A.M.2    Fonzi, W.A.3
  • 26
    • 0242606099 scopus 로고    scopus 로고
    • Nitrogen metabolism and virulence of Candida albicans require the GATA-type transcriptional activator encoded by GAT1
    • Limjindaporn T., Khalaf R.A., Fonzi W.A. Nitrogen metabolism and virulence of Candida albicans require the GATA-type transcriptional activator encoded by GAT1. Mol. Microbiol. 2003, 50:993-1004.
    • (2003) Mol. Microbiol. , vol.50 , pp. 993-1004
    • Limjindaporn, T.1    Khalaf, R.A.2    Fonzi, W.A.3
  • 27
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 28
    • 0037094434 scopus 로고    scopus 로고
    • Nitrogen regulation in Saccharomyces cerevisiae
    • Magasanik B., Kaiser C.A. Nitrogen regulation in Saccharomyces cerevisiae. Gene 2002, 290:1-18.
    • (2002) Gene , vol.290 , pp. 1-18
    • Magasanik, B.1    Kaiser, C.A.2
  • 29
    • 0030794656 scopus 로고    scopus 로고
    • Genetic regulation of nitrogen metabolism in the fungi
    • Marzluf G.A. Genetic regulation of nitrogen metabolism in the fungi. Microbiol. Mol. Biol. Rev. 1997, 61:17-32.
    • (1997) Microbiol. Mol. Biol. Rev. , vol.61 , pp. 17-32
    • Marzluf, G.A.1
  • 30
    • 77951028266 scopus 로고    scopus 로고
    • Coping with multiple virulence factors: which is most important?
    • McClelland E.E., Bernhardt P., Casadevall A. Coping with multiple virulence factors: which is most important?. PLoS Pathog. 2005, 1:e40.
    • (2005) PLoS Pathog. , vol.1
    • McClelland, E.E.1    Bernhardt, P.2    Casadevall, A.3
  • 31
    • 11144260147 scopus 로고    scopus 로고
    • UGD1, encoding the Cryptococcus neoformans UDP-glucose dehydrogenase, is essential for growth at 37°C and for capsule biosynthesis
    • Moyrand F., Janbon G. UGD1, encoding the Cryptococcus neoformans UDP-glucose dehydrogenase, is essential for growth at 37°C and for capsule biosynthesis. Eukaryot. Cell. 2004, 3:1601-1608.
    • (2004) Eukaryot. Cell. , vol.3 , pp. 1601-1608
    • Moyrand, F.1    Janbon, G.2
  • 35
    • 41449094147 scopus 로고    scopus 로고
    • Amt2 permease is required to induce ammonium-responsive invasive growth and mating in Cryptococcus neoformans
    • Rutherford J.C., Lin X., Nielsen K., Heitman J. Amt2 permease is required to induce ammonium-responsive invasive growth and mating in Cryptococcus neoformans. Eukaryot. Cell. 2008, 7:237-246.
    • (2008) Eukaryot. Cell. , vol.7 , pp. 237-246
    • Rutherford, J.C.1    Lin, X.2    Nielsen, K.3    Heitman, J.4
  • 36
    • 33745892068 scopus 로고    scopus 로고
    • Identification of direct and indirect targets of the Gln3 and Gat1 activators by transcriptional profiling in response to nitrogen availability in the short and long term
    • Scherens B., Feller A., Vierendeels F., Messenguy F., Dubois E. Identification of direct and indirect targets of the Gln3 and Gat1 activators by transcriptional profiling in response to nitrogen availability in the short and long term. FEMS Yeast Res. 2006, 6:777-791.
    • (2006) FEMS Yeast Res. , vol.6 , pp. 777-791
    • Scherens, B.1    Feller, A.2    Vierendeels, F.3    Messenguy, F.4    Dubois, E.5
  • 37
    • 0344842282 scopus 로고    scopus 로고
    • An alpha-1,3-mannosyltransferase of Cryptococcus neoformans
    • Sommer U., Liu H., Doering T.L. An alpha-1,3-mannosyltransferase of Cryptococcus neoformans. J. Biol. Chem. 2003, 278:47724-47730.
    • (2003) J. Biol. Chem. , vol.278 , pp. 47724-47730
    • Sommer, U.1    Liu, H.2    Doering, T.L.3
  • 38
    • 0028832649 scopus 로고
    • Role of the GATA factors Gln3p and Nil1p of Saccharomyces cerevisiae in the expression of nitrogen-regulated genes
    • Stanbrough M., Rowen D.W., Magasanik B. Role of the GATA factors Gln3p and Nil1p of Saccharomyces cerevisiae in the expression of nitrogen-regulated genes. Proc. Natl. Acad. Sci. USA 1995, 92:9450-9454.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9450-9454
    • Stanbrough, M.1    Rowen, D.W.2    Magasanik, B.3
  • 39
    • 34547781750 scopus 로고    scopus 로고
    • MEGA4: molecular evolutionary genetics analysis (MEGA) software version 4.0
    • Tamura K., Dudley J., Nei M., Kumar S. MEGA4: molecular evolutionary genetics analysis (MEGA) software version 4.0. Mol. Biol. Evol. 2007, 24:1596-1599.
    • (2007) Mol. Biol. Evol. , vol.24 , pp. 1596-1599
    • Tamura, K.1    Dudley, J.2    Nei, M.3    Kumar, S.4
  • 40
    • 0030707562 scopus 로고    scopus 로고
    • TOR signalling and control of cell growth
    • Thomas G., Hall M.N. TOR signalling and control of cell growth. Curr. Opin. Cell Biol. 1997, 9:782-787.
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 782-787
    • Thomas, G.1    Hall, M.N.2
  • 42
    • 0029951165 scopus 로고    scopus 로고
    • Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type
    • Wickes B.L., Mayorga M.E., Edman U., Edman J.C. Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type. Proc. Natl. Acad. Sci. USA 1996, 93:7327-7331.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7327-7331
    • Wickes, B.L.1    Mayorga, M.E.2    Edman, U.3    Edman, J.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.