Reduction of Pten dose leads to neoplastic development in multiple organs of PtenshRNA mice

Cancer Biology and Therapy

Volumn 10, Issue 11, 2010, Pages 1194-1200

  Shen Li, Hong ^a   Koujak, Susan ^a   Szablocs, Matthias ^a   Parsons, Ramon ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

Haploinsufficiency; Neoplasia; Pten; RNAi; shRNA; Tumor suppressor

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SHORT HAIRPIN RNA;

ADRENAL GLAND; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SIZE; CARCINOGENESIS; CONTROLLED STUDY; FEMALE; GERMLINE MICRONUCLEUS; LIFESPAN; LYMPHOID HYPERPLASIA; MOUSE; NONHUMAN; PHENOTYPE; PROSTATE HYPERTROPHY; PROSTATE TUMOR; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SEBACEOUS CARCINOMA; SPLENOMEGALY; SURVIVAL RATE; TRANSGENE; UTERUS;

ADENOMA; ADRENAL GLANDS; ANIMALS; BRAIN; ENDOMETRIUM; FEMALE; HYPERPLASIA; LYMPHATIC DISEASES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOPLASMS, EXPERIMENTAL; ORGAN SIZE; PHOSPHORYLATION; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RNA, SMALL INTERFERING; SEBACEOUS GLAND NEOPLASMS;

EID: 78649861614     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.10.11.13814     Document Type: Article

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