Protective effect of l-carnitine against acrylamide-induced DNA damage in somatic and germ cells of mice

Saudi Journal of Biological Sciences

Volumn 18, Issue 1, 2011, Pages 29-36

  Alzahrani, Hind Abdullah Seed ^a  

^a IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY   (Saudi Arabia)

Author keywords

Acrylamide; Antimutagenicity; Chromosomal aberrations; L carnitine; Mice; Micronuclei; Sperm abnormalities

Indexed keywords

MUS;

EID: 78649851015     PISSN: 1319562X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sjbs.2010.07.004     Document Type: Article

References (65)

1. Abramsson-Zetterberg L. The dose-response relationship at very low doses of acrylamide is linear in the flow cytometer-based mouse micronucleus assay. Mutat. Res. 2003, 535-2:215-222.
2. Abramsson-Zetterberg L., Vikstr A.C., Tornqvist M., Hellenas K.E. Differences in the frequency of micronucleated erythrocytes in humans in relation to consumption of fried carbohydrate-rich food. Mut. Res. 2008, 653:50-56.
3. Adler D., Reitmeir P., Schmoller R., Schriever-Schwemmer G. Dose response for heritable translocations induced by acrylamide in spermatids of mice. Mutat. Res. 1994, 309:285-291.
4. Adler I., Ingwersen I., Kliesch U. Clastogenic effect of acrylamide in mouse bone marrow cells. Mutat. Res. 1988, 206:379-385.
5. Baccetti B., Renieri T., Rosati F., Selmi M.G., Casanova S. Further observations on the morphogenesis of the round headed human spermatozoa. Andrologia 1977, 9:255-264.
6. Backer L., Dearrfield K., Erexson G., et al. The effects of acrylamide on mouse germ line and somatic cell chromosome. Envirnmental and Molecular Mutagenesis 1989, 13:218-226.
7. Berni A., Meschini R., Filippi S., Palitti F., Arnicisb A., Chessab L. l-carnitme enhances resistance to oxidative stress by reducing DNA damage in Ataxia telangiectasia cells. Mut. Res. 2008, 650:165-174.
8. Blasiak J., Gloc E., Wozniak K., Czechowska A. Genotoxicity of acrylamide in human lymphocytes. Chem. Biol. Interact. 2004, 149:137-149.
9. Boerrigter M.E., Franceschi C., Arrigoni-Martelli E., Wei J.Y., Vijg J. The effect of l-carnitine and acetyl-l-carnitine on the disappearance of DNA single-strand breaks in human peripheral blood lymphocytes. Carcinogenesis 1993, 14:2131-2136.
10. Chang B.J., Nishikawa M., Sato E., Utsumi K., Inoue M. l-carnitine inhibits ciplastin-induced injury of the kidney and small intestine. Arch. Biochem. Biophys. 2002, 405:55-64.
11. Chiak R., Vontorkva M. Cytogenetic effects of acrylamide in the bone marrow of mice. Mutat. Res. 1988, 234:91-94.
12. Collins J.J., Swaen G.M.H., Marsh G.M., Utidjian H.M.D., Caporossi J.C., Lucas J.J. Mortality patterns among workers exposed to acrylamide. J. Occup. Med. 1989, 31:614-617.
13. da Costa G.G., Churchwell M.I., Hamilton L.P., Von Tungeln L.S., Beland F.A., Marques M.M., Doerge D.R. DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice. Chem. Res. Toxicol. 2003, 16:1328-1337.
14. Daniel W.W. Biostatistics, a foundation for analysis in the health sciences 1974, 448. Wilely Sono, London. John (Ed.).
15. Dearfield K.L., Douglas G.R., Ehling U.H., Moore M.M., Sega G.A., Brusick D.J. Acrylamide: a review of its genotoxicity and an assessment of heritable genetic risk. Mut. Res. 1995, 330:71-99.
16. Dokmeci D., Akpolat M., Aydogu N., Uzal C., Doganay L., Turan F.N. The protective effect of l-carnitine on ionizing radiation induced free oxygen radicals. Scand. J. Lab. Anim. Sci. 2006, 33(2):75-83.
17. Dragland S., Senoo H., Wake K., Holte K., Blomhoff R. Several culinary and medicinal herbs are important sources of dietary antioxidants. J. Nutr. 2003, 133:1286-1290.
18. Friedman M. Chemistry, biochemistry, and safety of acrylamide. A review. J. Agric. Food Chem. 2003, 51:4504-4526.
19. Galli G., Fratelli M. Activation of apoptosis by serum deprivation in a teratocarcinoma cell line: inhibition by lacetyl carnitine. Exp. Cell Res. 1993, 204:54-60.
20. Garcia C.L., Filippi S., Mosesso P., Calvani M., Nicolai R., Mosconi L., Palitti F. The protective effect of l-carnitine in peripheral blood human lymphocytes exposed to oxidative agents. Mut. Res. 2006, 1:21-27.
21. Generoso W.M., Sega G.A., Lockhart A.M., Hughes L.A., Cain K.T., Cacheiro N.L.A., Shelby M.D. Dominant lethal mutations, heritable translocations, and unscheduled DNA synthesis induced in male mouse germ cells by glycidamide, a metabolite of acrylamide. Mutat. Res. 1996, 371:175-183.
22. Hogervorst J., Schouten L.J., Konings E.J., Goldbohm R.A., van den Brandt P.A. Assessment of the relation between biomarkers for smoking and biomarkers for acrylamide exposure in humans. Cancer Epidemiol. Biomarkers Prev. 2007, 16(11):2471.
23. Ibrahim K., Seyithan T., Mustafa E., Ihsan K., Akcahan G., Orhan S., Korkmaz S. The effect of l-carnitine in the prevention of ionizing radiation induced cataracts, a rat model. Graefes. Archive Clinic. Exp.Ophthalm. 2007, 245(4):588-594.
24. Ito C., Suzuki-Toyota F., Maekawa M., Toyama Y., Yao R., Noda T., Toshimori K. Failure to assemble the peri-nuclear structures in GOPC deficient spermatids as found in round-headed spermatozoa. Arch. Histol. Cytol. 2004, 67:349-360.
25. Jouannet P., Ducot B., Feneux D., Spira A. Male factors and the likelihood of pregnancy in infertile couples. I. Study of sperm characteristics. Int. J. Androl. 1988, 11:379-394.
26. Kastenbaum M.A., Bowman K.O. Tables for determining the statistical significance of mutation frequencies. Mut. Res. 1970, 9:527-549.
27. Kligerman A.D., Atwater A.L., Bryant M.E., et al. Cytogenetic studies of ethyl acrylate using C57 BL/6 mice. Mutagenesis 1991, 3:263-268.
28. Knaap A., Kramer P., Voogd C. Mutagenic activity of acrylamide in eukariotic system but not in bacteria. Mutagenesis 1988, 3:263-266.
29. Koyama N., Sakamoto N., Sakuraba M., Koizumi T., et al. Genotoxicity of acrylamide and glycidamide in human lymphoblastoid TK6 cells. Mutat. Res. 2006, 603(2):1-158.
30. Krebayashi H., Ohno Y. Metabolism of acrylamide to glycidamide and their cytotoxicity in isolated rat hepatocytes: protective effects of GSH precursors. Arch. Toxicol. 2006, 80:820-828.
31. Liping J., Jun C., Yu A., Chengyan G., et al. Genotoxicity of acrylamide in human hepatoma G2 (HepG2) cells. Toxicol. In Vitro 2007, 21(8):1486-1492.
32. Llansola M., Felipo V. Carnitine prevents NMDA receptor mediated activation of MAP-kinase and phosphorilation of microtubule-associated protein 2 in cerebella neurons in culture. Brain Res. 2002, 947:50-56.
33. Luo X., Reichetzer B., Trines J., Benson L.N., Lehotay D.C. l-carnitine attenuates doxorubicin-induced lipid peroxidation in rats. Free Radic. Biol. Med. 1999, 26:1158-1165.
34. Molnar A., Sarlos P., Fancsi G., Ratky J., Nagy S., Kovacs A. A sperm tail defect associated with infertility in a goat-case report. Acta Vet. Hung. 2001, 49:341-348.
35. Mucci L.A., Dickman P.W., Steineck G., Adami O., Augustsson K. Dietary acrylamide and cancer of the large bowel, kidney, and bladder. Absence of an association in a population based study in Sweden. Br. J. Cancer 2003, 88:84-89.
36. Mucci L.A., Dickman P.W., Steineck G., Adami O., Augustsson K. Letter to the editor: reply: dietary acrylamide and cancer risk: additional data on coffee. Br. J. Cancer 2003, 89:774-776.
37. Oliveira,N. G.; Pingarilho, M.: Martins, C.; Fernandes, A.S.; Sofie Vazb, S.; Martins, V.; Rueff, J. and Gaspar, J.F.(2009). Cytotoxicity and chromosomal aberrations induced by acrylamide in V79 cells: Role of glutathione modulators. Mut. Res., in press.
38. Park J., Kamendulis L.M., Friedman M.A., Klaunig J.E. Arcylamide-induced cellular transformation. Toxicol. Sci. 2002, 65:177-183.
39. Paulsson B., Kotova N., Grawe J., Henderson A., Granath F., Golding B., Tornqvist M. Induction of micronuclei in mouse and rat by glycidamide, genotoxic metabolite of acrylamide. Mutat. Res. 2003, 535:13-24.
40. Ramadan L.A., Abd-Allah A.R., Aly H.A., Saad-El-Din A.A. toxicity effects of magnetic field exposure and prophylactic role of coenzyme Q1O and l-carnitine in mice. Pharmacol. Res. 2002, 46(4):363-370.
41. Rebouche C.J., Seim H. Carnitine metabolism and its regulation in microorganisms and mammals. Annu. Rev. Nutr. 1998, 18:39-61.
42. Reznick A.Z., Kagan V.E., Ramsey R., Tsuchiya M., Khwaja S., Serbinova E.A., Packer L. Antiradical effects in l-propionyl carnitine protection of the heart against ischemia-reperfusion injury: The possible role of iron chelation. Arch. Biochem. Biophys. 1992, 296:394-401.
43. Santoro A., Lioi M.B., Monfregola J., Salzano S., Rocchina Barbieri R., Ursini M.V. l-carnitine protects mammalian cells from chromosome aberrations but not from inhibition of cell proliferation induced by hydrogen peroxide. Mut. Res. 2005, 587:16-25.
44. Schmid W. Chemical mutagen testing on in vivo somatic mammalian cells. Agents and Actions 1973, 3(2):77-85.
45. Schulz M.R., Hertz-Picciotto I., van Wijngaarden E., Hernandez J.C., Ball L.M. Dose-response relation between acrylamide and pancreatic cancer. Occup. Environ. Med. 2001, 58:609.
46. Segerback D., Calleman C.J., Schroeder J.L., Costa L.G., Faustman E.M. Formation of N-7-(2-carbamoyl-2- hydroxyethyl)guanine in DNA of the mouse and the rat following intraperitoneal administration of [14C]acrylamide. Carcinogenesis 1995, 16:1161-1165.
47. Shan X.Q., Aw T.Y., Jones D.P. Glutathione-dependent protection against oxidative injury. Pharmacol. Ther. 1990, 47(1):61-71.
48. Shelby M.D., Cain K.T., Hughes L.A., Braden P.W., Generoso W.M. Dominant lethal effects of acrylamide in male mice. Mutat. Res. 1986, 173:35-40.
49. Shiraishi Y. Chromosome aberrations induced by monomeric acrylamide in bone marrow and germ cells of mice. Mut. Res. 1978, 57:313-324.
50. Singh R.B., Niaz M.A., Agarwal P., Beegun R., Rastogi S.S., Sachan D.S. A randomised, double-blind, placebo-controlled trial of l-carnitine in suspected acute myocardial infarction. Post-grad. Med. J. 1996, 72:45-50.
51. Solomon J.J., Fedyk J., Mukai F., Segal A. alkylation of 2-desoxynucleosides and DNA following in vitro reactions with acrylamide. Cancer Res. 1985, 45:3465-3470.
52. Stadler R.H., Blak I., Varga N., Robert F., Hau J., Guy P.A., Robert M.C., Riediker S. Food chemistry: acrylamide from Maillard reaction products. Nature 2002, 419:449-450.
53. Sumner S.C.J., Fennell T.R., Moore T.A., Chanas B., Gonzalez F., Ghanayem B.I. Role of cytochrome P4502E1 in the metabolism of acrylamide and acrylonitrile in mice. Chem. Res. Toxicol. 1999, 12:1110-1116.
54. Svensson K., Abramsson L., Becker W., Glynn A., Hellenas K.E., Lind Y., Rosen J. Dietary intake of acrylamide in Sweden. Food Chem. Toxicol. 2003, 41:1581-1586.
55. Tong G.C., Cornwell W.K., Means G.E. Reactions of arcylamide with glutathione and serum albumin. Toxicol. Lett. 2004, 147:127-131.
56. Trichopoulou A., Lagiou P. Healthy traditional Mediterranean diet: an expression of culture, history, and lifestyle. Nutr. Rev. 1997, 55:383-389.
57. Vanella A., Russo A., Acquaviva R., Campisi A., Di Giacomo C., Sorrenti V., Barcellona M.L. l-propionyl-carnitine as superoxide scavenger, antioxidant, and cleavage protector. Cell Biol. Toxicol. 2000, 16:99-104.
58. Vescovo G., Ravara B., Sandri M., Angelini A., Della Barbera M., Dona M., Peluso G., Calvani M., Mosconi L., Dalla Libera L. l-carnitine: A potential treatment for blocking apoptosis and preventing skeletal muscle myopathy in hearth failure. Am. J. Physiol. Cell Physiol. 2002, 283:802-810.
59. Wang Y., Ye J., Ganapathy V., Longo N. Mutations in the organic/carnitine transporter OCTN2 in primary carnitine deficiency. Proc. Natl. Acad. Sci. USA 1999, 96:2356-2360.
60. Wang H., Huang P., Lie T., Li J., Reinhold J., Hutz R.J., Li K., Shi F. Reproductive toxicity of acrylamide-treated male rats. Reprod. Toxicol. 2010, 29(2):225-230.
61. Wyrobek A.J., Bruce W.R. The induction of sperm-shape abnormalities in mice and humans. Principles and Methods for their Detection 1978, vol. 5:257-285. Plenum Press, New York.
62. Wyrobek A.J., Gordon L.A., Burkhart J.G., Francis M.W., Kapp R.W., Letz G., Malling H.V., Tapham J.C., Whorton M.D. An evaluation of the mouse sperm morphology test and other sperm tests in nonhuman mammals: a report of the gene. Tox. Program. Mutat. Res. 1983, 115:1-72.
63. Yosida T.H., Amano K. Autosomal polymorphism in laboratory bred and wild Norway rats, Rattus norvegicus. Misima Chromosoma 1965, 16:658-667.
64. Zamorano-Ponce E., Morales C., Ramos D., Sepulveda C., Cares S., Rivera P., Fernandez J., Carballo M.A. Anti-genotoxic effect of Aloysia triphylla infusion against acrylamide-induced DNA damage as shown by the comet assay technique. Mut. Res. 2006, 603:145-150.
65. Zhang X., Cao J., Jiang L., Geng C., Zhong L. Protective effect of hydroxytyrosol against acrylamide-induced cytotoxicity and DNA damage in HepG2 cells. Mut. Res. 2009, 664:64-68.