Protective effect of hydroxytyrosol against acrylamide-induced cytotoxicity and DNA damage in HepG2 cells

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 664, Issue 1-2, 2009, Pages 64-68

  Zhang, Xiaomei ^a,b   Cao, Jun ^b   Jiang, Liping ^b   Geng, Chenyan ^b   Zhong, Laifu ^b  

^a DALIAN UNIVERSITY   (China)

^b DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Acrylamide; Chemoprotective; DNA damage; HepG2 cells; Hydroxytyrosol

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ACRYLAMIDE; BROMINE DERIVATIVE; DNA; FLUORESCEIN DIACETATE; FLUORESCENT DYE; GLUTATHIONE; HYDROXYTYROSOL; REACTIVE OXYGEN METABOLITE;

ARTICLE; CANCER CELL CULTURE; CELL STRAIN HEPG2; COMET ASSAY; CONCENTRATION RESPONSE; CYTOTOXICITY; DNA DAMAGE; DRUG EFFECT; FLUOROMETRY; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MONITORING; PRIORITY JOURNAL; PROTECTION;

ACRYLAMIDE; ANTIOXIDANTS; CELL LINE; DEOXYGUANOSINE; DNA BREAKS; DNA DAMAGE; GLUTATHIONE; HUMANS; MUTAGENS; PHENYLETHYL ALCOHOL; REACTIVE OXYGEN SPECIES;

EID: 65049086069     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2009.02.013     Document Type: Article

References (36)

1. Trichopoulou A., and Lagiou P. Healthy traditional Mediterranean diet: an expression of culture, history, and lifestyle. Nutr. Rev. 55 (1997) 383-389
2. Fitó M., de la R.T., Farré-Albaladejo M., Khymenetz O., Marrugat J., and Covas M.I. Bioavailability and antioxidant effects of olive oil phenolic compounds in humans: a review. Ann. Ist Super Sanita 43 4 (2007) 375-381
3. Visioli F., and Galli C. Biological properties of olive oil phytochemicals. Crit. Rev. Food Sci. Nutr. 42 3 (2002) 209-221
4. Montedoro G.F., Servili M., and Baldioli M. Simple and hydrolyzable compounds in virgin olive oil. Spectroscopic characterization of the secoiridoids derivatives. J. Agric. Food Chem. 41 (1993) 2228-2234
5. Papadopoulos G., and Boskou D. Antioxidantive effect of natural phenols on olive oil. J. Am. Oil Chem. Soc. 68 (1991) 669-671
6. Baldioli M., Servili M., Perretti G., and Montedoro G.F. Antioxidant activity of tocopherols and phenolic compounds of virgin olive oil. J. Am. Oil Chem. Soc. 73 (1996) 1589-1593
7. Weinbrenner T., Fitó M., de la T.R., Saez G.T., et al. Olive oils high in phenolic compounds modulate oxidative/antioxidative status in men. J. Nutr. 134 9 (2004) 2314-2321
8. Salvini S., Sera F., Caruso D., Giovannelli L., et al. Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal women. Br. J. Nutr. 95 4 (2006) 742-751
9. IARC, Acrylamide, IARC Monographs on the Evaluation of Carcinogen Risk to Human: Some Industrial Chemicals, vol. 60, International Agency for Research on Cancer, Lyon, 1994, pp. 389-443.
10. Acrylamide is formed during the preparation of food and occurs in many foodstuffs. Swedish National Food Administration, Uppsala (www.slv.se). FA, 2002.
11. Mottram D.S., Wedzicha B.L., and Dodson A.T. Acrylamide is formed in the Maillard reaction. Nature 419 (2002) 448-449
12. Chico G.V., Massart C., Jin L., Vanvooren V., et al. Acrylamide, an in vivo thyroid carcinogenic agent, induces DNA damage in rat thyroid cell lines and primary cultures. Mol. Cell Endocrinol. 257-258 (2006) 6-14
13. Koyama N., Sakamoto H., Sakuraba M., Koizumi T., et al. Genotoxicity of acrylamide and glycidamide in human lymphoblastoid TK6 cells. Mutat. Res. 603 2 (2006) 151-158
14. Park J., Kamendulis L.M., Friedman M.A., and Klaunig J.E. Arcylamide-induced cellular transformation. Toxicol. Sci. 65 (2002) 177-183
15. 13C nuclear magnetic resonance spectroscopy. Chem. Res. Toxicol. 5 (1992) 81-89
16. Tong G.C., Cornwell W.K., and Means G.E. Reactions of arcylamide with glutathione and serum albumin. Toxicol. Lett. 147 (2004) 127-131
17. Liping J., Jun C., Yu A., Chengyan G., et al. Genotoxicity of acrylamide in human hepatoma G2 (HepG2) cells. Toxicol. In Vitro 21 8 (2007) 1486-1492
18. Mersch-Sundermanna V., Knasmüller S., Wu X.J., Darraoudi F., et al. Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents. Toxicology 198 (2004) 329-340
19. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 (1983) 55-63
20. Singh N.P., and Stephens R.E. Microgel electrophoresis: sensitivity, mechanisms, and DNA electrostretching. Mutat. Res. 383 (1997) 167-175
21. Bass D.A., Parce J.W., Dechatelet L.R., Szejda P., Seeds M.C., and Thomas M. Flow cytometry studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J. Immunol. 130 (1983) 1910-1917
22. Halliwell B., and Whiteman M. Measuring reactive species and oxidative damage in vivo and cell culture. How should you do it and what does it mean?. Br. J. Pharmacol. 142 (2004) 231-255
23. Hissin P.J., and Hilf R.A. Fluorimetric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 74 (1976) 214-226
24. Goya L., Mateos R., and Bravo L. Effect of the olive oil phenol hydroxytyrosol on human hepatoma HepG2 cells, protection against oxidative stress induced by tert-butylhydroperoxide. Eur. J. Nutr. 46 (2007) 70-78
25. Zhang X., Jiang L., Geng C., Hu C., Yoshimura H., and Zhong L. Inhibition of Sudan I genotoxicity in human liver-derived HepG2 cells by the antioxidant hydroxytyrosol. Free Radic. Res. 42 2 (2008) 189-195
26. Knowles B.B., Howe C.C., and Aden D.P. Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 209 (1980) 497-499
27. Scharf G., Prustomersky S., Knasmuller S., Schulte H.R., et al. Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2. Nutr. Cancer 45 (2003) 74-83
28. In: Sies H. (Ed). Oxidative Stress, Oxidants, and Antioxidants (1991), Academic Press, London, New York
29. Manna C., Galletti P., Cucciolla V., Montedoro G., and Zappia V. Olive oil hydroxytyrosol protects human erythrocytes against oxidative damages. J. Nutr. Biochem. 10 (1996) 159-165
30. Caterina M., Fulvio D.R., Valeria C., Adriana B., Stefania DA., Patrizia G., and Vincenzo Z. Biological effects of hydroxytyrosol, a polyphenol from olive oil endowed with antioxidant activity. In: Zappoa V. (Ed). Advances in Nutrition and Cancer (1999), Kluwer Academic/Plenum Publishers, New York
31. Shan X.Q., Aw T.Y., and Jones D.P. Glutathione-dependent protection against oxidative injury. Pharmacol. Ther. 47 1 (1990) 61-71
32. Nicole P., Zeina T., Florian F., and Doris M. DNA strand breaking capacity of acrylamide and glycidamide in mammalian cells. Mutat. Res. 580 (2005) 71-80
33. Kurebayashi H., and Ohno Y. Metabolism of acrylamide to glycidamide and their cytotoxicity in isolated rat hepatocytes: protective effects of GSH precursors. Arch. Toxicol. 80 (2006) 820-828
34. Sai K., Umemura T., Takagi A., Hasegawa R., and Kurokawa Y. The protective role of glutathione, cysteine and Vitamin C against oxidative DNA damage induced in rat kidney by potassium bromate. Jpn. J. Cancer Res. 1 (1992) 45-51
35. Kasai H., and Nishimura S. Hydroxylation of deoxyguanosine at the C8 position by ascorbic acid and other reducing agents. Nucleic Acids Res. 12 (1984) 2137-2145
36. Reliene R., and Schiestl R.H. Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice. Carcinogenesis 27 (2006) 240-244