Metabolism of acrylamide to glycidamide and their cytotoxicity in isolated rat hepatocytes: Protective effects of GSH precursors

Archives of Toxicology

Volumn 80, Issue 12, 2006, Pages 820-828

  Kurebayashi, Hideo ^a   Ohno, Yasuo ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Acrylamide; CYP2E1; Cytotoxicity; Glycidamide; GSH precursor; Isolated hepatocytes

Indexed keywords

ACETONE; ACETYLCYSTEINE; ACRYLAMIDE; CYTOCHROME P450 2E1; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GLYCIDAMIDE; LACTATE DEHYDROGENASE; METHIONINE;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME RELEASE; LIVER CELL; MALE; METABOLISM; MICHAELIS MENTEN KINETICS; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCYSTEINE; ACRYLAMIDE; ANIMALS; ASCORBIC ACID; BIOTRANSFORMATION; CARCINOGENS; CELL SURVIVAL; CYTOCHROME P-450 CYP2E1; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOXY COMPOUNDS; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEPATOCYTES; KINETICS; L-LACTATE DEHYDROGENASE; MALE; METHIONINE; MODELS, BIOLOGICAL; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY;

RODENTIA;

EID: 33751518045     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-006-0109-x     Document Type: Article

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