Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells

Blood

Volumn 113, Issue 8, 2009, Pages 1786-1793

  Maxson, Julia E ^a   Enns, Caroline A ^a   Zhang, An Sheng ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; HEMOJUVELIN; HEPCIDIN; MANNOSE OLIGOSACCHARIDE; NEOGENIN;

ARTICLE; CELL MEMBRANE; CELL MIGRATION; CELL STRAIN HEPG2; CELL SURFACE; CONTROLLED STUDY; GOLGI COMPLEX; HUMAN; HUMAN CELL; IRON BALANCE; IRON TRANSPORT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

EID: 61849129278     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-08-174565     Document Type: Article

References (40)

1. Niederkofler V, Salie R, Sigrist M, Arber S. Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system. J Neuro-sci. 2004;24:808-818.
2. Papanikolaou G, Samuels ME, Ludwig EH, et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet. 2004;36:77-82.
3. Niederkofler V, Salie R, Arber S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest. 2005; 115:2180-2186.
4. Huang FW, Pinkus JL, Pinkus GS, Fleming MD, Andrews NC. Amouse model of juvenile hemo-chromatosis. J Clin Invest. 2005;115:2187-2191.
5. Lin L, Goldberg YP, Ganz T. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood. 2005;106:2884-2889.
6. Kuninger D, Kuns-Hashimoto R, Kuzmickas R, Rotwein P. Complex biosynthesis of the muscle-enriched iron regulator RGMc. J Cell Sci. 2006; 119:3273-3283.
7. Zhang AS, West AP Jr, Wyman AE, Bjorkman PJ, Enns CA. Interaction of hemojuvelin with neoge-nin results in iron accumulation in human embryonic kidney 293 cells. J Biol Chem. 2005;280: 33885-33894.
8. Silvestri L, Pagani A, Camaschella C. Furin-medi-ated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis. Blood. 2008;111:924-931.
9. Lin L, Nemeth E, Goodnough JB, Thapa DR, Gabayan V, Ganz T. Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site. Blood Cells Mol Dis. 2008;40:122-131.
10. Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. 2007; 110:2182-2189.
11. Babitt JL, Huang FW, Wrighting DM, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006; 38:531-539.
12. Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY. He-mojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood. 2008;111: 5195-5204.
13. Wang RH, Li C, Xu X, et al. Arole of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2005;2:399-409.
14. Babitt JL, Huang FW, Xia Y, Sidis Y,Andrews NC, Lin HY. Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest. 2007;117:1933-1939.
15. Zhang AS, Anderson SA, Meyers KR, Hernandez C, Eisenstein RS, Enns CA. Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin. J Biol Chem. 2007;282:12547-12556.
16. Yang F, West AP Jr, Allendorph GP, Choe S, Bjorkman PJ. Neogenin interacts with hemojuvelin through its two membrane-proximal fibronectin type III domains. Biochemistry. 2008;47:4237-4245.
17. Kuns-Hashimoto R, Kuninger D, Nili M, Rotwein P. Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin. Am J Physiol Cell Physiol. 2008; 294:C994-C1003.
18. Zhang AS, Yang F, Meyer K, et al. Neogenin-me-diated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane. J Biol Chem. 2008;283:17494-17502.
19. Nichols BJ, KenworthyAK, Polishchuk RS, et al. Rapid cycling of lipid raft markers between the cell surface and Golgi complex. J Cell Biol. 2001; 153:529-541.
20. Chadda R, Howes MT, Plowman SJ, Hancock JF Parton RG, Mayor S. Cholesterol-sensitive Cdc42 activation regulates actin polymerization for endocytosis viathe GEEC pathway. Traffic. 2007;8:702-717.
21. Feng Y, Longmore GD. The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. Mol Cell Biol. 2005;25:4010-4022.
22. Knowles BB, Howe CC, Aden DP. Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science. 1980;209:497-499.
23. YoshimoriT, YamamotoA, Moriyama Y, Futai M, Tashiro Y Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. J Biol Chem. 1991;266:17707-17712.
24. Silvestri L, Pagani A, Fazi C, et al. Defective targeting of hemojuvelin to plasma membrane is a common pathogenetic mechanism in juvenile hemochromatosis. Blood. 2007;109:4503-4510.
25. Orlandi PA, Fishman PH. Filipin-dependent inhibition of cholera toxin: evidence for toxin internalization and activation through caveolae-like domains. J Cell Biol. 1998;141:905-915.
26. Lang T, Bruns D, Wenzel D, et al. SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocyto-sis. EMBO J. 2001;20:2202-2213.
27. Larsson S, Wierup N, Sundler F, Eliasson L, Holm C. Lack of cholesterol mobilization in islets of hormone-sensitive lipase deficient mice impairs insulin secretion. Biochem Biophys Res Commun. 2008;376:558-562.
28. Vikman J, Jimenez-Feltstrom J, Nyman P, Thelin J, Eliasson L. Insulin secretion is highly sensitive to desorption of plasma membrane cholesterol. FASEB J. 2009;23:58-67.
29. ZacchignaL, Vecchione C, Notte A, et al. Emilin1 links TGF-beta maturation to blood pressure homeostasis. Cell. 2006;124:929-942.
30. Muniz M, Nuoffer C, Hauri HP, Riezman H. The Emp24 complex recruits a specific cargo molecule into endoplasmic reticulum-derived vesicles. J Cell Biol. 2000;148:925-930.
31. Takida S, Maeda Y, KinoshitaT Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane. Biochem J. 2008;409:555-562.
32. Hellman NE, Kono S, MiyajimaH, Gitlin JD. Biochemical analysis of a missense mutation in aceruloplasminemia. J Biol Chem. 2002;277: 1375-1380.
33. Schell MJ, Maurice M, Stieger B, Hubbard AL. 5'Nucleotidase is sorted to the apical domain of hepatocytes via an indirect route. J Cell Biol. 1992;119:1173-1182.
34. Molloy SS, Thomas L, VanSlyke JK, Stenberg PE, Thomas G. Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface. EMBO J. 1994;13:18-33.
35. Mellman I. Endocytosis and molecular sorting. Annu Rev Cell DevBiol. 1996;12:575-625.
36. Snider MD, Rogers OC. Intracellular movement of cell surface receptors after endocytosis: resia-lylation of asialo-transferrin receptor in human erythroleukemia cells. J Cell Biol. 1985;100:826-834.
37. Snider MD, Rogers OC. Membrane traffic in animal cells: cellular glycoproteins return to the site of Golgi mannosidase I. J Cell Biol. 1986;103: 265-275.
38. Sabharanjak S, Sharma P, Parton RG, Mayor S. GPI-anchored proteins are delivered to recycling endosomes via a distinct cdc42-regulated, clath-rin-independent pinocytic pathway. Dev Cell. 2002;2:411-423.
39. Davies PS, Zhang AS, Anderson EL, et al. Evidence for the interaction of the hereditary haemo-chromatosis protein, HFE, with the transferrin receptor in endocytic compartments. Biochem J. 2003;373:145-153.
40. VanSlyke JK, Musil LS. Cytosolic stress reduces degradation of connexin43 internalized from the cell surface and enhances gap junction formation and function. Mol Biol Cell. 2005;16:5247-5257.