Methylprednisolone applied directly to the round window reduces dizziness after cochlear implantation: A randomized clinical trial

Audiology and Neurotology

Volumn 16, Issue 5, 2011, Pages 289-303

  Enticott, J C ^a   Eastwood, H T ^a   Briggs, R J ^a   Dowell, R C ^a   O'Leary, S J ^a  

^a ROYAL VICTORIAN EYE AND EAR HOSPITAL   (Australia)

Author keywords

Clinical drug trial, double blind; Cochlear implant; Methylprednisolone; Randomized control clinical trial; Vestibular dysfunction; Vestibular function

Indexed keywords

GLUCOCORTICOID; METHYLPREDNISOLONE;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL TRIAL; COCHLEA FENESTRA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; IMPLANTATION; MALE; MIDDLE AGED; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; COCHLEAR IMPLANTATION; DIZZINESS; DOUBLE-BLIND METHOD; FEMALE; GLUCOCORTICOIDS; HUMANS; MALE; METHYLPREDNISOLONE; MIDDLE AGED; PROSPECTIVE STUDIES; ROUND WINDOW, EAR; TREATMENT OUTCOME;

EID: 78649766741     PISSN: 14203030     EISSN: 14219700     Source Type: Journal    
DOI: 10.1159/000322137     Document Type: Article

References (58)

1. Banerjee A, Parnes LS: The biology of intratym-panic drug administration and pharmaco-dynamics of round window drug absorption. Otolar yngol Clin Nort h Am 2004; 37: 1035-1051. (Pubitemid 39335771)
2. Briggs RJ, Tykocinski M, Saunders E, Hellier W, Dahm M, Pyman B, Clark GM: Surgical implications of perimodiolar cochlear implant electrode design: avoiding intracochlear damage and scala vestibuli insertion. Co-chlear Implants Int 2001; 2:135-149.
3. Buchman CA, Joy J, Hodges A, Telischi FF, Bal-kany TJ: Vestibular effects of cochlear im-plantat ion. Laryngoscope 2004; 114: 1-22. (Pubitemid 39334853)
4. Chang A, Eastwood H, Sly D, James D, Richardson R, O'Leary S: Factors influencing the efficacy of round window dexamethasone protection of residual hearing post-cochlear implant surgery. Hear Res 2009; 255:67-72.
5. Coelho DH, Lalwani AK: Medical management of Meniere's disease. Laryngoscope 2008; 118: 1099-1108.
6. Cohen NL: Cochlear implant soft surgery: fact or fantasy? Otolaryngol Head Neck Surg 1997; 117:214-216. (Pubitemid 27426273)
7. Colletti V, Mandala M, Carner M, Barillari M, Cerini R, Pozzi Mucelli R, Colletti L: Evidence of gadolinium distribution from the endolymphatic sac to the endolymphatic compartments of the human inner ear. Au-diol Neurootol 2010; 15: 353-363.
8. Connolly TM, Eastwood H, Kel G, Lisnichuk H, Richardson R, O'Leary S: Pre-Operative intravenous dexamethasone prevents auditory threshold shift in a guinea pig model of co-chlear implantation. Audiol Neurootol 2010; 16:137-144.
9. Dallan I, Bruschini L, Nacci A, Bruschini P, Traino C, Rognini F, Fattori B: Transtym-panic steroids as a salvage therapy in sudden hearing loss: preliminary results. ORL J Oto-rhinolaryngol Relat Spec 2006; 68: 247-252. (Pubitemid 44352662)
10. Dallan I, De Vito A, Fattori B, Casani AP, Panicucci E, Berrettini S, Marchetti M, Nacci A: Intratympanic methylprednisolone in refractory sudden hearing loss: a 27-patient case series with univariate and multivariate analysis. Otol Neurotol 2010; 31: 25-30.
11. De Ceulaer G, Johnson S, Yperman M, Daemers K, Offeciers F, O'Donoghue G, Govaerts P: Long-term evaluation of the effect of intra-cochlear steroid deposition on electrode impedance in cochlear implant patients. Otol Neurotol 2003; 24:769-774. (Pubitemid 37122544)
12. Dinh CT, Van De Water TR: Blocking pro-cell-death signal pathways to conserve hearing. Audiol Neurootol 2009; 14:383-392.
13. Dowell RC, Hollow R, Winton E: Outcomes for cochlear implant users with significant residual hearing: implications for selection criteria in children. Arch Otolaryngol Head Neck Surg 2004; 130: 575-581. (Pubitemid 38609667)
14. El-Hennawi DM, El-Deen MH, Abou-Halawa AS, Nadeem HS, Ahmed MR: Efficacy of in-tratympanic methylprednisolone acetate in treatment of drill-induced sensorineural hearing loss in guinea pigs. J Laryngol Otol 2005; 119:2-7. (Pubitemid 40269408)
15. Enticott JC, Tari S, Koh SM, Dowell RC, O'Leary SJ: Cochlear implant and vestibular function. Otol Neurotol 2006; 27:826-832.
16. Eshraghi AA, Van de Water TR: Cochlear implantation trauma and noise-induced hearing loss: apoptosis and therapeutic strategies. Anat Rec A Discov Mol Cell Evol Biol 2006; 288:473-481.
17. Eshraghi AA, Wang J, Adil E, He J, Zine A, Bub-lik M, Bonny C, Puel JL, Balkany TJ, Van De Water TR: Blocking c-Jun-N-terminal ki-nase signaling can prevent hearing loss induced by both electrode insertion trauma and neomycin ototoxicity. Hear Res 2007; 226: 16 8-17 7. (Pubitemid 46437290)
18. Fayad JN, Linthicum FH Jr: Multichannel co-chlear implants: relation of histopathology to performance. Laryngoscope 2006; 116: 1310-1320. (Pubitemid 44181441)
19. Filipo R, Patrizi M, La Gamma R, D'Elia C, La Rosa G, Barbara M: Vestibular impairment and cochlear implantation. Acta Otolaryn-gol 2006; 126:1266-1274. (Pubitemid 44764325)
20. Friedland DR, Runge-Samuelson C: Soft cochle-ar implantation: rationale for the surgical approach. Trends Amplif 2009; 13: 12 4-138.
21. Gantz BJ, Turner C, Gfeller KE, Lowder MW: Preservation of hearing in cochlear implant surgery: advantages of combined electrical and acoustical speech processing. Laryngoscope 2005; 11 5: 796-802. (Pubitemid 40604682)
22. Garduno-Anaya MA, Couthino De Toledo H, Hinojosa-Gonzalez R, Pane-Pianese C, Rios-Castaneda LC: Dexamethasone inner ear perfusion by intratympanic injection in unilateral Meniere's disease: a 2-year prospective, placebo-controlled, double-blind, randomized trial. Otolaryngol Head Neck Surg 2005; 133: 285-294. (Pubitemid 41125682)
23. Gianoli GJ, Li JC: Transtympanic steroids for treatment of sudden hearing loss. Otolaryn-gol Head Neck Surg 2001; 125:142-146. (Pubitemid 33662658)
24. Gstoettner WK, Helbig S, Maier N, Kiefer J, Radeloff A, Adunka OF: Ipsilateral electric acoustic stimulation of the auditory system: results of long-term hearing preservation. Audiol Neurootol 2006; 11(suppl 1):49-56. (Pubitemid 44629843)
25. Harner SG, Driscoll CL, Facer GW, Beatty CW, McDonald TJ: Long-term follow-up of trans-tympanic gentamicin for Ménière's syndrome. Otol Neurotol 2001; 22:210-214. (Pubitemid 32233476)
26. Herraiz C, Plaza G, Aparicio JM, Gallego I, Marcos S, Ruiz C: Transtympanic steroids for Ménière's disease. Otol Neurotol 2010; 31: 162-167.
27. Hoffer ME, Wester D, Kopke RD, Weisskopf P, Gottshall K: Transtympanic management of tinnitus. Otolaryngol Clin North Am 2003; 36: 353-358. (Pubitemid 36529950)
28. Jacobson GP, Newman CW: The development of the dizziness handicap inventory. Arch Oto-laryngol Head Neck Surg 1990; 116:424-427. (Pubitemid 20142463)
29. James C, Albegger K, Battmer R, Burdo S, Deggouj N, Deguine O, Dillier N, Gersdorff M, Laszig R, Lenarz T, Rodriguez MM, Mon-dain M, Offeciers E, Macias AR, Ramsden R, Sterkers O, Von Wallenberg E, Weber B, Fraysse B: Preservation of residual hearing with cochlear implantation: how and why. Acta Otolaryngol 2005; 125:481-491. (Pubitemid 40676887)
30. James DP, Eastwood H, Richardson RT, O'Leary SJ: Effects of round window dexamethasone on residual hearing in a Guinea pig model of cochlear implantation. Audiol Neurootol 2008; 13: 86-96. (Pubitemid 351225887)
31. Jolly C, Garnham C, Mirzadeh H, Truy E, Martini A, Kiefer J, Braun S: Electrode features for hearing preservation and drug delivery strategies. Adv Otorhinolaryngol 2010; 67: 28-42.
32. Jongkees LB: Thermic test and electronystag-mography. Acta Otorhinolaryngol Belg 1965; 19: 455-464. (Article in French.)
33. Lehnhardt E: Intracochlear electrode placement facilitated by Healon. Adv Otorhinolaryngol 1993; 48: 62-64.
34. Maini S, Lisnichuk H, Eastwood H, Pinder D, James D, Richardson RT, Chang A, Connolly T, Sly D, Kel G, O'Leary SJ: Targeted therapy of the inner ear. Audiol Neurootol 2009; 14: 402-410.
35. Movafegh A, Soroush AR, Navi A, Sadeghi M, Esfehani F, Akbarian-Tefaghi N: The effect of intravenous administration of dexameth-asone on postoperative pain, nausea, and vomiting after intrathecal injection of me-peridine. Anesth Analg 2007; 104:987-989. (Pubitemid 46548335)
36. Nadol JB Jr, Eddington DK: Histologic evaluation of the tissue seal and biologic response around cochlear implant electrodes in the human. Otol Neurotol 2004; 25:257-262. (Pubitemid 39079805)
37. Nadol JB Jr, Shiao JY, Burgess BJ, Ketten DR, Ed-dington DK, Gantz BJ, Kos I, Montandon P, Coker NJ, Roland JT Jr, Shallop JK: Histopa-thology of cochlear implants in humans. Ann Otol Rhinol Laryngol 2001; 110:883-891.
38. Newbold C: Electrode Tissue Interface: Development and Findings of aninvitro Model; Ph D thesis, University of Melbourne, 2006.
39. Paasche G, Bockel F, Tasche T, Lesinski-Scedat A, Lenarz T: Changes of postoperative impedances in cochlear implant patients: The short-term effects of modified electrode surfaces and intracochlear corticosteroids. Otol Neurotol 2006; 27:639-647. (Pubitemid 44180475)
40. Paasche G, Tasche C, Stover T, Lesinski-Schiedat A, Lenarz T: The long-term effects of modified electrode surfaces and intracochlear corticosteroids on postoperative impedances in cochlear implant patients. Otol Neu-rotol 2009; 30: 592-598.
41. Parnes LS, Sun AH, Freeman DJ: Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application. Laryngoscope 1999; 109:1-17. (Pubitemid 29315126)
42. Powell LE, Myers AM: The Activities-specific Balance Confidence (ABC) scale. J Gerontol A Biol Sci Med Sci 1995; 50A:M28-M34.
43. Rauch SD: Intratympanic steroids for sensori-neural hearing loss. Otolaryngol Clin North Am 2004; 37: 10 61-1074. (Pubitemid 39335773)
44. Rice WR: Analysing tables of statistical tests. Evolution 1989; 43:223-225.
45. Riechelmann H, Tholen M, Keck T, Rettinger G: Perioperative glucocorticoid treatment does not influence early post-laser stapedotomy hearing thresholds. Am J Otol 2000; 21: 809-812.
46. Salt AN: Simulation of methods for drug delivery to the cochlear fluids. Adv Otorhinolar-yngol 2002; 59: 140-148.
47. Salt AN, Gill RM, Plontke SK: Dependence of hearing changes on the dose of intratympan-ically applied gentamicin: a meta-analysis using mathematical simulations of clinical drug delivery protocols. Laryngoscope 2008; 118: 1793-1800.
48. Selivanova OA, Gouveris H, Victor A, Amedee RG, Mann W: Intratympanic dexametha-sone and hyaluronic acid in patients with low-frequency and Ménière's-associated sudden sensorineural hearing loss. Otol Neurotol 2005; 26: 890-895. (Pubitemid 41330703)
49. Silverstein H, Wazen J, Van Ess MJ, Daugherty J, Alameda YA: Intratympanic gentamicin treatment of patients with Ménière's disease with normal hearing. Otolaryngol Head Neck Surg 2010; 142:570-575.
50. Simpson A, McDermott H, Dowell R, Sucher C, Briggs RJS: Comparison of two frequency-to-electrode maps for acoustic-electric stimulation. Int J Audiol 2009; 48:63.
51. Somdas MA, Li PM, Whiten DM, Eddington DK, Nadol JB Jr: Quantitative evaluation of new bone and fibrous tissue in the cochlea following cochlear implantation in the human. Audiol Neurootol 2007; 12:277-284. (Pubitemid 47236968)
52. Strupp M, Zingler VC, Arbusow V, Niklas D, Maag KP, Dieterich M, Bense S, Theil D, Jahn K, Brandt T: Methylprednisolone, valacyclo-vir, or the combination for vestibular neuritis. N Engl J Med 2004; 351: 354-361.
53. Todt I, Basta D, Ernst A: Does the surgical approach in cochlear implantation influence the occurrence of postoperative vertigo? Otolar yngol Head Neck Surg 2008; 138: 8-12. (Pubitemid 350299634)
54. Turner C, Gantz BJ, Reiss L: Integration of acoustic and electrical hearing. J Rehabil Res Dev 2008; 45:769-778.
55. van de Water TR, Dinh CT, Vivero R, Hoosien G, Eshraghi AA, Balkany TJ: Mechanisms of hearing loss from trauma and inf lammation: otoprotective therapies from the laboratory to the clinic. Acta Otolar y ngol 2010; 130: 308-311.
56. Vivero RJ, Joseph DE, Angeli S, He J, Chen S, Eshraghi AA, Balkany TJ, Van de Water TR: Dexamethasone base conserves hearing from electrode trauma-induced hearing loss. Laryngoscope 2008; 118:2028-2035.
57. Woodson EA, Reiss LA, Turner CW, Gfeller K, Gantz BJ: The Hybrid cochlear implant: a review. Adv Otorhinolaryngol 2010; 67:125-134.
58. Xenellis J, Papadimitriou N, Nikolopoulos T, Maragoudakis P, Segas J, Tzagaroulakis A, Ferekidis E: Intratympanic steroid treatment in idiopathic sudden sensorineural hearing loss: a control study. Otolaryngol Head Neck Surg 2006; 134: 940-945. (Pubitemid 43766563)