The Endotoxin Receptor TLR4 Polymorphism Is Not Associated with Diabetes or Components of the Metabolic Syndrome

Diabetes

Volumn 52, Issue 11, 2003, Pages 2861-2864

  Illig, Thomas ^a   Bongardt, Friedhelm ^a   Schöpfer, Andreas ^a   Holle, Rolf ^a   Müller, Sylvia ^b   Rathmann, Wolfgang ^b   Koenig, Wolfgang ^c   Meisinger, Christa ^a   Wichmann, H Erich ^a   Kolb, Hubert ^b  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; GENE PRODUCT; TOLL LIKE RECEPTOR 4;

ADULT; AGED; ANTHROPOMETRIC PARAMETERS; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; FEMALE; GENE; GENETIC POLYMORPHISM; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TLR4 GENE;

AMINO ACID SUBSTITUTION; C-REACTIVE PROTEIN; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 2; GERMANY; HUMANS; MEMBRANE GLYCOPROTEINS; METABOLIC SYNDROME X; POLYMORPHISM, GENETIC; RECEPTORS, CELL SURFACE; REFERENCE VALUES; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 10744226206     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.11.2861     Document Type: Article

References (21)

1. Smirnova I, Poltorak A, Chan EK, McBride C, Beutler B: Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4). Genome Biol 1:RESEARCH002, Epub 2000
2. Schwartz DA: TLR4 and LPS hyporesponsiveness in humans. Int J Hyg Environ Health 205:221-227, 2002
3. Schmitt C, Humeny A, Becker CM, Brune K, Pahl A: Polymorphisms of TLR4: rapid genotyping and reduced response to lipopolysaccharide of TLR4 mutant alleles. Clin Chem 48:1661-1667, 2002
4. Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA: TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25:187-191, 2000
5. Agnese DM, Calvano JE, Hahm SJ, Coyle SM, Corbett SA, Calvano SE, Lowry SF: Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis 186:1522-1525, 2002
6. Lorenz E, Mira JP, Frees KL, Schwartz DA: Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med 162:1028-1032, 2002
7. Lorenz E, Hallman M, Marttila R, Haataja R, Schwartz DA: Association between the Asp299Gly polymorphisms in the toll-like receptor 4 and premature births in the Finnish population. Pediatr Res 52:373-376, 2002
8. Lorenz E, Schwartz DA, Martin PJ, Gooley T, Lin MT, Chien JW, Hansen JA, Clark JG: Association of TLR4 mutations and the risk for acute GVHD after HLA-matched-sibling hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 7:384-387, 2001
9. Read RC, Pullin J, Gregory S, Borrow R, Kaczmarski EB, di Giovine FS, Dower SK, Cannings C, Wilson AG: A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease. J Infect Dis 184:640-642, 2001
10. Ferrand PE, Fujimoto T, Chennathukuzhi V, Parry S, Macones GA, Sammel M, Kuivaniemi H, Romero R, Strauss JF III: The CARD15 2936insC mutation and TLR4 896 A>G polymorphism in African Americans and risk of preterm premature rupture of membranes (PPROM). Mol Hum Reprod 8:1031-1034, 2002
11. Raby BA, Klimecki WT, Laprise C, Renaud Y, Faith J, Lemire M, Greenwood C, Weiland KM, Lange C, Palmer LJ, Lazarus R, Vercelli D, Kwiatkowski DJ, Silverman EK, Martinez FD, Hudson TJ, Weiss ST: Polymorphisnis in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes. Am J Respir Crit Care Med 166:1449-1456, 2002
12. Ohashi K, Burkart V, Flohe S, Kolb H: Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 164:558-561, 2000
13. Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Bonora E, Willeit J, Schwartz DA: Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 347:185-192, 2002
14. Muller S, Martin S, Koenig W, Hanifi-Moghaddam P, Rathmann W, Haastert B, Giani G, Illig T, Thorand B, Kolb H: Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptors. Diabetologia 45:805-812, 2002
15. Pickup JC, Crook MA: Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 41:1241-1248, 1998
16. Festa A, D'Agostino R, Howard G, Mykkanen L, Tracy RP, Haffner SM: Inflammation and microalbuminuria in nondiabetic and type 2 diabetic subjects: the Insulin Resistance Atherosclerosis study. Kidney Int 58: 1703-1710, 2000
17. Greenberg AS, McDaniel ML: Identifying the links between obesity, insulin resistance and beta-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes. Eur J Clin Invest (32 Suppl. 3):24-34, 2002
18. Rathmann W, Haastert B, Icks A, Lowel H, Meisinger C, Holle R, Giani G: High prevalence of undiagnosed diabetes mellitus in Southern Germany: Target populations for efficient screening: the KORA survey 2000. Diabetologia 46:182-189, 2003
19. Rifai N, Tracy RP, Ridker PM: Clinical efficacy of an automated high-sensitivity C-reactive protein assay. Clin Chem 45: 2136-2141, 1999
20. Hoffmeister A, Rothenbacher D, Bazner U, Frohlich M, Brenner H, Hombach V, Koenig W: Role of novel markers of inflammation in patients with stable coronary heart disease. Am J Cardiol 87:262-266, 2001
21. Erridge C, Stewart J, Poxton IR: Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling. J Exp Med 197:1787-1791, 2003