-
1
-
-
0032792665
-
AMP-activated protein kinase, a metabolic master switch: Possible roles in type 2 diabetes
-
Winder WW, Hardie DG (1999) AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol 277:E1-E10
-
(1999)
Am J Physiol
, vol.277
-
-
Winder, W.W.1
Hardie, D.G.2
-
3
-
-
0037329494
-
AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins
-
Leff T (2003) AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins. Biochem Soc Trans 31:224-227
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 224-227
-
-
Leff, T.1
-
4
-
-
33745815985
-
AMP-activated protein kinase signaling in metabolic regulation
-
Long YC, Zierath JR (2006) AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest 116:1776-1783
-
(2006)
J Clin Invest
, vol.116
, pp. 1776-1783
-
-
Long, Y.C.1
Zierath, J.R.2
-
5
-
-
0032742992
-
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
-
Weyer C, Bogardus C, Mott DM, Pratley RE (1999) The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104:787-794
-
(1999)
J Clin Invest
, vol.104
, pp. 787-794
-
-
Weyer, C.1
Bogardus, C.2
Mott, D.M.3
Pratley, R.E.4
-
6
-
-
33749479230
-
AMP-activated protein kinase: Role in metabolism and therapeutic implications
-
Schimmack G, Defronzo RA, Musi N (2006) AMP-activated protein kinase: role in metabolism and therapeutic implications. Diabetes Obes Metab 8:591-602
-
(2006)
Diabetes Obes Metab
, vol.8
, pp. 591-602
-
-
Schimmack, G.1
Defronzo, R.A.2
Musi, N.3
-
7
-
-
33846030181
-
A revised model for AMP-activated protein kinase structure: The alpha-subunit binds to both the beta- and gamma-subunits although there is no direct binding between the beta- and gamma-subunits
-
Wong KA, Lodish HF (2006) A revised model for AMP-activated protein kinase structure: The alpha-subunit binds to both the beta- and gamma-subunits although there is no direct binding between the beta- and gamma-subunits. J Biol Chem 281:36434-36442
-
(2006)
J Biol Chem
, vol.281
, pp. 36434-36442
-
-
Wong, K.A.1
Lodish, H.F.2
-
8
-
-
0942265675
-
Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle
-
Mahlapuu M, Johansson C, Lindgren K et al (2004) Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle. Am J Physiol Endocrinol Metab 286:E194-E200
-
(2004)
Am J Physiol Endocrinol Metab
, vol.286
-
-
Mahlapuu, M.1
Johansson, C.2
Lindgren, K.3
-
9
-
-
0034654362
-
Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding
-
Cheung PC, Salt IP, Davies SP, Hardie DG, Carling D (2000) Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem J 346:659-669
-
(2000)
Biochem J
, vol.346
, pp. 659-669
-
-
Cheung, P.C.1
Salt, I.P.2
Davies, S.P.3
Hardie, D.G.4
Carling, D.5
-
10
-
-
33644701630
-
Changes in exercise-induced gene expression in 5′-AMP-activated protein kinase gamma3-null and gamma3 R225Q transgenic mice
-
Barnes BR, Long YC, Steiler TL et al (2005) Changes in exercise-induced gene expression in 5′-AMP-activated protein kinase gamma3-null and gamma3 R225Q transgenic mice. Diabetes 54:3484-3489
-
(2005)
Diabetes
, vol.54
, pp. 3484-3489
-
-
Barnes, B.R.1
Long, Y.C.2
Steiler, T.L.3
-
11
-
-
4644309036
-
The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle
-
Barnes BR, Marklund S, Steiler TL et al (2004) The 5′-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle. J Biol Chem 279:38441-38447
-
(2004)
J Biol Chem
, vol.279
, pp. 38441-38447
-
-
Barnes, B.R.1
Marklund, S.2
Steiler, T.L.3
-
12
-
-
33644753961
-
Haplotype structures and large-scale association testing of the 5′ AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 with type 2 diabetes
-
Sun MW, Lee JY, de Bakker PI et al (2006) Haplotype structures and large-scale association testing of the 5′ AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 with type 2 diabetes. Diabetes 55:849-855
-
(2006)
Diabetes
, vol.55
, pp. 849-855
-
-
Sun, M.W.1
Lee, J.Y.2
De Bakker, P.I.3
-
13
-
-
33745289664
-
A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population
-
Horikoshi M, Hara K, Ohashi J et al (2006) A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population. Diabetes 55:919-923
-
(2006)
Diabetes
, vol.55
, pp. 919-923
-
-
Horikoshi, M.1
Hara, K.2
Ohashi, J.3
-
14
-
-
33846130037
-
AMP-kinase alpha2 subunit gene PRKAA2 variants are associated with total cholesterol, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol in normal women
-
Spencer-Jones NJ, Ge D, Snieder H et al (2006) AMP-kinase alpha2 subunit gene PRKAA2 variants are associated with total cholesterol, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol in normal women. J Med Genet 43:936-942
-
(2006)
J Med Genet
, vol.43
, pp. 936-942
-
-
Spencer-Jones, N.J.1
Ge, D.2
Snieder, H.3
-
15
-
-
27644596642
-
Glucose and lipid metabolism in relation to novel polymorphisms in the 5′-AMP-activated protein kinase gamma2 gene in Chinese
-
Xu M, Li X, Wang JG et al (2005) Glucose and lipid metabolism in relation to novel polymorphisms in the 5′-AMP-activated protein kinase gamma2 gene in Chinese. Mol Genet Metab 86:372-378
-
(2005)
Mol Genet Metab
, vol.86
, pp. 372-378
-
-
Xu, M.1
Li, X.2
Wang, J.G.3
-
16
-
-
0037185021
-
Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome
-
Daniel T, Carling D (2002) Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome. J Biol Chem 277:51017-51024
-
(2002)
J Biol Chem
, vol.277
, pp. 51017-51024
-
-
Daniel, T.1
Carling, D.2
-
17
-
-
18944396765
-
Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency
-
Burwinkel B, Scott JW, Buhrer C et al (2005) Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency. Am J Hum Genet 76:1034-1049
-
(2005)
Am J Hum Genet
, vol.76
, pp. 1034-1049
-
-
Burwinkel, B.1
Scott, J.W.2
Buhrer, C.3
-
18
-
-
19944434362
-
Glycogen storage diseases presenting as hypertrophic cardiomyopathy
-
Arad M, Maron BJ, Gorham JM et al (2005) Glycogen storage diseases presenting as hypertrophic cardiomyopathy. N Engl J Med 352:362-372
-
(2005)
N Engl J Med
, vol.352
, pp. 362-372
-
-
Arad, M.1
Maron, B.J.2
Gorham, J.M.3
-
19
-
-
0035859215
-
Identification of a gene responsible for familial Wolff-Parkinson-White syndrome
-
Gollob MH, Green MS, Tang AS et al (2001) Identification of a gene responsible for familial Wolff-Parkinson-White syndrome. N Engl J Med 344:1823-1831
-
(2001)
N Engl J Med
, vol.344
, pp. 1823-1831
-
-
Gollob, M.H.1
Green, M.S.2
Tang, A.S.3
-
20
-
-
0032960890
-
Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects
-
Jacob S, Machann J, Rett K et al (1999) Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 48:1113-1119
-
(1999)
Diabetes
, vol.48
, pp. 1113-1119
-
-
Jacob, S.1
MacHann, J.2
Rett, K.3
-
21
-
-
23044471410
-
Liver fat and insulin resistance are independently associated with the -514C>T polymorphism of the hepatic lipase gene
-
Stefan N, Schafer S, Machicao F et al (2005) Liver fat and insulin resistance are independently associated with the -514C>T polymorphism of the hepatic lipase gene. J Clin Endocrinol Metab 90:4238-4243
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 4238-4243
-
-
Stefan, N.1
Schafer, S.2
MacHicao, F.3
-
22
-
-
0031851293
-
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation
-
Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabet Med 15:539-553
-
(1998)
Diabet Med
, vol.15
, pp. 539-553
-
-
Alberti, K.G.1
Zimmet, P.Z.2
-
23
-
-
0032821965
-
Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp
-
Matsuda M, DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22:1462-1470
-
(1999)
Diabetes Care
, vol.22
, pp. 1462-1470
-
-
Matsuda, M.1
Defronzo, R.A.2
-
24
-
-
0345138088
-
Estimating haplotype frequencies and standard errors for multiple single nucleotide polymorphisms
-
Li SS, Khalid N, Carlson C, Zhao LP (2003) Estimating haplotype frequencies and standard errors for multiple single nucleotide polymorphisms. Biostatistics 4:513-522
-
(2003)
Biostatistics
, vol.4
, pp. 513-522
-
-
Li, S.S.1
Khalid, N.2
Carlson, C.3
Zhao, L.P.4
-
26
-
-
79959524146
-
A haplotype map of the human genome
-
The International HapMap Consortium
-
The International HapMap Consortium (2005) A haplotype map of the human genome. Nature 437:1299-1320
-
(2005)
Nature
, vol.437
, pp. 1299-1320
-
-
-
27
-
-
0034685949
-
A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle
-
Milan D, Jeon JT, Looft C et al (2000) A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle. Science 288:1248-1251
-
(2000)
Science
, vol.288
, pp. 1248-1251
-
-
Milan, D.1
Jeon, J.T.2
Looft, C.3
-
28
-
-
18144363560
-
5′-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics
-
Barnes BR, Glund S, Long YC, Hjalm G, Andersson L, Zierath JR (2005) 5′-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics. FASEB J 19:773-779
-
(2005)
FASEB J
, vol.19
, pp. 773-779
-
-
Barnes, B.R.1
Glund, S.2
Long, Y.C.3
Hjalm, G.4
Andersson, L.5
Zierath, J.R.6
-
29
-
-
0034945787
-
Morphometric documentation of abnormal intramyocellular fat storage and reduced glycogen in obese patients with type II diabetes
-
Levin K, Daa Schroeder H, Alford FP, Beck-Nielsen H (2001) Morphometric documentation of abnormal intramyocellular fat storage and reduced glycogen in obese patients with type II diabetes. Diabetologia 44:824-833
-
(2001)
Diabetologia
, vol.44
, pp. 824-833
-
-
Levin, K.1
Daa Schroeder, H.2
Alford, F.P.3
Beck-Nielsen, H.4
-
30
-
-
27544438601
-
Apolipoprotein B: A clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis
-
Olofsson SO, Boren J (2005) Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis. J Intern Med 258:395-410
-
(2005)
J Intern Med
, vol.258
, pp. 395-410
-
-
Olofsson, S.O.1
Boren, J.2
-
31
-
-
33947679772
-
Mechanisms of disease: Genetic causes of familial hypercholesterolemia
-
Soutar AK, Naoumova RP (2007) Mechanisms of disease: genetic causes of familial hypercholesterolemia. Nat Clin Pract Cardiovasc Med 4:214-225
-
(2007)
Nat Clin Pract Cardiovasc Med
, vol.4
, pp. 214-225
-
-
Soutar, A.K.1
Naoumova, R.P.2
-
32
-
-
0034161543
-
Crystal structure of the catalytic portion of human HMG-CoA reductase: Insights into regulation of activity and catalysis
-
Istvan ES, Palnitkar M, Buchanan SK, Deisenhofer J (2000) Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis. EMBO J 19:819-830
-
(2000)
EMBO J
, vol.19
, pp. 819-830
-
-
Istvan, E.S.1
Palnitkar, M.2
Buchanan, S.K.3
Deisenhofer, J.4
-
33
-
-
0026604926
-
Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase
-
Hardie DG (1992) Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase. Biochim Biophys Acta 1123:231-238
-
(1992)
Biochim Biophys Acta
, vol.1123
, pp. 231-238
-
-
Hardie, D.G.1
-
34
-
-
0028231978
-
Modulation of Syrian hamster 3-hydroxy-3-methylglutaryl-CoA reductase activity by phosphorylation. Role of serine 871
-
Omkumar RV, Darnay BG, Rodwell VW (1994) Modulation of Syrian hamster 3-hydroxy-3-methylglutaryl-CoA reductase activity by phosphorylation. Role of serine 871. J Biol Chem 269:6810-6814
-
(1994)
J Biol Chem
, vol.269
, pp. 6810-6814
-
-
Omkumar, R.V.1
Darnay, B.G.2
Rodwell, V.W.3
-
35
-
-
0034983188
-
The sterol regulatory element-binding protein pathway: Control of lipid homeostasis through regulated intracellular transport
-
Sakai J, Rawson RB (2001) The sterol regulatory element-binding protein pathway: control of lipid homeostasis through regulated intracellular transport. Curr Opin Lipidol 12:261-266
-
(2001)
Curr Opin Lipidol
, vol.12
, pp. 261-266
-
-
Sakai, J.1
Rawson, R.B.2
-
36
-
-
33646366162
-
Opposite transcriptional regulation in skeletal muscle of AMP-activated protein kinase gamma3 R225Q transgenic versus knock-out mice
-
Nilsson EC, Long YC, Martinsson S et al (2006) Opposite transcriptional regulation in skeletal muscle of AMP-activated protein kinase gamma3 R225Q transgenic versus knock-out mice. J Biol Chem 281:7244-7252
-
(2006)
J Biol Chem
, vol.281
, pp. 7244-7252
-
-
Nilsson, E.C.1
Long, Y.C.2
Martinsson, S.3
-
37
-
-
27744536355
-
Role of AMP-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle
-
Long YC, Barnes BR, Mahlapuu M et al (2005) Role of AMP-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle. Diabetologia 48:2354-2364
-
(2005)
Diabetologia
, vol.48
, pp. 2354-2364
-
-
Long, Y.C.1
Barnes, B.R.2
Mahlapuu, M.3
-
38
-
-
0346842693
-
Tissue sites of degradation of low density lipoprotein: Application of a method for determining the fate of plasma proteins
-
Pittman RC, Attie AD, Carew TE, Steinberg D (1979) Tissue sites of degradation of low density lipoprotein: application of a method for determining the fate of plasma proteins. Proc Natl Acad Sci USA 76:5345-5349
-
(1979)
Proc Natl Acad Sci USA
, vol.76
, pp. 5345-5349
-
-
Pittman, R.C.1
Attie, A.D.2
Carew, T.E.3
Steinberg, D.4
-
39
-
-
0020415437
-
14C]sucrose-labeled low density lipoprotein in rats. Contribution of receptor-dependent and receptor-independent pathways
-
14C]sucrose-labeled low density lipoprotein in rats. Contribution of receptor-dependent and receptor-independent pathways. J Biol Chem 257:8001-8008
-
(1982)
J Biol Chem
, vol.257
, pp. 8001-8008
-
-
Carew, T.E.1
Pittman, R.C.2
Steinberg, D.3
|