Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity

Journal of Cell Science

Volumn 123, Issue 23, 2010, Pages 4128-4144

  Cho, Kyucheol ^a,b   Vaught, Travis G ^a,b   Ji, Hong ^a   Gu, Dongmin ^a,b   Papasakelariou Yared, Catherine ^a,b   Horstmann, Nicola ^a   Jennings, Jean Marie ^c   Lee, Moonsup ^a,b   Sevilla, Lisa M ^d   Kloc, Malgorzata ^e   Reynolds, Albert B ^f   Watt, Fiona M ^d   Brennan, Richard G ^a,b   Kowalczyk, Andrew P ^c   McCrea, Pierre D ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CANCER RESEARCH UK CAMBRIDGE RESEARCH INSTITUTE   (United Kingdom)

^e HOUSTON METHODIST HOSPITAL   (United States)

^f VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

ARVCF; Cadherin; Kazrin

Indexed keywords

CATENIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SPECTRIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVITY; CELL ADHESION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; KERATINOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RAT; SEQUENCE ALIGNMENT; XENOPUS;

ANIMALS; ARMADILLO DOMAIN PROTEINS; CADHERINS; CELL ADHESION MOLECULES; CELL LINE; EPITHELIAL CELLS; GTPASE-ACTIVATING PROTEINS; HUMANS; MEMBRANE PROTEINS; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RHOA GTP-BINDING PROTEIN; SPECTRIN; TWO-HYBRID SYSTEM TECHNIQUES; XENOPUS; XENOPUS PROTEINS;

EID: 78649747461     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.072041     Document Type: Article

References (118)

1. Aho, S., McLean, W. H., Li, K. and Uitto, J. (1998). cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes. Genomics 48, 242-247.
2. Akhtar, N. and Hotchin, N. A. (2001). RAC1 regulates adherens junctions through endocytosis of E-cadherin. Mol. Biol. Cell 12, 847-862.
3. Anastasiadis, P. Z. (2007). p120-ctn: A nexus for contextual signaling via Rho GTPases. Biochim. Biophys. Acta 1773, 34-46.
4. Anastasiadis, P. Z., Moon, S. Y., Thoreson, M. A., Mariner, D. J., Crawford, H. C., Zheng, Y. and Reynolds, A. B. (2000). Inhibition of RhoA by p120 catenin. Nat. Cell Biol. 2, 637-644.
5. Aono, S., Nakagawa, S., Reynolds, A. B. and Takeichi, M. (1999). p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells. J. Cell Biol. 145, 551-562.
6. Baines, A. J. (2009). Evolution of spectrin function in cytoskeletal and membrane networks. Biochem. Soc. Trans. 37, 796-803.
7. Baines, A. J., Bignone, P. A., King, M. D., Maggs, A. M., Bennett, P. M., Pinder, J. C. and Phillips, G. W. (2009). The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins. Mol. Biol. Evol. 26, 2005-2014.
8. Baki, L., Marambaud, P., Efthimiopoulos, S., Georgakopoulos, A., Wen, P., Cui, W., Shioi, J., Koo, E., Ozawa, M., Friedrich, V. L., Jr et al. (2001). Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex. Proc. Natl. Acad. Sci. USA 98, 2381-2386.
9. Bedford, M. T. and Leder, P. (1999). The FF domain: a novel motif that often accompanies WW domains. Trends Biochem. Sci. 24, 264-265.
10. Bennett, V. and Healy, J. (2009). Membrane domains based on ankyrin and spectrin associated with cell-cell interactions. Cold Spring Harbor Perspect. Biol. 1, a003012.
11. Borrmann, C. M., Grund, C., Kuhn, C., Hofmann, I., Pieperhoff, S. and Franke, W. W. (2006). The area composita of adhering junctions connecting heart muscle cells of vertebrates. II. Colocalizations of desmosomal and fascia adhaerens molecules in the intercalated disk. Eur. J. Cell Biol. 85, 469-485.
12. Brouns, M. R., Matheson, S. F. and Settleman, J. (2001). p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation. Nat. Cell Biol. 3, 361-367.
13. Bryant, D. M. and Stow, J. L. (2004). The ins and outs of E-cadherin trafficking. Trends Cell Biol. 14, 427-434.
14. Burkhard, P., Stetefeld, J. and Strelkov, S. V. (2001). Coiled coils: a highly versatile protein folding motif. Trends Cell. Biol. 11, 82-88.
15. Bustos, R. I., Forget, M. A., Settleman, J. E. and Hansen, S. H. (2008). Coordination of Rho and Rac GTPase function via p190B RhoGAP. Curr. Biol. 18, 1606-1611.
16. Cadigan, K. M. and Peifer, M. (2009). Wnt signaling from development to disease: insights from model systems. Cold Spring Harbor Perspect. Biol. 1, a002881.
17. Calkins, C. C., Setzer, S. V., Jennings, J. M., Summers, S., Tsunoda, K., Amagai, M. and Kowalczyk, A. P. (2006). Desmoglein endocytosis and desmosome disassembly are coordinated responses to pemphigus autoantibodies. J. Biol. Chem. 281, 7623-7634.
18. Carmo-Fonseca, M. (2007). How genes find their way inside the cell nucleus. J. Cell Biol. 179, 1093-1094.
19. Charrasse, S., Comunale, F., Grumbach, Y., Poulat, F., Blangy, A. and Gauthier-Rouviere, C. (2006). RhoA GTPase regulates M-cadherin activity and myoblast fusion. Mol. Biol. Cell 17, 749-759.
20. Chen, X., Kojima, S., Borisy, G. G. and Green, K. J. (2003). p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions. J. Cell Biol. 163, 547-557.
21. Choi, H. J. and Weis, W. I. (2005). Structure of the armadillo repeat domain of plakophilin 1. J. Mol. Biol. 346, 367-376.
22. Chuang, C. H., Carpenter, A. E., Fuchsova, B., Johnson, T., de Lanerolle, P. and Belmont, A. S. (2006). Long-range directional movement of an interphase chromosome site. Curr. Biol. 16, 825-831.
23. Cokol, M., Nair, R. and Rost, B. (2000). Finding nuclear localization signals. EMBO Rep. 1, 411-415.
24. Daniel, J. M. (2007). Dancing in and out of the nucleus: p120(ctn) and the transcription factor Kaiso. Biochim. Biophys. Acta 1773, 59-68.
25. Daniel, J. M. and Reynolds, A. B. (1999). The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol. Cell. Biol. 19, 3614-3623.
26. Davis, M. A., Ireton, R. C. and Reynolds, A. B. (2003). A core function for p120-catenin in cadherin turnover. J. Cell Biol. 163, 525-534.
27. Delva, E. and Kowalczyk, A. P. (2009). Regulation of cadherin trafficking. Traffic 10, 259-267.
28. DiColandrea, T., Karashima, T., Maatta, A. and Watt, F. M. (2000). Subcellular distribution of envoplakin and periplakin: insights into their role as precursors of the epidermal cornified envelope. J. Cell Biol. 151, 573-586.
29. D'Souza-Schorey, C. (2005). Disassembling adherens junctions: breaking up is hard to do. Trends Cell Biol. 15, 19-26.
30. Dundr, M., Ospina, J. K., Sung, M. H., John, S., Upender, M., Ried, T., Hager, G. L. and Matera, A. G. (2007). Actin-dependent intranuclear repositioning of an active gene locus in vivo. J. Cell Biol. 179, 1095-1103.
31. Ellis, S. and Mellor, H. (2000). Regulation of endocytic traffic by rho family GTPases. Trends Cell Biol. 10, 85-88.
32. Fang, X., Ji, H., Kim, S. W., Park, J. I., Vaught, T. G., Anastasiadis, P. Z., Ciesiolka, M. and McCrea, P. D. (2004). Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac. J. Cell Biol. 165, 87-98.
33. Fujita, Y., Krause, G., Scheffner, M., Zechner, D., Leddy, H. E., Behrens, J., Sommer, T. and Birchmeier, W. (2002). Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat. Cell Biol. 4, 222-231.
34. Gallicano, G. I., Foshay, K., Pengetnze, Y. and Zhou, X. (2005). Dynamics and unexpected localization of the plakin binding protein, kazrin, in mouse eggs and early embryos. Dev. Dyn. 234, 201-214.
35. Giebelhaus, D. H., Zelus, B. D., Henchman, S. K. and Moon, R. T. (1987). Changes in the expression of alpha-fodrin during embryonic development of Xenopus laevis. J. Cell Biol. 105, 843-853.
36. Gliem, M., Heupel, W. M., Spindler, V., Harms, G. S. and Waschke, J. (2010). Actin reorganization contributes to loss of cell adhesion in pemphigus vulgaris. Am. J. Physiol. Cell Physiol. 299, C606-C613.
37. Groot, K. R., Sevilla, L. M., Nishi, K., DiColandrea, T. and Watt, F. M. (2004). Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane. J. Cell Biol. 166, 653-659.
38. Grosheva, I., Shtutman, M., Elbaum, M. and Bershadsky, A. D. (2001). p120 catenin affects cell motility via modulation of activity of Rho-family GTPases: a link between cell-cell contact formation and regulation of cell locomotion. J. Cell Sci. 114, 695-707.
39. Gu, D., Sater, A. K., Ji, H., Cho, K., Clark, M., Stratton, S. A., Barton, M. C., Lu, Q. and McCrea, P. D. (2009). Xenopus ?-catenin is essential in early embryogenesis and is functionally linked to cadherins and small GTPases. J. Cell Sci. 122, 4049-4061.
40. Hall, R. A. (2004). Studying protein-protein interactions via blot overlay or far western blot. Methods Mol. Biol. 261, 167-174.
41. Heasman, J., Ginsberg, D., Geiger, B., Goldstone, K., Pratt, T., Yoshida-Noro, C. and Wylie, C. (1994). A functional test for maternally inherited cadherin in Xenopus shows its importance in cell adhesion at the blastula stage. Development 120, 49-57.
42. Hernandez, S. E., Settleman, J. and Koleske, A. J. (2004). Adhesion-dependent regulation of p190RhoGAP in the developing brain by the Abl-related gene tyrosine kinase. Curr. Biol. 14, 691-696.
43. Hong, J. Y., Park, J., Cho, K., Gu, D., Ji, H., Artandi, S. E. and McCrea, P. D. (2010). Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members J. Cell Sci. in press.
44. Huber, A. H., Nelson, W. J. and Weis, W. I. (1997). Three-dimensional structure of the armadillo repeat region of beta-catenin. Cell 90, 871-882.
45. Iioka, H., Doerner, S. K. and Tamai, K. (2009). Kaiso is a bimodal modulator for Wnt/beta-catenin signaling. FEBS Lett. 583, 627-632.
46. Ireton, R. C., Davis, M. A., van Hengel, J., Mariner, D. J., Barnes, K., Thoreson, M. A., Anastasiadis, P. Z., Matrisian, L., Bundy, L. M., Sealy, L. et al. (2002). A novel role for p120 catenin in E-cadherin function. J. Cell Biol. 159, 465-476.
47. Ivanov, A. I., Nusrat, A. and Parkos, C. A. (2004). Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment. Mol. Biol. Cell 15, 176-188.
48. Izawa, I., Nishizawa, M., Tomono, Y., Ohtakara, K., Takahashi, T. and Inagaki, M. (2002). ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells. Genes Cells 7, 475-485.
49. Izumi, G., Sakisaka, T., Baba, T., Tanaka, S., Morimoto, K. and Takai, Y. (2004). Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments. J. Cell Biol. 166, 237-248.
50. Johnson, K. J. and Boekelheide, K. (2002). Dynamic testicular adhesion junctions are immunologically unique. I. Localization of p120 catenin in rat testis. Biol. Reprod. 66, 983-991.
51. Jones, D. T., Tress, M., Bryson, K. and Hadley, C. (1999). Successful recognition of protein folds using threading methods biased by sequence similarity and predicted secondary structure. Proteins 3, 104-111.
52. 2+ medium in DJM-1 cells. J. Dermatol. 35, 317-324.
53. Kanno, M., Isa, Y., Aoyama, Y., Yamamoto, Y., Nagai, M., Ozawa, M. and Kitajima, Y. (2008b). P120-catenin is a novel desmoglein 3 interacting partner: identification of the p120-catenin association site of desmoglein 3. Exp. Cell Res. 314, 1683-1692.
54. Kaufmann, T., Schlipf, S., Sanz, J., Neubert, K., Stein, R. and Borner, C. (2003). Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane. J. Cell Biol. 160, 53-64.
55. Kaufmann, U., Zuppinger, C., Waibler, Z., Rudiger, M., Urbich, C., Martin, B., Jockusch, B. M., Eppenberger, H. and Starzinski-Powitz, A. (2000). The armadillo repeat region targets ARVCF to cadherin-based cellular junctions. J. Cell Sci. 113, 4121-4135.
56. Kausalya, P. J., Phua, D. C. and Hunziker, W. (2004). Association of ARVCF with zonula occludens (ZO)-1 and ZO-2: binding to PDZ-domain proteins and cell-cell adhesion regulate plasma membrane and nuclear localization of ARVCF. Mol. Biol. Cell 15, 5503-5515.
57. Keon, B. H., Schafer, S., Kuhn, C., Grund, C. and Franke, W. W. (1996). Symplekin, a novel type of tight junction plaque protein. J. Cell Biol. 134, 1003-1018.
58. Kikuno, R., Nagase, T., Ishikawa, K., Hirosawa, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N. and Ohara, O. (1999). Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 6, 197-205.
59. Kim, S. W., Fang, X., Ji, H., Paulson, A. F., Daniel, J. M., Ciesiolka, M., van Roy, F. and McCrea, P. D. (2002). Isolation and characterization of XKaiso, a transcriptional repressor that associates with the catenin Xp120(ctn) in Xenopus laevis. J. Biol. Chem. 277, 8202-8208.
60. Kim, S. W., Park, J. I., Spring, C. M., Sater, A. K., Ji, H., Otchere, A. A., Daniel, J. M. and McCrea, P. D. (2004). Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin. Nat. Cell Biol. 6, 1212-1220.
61. Kizhatil, K., Davis, J. Q., Davis, L., Hoffman, J., Hogan, B. L. and Bennett, V. (2007). Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos. J. Biol. Chem. 282, 26552-26561.
62. Klein, S. L., Strausberg, R. L., Wagner, L., Pontius, J., Clifton, S. W. and Richardson, P. (2002). Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Dev. Dyn. 225, 384-391.
63. Kowalczyk, A. P. and Reynolds, A. B. (2004). Protecting your tail: regulation of cadherin degradation by p120-catenin. Curr. Opin. Cell Biol. 16, 522-527.
64. Lamaze, C., Chuang, T. H., Terlecky, L. J., Bokoch, G. M. and Schmid, S. L. (1996). Regulation of receptor-mediated endocytosis by Rho and Rac. Nature 382, 177-179.
65. Laura, R. P., Witt, A. S., Held, H. A., Gerstner, R., Deshayes, K., Koehler, M. F., Kosik, K. S., Sidhu, S. S. and Lasky, L. A. (2002). The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. J. Biol. Chem. 277, 12906-12914.
66. Le T. L., Yap, A. S. and Stow, J. L. (1999). Recycling of E-cadherin: a potential mechanism for regulating cadherin dynamics. J. Cell Biol. 146, 219-232.
67. Lee, C. H. and Gumbiner, B. M. (1995). Disruption of gastrulation movements in Xenopus by a dominant-negative mutant for C-cadherin. Dev. Biol. 171, 363-373.
68. Leung, S. M., Rojas, R., Maples, C., Flynn, C., Ruiz, W. G., Jou, T. S. and Apodaca, G. (1999). Modulation of endocytic traffic in polarized Madin-Darby canine kidney cells by the small GTPase RhoA. Mol. Biol. Cell 10, 4369-4384.
69. Lim, J., Hao, T., Shaw, C., Patel, A. J., Szabo, G., Rual, J. F., Fisk, C. J., Li, N., Smolyar, A., Hill, D. E. et al. (2006). A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell 125, 801-814.
70. Lupas, A., Van Dyke, M. and Stock, J. (1991). Predicting coiled coils from protein sequences. Science 252, 1162-1164.
71. Macia, E., Ehrlich, M., Massol, R., Boucrot, E., Brunner, C. and Kirchhausen, T. (2006). Dynasore, a cell-permeable inhibitor of dynamin. Dev. Cell 10, 839-850.
72. Magie, C. R., Pinto-Santini, D. and Parkhurst, S. M. (2002). Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila. Development 129, 3771-3782.
73. Marambaud, P., Shioi, J., Serban, G., Georgakopoulos, A., Sarner, S., Nagy, V., Baki, L., Wen, P., Efthimiopoulos, S., Shao, Z. et al. (2002). A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 21, 1948-1956.
74. Mariner, D. J., Wang, J. and Reynolds, A. B. (2000). ARVCF localizes to the nucleus and adherens junction and is mutually exclusive with p120(ctn) in E-cadherin complexes. J. Cell Sci. 113, 1481-1490.
75. McCrea, P. D., Gu, D. and Balda, M. S. (2009). Junctional music that the nucleus hears: cell-cell contact signaling and the modulation of gene activity. Cold Spring Harbor Perspect. Biol. 1, a002923.
76. Nachat, R., Cipolat, S., Sevilla, L. M., Chhatriwala, M., Groot, K. R. and Watt, F. M. (2009). KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules. J. Cell Sci. 122, 4035-4041.
77. Niessen, C. M. and Yap, A. S. (2006). Another job for the talented p120-catenin. Cell 127, 875-877.
78. Noren, N. K., Liu, B. P., Burridge, K. and Kreft, B. (2000). p120 catenin regulates the actin cytoskeleton via Rho family GTPases. J. Cell Biol. 150, 567-580.
79. Noren, N. K., Arthur, W. T. and Burridge, K. (2003). Cadherin engagement inhibits RhoA via p190RhoGAP. J. Biol. Chem. 278, 13615-13618.
80. Ohkubo, T. and Ozawa, M. (1999). p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity. J. Biol. Chem. 274, 21409-21415.
81. Ozawa, M. and Kemler, R. (1998). The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activity. J. Cell Biol. 142, 1605-1613.
82. Ozawa, M., Baribault, H. and Kemler, R. (1989). The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 8, 1711-1717.
83. Papkoff, J. (1997). Regulation of complexed and free catenin pools by distinct mechanisms. Differential effects of Wnt-1 and v-Src. J. Biol. Chem. 272, 4536-4543.
84. Park, J. I., Kim, S. W., Lyons, J. P., Ji, H., Nguyen, T. T., Cho, K., Barton, M. C., Deroo, T., Vleminckx, K., Moon, R. T. et al. (2005). Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets. Dev. Cell 8, 843-854.
85. Park, J. I., Ji, H., Jun, S., Gu, D., Hikasa, H., Li, L., Sokol, S. Y. and McCrea, P. D. (2006). Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals. Dev. Cell 11, 683-695.
86. Pascual, J., Pfuhl, M., Walther, D., Saraste, M. and Nilges, M. (1997). Solution structure of the spectrin repeat: a left-handed antiparallel triple-helical coiled-coil. J. Mol. Biol. 273, 740-751.
87. Paterson, H. F., Self, A. J., Garrett, M. D., Just, I., Aktories, K. and Hall, A. (1990). Microinjection of recombinant p21rho induces rapid changes in cell morphology. J. Cell Biol. 111, 1001-1007.
88. Paulson, A. F., Mooney, E., Fang, X., Ji, H. and McCrea, P. D. (2000). Xarvcf, Xenopus member of the p120 catenin subfamily associating with cadherin juxtamembrane region. J. Biol. Chem. 275, 30124-30131.
89. Peifer, M., Berg, S. and Reynolds, A. B. (1994). A repeating amino acid motif shared by proteins with diverse cellular roles. Cell 76, 789-791.
90. Rain, J. C., Cribier, A., Gerard, A., Emiliani, S. and Benarous, R. (2009). Yeast twohybrid detection of integrase-host factor interactions. Methods 47, 291-297.
91. Reynolds, A. B. and Carnahan, R. H. (2004). Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer. Semin. Cell Dev. Biol. 15, 657-663.
92. Ruzov, A., Hackett, J. A., Prokhortchouk, A., Reddington, J. P., Madej, M. J., Dunican, D. S., Prokhortchouk, E., Pennings, S. and Meehan, R. R. (2009a). The interaction of xKaiso with xTcf3: a revised model for integration of epigenetic and Wnt signalling pathways. Development 136, 723-727.
93. Ruzov, A., Savitskaya, E., Hackett, J. A., Reddington, J. P., Prokhortchouk, A., Madej, M. J., Chekanov, N., Li, M., Dunican, D. S., Prokhortchouk, E. et al. (2009b). The non-methylated DNA-binding function of Kaiso is not required in early Xenopus laevis development. Development 136, 729-738.
94. Schmalzing, G., Richter, H. P., Hansen, A., Schwarz, W., Just, I. and Aktories, K. (1995). Involvement of the GTP binding protein Rho in constitutive endocytosis in Xenopus laevis oocytes. J. Cell Biol. 130, 1319-1332.
95. Schmelzl, B. and Geli, M. I. (2002). An efficient genetic screen in mammalian cultured cells. EMBO Rep. 3, 682-687.
96. Sevilla, L. M., Nachat, R., Groot, K. R. and Watt, F. M. (2008a). Kazrin regulates keratinocyte cytoskeletal networks, intercellular junctions and differentiation. J. Cell Sci. 121, 3561-3569.
97. Sevilla, L. M., Rana, A. A., Watt, F. M. and Smith, J. C. (2008b). KazrinA is required for axial elongation and epidermal integrity in Xenopus tropicalis. Dev. Dyn. 237, 1718-1725.
98. Sirotkin, H., O'Donnell, H., DasGupta, R., Halford, S., St Jore, B., Puech, A., Parimoo, S., Morrow, B., Skoultchi, A., Weissman, S. M. et al. (1997). Identification of a new human catenin gene family member (ARVCF) from the region deleted in velo-cardiofacial syndrome. Genomics 41, 75-83.
99. Sive, H. L., Grainger, R. M. and Harland, R. M. (2000). Early Development of Xenopus laevis: a Laboratory Manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
100. Sparrow, D. B., Kotecha, S., Towers, N. and Mohun, T. J. (1998). Xenopus eHAND: a marker for the developing cardiovascular system of the embryo that is regulated by bone morphogenetic proteins. Mech. Dev. 71, 151-163.
101. Spring, C. M., Kelly, K. F., O'Kelly, I., Graham, M., Crawford, H. C. and Daniel, J. M. (2005). The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin. Exp. Cell Res. 305, 253-265.
102. Stenzel, N., Fetzer, C. P., Heumann, R. and Erdmann, K. S. (2009). PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells. J. Cell Sci. 122, 3374-3384.
103. Sullivan, R., Price, L. S. and Koffer, A. (1999). Rho controls cortical F-actin disassembly in addition to, but independently of, secretion in mast cells. J. Biol. Chem. 274, 38140-38146.
104. Symons, M. and Rusk, N. (2003). Control of vesicular trafficking by Rho GTPases. Curr. Biol. 13, R409-R418.
105. Thoreson, M. A., Anastasiadis, P. Z., Daniel, J. M., Ireton, R. C., Wheelock, M. J., Johnson, K. R., Hummingbird, D. K. and Reynolds, A. B. (2000). Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion. J. Cell Biol. 148, 189-202.
106. Turner, A. P., Brown, D., Heasman, J., Cook, G. M., Evans, J., Vickers, L. and Wylie, C. C. (1992). Involvement of a neutral glycolipid in differential cell adhesion in the Xenopus blastula. EMBO J. 11, 3845-3855.
107. Vargo-Gogola, T., Heckman, B. M., Gunther, E. J., Chodosh, L. A. and Rosen, J. M. (2006). P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland. Mol. Endocrinol. 20, 1391-1405.
108. Vincent, S. and Settleman, J. (1999). Inhibition of RhoGAP activity is sufficient for the induction of Rho-mediated actin reorganization. Eur. J. Cell Biol. 78, 539-548.
109. Waibler, Z., Schafer, A. and Starzinski-Powitz, A. (2001). mARVCF cellular localisation and binding to cadherins is influenced by the cellular context but not by alternative splicing. J. Cell Sci. 114, 3873-3884.
110. Wang, Q., Liu, M., Li, X., Chen, L. and Tang, H. (2009). Kazrin F is involved in apoptosis and interacts with BAX and ARC. Acta Biochim. Biophys. Sin. (Shanghai) 41, 763-772.
111. Wennerberg, K., Forget, M. A., Ellerbroek, S. M., Arthur, W. T., Burridge, K., Settleman, J., Der, C. J. and Hansen, S. H. (2003). Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. Curr. Biol. 13, 1106-1115.
112. Wildenberg, G. A., Dohn, M. R., Carnahan, R. H., Davis, M. A., Lobdell, N. A., Settleman, J. and Reynolds, A. B. (2006). p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho. Cell 127, 1027-1039.
113. Xiao, K., Allison, D. F., Buckley, K. M., Kottke, M. D., Vincent, P. A., Faundez, V. and Kowalczyk, A. P. (2003). Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells. J. Cell Biol. 163, 535-545.
114. Xiao, K., Garner, J., Buckley, K. M., Vincent, P. A., Chiasson, C. M., Dejana, E., Faundez, V. and Kowalczyk, A. P. (2005). p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherin. Mol. Biol. Cell 16, 5141-5151.
115. Xiao, K., Oas, R. G., Chiasson, C. M. and Kowalczyk, A. P. (2007). Role of p120-catenin in cadherin trafficking. Biochim. Biophys. Acta 1773, 8-16.
116. Yamamoto, M., Yoshimura, K., Kitada, M., Nakahara, J., Seiwa, C., Ueki, T., Shimoda, Y., Ishige, A., Watanabe, K. and Asou, H. (2009). A new monoclonal antibody, A3B10, specific for astrocyte-lineage cells recognizes calmodulin-regulated spectrin-associated protein 1 (Camsap1). J. Neurosci. Res. 87, 503-513.
117. Yap, A. S., Niessen, C. M. and Gumbiner, B. M. (1998). The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn. J. Cell Biol. 141, 779-789.
118. Yap, A. S., Crampton, M. S. and Hardin, J. (2007). Making and breaking contacts: the cellular biology of cadherin regulation. Curr. Opin. Cell Biol. 19, 508-514.