Factor VIIa binding and internalization in hepatocytes

Journal of Thrombosis and Haemostasis

Volumn 3, Issue 10, 2005, Pages 2264-2273

  Hjortoe, G ^a,b   Sorensen, B B ^a   Petersen, L C ^a   Rao, L Vijaya Mohan ^b  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

Author keywords

Factor VIIa; Hepatocytes; Internalization; Liver

Indexed keywords

ANTIBODY; BLOOD CLOTTING FACTOR 7; IODINE 125; LIPOCORTIN 5;

ARTICLE; CELL LINE; CELL TRANSPORT; CONTROLLED STUDY; ENDOCYTOSIS; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL;

ANIMALS; ANNEXIN A5; CELL LINE; CELL MEMBRANE; CELLS, CULTURED; FACTOR VIIA; HEPATOCYTES; HUMANS; PHOSPHATIDYLSERINES; PROTEIN BINDING; PROTEIN TRANSPORT; RATS; THROMBOPLASTIN;

EID: 28444445915     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2005.01542.x     Document Type: Article

References (31)

1. Hasselback R, Hjort PF. Effect of heparin on in vivo turnover of clotting factor. J Appl Physiol 1960; 15: 945-48.
2. O'Reilly RA, Aggeler PM, Leong LS. Studies on the coumarin anti-coagulation drugs: The pharmacodynamics of warfarin in man. J Clin Invest 1963; 42: 1542-51.
3. Bjorkman S, Berntorp E. Pharmacokinetics of coagulation factors: clinical relevance for patients with haemophilia. Clin Pharmacokinet 2001; 40: 815-32.
4. Loeliger EA, van der Esch B, ten Haar Romney-Wachter CC, Booij HL. Factor VII; its turnover rate and its possible role in thrombogenesis. Thromb Diath Haemorrh 1960; 4: 196-200.
5. Fair DS. Quantitation of factor VII in the plasma of normal and warfarin-treated individuals by radioimmunoassay. Blood 1983; 62: 784-91.
6. Fuchs HE, Pizzo SV. Regulation of factor Xa in vitro in human and mouse plasma and in vivo in mouse. J Clin Invest N Y 1983; 72: 2041-49.
7. Fuchs HE, Trapp HG, Griffith MJ, Roberts HR, Pizzo SV. Regulation of factor IXa in vitro in human and mouse plasma and in vivo in the mouse. Role of the endothelium and the plasma proteinase inhibitors. J Clin Invest 1984; 73: 1696-703.
8. Seligsohn U, Kasper CK, Osterud B, Rapaport SI. Activated factor VII: presence in factor IX concentrates and persistence in the circulation after infusion. Blood 1979; 53: 828-37.
9. Erhardtsen E. Pharmacokinetics of recombinant activated factor VII (rFVIIa). Semin Thromb Hemost 2000; 26: 385-91.
10. Iakhiaev A, Pendurthi UR, Voigt J, Ezban M, Rao LVM. Catabolism of factor VIIa bound to tissue factor in fibroblasts in the presence and absence of tissue factor pathway inhibitor. J Biol Chem 1999; 274: 36995-7003.
11. Fleck RA, Rao LVM, Rapaport SI, Varki N. Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody. Thromb Res 1990; 59: 421-37.
12. Drake TA, Morrissey JH, Edgington TS. Selective cellular expression of tissue factor in human tissues: implications for disorders of hemostasis and thrombosis. Am J Pathol 1989; 134: 1087-97.
13. Chang GTG, Kisiel W. Internalization and degradation of recombinant human coagulation factor Vila in the human hepatoma cell line HuH7. Thromb Haemost 1995; 73: 231-38.
14. Nakabayashi H, Taketa K, Miyano K, Yamane T, Sato J. Growth of human hepatoma cells lines with differentiated functions in chemically defined medium. Cancer Res 1982; 42: 3858-63.
15. Biessen EA, Noorman F, van Teijlingen ME, Kuiper J, Barrett-Bergshoeff M, Bijsterbosch MK, Rijken DC, van Berkel TJ. Lysine-based cluster mannosides that inhibit ligand binding to the human mannose receptor at nanomolar concentration. J Biol Chem 1996; 271: 28024-30.
16. Bajaj SP, Rapaport SI, Prodanos C. A simplified procedure for purification of human prothrombin, factor IX and factor X. Prep Biochem 1981; 11: 397-412.
17. Rao LVM. Characterization of anti-tissue factor antibody and its use in immunoaffinity purification of human tissue factor. Thromb Res 1988; 51: 373-84.
18. Seglen PO. Preparation of isolated rat liver cells. Methods Cell Biol 1976; 13: 29-83.
19. Le DT, Rapaport SI, Rao LVM. Relations between factor VIIa binding and expression of factor VIIa/tissue factor catalytic activity on cell surfaces. J Biol Chem 1992; 267: 15447-54.
20. Iakhiaev A, Pendurthi UR, Rao LVM. Active site blockade of factor VIIa alters its intracellular distribution. J Biol Chem 2001; 276: 45895-901.
21. Tait JF, Gibson D, Fujikawa K. Phospholipid binding properties of human placental anticoagulant protein-I, a member of the lipocortin family. J Biol Chem 1989; 264: 7944-49.
22. Schwartz AL. The hepatic asialoglycoprotein receptor. CRC Crit Rev Biochem 1984; 16: 207-33.
23. 125I-rFVIIa in rats. Thromb Haemost 1993; 70: 465-68.
24. Thomsen MK, Diness V, Nilsson P, Rasmussen SN, Taylor T, Hedner U. Pharmacokinetics of recombinant factor Vila in the rat - a comparison of bio-, immuno- and isotope assays. Thromb Haemost 1993; 70: 458-64.
25. Deykin D. The role of the liver in serum-induced hypercoagulability. J Clin Invest 1966; 45: 256-63.
26. Meijer DK, Scholtens HB, Hardonk MJ. The role of the liver in clearance of glycoproteins from the general circulation, with special reference to intestinal alkaline phosphatase. Pharm Weekbl Sci 1982; 4: 57-70.
27. Kelly DA, Summerfield JA. Hemostasis in liver disease. Semin Liver Dis 1987; 7: 182-91.
28. Rao LVM, Rapaport SI, Hoang AD. Binding of factor VIIa to tissue factor permits rapid antithrombin III/heparin inhibition of factor VIIa. Blood 1993; 81: 2600-7.
29. Broze Jr GJ, Girard TJ, Novotny WF. Regulation of coagulation by a multivalent Kunitz-type inhibitor. Biochem 1990; 29: 7539-45.
30. Scharschmidt BF, Lake JR, Renner EL, Licko V, Van Dyke RW. Fluid phase endocytosis by cultured rat hepatocytes and perfused rat liver: implications for plasma membrane turnover and vesicular trafficking of fluid phase markers. Proc Natl Acad Sci USA 1986; 83: 9488-92.
31. McDonald JF, Shah AM, Schwalbe RA, Kisiel W, Dahlback B, Nelsestuen GL. Comparison of naturally occurring vitamin K-dependent proteins: correlation of amino acid sequences and membrane binding properties suggests a membrane contact site. Biochem 1997; 36: 5120-7.