Corticotropin-Releasing factor regulates TLR4 expression in the colon and protects mice from colitis

Gastroenterology

Volumn 139, Issue 6, 2010, Pages 2083-2092

  Chaniotou, Zoi ^a   Giannogonas, Panagiotis ^a   Theoharis, Stamatis ^b   Teli, Thalia ^a   Gay, Jerome ^c   Savidge, Tor ^d   Koutmani, Yassemi ^a   Brugni, James ^e   Kokkotou, Efi ^f   Pothoulakis, Charalabos ^e   Karalis, Katia P ^a,c  

^a BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

CRF; DSS Colitis; Intestinal Inflammation; TLR4

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; GLUCOCORTICOID; INTERLEUKIN 12; PROSTAGLANDIN E2; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; COLITIS; CRYPT CELL; DISEASE PREDISPOSITION; DOWN REGULATION; ENTERITIS; FETUS; HISTOPATHOLOGY; INNATE IMMUNITY; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 78649693509     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.08.024     Document Type: Article

References (59)

1. C. Abraham, and J.H. Cho Inflammatory bowel disease N Engl J Med 361 2009 2066 2078
2. R.J. Xavier, and D.K. Podolsky Unravelling the pathogenesis of inflammatory bowel disease Nature 448 2007 427 434
3. M.T. Abreu Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function Nat Rev Immunol 10 2010 131 144
4. K.O. Arseneau, H. Tamagawa, and T.T. Pizarro Innate and adaptive immune responses related to IBD pathogenesis Curr Gastroenterol Rep 9 2007 508 512
5. P.L. De Jager, D. Franchimont, and A. Waliszewska The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases Genes Immun 8 2007 387 397
6. C.O. Elson, Y. Cong, and V.J. McCracken Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota Immunol Rev 206 2005 260 276
7. S. Rakoff-Nahoum, J. Paglino, and F. Eslami-Varzaneh Recognition of commensal microflora by TLRs is required for intestinal homeostasis Cell 118 2004 229 241
8. S. Akira, K. Takeda, and T. Kaisho TLRs: critical proteins linking innate and acquired immunity Nat Immunol 2 2001 675 680
9. J.P. Hugot CARD15/NOD2 mutations in Crohn's disease Ann N Y Acad Sci 1072 2006 9 18
10. M.T. Abreu, and M. Arditi Innate immunity and TLRs: clinical implications of basic science research J Pediatr 144 2004 421 429
11. E. Cario, and D.K. Podolsky Intestinal epithelial TOLLerance versus inTOLLerance of commensals Mol Immunol 42 2005 887 893
12. M. Fukata, K.S. Michelsen, and R. Eri TLR4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis Am J Physiol Gastrointest Liver Physiol 288 2005 G1055 G1065
13. S. Rakoff-Nahoum, L. Hao, and R. Medzhitov Role of TLRs in spontaneous commensal-dependent colitis Immunity 25 2006 319 329
14. W. Strober, I.J. Fuss, and R.S. Blumberg The immunology of mucosal models of inflammation Annu Rev Immunol 20 2002 495 549
15. S. Wirtz, and M.F. Neurath Mouse models of IBD Adv Drug Deliv Rev 59 2007 1073 1083
16. L.V. Hooper, and J.I. Gordon Commensal host-bacterial relationships in the gut Science 292 2001 1115 1118
17. R.B. Sartor, and M. Muehlbauer Microbial host interactions in IBD: implications for pathogenesis and therapy Curr Gastroenterol Rep 9 2007 497 507
18. A. Araki, T. Kanai, and T. Ishikura MyD88-deficient mice develop severe intestinal inflammation in DSS J Gastroenterol 40 2005 16 23
19. W.S. Garrett, G.M. Lord, and S. Punit Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system Cell 131 2007 33 45
20. E. Mizoguchi, Y. Hachiya, and M. Kawada TNF receptor type I-dependent activation of innate responses to reduce intestinal damage-associated mortality Gastroenterology 134 2008 470 480
21. W. Vale, J. Spiess, and C. Rivier Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin Science 213 1981 1394 1397
22. J. Donelan, W. Boucher, and N. Papadopoulou CRH induces skin vascular permeability through a neurotensin-dependent process Proc Natl Acad Sci U S A 103 2006 7759 7764
23. K. Karalis, L.J. Muglia, and D. Bae CRH and the immune system J Neuroimmunol 72 1997 131 136
24. E.A. van Tol, P. Petrusz, and P.K. Lund Local production of CRH is increased in experimental intestinal inflammation in rats Gut 39 1996 385 392
25. G.P. Chrousos The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation N Engl J Med 332 1995 1351 1362
26. K. Karalis, H. Sano, and J. Redwine Autocrine or paracrine inflammatory actions of CRH in vivo Science 254 1991 421 423
27. P.M. Anton, J. Gay, and A. Mykoniatis CRH requirement in Clostridium difficile toxin A-mediated intestinal inflammation Proc Natl Acad Sci U S A 101 2004 8503 8508
28. I. Castagliuolo, K. Karalis, and L. Valenick Endogenous corticosteroids modulate Clostridium difficile toxin A-induced enteritis in rats Am J Physiol Gastrointest Liver Physiol 280 2001 G539 G545
29. Y. Kawahito, H. Sano, and S. Mukai CRH in colonic mucosa in patients with ulcerative colitis Gut 37 1995 544 551
30. L. Muglia, L. Jacobson, and P. Dikkes CRH deficiency reveals major fetal but not adult glucocorticoid need Nature 373 1995 427 432
31. K.P. Karalis, E. Kontopoulos, and L.J. Muglia CRH deficiency unmasks the proinflammatory effect of epinephrine Proc Natl Acad Sci U S A 96 1999 7093 7097
32. M. Venihaki, P. Dikkes, and A. Carrigan CRH regulates IL-6 expression during inflammation J Clin Invest 108 2001 1159 1166
33. C. Benou, Y. Wang, and J. Imitola CRH contributes to the peripheral inflammatory response in experimental autoimmune encephalomyelitis J Immunol 174 2005 5407 5413
34. P. Mombaerts, J. Iacomini, and R.S. Johnson RAG-1-deficient mice have no mature B and T lymphocytes Cell 68 1992 869 877
35. T.W. Kim, J.N. Seo, and Y.H. Suh Involvement of lymphocytes in DSS-induced experimental colitis World J Gastroenterol 12 2006 302 305
36. M. Fukata, A. Chen, and A. Klepper Cox-2 is regulated by TLR4 signalling: role in proliferation and apoptosis in the intestine Gastroenterology 131 2006 862 877
37. M. Fukata, A. Chen, and A.S. Vamadevan TLR-4 promotes the development of colitis-associated colorectal tumors Gastroenterology 133 2007 1869 1881
38. M.A. Hermoso, T. Matsuguchi, and K. Smoak Glucocorticoids and TNF alpha cooperatively regulate TLR-2 gene expression Mol Cell Biol 24 2004 4743 4756
39. C. Tsatsanis, A. Androulidaki, and T. Alissafi CRF and the urocortins induce the expression of TLR4 in macrophages via activation of the transcription factors PU.1 and AP-1 J Immunol 176 2006 1869 1877
40. M.P. Buisine, J.P. Aubert, and W.A. Walker Developmental patterns of mucin gene expression in human fetal small intestinal xenografts maintained in severe-combined immunodeficient mice Pediatr Res 53 2003 898 904
41. T.C. Savidge, W.H. Pan, and P. Newman Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine Gastroenterology 125 2003 413 420
42. R.P. Schleimer Glucocorticoids suppress inflammation but spare innate immune responses in airway epithelium Proc Am Thorac Soc 1 2004 222 230
43. R.E. MacRedmond, C.M. Greene, and D.R. Dorscheid Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke Respir Res 8 2007 84
44. M. Venihaki, A. Carrigan, and P. Dikkes Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency Proc Natl Acad Sci U S A 97 2000 7336 7341
45. M.T. Abreu, P. Vora, and E. Faure Decreased expression of TLR-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide J Immunol 167 2001 1609 1616
46. P. Rutgeerts, S. Vermeire, and G. Van Assche Mucosal healing in inflammatory bowel disease: impossible ideal or therapeutic target? Gut 56 2007 453 455
47. N. Buchon, N.A. Broderick, and M. Poidevin Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation Cell Host Microbe 5 2009 200 211
48. W. Wang, X. Nan, and P. Ji CRH modulates endotoxin-induced inflammatory cytokine expression in human trophoblast cells Placenta 28 2007 1032 1038
49. A. Arranz, A. Androulidaki, and V. Zacharioudaki Vasoactive intestinal peptide suppresses TLR-4 expression in macrophages via Akt1 reducing their responsiveness to lipopolysaccharide Mol Immunol 45 2008 2970 2980
50. K.L. Styer, V. Singh, and E. Macosko Innate immunity in C elegans is regulated by neurons expressing NPR-1/GPCR Science 322 2008 460 464
51. E. Hollenbach, M. Neumann, and M. Vieth Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signalling suppresses inflammatory bowel disease FASEB J 18 2004 1550 1552
52. G.H. Waetzig, D. Seegert, and P. Rosenstiel p38 mitogen-activated protein kinase is activated and linked to TNFα signalling in IBD J Immunol 168 2002 5342 5351
53. Y. Liu, Z. Zhang, and L. Wang TLR4 monoclonal antibody blockade suppresses DSS-induced colitis in mice J Gastroenterol Hepatol 25 2010 209 214
54. S.N. Agoff, T.A. Brentnall, and D.A. Crispin The role of cyclooxygenase 2 in ulcerative colitis-associated neoplasia Am J Pathol 157 2000 737 745
55. M. Fukata, Y. Hernandez, and D. Conduah Innate immune signaLling by TLR4 shapes the inflammatory microenvironment in colitis-associated tumors Inflamm Bowel Dis 15 2009 997 1006
56. R.B. Gupta, N. Harpaz, and S. Itzkowitz Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study Gastroenterology 133 2007 1099 1105 quiz 13401341
57. M.G. Gareau, M.A. Silva, and M.H. Perdue Pathophysiological mechanisms of stress-induced intestinal damage Curr Mol Med 8 2008 274 281
58. D.T. Chalmers, T.W. Lovenberg, and D.E. Grigoriadis CRF receptors: from molecular biology to drug design Trends Pharmacol Sci 17 1996 166 172
59. A. Gravanis, and A.N. Margioris The CRF family of neuropeptides in inflammation: potential therapeutic applications Curr Med Chem 12 2005 1503 1512