Corticotropin-releasing hormone regulates IL-6 expression during inflammation

Journal of Clinical Investigation

Volumn 108, Issue 8, 2001, Pages 1159-1166

  Venihaki, M ^a   Dikkes, P ^a   Carrigan, A ^a   Karalis, K P ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR; CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; RNA; TUMOR NECROSIS FACTOR ALPHA; TURPENTINE;

ADRENALECTOMY; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INFLAMMATION; INFLAMMATORY DISEASE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0034782454     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI12869     Document Type: Article

References (48)

1. The syntax of immune-neuroendocrine communication
2. Shared ligands and receptors as a molecular mechanism for communication between the immune and neuroendocrine systems
3. The immunehypothalamic-pituitary-adrenal axis
4. Mechanisms of the immunosuppressive and antiinflammatory effects of glucocorticosteroids
5. Autocrine or paracrine inflammatory actions of corticotropin-releasing hormone in vivo
6. Corticotrophin-releasing factor-like immunoreactivity and mRNA in human leukocytes
7. Corticotropin-releasing factor mRNA in rat thymus and spleen
8. Corticotropin releasing factor induction of leukocyte-derived immunoreactive ACTH and endorphins
9. Neuroendocrine-immune system interactions and autoimmunity
10. Production of mice deficient in genes for inter. Leukin (IL)-1alpha, IL- 1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion
11. IL-6: Insights into novel biological activities
12. Interleukin-6 is a needed proinflammatory cycokine in the prolonged neural activity and transcriptional activation of corticotropin-releasing factor during endotoxemia
13. Interleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation
14. Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving rats
15. The effect of interleukin-6 on pituitary hormone release in vivo and in vitro
16. Role of circulating endotoxin and interleukin-6 in the ACTH and corticosterone response to intraperitoneal LPS
17. Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans
18. Dose effects of recombinant human interleukin-6 on pituitary hormone secretion and energy expenditure
19. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation
20. Tissue CRF: An extra-hypothalamic corticotrophin releasing factor (CRF) in the peripheral blood of stressed rats
21. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need
22. CRH deficiency impairs but does not block pituitary-adrenal responses to diverse stressors
23. Corticotropin-releasing hormone deficiency unmasks the proinflammatory effect of epinephrine
24. Physiological regulation of tissue-CRF
25. Mechanisms of activation of the pituitary-adrenal axis by tissue injury in the rat
26. Corticotropin-releasing factor, vasopressin, and prostaglandins mediate, and nitric oxide restrains, the hypothalamic-pituitary-adrenal response to acute local inflammation in the rat
27. Interleukin 6, but not ciliary neurotrophic factor or leukaemia inhibitory factor, is responsible for the acute phase response to turpentine-induced myositis
28. Sickness behavior in mice deficient in interleukin-6 during turpentine abscess and influenza pneumonitis
29. CRF type I receptor-deficient mice exhibit a pronounced pituitary-adrenal response to local inflammation
30. Expression of the rat arginine vasopressin gene in transgenic mice
31. Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency
32. Differential involvement of central and peripheral norepinephrine in the central lipopolysaccharide-induced interleukin-6 responses in mice
33. Induction of tumor necrosis factor-alpha mRNA in the brain after peripheral endotoxin treatment: Comparison with interleukin-1 family and interleukin-6
34. Impaired diurnal adrenal rhythmicity restored by constant infusion of corticotropin-releasing hormone in corticotropin-releasing hormone-deficient mice
35. Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH
36. Normal suppression of the reproductive axis following stress in corticotropin-releasing hormone-deficient mice
37. Defective inflammatory response in interleukin 6-deficient mice
38. Chronic effects of a nonpeptide corticotropin-releasing hormone type I receptor antagonist on pituitary-adrenal function, body weight, and metabolic regulation
39. Corticotrophin release induced by E. Coli endotoxin after removal of the medial hypothalamus
40. ACTH release in rats after removal of the medial hypothalamus
41. Complement component C3derived neutrophil chemotactic factors purified from exudate of rat carrageenin-induced inflammation
42. Cytokine activity in cancer-related anorexia/cachexia: Role of megestrol acetate and medroxyprogesterone acetate
43. The relationship between weight loss and interleukin 6 in non-small-cell lung cancer
44. Intraventricular corricorropin-releasing factor enhances behavioral effects of novelty
45. Corticotrophin releasing factor, grooming and ingestive behavior
46. CRF antagonist partially reverses CRF- and stress-induced effects on feeding
47. CRHdeficient mice have a normal anorectic response to chronic stress
48. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight