A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells

Molecular Cancer Therapeutics

Volumn 9, Issue 11, 2010, Pages 2934-2942

  Kunoh, Tatsuki ^a   Noda, Takanori ^a   Koseki, Koichi ^a   Sekigawa, Masayuki ^a   Takagi, Motoki ^c   Shin ya, Kazuo ^d   Goshima, Naoki ^d   Iemura, Shun Ichiro ^d   Natsume, Tohru ^d   Wada, Shu Ichi ^a   Mukai, Yukio ^a   Ohta, Shinji ^a   Sasaki, Ryuzo ^b   Mizukami, Tamio ^a  

^a NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY   (Japan)

^b Frontier Pharma   (Japan)

^c Japan Biological Informatics Consortium   (Japan)

^d NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DYNACTIN; DYNACTIN 2; DYNACTIN ASSOCIATED PROTEIN; DYNEIN ADENOSINE TRIPHOSPHATASE; ERGOSTEROL; MEMBRANE PROTEIN; PROTEIN KINASE B; PROTEIN MAD2; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL MEMBRANE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; DRUG ACTIVITY; DRUG TARGETING; ENZYME ACTIVATION; FIBROBLAST; GOLGI COMPLEX; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

APOPTOSIS; CACO-2 CELLS; CELLS, CULTURED; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; ERGOSTEROL; HCT116 CELLS; HELA CELLS; HEP G2 CELLS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASMS; ONCOGENE PROTEIN V-AKT; ORGANISMS, GENETICALLY MODIFIED; PROTEIN BINDING; STEROLS; UP-REGULATION; YEASTS;

EID: 78649683101     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-10-0730     Document Type: Article

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