Binucleine 2, an isoform-specific inhibitor of drosophila aurora B kinase, provides insights into the mechanism of cytokinesis

ACS Chemical Biology

Volumn 5, Issue 11, 2010, Pages 1015-1020

  Smurnyy, Yegor ^a   Toms, Angela V ^a   Hickson, Gilles R ^b,c   Eck, Michael J ^a   Eggert, Ulrike S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MONTREAL   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA B KINASE; AURORA KINASE INHIBITOR; BINUCLEINE 2; STAUROSPORINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINESIS; DOSE RESPONSE; DROSOPHILA; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; IC 50; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RESIDUE ANALYSIS;

EID: 78649682015     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb1001685     Document Type: Article

References (24)

1. Eggert, U. S., Mitchison, T. J., and Field, C. M. (2006) Animal cytokinesis: from parts list to mechanisms Annu. Rev. Biochem. 75, 543-566
2. Carmena, M., Ruchaud, S., and Earnshaw, W. C. (2009) Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins Curr. Opin. Cell Biol. 21, 796-805
3. Carmena, M. and Earnshaw, W. C. (2003) The cellular geography of aurora kinases Nat. Rev. Mol. Cell Biol. 4, 842-854
4. Marumoto, T., Zhang, D., and Saya, H. (2005) Aurora-A - a guardian of poles Nat. Rev. Cancer 5, 42-50
5. Andrews, P. D. (2005) Aurora kinases: shining lights on the therapeutic horizon? Oncogene 24, 5005-5015
6. Harrington, E. A., Bebbington, D., Moore, J., Rasmussen, R. K., Ajose-Adeogun, A. O., Nakayama, T., Graham, J. A., Demur, C., Hercend, T., Diu-Hercend, A., Su, M., Golec, J. M., and Miller, K. M. (2004) VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo Nat. Med. 10, 262-267
7. Manfredi, M. G., Ecsedy, J. A., Meetze, K. A., Balani, S. K., Burenkova, O., Chen, W., Galvin, K. M., Hoar, K. M., Huck, J. J., LeRoy, P. J., Ray, E. T., Sells, T. B., Stringer, B., Stroud, S. G., Vos, T. J., Weatherhead, G. S., Wysong, D. R., Zhang, M., Bolen, J. B., and Claiborne, C. F. (2007) Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase Proc. Natl. Acad. Sci. U.S.A. 104, 4106-4111
8. Wilkinson, R. W., Odedra, R., Heaton, S. P., Wedge, S. R., Keen, N. J., Crafter, C., Foster, J. R., Brady, M. C., Bigley, A., Brown, E., Byth, K. F., Barrass, N. C., Mundt, K. E., Foote, K. M., Heron, N. M., Jung, F. H., Mortlock, A. A., Boyle, F. T., and Green, S. (2007) AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis Clin. Cancer Res. 13, 3682-3688
9. Pollard, J. R. and Mortimore, M. (2009) Discovery and development of aurora kinase inhibitors as anticancer agents J. Med. Chem. 52, 2629-2651
10. Zhang, J., Yang, P. L., and Gray, N. S. (2009) Targeting cancer with small molecule kinase inhibitors Nat. Rev. Cancer 9, 28-39
11. Eggert, U. S., Kiger, A. A., Richter, C., Perlman, Z. E., Perrimon, N., Mitchison, T. J., and Field, C. M. (2004) Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets PLoS Biol. 2 e379
12. Sessa, F., Mapelli, M., Ciferri, C., Tarricone, C., Areces, L. B., Schneider, T. R., Stukenberg, P. T., and Musacchio, A. (2005) Mechanism of Aurora B activation by INCENP and inhibition by hesperadin Mol. Cell 18, 379-391
13. Ohi, R., Sapra, T., Howard, J., and Mitchison, T. J. (2004) Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation Mol. Biol. Cell 15, 2895-2906
14. Ghose, A. K., Herbertz, T., Pippin, D. A., Salvino, J. M., and Mallamo, J. P. (2008) Knowledge based prediction of ligand binding modes and rational inhibitor design for kinase drug discovery J. Med. Chem. 51, 5149-5171
15. Girdler, F., Sessa, F., Patercoli, S., Villa, F., Musacchio, A., and Taylor, S. (2008) Molecular basis of drug resistance in aurora kinases Chem. Biol. 15, 552-562
16. Branford, S., Rudzki, Z., Walsh, S., Grigg, A., Arthur, C., Taylor, K., Herrmann, R., Lynch, K. P., and Hughes, T. P. (2002) High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance Blood 99, 3472-3475
17. Taylor, S. and Peters, J. M. (2008) Polo and Aurora kinases: lessons derived from chemical biology Curr. Opin. Cell Biol. 20, 77-84
18. Atilla-Gokcumen, G. E., Castoreno, A. B., Sasse, S., and Eggert, U. S. (2010) Making the cut: the chemical biology of cytokinesis ACS Chem. Biol. 5, 79-90
19. Guse, A., Mishima, M., and Glotzer, M. (2005) Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis Curr. Biol. 15, 778-786
20. Steigemann, P., Wurzenberger, C., Schmitz, M. H., Held, M., Guizetti, J., Maar, S., and Gerlich, D. W. (2009) Aurora B-mediated abscission checkpoint protects against tetraploidization Cell 136, 473-484
21. Sunkel, C. E. and Glover, D. M. (1988) polo, a mitotic mutant of Drosophila displaying abnormal spindle poles J Cell Sci 89, 25-38
22. Glover, D. M., Leibowitz, M. H., McLean, D. A., and Parry, H. (1995) Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles Cell 81, 95-105
23. Fuller, B. G., Lampson, M. A., Foley, E. A., Rosasco-Nitcher, S., Le, K. V., Tobelmann, P., Brautigan, D. L., Stukenberg, P. T., and Kapoor, T. M. (2008) Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient Nature 453, 1132-1136
24. Xu, Z., Ogawa, H., Vagnarelli, P., Bergmann, J. H., Hudson, D. F., Ruchaud, S., Fukagawa, T., Earnshaw, W. C., and Samejima, K. (2009) INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization J. Cell Biol. 187, 637-653