Thrombin inhibition by serpins disrupts exosite II

Journal of Biological Chemistry

Volumn 285, Issue 49, 2010, Pages 38621-38629

  Li, Wei ^a   Johnson, Daniel J D ^a   Adams, Ty E ^a   Pozzi, Nicola ^b   De Filippis, Vincenzo ^b   Huntington, James A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BLOOD COAGULATION; COFACTOR BINDING; COFACTORS; COMPLEX DISORDER; COMPLEX FORMATIONS; CONFORMATIONAL CHANGE; CRYPTIC SITES; LIMITED PROTEOLYSIS; RECEPTOR BINDING; SERPINS; THROMBIN INHIBITION;

BINDING ENERGY; COAGULATION;

BINDING SITES;

FIBRINOGEN; HEPARIN; SERINE PROTEINASE INHIBITOR; THROMBIN;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME STRUCTURE; EXOSITE I; EXOSITE II; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION;

BINDING SITES; FIBRINOGEN; HEPARIN; HUMANS; SERPINS; THROMBIN;

EID: 78649654335     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.144964     Document Type: Article

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