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Volumn 5, Issue 4, 2010, Pages 574-581

Changes in the NMR metabolic profile of human microglial cells exposed to lipopolysaccharide or morphine

Author keywords

activation; LPS; metabolomics; microglia; morphine; NMR

Indexed keywords

ACETIC ACID; ADENINE; ALANINE; ASPARTIC ACID; BETA ALANINE; CHOLINE; CREATININE; ETHANOLAMINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLUTAMIC ACID; INOSITOL; INTERLEUKIN 1BETA; LACTIC ACID; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; MORPHINE; PHOSPHOETHANOLAMINE; PYRUVIC ACID; TAURINE; THYMINE; TUMOR NECROSIS FACTOR ALPHA; VALINE; XANTHINE;

EID: 78649644689     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-010-9197-8     Document Type: Article
Times cited : (9)

References (40)
  • 2
    • 0035449358 scopus 로고    scopus 로고
    • Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity
    • 1:CAS:528:DC%2BD3MXmt1WjtbY%3D 11517237
    • A Bal-Price GC Brown 2001 Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity J Neurosci 21 6480 6491 1:CAS:528:DC%2BD3MXmt1WjtbY%3D 11517237
    • (2001) J Neurosci , vol.21 , pp. 6480-6491
    • Bal-Price, A.1    Brown, G.C.2
  • 3
    • 0035960894 scopus 로고    scopus 로고
    • Filamentous actin is concentrated in specific subpopulations of neuronal and glial structures in rat central nervous system
    • DOI 10.1016/S0006-8993(01)03189-4, PII S0006899301031894
    • F Capani MH Ellisman ME Martone 2001 Filamentous actin is concentrated in specific subpopulations of neuronal and glial structures in rat central nervous system Brain Res 923 1 11 1:CAS:528:DC%2BD3MXovF2js7s%3D 10.1016/S0006-8993(01) 03189-4 11743966 (Pubitemid 34024930)
    • (2001) Brain Research , vol.923 , Issue.1-2 , pp. 1-11
    • Capani, F.1    Ellisman, M.H.2    Martone, M.E.3
  • 4
    • 23044466731 scopus 로고    scopus 로고
    • 1HMRS
    • DOI 10.1016/j.jneuroim.2005.04.021, PII S0165572805001931
    • SL Chang CC Cloak L Malellari L Chang 2005 The effects of repeated endotoxin exposure on rat brain metabolites as measured by ex vivo 1HMRS J Neuroimmunol 166 39 46 1:CAS:528:DC%2BD2MXntVCrur0%3D 10.1016/j.jneuroim.2005. 04.021 15996758 (Pubitemid 41074655)
    • (2005) Journal of Neuroimmunology , vol.166 , Issue.1-2 , pp. 39-46
    • Chang, S.L.1    Cloak, C.C.2    Malellari, L.3    Chang, L.4
  • 5
    • 0026662652 scopus 로고
    • Cytokine release from microglia: Differential inhibition by pentoxifylline and dexamethasone
    • 1:CAS:528:DyaK38XmsVGiu7Y%3D 1527422
    • CC Chao S Hu K Close CS Choi TW Molitor WJ Novick PK Peterson 1992 Cytokine release from microglia: differential inhibition by pentoxifylline and dexamethasone J Infect Dis 166 847 853 1:CAS:528:DyaK38XmsVGiu7Y%3D 1527422
    • (1992) J Infect Dis , vol.166 , pp. 847-853
    • Chao, C.C.1    Hu, S.2    Close, K.3    Choi, C.S.4    Molitor, T.W.5    Novick, W.J.6    Peterson, P.K.7
  • 6
    • 0028597563 scopus 로고
    • Transforming growth factor-beta protects human neurons against beta-amyloid-induced injury
    • 1:CAS:528:DyaK2MXjvFSjsb0%3D 10.1007/BF02815409 7702706
    • CC Chao S Hu FH Kravitz M Tsang WR Anderson PK Peterson 1994 Transforming growth factor-beta protects human neurons against beta-amyloid-induced injury Mol Chem Neuropathol 23 159 178 1:CAS:528:DyaK2MXjvFSjsb0%3D 10.1007/BF02815409 7702706
    • (1994) Mol Chem Neuropathol , vol.23 , pp. 159-178
    • Chao, C.C.1    Hu, S.2    Kravitz, F.H.3    Tsang, M.4    Anderson, W.R.5    Peterson, P.K.6
  • 7
    • 0029087348 scopus 로고
    • Modulation of human microglial cell superoxide production by cytokines
    • 1:CAS:528:DyaK2MXntVWiurw%3D 7616108
    • CC Chao S Hu PK Peterson 1995 Modulation of human microglial cell superoxide production by cytokines J Leukoc Biol 58 65 70 1:CAS:528: DyaK2MXntVWiurw%3D 7616108
    • (1995) J Leukoc Biol , vol.58 , pp. 65-70
    • Chao, C.C.1    Hu, S.2    Peterson, P.K.3
  • 8
    • 0029078126 scopus 로고
    • Tumor necrosis factor-alpha production by human fetal microglial cells: Regulation by other cytokines
    • 1:CAS:528:DyaK2MXnsVyitbY%3D 10.1159/000111278 7555742
    • CC Chao S Hu WS Sheng PK Peterson 1995 Tumor necrosis factor-alpha production by human fetal microglial cells: regulation by other cytokines Dev Neurosci 17 97 105 1:CAS:528:DyaK2MXnsVyitbY%3D 10.1159/000111278 7555742
    • (1995) Dev Neurosci , vol.17 , pp. 97-105
    • Chao, C.C.1    Hu, S.2    Sheng, W.S.3    Peterson, P.K.4
  • 9
    • 0030108525 scopus 로고    scopus 로고
    • Cytokine-stimulated astrocytes damage human neurons via a nitric oxide mechanism
    • DOI 10.1002/(SICI)1098-1136(1996 03)16:3<276::AID-GLIA10>3.0.CO;2-X
    • CC Chao S Hu WS Sheng D Bu MI Bukrinsky PK Peterson 1996 Cytokine-stimulated astrocytes damage human neurons via a nitric oxide mechanism Glia 16 276 284 1:STN:280:DyaK28vjtVSnug%3D%3D 10.1002/(SICI)1098-1136(199603) 16:3<276::AID-GLIA10>3.0.CO;2-X 8833198 (Pubitemid 26309470)
    • (1996) GLIA , vol.16 , Issue.3 , pp. 276-284
    • Chao, C.C.1    Hu, S.2    Sheng, W.S.3    Bu, D.4    Bukrinsky, M.I.5    Peterson, P.K.6
  • 10
    • 0030912542 scopus 로고    scopus 로고
    • Activation of mu opioid receptors inhibits microglial cell chemotaxis
    • 1:CAS:528:DyaK2sXjtFyru7w%3D 9152411
    • CC Chao S Hu KB Shark WS Sheng G Gekker PK Peterson 1997 Activation of mu opioid receptors inhibits microglial cell chemotaxis J Pharmacol Exp Ther 281 998 1004 1:CAS:528:DyaK2sXjtFyru7w%3D 9152411
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 998-1004
    • Chao, C.C.1    Hu, S.2    Shark, K.B.3    Sheng, W.S.4    Gekker, G.5    Peterson, P.K.6
  • 11
    • 33646023117 scopus 로고    scopus 로고
    • An introduction to ROC analysis
    • 10.1016/j.patrec.2005.10.010
    • T Fawcett 2006 An introduction to ROC analysis Pattern Recogn Lett 27 861 874 10.1016/j.patrec.2005.10.010
    • (2006) Pattern Recogn Lett , vol.27 , pp. 861-874
    • Fawcett, T.1
  • 13
    • 59649089153 scopus 로고    scopus 로고
    • Morphine enhances microglial migration through modulation of P2X4 receptor signaling
    • 1:CAS:528:DC%2BD1MXhs1Kqsbg%3D 10.1523/JNEUROSCI.4595-08.2009 19176808
    • RJ Horvath JA DeLeo 2009 Morphine enhances microglial migration through modulation of P2X4 receptor signaling J Neurosci 29 998 1005 1:CAS:528:DC%2BD1MXhs1Kqsbg%3D 10.1523/JNEUROSCI.4595-08.2009 19176808
    • (2009) J Neurosci , vol.29 , pp. 998-1005
    • Horvath, R.J.1    Deleo, J.A.2
  • 14
    • 0033728872 scopus 로고    scopus 로고
    • Morphine inhibits human microglial cell production of, and migration towards, RANTES
    • 1:CAS:528:DC%2BD3cXovVeru7Y%3D 10.1177/026988110001400307 11106302
    • S Hu CC Chao CC Hegg S Thayer PK Peterson 2000 Morphine inhibits human microglial cell production of, and migration towards, RANTES J Psychopharmacol 14 238 243 1:CAS:528:DC%2BD3cXovVeru7Y%3D 10.1177/026988110001400307 11106302
    • (2000) J Psychopharmacol , vol.14 , pp. 238-243
    • Hu, S.1    Chao, C.C.2    Hegg, C.C.3    Thayer, S.4    Peterson, P.K.5
  • 16
    • 42749086196 scopus 로고    scopus 로고
    • Excitatory amino acid transporter expression by astrocytes is neuroprotective against microglial excitotoxicity
    • 1:CAS:528:DC%2BD1cXlslWmtbs%3D 10.1016/j.brainres.2008.03.012 18410911
    • J Liang H Takeuchi Y Doi J Kawanokuchi Y Sonobe S Jin I Yawata H Li S Yasuoka T Mizuno, et al. 2008 Excitatory amino acid transporter expression by astrocytes is neuroprotective against microglial excitotoxicity Brain Res 1210 11 19 1:CAS:528:DC%2BD1cXlslWmtbs%3D 10.1016/j.brainres.2008.03.012 18410911
    • (2008) Brain Res , vol.1210 , pp. 11-19
    • Liang, J.1    Takeuchi, H.2    Doi, Y.3    Kawanokuchi, J.4    Sonobe, Y.5    Jin, S.6    Yawata, I.7    Li, H.8    Yasuoka, S.9    Mizuno, T.10
  • 17
    • 71849104860 scopus 로고
    • Protein measurement with the folin reagent
    • 1:CAS:528:DyaG38XhsVyrsw%3D%3D 14907713
    • O Lowry NJ Rosebrough AL Farr RJ Randall 1951 Protein measurement with the folin reagent J Biol Chem 193 265 275 1:CAS:528:DyaG38XhsVyrsw%3D%3D 14907713
    • (1951) J Biol Chem , vol.193 , pp. 265-275
    • Lowry, O.1    Rosebrough, N.J.2    Farr, A.L.3    Randall, R.J.4
  • 18
    • 0026147120 scopus 로고
    • A review of chemical issues in 1H NMR spectroscopy: N-acetyl-L-aspartate, creatine and choline
    • 1:STN:280:DyaK3MzhsF2ltg%3D%3D 10.1002/nbm.1940040203 1650241
    • BL Miller 1991 A review of chemical issues in 1H NMR spectroscopy: N-acetyl-L-aspartate, creatine and choline NMR Biomed 4 47 52 1:STN:280:DyaK3MzhsF2ltg%3D%3D 10.1002/nbm.1940040203 1650241
    • (1991) NMR Biomed , vol.4 , pp. 47-52
    • Miller, B.L.1
  • 19
    • 1642384019 scopus 로고    scopus 로고
    • Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2
    • DOI 10.1016/j.tim.2004.02.009, PII S0966842X04000502
    • K Miyake 2004 Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2 Trends Microbiol 12 186 192 1:CAS:528:DC%2BD2cXis1WnsLs%3D 10.1016/j.tim.2004.02.009 15051069 (Pubitemid 38393739)
    • (2004) Trends in Microbiology , vol.12 , Issue.4 , pp. 186-192
    • Miyake, K.1
  • 20
    • 19744380563 scopus 로고    scopus 로고
    • Neuroscience: Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • DOI 10.1126/science.1110647
    • A Nimmerjahn F Kirchhoff F Helmchen 2005 Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo Science 308 1314 1318 1:CAS:528:DC%2BD2MXks1Ciuro%3D 10.1126/science.1110647 15831717 (Pubitemid 40746128)
    • (2005) Science , vol.308 , Issue.5726 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 21
    • 0342592138 scopus 로고    scopus 로고
    • Complement 5a controls motility of murine microglial cells in vitro via activation of an inhibitory G-protein and the rearrangement of the actin cytoskeleton
    • DOI 10.1016/0306-4522(96)00106-6
    • C Nolte T Moller T Walter H Kettenmann 1996 Complement 5a controls motility of murine microglial cells in vitro via activation of an inhibitory G-protein and the rearrangement of the actin cytoskeleton Neuroscience 73 1091 1107 1:CAS:528:DyaK28XktFWitbs%3D 10.1016/0306-4522(96)00106-6 8809827 (Pubitemid 26194334)
    • (1996) Neuroscience , vol.73 , Issue.4 , pp. 1091-1107
    • Nolte, C.1    Moller, T.2    Walter, T.3    Kettenmann, H.4
  • 22
    • 0028342494 scopus 로고
    • Nitric oxide production and neurotoxicity mediated by activated microglia from human versus mouse brain
    • 1:CAS:528:DyaK2cXmvFyqsbo%3D 8035037
    • PK Peterson S Hu WR Anderson CC Chao 1994 Nitric oxide production and neurotoxicity mediated by activated microglia from human versus mouse brain J Infect Dis 170 457 460 1:CAS:528:DyaK2cXmvFyqsbo%3D 8035037
    • (1994) J Infect Dis , vol.170 , pp. 457-460
    • Peterson, P.K.1    Hu, S.2    Anderson, W.R.3    Chao, C.C.4
  • 23
    • 0029160273 scopus 로고
    • Thalidomide inhibits tumor necrosis factor-alpha production by lipopolysaccharide- and lipoarabinomannan-stimulated human microglial cells
    • 1:CAS:528:DyaK2MXptlanur8%3D 7561198
    • PK Peterson S Hu WS Sheng FH Kravitz TW Molitor D Chatterjee CC Chao 1995 Thalidomide inhibits tumor necrosis factor-alpha production by lipopolysaccharide- and lipoarabinomannan-stimulated human microglial cells J Infect Dis 172 1137 1140 1:CAS:528:DyaK2MXptlanur8%3D 7561198
    • (1995) J Infect Dis , vol.172 , pp. 1137-1140
    • Peterson, P.K.1    Hu, S.2    Sheng, W.S.3    Kravitz, F.H.4    Molitor, T.W.5    Chatterjee, D.6    Chao, C.C.7
  • 24
    • 0031024047 scopus 로고    scopus 로고
    • Differential production of and migratory response to beta chemokines by human microglia and astrocytes
    • 1:CAS:528:DyaK2sXht1Gguro%3D 9203678
    • PK Peterson S Hu J Salak-Johnson TW Molitor CC Chao 1997 Differential production of and migratory response to beta chemokines by human microglia and astrocytes J Infect Dis 175 478 481 1:CAS:528:DyaK2sXht1Gguro%3D 9203678
    • (1997) J Infect Dis , vol.175 , pp. 478-481
    • Peterson, P.K.1    Hu, S.2    Salak-Johnson, J.3    Molitor, T.W.4    Chao, C.C.5
  • 25
    • 0036396282 scopus 로고    scopus 로고
    • Reciprocal interactions between microglia and neurons: From survival to neuropathology
    • 12405226
    • E Polazzi A Contestabile 2002 Reciprocal interactions between microglia and neurons: from survival to neuropathology Rev Neurosci 13 221 242 12405226
    • (2002) Rev Neurosci , vol.13 , pp. 221-242
    • Polazzi, E.1    Contestabile, A.2
  • 26
    • 34548806001 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity is inhibited by morphine through an opioid receptor-independent reduction of NADPH oxidase activity
    • 1:CAS:528:DC%2BD2sXnt1Wntrk%3D 17617613
    • L Qian KS Tan SJ Wei HM Wu Z Xu B Wilson RB Lu JS Hong PM Flood 2007 Microglia-mediated neurotoxicity is inhibited by morphine through an opioid receptor-independent reduction of NADPH oxidase activity J Immunol 179 1198 1209 1:CAS:528:DC%2BD2sXnt1Wntrk%3D 17617613
    • (2007) J Immunol , vol.179 , pp. 1198-1209
    • Qian, L.1    Tan, K.S.2    Wei, S.J.3    Wu, H.M.4    Xu, Z.5    Wilson, B.6    Lu, R.B.7    Hong, J.S.8    Flood, P.M.9
  • 27
    • 33747494572 scopus 로고    scopus 로고
    • Microglia as a pharmacological target in infectious and inflammatory diseases of the brain
    • DOI 10.1007/s11481-006-9012-8
    • RB Rock PK Peterson 2006 Microglia as a pharmacological target in infectious and inflammatory diseases of the brain J Neuroimmune Pharmacol 1 117 126 10.1007/s11481-006-9012-8 18040778 (Pubitemid 44257487)
    • (2006) Journal of Neuroimmune Pharmacology , vol.1 , Issue.2 , pp. 117-126
    • Rock, R.B.1    Peterson, P.K.2
  • 29
    • 0029153012 scopus 로고
    • Tumor necrosis factor alpha upregulates human microglial cell production of interleukin-10 in vitro
    • 1:CAS:528:DyaK2MXoslKluro%3D 8548541
    • WS Sheng S Hu FH Kravitz PK Peterson CC Chao 1995 Tumor necrosis factor alpha upregulates human microglial cell production of interleukin-10 in vitro Clin Diagn Lab Immunol 2 604 608 1:CAS:528:DyaK2MXoslKluro%3D 8548541
    • (1995) Clin Diagn Lab Immunol , vol.2 , pp. 604-608
    • Sheng, W.S.1    Hu, S.2    Kravitz, F.H.3    Peterson, P.K.4    Chao, C.C.5
  • 30
    • 13244283049 scopus 로고    scopus 로고
    • Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1β-stimulated human astrocytes
    • DOI 10.1002/glia.20108
    • WS Sheng S Hu X Min GA Cabral JR Lokensgard PK Peterson 2005 Synthetic cannabinoid WIN55, 212-2 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes Glia 49 211 219 10.1002/glia.20108 15390091 (Pubitemid 40188500)
    • (2005) GLIA , vol.49 , Issue.2 , pp. 211-219
    • Sheng, W.S.1    Hu, S.2    Min, X.3    Cabral, G.A.4    Lokensgard, J.R.5    Peterson, P.K.6
  • 31
    • 0032937860 scopus 로고    scopus 로고
    • The role of microglia and macrophages in the pathophysiology of the CNS
    • DOI 10.1016/S0301-0082(98)00083-5, PII S0301008298000835
    • G Stoll S Jander 1999 The role of microglia and macrophages in the pathophysiology of the CNS Prog Neurobiol 58 233 247 1:STN:280: DyaK1M3nt12jug%3D%3D 10.1016/S0301-0082(98)00083-5 10341362 (Pubitemid 29193056)
    • (1999) Progress in Neurobiology , vol.58 , Issue.3 , pp. 233-247
    • Stollg, G.1    Jander, S.2
  • 32
    • 15444363122 scopus 로고    scopus 로고
    • Neuritic beading induced by activated microglia is an early feature of neuronal dysfunction toward neuronal death by inhibition of mitochondrial respiration and axonal transport
    • DOI 10.1074/jbc.M413863200
    • H Takeuchi T Mizuno G Zhang J Wang J Kawanokuchi R Kuno A Suzumura 2005 Neuritic beading induced by activated microglia is an early feature of neuronal dysfunction toward neuronal death by inhibition of mitochondrial respiration and axonal transport J Biol Chem 280 10444 10454 1:CAS:528:DC%2BD2MXit1ers7g%3D 10.1074/jbc.M413863200 15640150 (Pubitemid 40395902)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.11 , pp. 10444-10454
    • Takeuchi, H.1    Mizuno, T.2    Zhang, G.3    Wang, J.4    Kawanokuchi, J.5    Kuno, R.6    Suzumura, A.7
  • 33
    • 5444256254 scopus 로고    scopus 로고
    • Microglia
    • DOI 10.1023/B:MEBR.0000043984.73063.d8
    • D van Rossum UK Hanisch 2004 Microglia Metab Brain Dis 19 393 411 10.1023/B:MEBR.0000043984.73063.d8 15554430 (Pubitemid 39361196)
    • (2004) Metabolic Brain Disease , vol.19 , Issue.3-4 , pp. 393-411
    • Van Rossum, D.1    Hanisch, U.-K.2
  • 34
    • 4644308783 scopus 로고    scopus 로고
    • Microglia: Phagocyte and glia cell
    • DOI 10.1016/j.biocel.2004.06.010, PII S1357272504002481
    • F Vilhardt 2005 Microglia: phagocyte and glia cell Int J Biochem Cell Biol 37 17 21 1:CAS:528:DC%2BD2cXnslKgsrY%3D 10.1016/j.biocel.2004.06.010 15381143 (Pubitemid 39286017)
    • (2005) International Journal of Biochemistry and Cell Biology , vol.37 , Issue.1 , pp. 17-21
    • Vilhardt, F.1
  • 35
    • 0038414661 scopus 로고    scopus 로고
    • Anti-inflammatory effects of opioids
    • 1:CAS:528:DC%2BD3sXns1GrsLw%3D 12617572
    • JS Walker 2003 Anti-inflammatory effects of opioids Adv Exp Med Biol 521 148 160 1:CAS:528:DC%2BD3sXns1GrsLw%3D 12617572
    • (2003) Adv Exp Med Biol , vol.521 , pp. 148-160
    • Walker, J.S.1
  • 36
    • 70350334263 scopus 로고    scopus 로고
    • The "toll" of opioid-induced glial activation: Improving the clinical efficacy of opioids by targeting glia
    • 1:CAS:528:DC%2BD1MXhtlCku7zP 10.1016/j.tips.2009.08.002 19762094
    • LR Watkins MR Hutchinson KC Rice SF Maier 2009 The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia Trends Pharmacol Sci 30 581 591 1:CAS:528:DC%2BD1MXhtlCku7zP 10.1016/j.tips.2009.08.002 19762094
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 581-591
    • Watkins, L.R.1    Hutchinson, M.R.2    Rice, K.C.3    Maier, S.F.4
  • 37
    • 0020629312 scopus 로고
    • Apoprotein e is synthesized and secreted by resident and thioglycollate-elicited macrophages but not by pyran copolymer- or bacillus Calmette-Guerin-activated macrophages
    • 1:CAS:528:DyaL3sXmtFSmtLo%3D 10.1084/jem.158.4.1272 6619735
    • Z Werb JR Chin 1983 Apoprotein E is synthesized and secreted by resident and thioglycollate-elicited macrophages but not by pyran copolymer- or bacillus Calmette-Guerin-activated macrophages J Exp Med 158 1272 1293 1:CAS:528:DyaL3sXmtFSmtLo%3D 10.1084/jem.158.4.1272 6619735
    • (1983) J Exp Med , vol.158 , pp. 1272-1293
    • Werb, Z.1    Chin, J.R.2
  • 39
    • 1242338958 scopus 로고    scopus 로고
    • Lactate induced excitotoxicity in hippocampal slice cultures
    • DOI 10.1016/j.expneurol.2003.10.015
    • Z Xiang M Yuan GW Hassen M Gampel PJ Bergold 2004 Lactate induced excitotoxicity in hippocampal slice cultures Exp Neurol 186 70 77 1:CAS:528:DC%2BD2cXhsV2gt7c%3D 10.1016/j.expneurol.2003.10.015 14980811 (Pubitemid 38229906)
    • (2004) Experimental Neurology , vol.186 , Issue.1 , pp. 70-77
    • Xiang, Z.1    Yuan, M.2    Hassen, G.W.3    Gampel, M.4    Bergold, P.J.5
  • 40
    • 43049125769 scopus 로고    scopus 로고
    • Macrophage-induced neurotoxicity is mediated by glutamate and attenuated by glutaminase inhibitors and gap junction inhibitors
    • 1:CAS:528:DC%2BD1cXlslaitrc%3D 10.1016/j.lfs.2008.03.010 18452953
    • I Yawata H Takeuchi Y Doi J Liang T Mizuno A Suzumura 2008 Macrophage-induced neurotoxicity is mediated by glutamate and attenuated by glutaminase inhibitors and gap junction inhibitors Life Sci 82 1111 1116 1:CAS:528:DC%2BD1cXlslaitrc%3D 10.1016/j.lfs.2008.03.010 18452953
    • (2008) Life Sci , vol.82 , pp. 1111-1116
    • Yawata, I.1    Takeuchi, H.2    Doi, Y.3    Liang, J.4    Mizuno, T.5    Suzumura, A.6


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