From hydrolytically labile to hydrolytically stable RuII-arene anticancer complexes with carbohydrate-derived co-ligands

Journal of Inorganic Biochemistry

Volumn 105, Issue 2, 2011, Pages 224-231

  Hanif, Muhammad ^a   Meier, Samuel M ^a   Kandioller, Wolfgang ^a   Bytzek, Anna ^a   Hejl, Michaela ^a   Hartinger, Christian G ^a   Nazarov, Alexey A ^a,b   Arion, Vladimir B ^a   Jakupec, Michael A ^a   Dyson, Paul J ^b   Keppler, Bernhard K ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b EPFL   (Switzerland)

Author keywords

Anticancer activity; Aquation; Bioorganometallic chemistry; Carbohydrate ligands; Ruthenium

Indexed keywords

CARBOHYDRATE; CARBOXYLIC ACID; DNA; LIGAND; ORGANOMETALLIC COMPOUND; OXALATO(ETA6 PARA CYMENE)(3,5,6 BICYCLOPHOSPHITE 1,2 O CYCLOHEXYLIDENE ALPHA DEXTRO GLUCOFURANOSIDE)RUTHENIUM; OXALATO(ETA6 PARA CYMENE)(3,5,6 BICYCLOPHOSPHITE 1,2 O ISOPROPYLIDENE ALPHA DEXTRO GLUCOFURANOSIDE)RUTHENIUM; PHOSPHITE; POLYCYCLIC AROMATIC HYDROCARBON; RUTHENIUM COMPLEX; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; MICROEMULSION ELECTROKINETIC CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS; X RAY DIFFRACTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; COORDINATION COMPLEXES; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDROLYSIS; INHIBITORY CONCENTRATION 50; LIGANDS; MALONATES; MOLECULAR CONFORMATION; ORGANOMETALLIC COMPOUNDS; OSMIUM; OXALATES; RUTHENIUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649606532     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2010.10.004     Document Type: Article

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