Metabolization of [Ru(η6-C6H5CF 3)(pta)Cl 2]: A cytotoxic RAPTA-type complex with a strongly electron withdrawing arene ligand

Journal of Biological Inorganic Chemistry

Volumn 15, Issue 6, 2010, Pages 919-927

  Egger, Alexander E ^a,b   Hartinger, Christian G ^a,b   Renfrew, Anna K ^a   Dyson, Paul J ^a  

^a EPFL   (Switzerland)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Anticancer drugs; Bioorganometallic chemistry; DNA interactions; Mass spectrometry; Protein binding

Indexed keywords

CISPLATIN; OLIGONUCLEOTIDE; RUTHENIUM COMPLEX; UBIQUITIN;

ARTICLE; CYTOTOXICITY; DNA DEGRADATION; DRUG BINDING; DRUG CROSS REACTIVITY; DRUG RESPONSE; ELECTROSPRAY; GEL ELECTROPHORESIS; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; ELECTRONS; HYDROCARBONS, AROMATIC; HYDROLYSIS; LIGANDS; OLIGODEOXYRIBONUCLEOTIDES; ORGANOMETALLIC COMPOUNDS; TOLUENE;

EID: 77956201593     PISSN: 09498257     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00775-010-0654-x     Document Type: Article

References (44)

1. Jaouen G (ed) (2006) Bioorganometallics. Wiley, Weinheim
2. Hartinger CG, Dyson PJ (2009) Chem Soc Rev 38:391-401
3. Nguyen A, Vessieres A, Hillard EA, Top S, Pigeon P, Jaouen G (2007) Chimia 61:716-724
4. Strohfeldt K, Tacke M (2008) Chem Soc Rev 37:1174-1187
5. Casini A, Hartinger CG, Gabbiani C, Mini E, Dyson PJ, Keppler BK, Messori L (2008) J Inorg Biochem 102:564-575
6. Rademaker-Lakhai JM, Van Den Bongard D, Pluim D, Beijnen JH, Schellens JHM (2004) Clin Cancer Res 10:3717-3727
7. Hartinger CG, Zorbas-Seifried S, Jakupec MA, Kynast B, Zorbas H, Keppler BK (2006) J Inorg Biochem 100:891-904
8. Hartinger CG, Jakupec MA, Zorbas-Seifried S, Groessl M, Egger A, Berger W, Zorbas H, Dyson PJ, Keppler BK (2008) Chem Biodivers 5:2140-2155
9. Clarke MJ, Zhu F, Frasca DR (1999) Chem Rev 99:2511-2533
10. Allardyce CS, Dyson PJ, Ellis DJ, Heath SL (2001) Chem Commun 1396-1397
11. Ang WH, Dyson PJ (2006) Eur J Inorg Chem 2006 (20):4003-4018
12. Dyson PJ (2007) Chimia 61:698-703
13. Schmid WF, John RO, Mühlgassner G, Heffeter P, Jakupec MA, Galanski M, Berger W, Arion VB, Keppler BK (2007) J Med Chem 50:6343-6355
14. Peacock AFA, Sadler PJ (2008) Chem Asian J 3:1890-1899
15. Mendoza-Ferri MG, Hartinger CG, Eichinger RE, Stolyarova N, Jakupec MA, Nazarov AA, Severin K, Keppler BK (2008) Organometallics 27:2405-2407
16. Mendoza-Ferri MG, Hartinger CG, Mendoza MA, Groessl M, Egger AE, Eichinger RE, Mangrum JB, Farrell NP, Maruszak M, Bednarski PJ, Klein F, Jakupec MA, Nazarov AA, Severin K, Keppler BK (2009) J Med Chem 52:916-925
17. Kandioller W, Hartinger CG, Nazarov AA, Bartel C, Skocic M, Jakupec MA, Arion VB, Keppler BK (2009) Chem Eur J 15:12283-12291
18. Kandioller W, Hartinger CG, Nazarov AA, Kuznetsov ML, John RO, Bartel C, Jakupec MA, Arion VB, Keppler BK (2009) Organometallics 28:4249-4251
19. Scolaro C, Chaplin AB, Hartinger CG, Bergamo A, Cocchietto M, Keppler BK, Sava G, Dyson PJ (2007) Dalton Trans 5065-5072
20. Vock CA, Ang WH, Scolaro C, Phillips AD, Lagopoulos L, Juillerat-Jeanneret L, Sava G, Scopelliti R, Dyson PJ (2007) J Med Chem 50:2166-2175
21. Heffeter P, Jungwirth U, Jakupec M, Hartinger CG, Galanski M, Elbling L, Micksche M, Keppler B, Berger W (2008) Drug Res Update 11:1-16
22. Ang Wee H, Parker Lorien J, De Luca A, Juillerat-Jeanneret L, Morton Craig J, Lo Bello M, Parker Michael W, Dyson Paul J (2009) Angew Chem Int Ed 48:3854-3857
23. Timerbaev AR, Hartinger CG, Aleksenko SS, Keppler BK (2006) Chem Rev 106:2224-2248
24. Hartinger CG, Keppler BK (2007) Electrophoresis 28:3436-3446
25. Groessl M, Hartinger CG, Polec-Pawlak K, Jarosz M, Keppler BK (2008) Electrophoresis 29:2224-2232
26. Hartinger CG, Tsybin YO, Fuchser J, Dyson PJ (2008) Inorg Chem 47:17-19
27. Allardyce CS, Dyson PJ, Coffey J, Johnson N (2002) Rapid Commun Mass Spectrom 16:933-935
28. Pongratz M, Schluga P, Jakupec MA, Arion VB, Hartinger CG, Allmaier G, Keppler BK (2004) J Anal At Spectrom 19:46-51
29. Sulyok M, Hann S, Hartinger CG, Keppler BK, Stingeder G, Koellensperger G (2005) J Anal At Spectrom 20:856-863
30. Khalaila I, Allardyce CS, Verma CS, Dyson PJ (2005) Chembiochem 6:1788-1795
31. Timerbaev AR, Hartinger CG, Keppler BK (2006) Trends Anal Chem 25:868-875
32. Hartinger CG, Ang WH, Casini A, Messori L, Keppler BK, Dyson PJ (2007) J Anal At Spectrom 22:960-967
33. Groessl M, Hartinger CG, Dyson PJ, Keppler BK (2008) J Inorg Biochem 102:1060-1065
34. Egger AE, Hartinger CG, Ben Hamidane H, Tsybin YO, Keppler BK, Dyson PJ (2008) Inorg Chem 47:10626-10633
35. Hartinger CG, Casini A, Duhot C, Tsybin YO, Messori L, Dyson PJ (2008) J Inorg Biochem 102:2136-2141
36. Zhao T, King FL (2009) J Am Soc Mass Spectrom 20:1141-1147
37. Wu Z, Liu Q, Liang X, Yang X, Wang N, Wang X, Sun H, Lu Y, Guo Z (2009) J Biol Inorg Chem 14:1313-1323
38. Renfrew AK, Phillips AD, Tapavicza E, Scopelliti R, Rothlisberger U, Dyson PJ (2009) Organometallics 28:5061-5071
39. Galanski M, Baumgartner C, Meelich K, Arion VB, Fremuth M, Jakupec MA, Schluga P, Hartinger CG, von Keyserlingk NG, Keppler BK (2004) Inorg Chim Acta 357:3237-3244
40. Timerbaev AR, Aleksenko SS, Polec-Pawlak K, Ruzik R, Semenova O, Hartinger CG, Oszwaldowski S, Galanski M, Jarosz M, Keppler BK (2004) Electrophoresis 25:1988-1995
41. Aleksenko SS, Hartinger CG, Semenova O, Meelich K, Timerbaev AR, Keppler BK (2007) J Chromatogr A 1155:218-221
42. Scolaro C, Bergamo A, Brescacin L, Delfino R, Cocchietto M, Laurenczy G, Geldbach TJ, Sava G, Dyson PJ (2005) J Med Chem 48:4161-4171
43. Scolaro C, Hartinger CG, Allardyce CS, Keppler BK, Dyson PJ (2008) J Inorg Biochem 102:1743-1748
44. Hambley TW (2001) J Chem Soc Dalton Trans 2711-2718